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HBV vaccine efficacy and detection and genotyping of vaccineé asymptomatic breakthrough HBV infection in Egypt

World Journal of Hepatology 2011年第6期3卷 147-156页

作者： Eman AE Abushady Magda MA Gameel John D Klena Salwa F Ahmed kouka se abdel-wahab Sanya M Fahmy Microbiology department Faculty of Medicine Nourthern Border UniversityArar 1321Saudi Arabia Microbiology department Faculty of MedicineAL-Azhar UniversityCairo R695-11651Egypt Molecular Epidemiology unit Clinical Trials ProgramNAMRU-3Cairo 11157Egypt Pediatric department Faculty of MedicineAL-Azhar UniversityCairo R695-11651Egypt

AIM:To evaluate the impact of mass vaccination against the hepatitis B virus (HBV) in Egypt,and to search for vaccinee asymptomatic breakthrough HBV infection and its ***:seven hundred serum samples from vaccinated children and adults (aged 2-47 years) were used for quantitative and qualitative detection of HBsAb by *** hundred and sixty serum samples representing undetectable or low or high HBsAb were screened for markers of active HBV infection (HBsAg,HBcAb (IgG) and HBeAb by ELISA,plus HBsAg by AxSYM) and HBV-DNA genotyping by nested multiplex PCR and by DNA ***:It was found that 65% of children aged 2-4 years,and 20.5% aged 4-13 years,as well as 45% adults were good responders to HBV vaccination mounting protective level *** responders were 28%,59.5% and 34%,and non-responders were 7%,20% and 21% respectively,in the three studied *** of asymptomatic HBV infections were HBsAg detected by ELISA in 2.5% vs 11.39% by *** markers were HBcAb (IgG) in 1.38%,HBeAb in 0.83%,and HBV-DNA in 7.8%.All had HBV genotype E ***:It is concluded that HBV vaccine is efficient in controlling HBV infection among children and *** vaccine breakthrough infection was by HBV genotype E.A booster dose of vaccine is recommended,probably four years after initial vaccination.

关键词： HBV vaccine evaluation Egyptain children Adults Genotype E vaccine escape HBV

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