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Treatment of HBeAg-negative Chronic Hepatitis B Patients with Nucleos(t)ide Analogues in Burkina Faso

Open Journal of Gastroenterology 2016年第12期6卷 387-396页

作者： kounpiélimé sosthène somda Abdel Karim Sermé Aboubacar Coulibaly Steve Léonce Zoungrana Inès Compaoré Serges Kouamou Damien Ouattara Roger Sombié Alain Bougouma Hepato-Gastroenterology Unit Teaching Hospital Yalgado Ouédraogo Ouagadougou Burkina Faso Gastroenterology Unit UFR/SDS CUP Ouahigouya Burkina Faso

The treatment of chronic hepatitis B (CHB) has increased significantly in recent years. In patients affected by HBeAg-negative CHB, it is necessary to distinguish the inactive carriers (low viral DNA 2000 IU/mL, normal ALT, histological lesions absent or minimal) who does not need treatment, and patients suffering from active CHB (DNA > 2000 IU/ml, high transaminases or fluctuating, significant fibrosis and/or necro-inflammatory activity > 1) who must be treated. The main purpose of treatment is to obtain a long-lasting viral suppression to improve the histological lesions and reduce the risk of evolution towards cirrhosis, liver failure and hepatocellular carcinoma (HCC). It about an indefinite treatment (unless HBsAg seroclearance) expensive and often inaccessible for the majority of our patients. Our study aimed to report the results of four years follow-up of HBeAg-negative patients treated by Nucleos(t)ide analogues (NAs) in Ouagadougou (Burkina Faso). It was a clinical observational study with 133 patients including 95 men;the average age was 41.2 years, completing the criteria of treatment. One hundred and twelve patients were treated by tenofovir (TDF), fourteen by lamivudine and seven co-infected HIV/HBV patients by Atripla® (combination TDF, Emtricitabine and Efavirenz). Virological and biochemical responses were respectively 100% and 94% after 4 years. The rate of HBsAg seroclearance was 1.5%. Twelve of fourteen patients (85.7%) had lamivudine resistance and no cases of resistance in the TDF and Atripla® groups. One co-infected patient developed HCC during treatment. Among patients treated by TDF, two cases of hypophosphatemia were noticed and no case of kidney failure. The treatment of CHB is certainly progressing;updated guidelines (EASL, AASLD) exist but should be adapted to the African context.

关键词： Chronic Hepatitis B HBeAg-negative Nucleos(t)ide Analogues Tenofovir Lamivudine Burkina Faso

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Upper Gastrointestinal Endoscopy at University Hospital Souro Sanou Bobo-Dioulasso (Burkina Faso), about 1022 Cases: Signs and Lesions Observed

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Open Journal of Gastroenterology 2017年第11期7卷 287-296页

作者： Mali Koura Delphine Passolguewindé Zongo Napon Zanga Damien Ouattara kounpiélimé sosthène somda Aboubacar Coulibaly Steve Léonce Zoungrana Christine Couna Somé Bere Sandrine Hema Soudré Euloges Bébar Kamboulé Nogogna Zouré Honoré Zougmoré Inoussa Adama Zampou Appolinaire Sawadogo Gastroenterology Service of the University Hospital Souro Sanou Bobo-Dioulasso Burkina Faso Regional University Hospital of Ouahigouya Ouahigouya Burkina Faso Gastroenterology Service of the University Hospital Yalgado Ouédraogo Ouagadougou Burkina Faso Regional Hospital Kaya Kaya Burkina Faso National Hospital Blaise Compaoré Ouagadougou Burkina Faso

Upper gastrointestinal endoscopy is an excellent way for the diagnosis of high digestive pathology. We report the results of 1022 upper gastrointestinal endoscopy performed at Bobo-Dioulasso CHU-SS, in western Burkina Faso (West Africa). The aim of this study was to document the indications and lesions found in high endoscopy at the CHUSS. Patients and Methods: It was a cross-sectional study, prospective to describe the results of gastroscopy performed from 1st January 2015 to 30th June 2016 at the digestive endoscopy unit CHU-Souro Sanou Bobo-Dioulasso. Results: In the study period, 1022 upper gastrointestinal endoscopies were performed. The main indications were: The epigastric pain (48.6%), portal hypertension (10.7%) and gastroesophageal reflux disease (9.9%). The pathologies observed were dominated by gastropathies (48.11%), peptic ulcer (27%) and oesophageal varices (9.68%). Epigastralgias were the main circumstance for the discovery of: 52.3% of esophagitis, 49.17% of gastropathies and 46.12% of peptic ulcers. Histopathologically, the results of the 236 biopsies were dominated by gastritis (88.56%), stomach cancers (7.63%) and esophagus (3.81%). Conclusion: The main indication of the UGIE at the CHU-Souro Sanou in Bobo-Dioulasso was epigastralgia. The pathologies observed were dominated by gastropathy, esophagitis and PUD.

关键词： Upper Gastrointestinal Endoscopic Indications Lesions Observed Bobo-Dioulasso

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Estimating the Input Power of a Power Plant Using the Efficiency of the Inverter

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Smart Grid and Renewable Energy 2024年第3期15卷 99-106页

作者： Toussaint Tilado Guingane sosthène Tassembedo Eric Korsaga Dominique Bonkoungou Zacharie Koalaga François Zougmore Physics UFR/SEA Materials and Environment Laboratory (LAME) Pr. Joseph Ki ZERBO University Ouagadougou Burkina Faso Physics UFR/ST Science and Technology Laboratory (LaST) Thomas SANKARA University Ouagadougou Burkina Faso

The study focuses on estimating the input power of a power plant from available data, using the theoretical inverter efficiency as the key parameter. The paper addresses the problem of missing data in power generation systems and proposes an approach based on the efficiency formula widely documented in the literature. In the absence of input data, this method makes it possible to estimate the plant’s input power using data extracted from the site, in particular that provided by the Ministry of the Environment. The importance of this study lies in the need to accurately determine the input power in order to assess the overall performance of the energy system.

关键词： Estimation Data Missing Input Power Efficiency Inverter

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Novel N-doped multichannel carbon nanofiber architecture with porous CoS nanoprisms for high-performance potassium-ion batteries

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Rare Metals 2024年第3期43卷 971-983页

作者： Jae Bong lim Seung-Keun Park Department of Advanced Materials Engineering Chung-Ang UniversityGyeonggi-do17546Republic of Korea Department of Intelligence Energy and Industry Chung-Ang UniversitySeoul06974Republic of Korea Western Seoul Center Korea Basic Science InstituteSeoul03759Republic of Korea

Potassium-ion batteries(PIBs)have gained significant attention as an alternative to lithium-ion batteries(LIBs)due to the abundance of potassium(K)and low ***,the difficulty in finding appropriate electrode materials that can efficiently store the larger K ions has hindered their practical ***,we report a novel anode material,N-doped multichannel carbon nanofibers embedded with porous CoS nanoprisms(CSP@NMCNF),for high-performance *** CSP@NMCNF was synthesized using a two-step strategy comprising of the electrospinning of Co acetate hydroxide nanoprism/binary polymer blend and a subsequent heat *** porous CoS nanoprisms with an anisotropic morphology were well aligned along the length axis of the N-doped multichannel carbon nanofibers,thus ensuring their structural stability during the repeated charge-discharge *** addition,numerous pores facilitated the transport of electrons and ***,the CSP@NMCNF anode exhibited excellent electrochemical performance,delivering a high specific capacity of 368 mAh·g^(-1)at 0.5 A·g^(-1)after 200 cycles and excellent rate capability(232 mAh·g^(-1)at 2.0 A·g^(-1)).

关键词： K-ion batteries Cobalt sulfide Multichannel structured composite Electrospinning Nanoprism Porous structure

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A short overview of the lead iodide residue impact and regulation strategies in perovskite solar cells

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Journal of Energy Chemistry 2024年第3期90卷 504-510,I0012页

作者： Eng Liang lim Zhanhua Wei Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021FujianChina

Lead iodide(PbI2) is a vital raw material for preparing perovskite solar cells(PSCs),and it not only takes part in forming the light absorption layer but also remains in the grain boundary as a *** other words,the PbI2 content in the precursor and as formed film will affect the efficiency and stability of the *** moderate residual PbI2,it passivates the bulk/surface defects of perovskite,reduces the interfacial recombination,promotes the perovskite stability,minimizes the device hysteresis,and so *** PbI2 residue will reduce the interfacial passivation effect and device *** addition to facilitating the non-radiative recombination,over PbI2 residue can also lead to electronic insulation in the grain boundary and deteriorate the device ***,the impact and regulation of PbI2 residue on the device performance and stability is still not fully ***,a comprehensive and detailed review is presented by discussing the PbI2 residue impact and its regulation strategies(i.e., elimination,facilitation and conversion of the residue PbI2) to manipulate the PbI2 content,distribution and ***,we also show future outlooks in this field,with an aim to help further the progression of high-efficiency and stable PSCs.

关键词： Lead iodide Residue Regulation Perovskite solar cells Efficiency Stability

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Reconfigurable transmissive metasurface with a combination of scissor and rotation actuators for independently controlling beam scanning and polarization conversion

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Microsystems & Nanoengineering 2024年第2期10卷 173-180页

作者： Chhunheng Lor Ratanak Phon Sungjoon lim Intelligent Semiconductor Engineering Chung-Ang UniversityHeukseok-DongDongjak-GuSeoul06974Republic of Korea School of Electrical and Electronic Engineering Chung-Ang UniversityHeukseok-DongDongjak-GuSeoul06974Republic of Korea

Polarization conversion and beam scanning metasurfaces are commonly used to reduce polarization mismatch and direct electromagnetic waves in a specific direction to improve the strength of a wireless ***,identifying suitable active and mechanically reconfigurable metasurfaces for polarization conversion and beam scanning is a considerable challenge,and the reported metasurfaces have narrow scanning ranges,are expensive,and cannot be independently *** this paper,we propose a reconfigurable transmissive metasurface combined with a scissor and rotation actuator for independently controlling beam scanning and polarization conversion *** metasurface is constructed with rotatable unit cells(UCs)that can switch the polarization state between right-handed(RHCP)and left-handed circular polarization(LHCP)by flipping the UCs to reverse their phase ***,independent beam scanning is achieved using the scissor actuator to linearly change the distance between the *** and experimental results confirm that the proposed metasurface can perform beam scanning in the range of 28°for both the positive and negative regions of a radiation pattern(RHCP and LHCP beams)at an operational frequency of 10.5 GHz.

关键词： beam rotation controlling

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Detection and defending the XSS attack using novel hybrid stacking ensemble learning-based DNN approach

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Digital Communications and networks 2024年第3期10卷 716-727页

作者： Muralitharan Krishnan Yongdo lim Seethalakshmi Perumal Gayathri Palanisamy IMS Sungkyunkwan UniversitySuwon16419South Korea Department of Mathematics Sungkyunkwan UniversitySuwon16419South Korea Department of Information Technology Madras Institute of TechnologyChennaiIndia Department of Mathematics PSG College of Arts and ScienceTamilnaduIndia

Existing web-based security applications have failed in many situations due to the great intelligence of *** web applications,Cross-Site Scripting(XSS)is one of the dangerous assaults experienced while modifying an organization's or user's *** avoid these security challenges,this article proposes a novel,all-encompassing combination of machine learning(NB,SVM,k-NN)and deep learning(RNN,CNN,LSTM)frameworks for detecting and defending against XSS attacks with high accuracy and *** on the representation,a novel idea for merging stacking ensemble with web applications,termed“hybrid stacking”,is *** order to implement the aforementioned methods,four distinct datasets,each of which contains both safe and unsafe content,are *** hybrid detection method can adaptively identify the attacks from the URL,and the defense mechanism inherits the advantages of URL encoding with dictionary-based mapping to improve prediction accuracy,accelerate the training process,and effectively remove the unsafe JScript/JavaScript keywords from the *** simulation results show that the proposed hybrid model is more efficient than the existing detection *** produces more than 99.5%accurate XSS attack classification results(accuracy,precision,recall,f1_score,and Receiver Operating Characteristic(ROC))and is highly resistant to XSS *** order to ensure the security of the server's information,the proposed hybrid approach is demonstrated in a real-time environment.

关键词： Machine learning Deep neural networks Classification Stacking ensemble XSS attack URL encoding JScript/JavaScript Web security

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Alterations of protein homeostasis in Alzheimer's disease:beyond Procrustean bed of endoplasmic reticulum stress and unfolded protein response

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neural Regeneration Research 2024年第8期19卷 1645-1646页

作者： Dmitry lim Alexei Verkhratsky Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Center for neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain&Department of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Department of Stem Cell Biology State Research Institute Centre for Innovative MedicineVilniusLithuania Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina

Alzheimer’s disease(AD)is a major age-related form of dementia with a number of cases exponentially growing,causing enormous social and economic impact on individuals and *** hallmarks of AD,evident in postmortem AD brains,include a massive loss of the grey matter in the neocortex,extracellular deposition of amyloid-β(Aβ)in the form of senile plaques and cerebrovascular amyloid angiopathy,and intra-neuronal accumulation of neurofibrillary tangles,formed by hyper-phosphorylated tau protein.

关键词： Alzheimer homeostasis cortex

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A review of understanding electrocatalytic reactions in energy conversion and energy storage systems via scanning electrochemical microscopy

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Journal of Energy Chemistry 2024年第4期91卷 155-177页

作者： Jihye Park Jong Hwan lim Jin-Hyuk Kang Jiheon lim Ho Won Jang Hosun Shin Sun Hwa Park Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Material Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Applied Measurement Science University of Science and TechnologyDaejeon 34113Republic of Korea

To address climate change and promote environmental sustainability,electrochemical energy conversion and storage systems emerge as promising alternative to fossil fuels,catering to the escalating demand for *** optimal energy efficiency and cost competitiveness in these systems requires the strategic design of electrocatalysts,coupled with a thorough comprehension of the underlying mechanisms and degradation behavior occurring during the electrocatalysis *** electrochemical microscopy(SECM),an analytical technique for studying surface electrochemically,stands out as a powerful tool offering electrochemical *** possesses remarkable spatiotemporal resolution,enabling the visualization of the localized electrochemical activity and surface *** review compiles crucial research findings and recent breakthroughs in electrocatalytic processes utilizing the SECM methodology,specifically focusing on applications in electrolysis,fuel cells,and metal–oxygen batteries within the realm of energy conversion and storage *** with an overview of each energy system,the review introduces the fundamental principles of SECM,and aiming to provide new perspectives and broadening the scope of applied research by describing the major research categories within SECM.

关键词： Scanning electrochemical microscopy Electrocatalyst Electrocatalysis Water splitting Fuel cell Metal-oxygen battery

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Probing the endoplasmic reticulummitochondria interaction in Alzheimer's disease:searching far and wide

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neural Regeneration Research 2024年第10期19卷 2103-2104页

作者： Giulia Dematteis Laura Tapella Dmitry lim Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly

Alzheimer's disease(AD)is the most frequent,form of dementia in elderly people and is an incurable disease with an exponentially growing number of *** deposition of amyloid-β(Aβ)plaques and intraneuronal formation o... 详细信息

关键词： Alzheimer Aβ reticulum

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