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Aspartate aminotransferase-immunoglobulin complexes in patients with chronic liver disease

World Journal of Gastroenterology 2005年第10期11卷 1529-1531页

作者： Masahiko Tameda Katsuya Shiraki Kinue Ooi koujirou takase Yoshitane Kosaka Tsutomu Nobori Yukihiko Tameda Department of Clinical Laboratory Medicine The First Department of Internal Medicine

AIM: To determine the complex of AST and immunoglobulin and to investigate its clinical significance in patients with liver ***: The complex of AST and immunoglobulin was determined by encounter immunoelectrophoresis and its clinical significance was investigated in 128 patients with liver ***: AST was bound to immunoglobulin of antiimmunoglobulin A (IgA) class, but any binding to antiimmunoglobulin G and anti-immunoglobulin M classes was not observed. Although the incidence of ASTimmunoglobulin complex was 41.8% in chronic hepatitis (CH), the incidences in liver cirrhosis and hepatocellular carcinoma were 62.2 and 90.0%, respectively. In alcoholic liver disease with high level of serum IgA, the incidence of the complex was 66.7%, which was higher than that in CH. The ratio of binding to lambda-chain of IgA was higher than that to kappa-chain of IgA. The serum level of IgA and the ratio of AST/alanine aminotransferase (ALT) were significantly higher in patients with AST-IgA complex than in those without ***: These results suggest that AST-IgA complex in patients with progressive liver diseases and alcoholic liver injury can lead to elevation of the ratio of AST/ALT.

关键词： Alcoholic liver disease Aspartate aminot-ransferase AST/ALT Chronic hepatitis Chronic liver disease Hepatocellular carcinoma Immunoglobulin Liver cirrhosis

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