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Preliminary study of photodynamic diagnosis using 5-aminolevulinic acid in gastric and colorectal tumors

World Journal of Gastroenterology 2015年第21期21卷 6706-6712页

作者： Munetaka Nakamura Jun Nishikawa kouichi hamabe Atsushi Goto Junichi Nishimura Hiroaki Shibata Misato Nagao Sho Sasaki Shinichi Hashimoto Takeshi Okamoto Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine

AIM:To investigate the utility of photodynamic diagnosis(PDD) using 5-aminolevulinic acid(5-ALA) to detect gastric/colorectal ***:This prospective single-center study investigated inter-subject variability in patients with early-stage gastric/colorectal tumor indicated for endoscopic *** were patients with gastric or colorectal tumors who had undergone endoscopic resection between November 2012 and November *** criteria included age 20-80 years,either sex,and provision of informed *** were orally administered 20 mg/kg of 5-ALA enteric-coated capsules(SBI ALApromo Co.,Tokyo,Japan).Administration of5-ALA was followed by endoscopic resection of gastric or colorectal tumors,and the resected specimens were examined using a video autofluorescence processor and a fluorescence endoscope(SAFE-3000 and EB-1970 AK,respectively;Pentax,Tokyo,Japan).The primary endpoint was the presence of fluorescence in ***,macroscopic,and histopathologic findings of tumors were *** also evaluated adverse events of the present procedure as a secondary endpoint and examined each patient for the presence of known adverse effects of 5-ALA,namely,hematocytopenia,liver dysfunction,hypotension,nausea,and ***:We enrolled 10 patients(7 men,3 women)(n = 13 lesions:10 gastric/3 colorectal tumors).Fluorescence was detected in 7/13(53.8%) *** significant differences in sex(male:55.6%vs female:50.5%,P = 1.00),age(67.1 ± 1.9 years vs 65.0 ±2.0 years,P= 0.45),tumor color(reddish:60.0%vs discolored:33.3%,P = 0.56),tumor diameter(15.0± 2.1 mm vs 14.2 ± 2.3 mm,P= 0.80),macroscopic type(protruded:70.0%vs depressed 0%,P = 0.07),histologic type(differentiated type:58.3%vs 0%,P = 0.46),invasion depth(mucosal layer:55.6%vs submucosal layer:33.3%,P = 1.00),lymphatic invasion(present:33.3%vs absent:50.0%,P= 1.00),venous invasion(present:0%vs absent:54.5%,P= 1.00) or procedure time of endoscopic resection(36.3 ± 8.3 min v

关键词： Photodynamic diagnosis 5-aminolevulinicacid Protoporphyrin IX, Gastric tumor Colorectaltumor

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