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Exploring Passive Exoskeleton-Induced Changes in Lumbar Muscle Activity

Open Journal of Therapy and Rehabilitation 2023年第4期11卷 149-157页

作者： Ryo Fujitani Hiroko Kawasaki Mika Suzuki Shogo Sakai Souma Hori Ryoga Muranishi Shinichi Noguchi Takumi Jiroumaru Michio Wachi kouhei okuyama Department of Physical Therapy Biwako Professional University of Rehabilitation Higashiomi Japan Department of Physical Therapy Bukkyo University Kyoto Japan

Purpose: The purpose of this study was to evaluate the effect of using a passive exoskeleton on lumbar muscle activity during lifting movements, and to determine whether muscle activity remains altered after exoskeleton removal. This study sought to identify the potential risks and benefits associated with the use of passive exoskeletons for the prevention and treatment of low back pain. Methods: Eighteen healthy adult participants lifted a 10 kg suitcase while wearing a passive exoskeleton. Muscle activity and postures were measured during lifting and before, during, and after exoskeleton use. This study examined whether the reduced muscle activity observed during exoskeleton use persisted after exoskeleton removal. Muscle activity was assessed using electromyography and postures were recorded using reflective markers and a camera. Results: The study found that Lumbar muscle activity decreased significantly (approximately 40%) during exoskeleton use compared to that without exoskeleton use. Importantly, lumbar muscle activity remained low after exoskeleton removal, at levels similar to those observed during exoskeleton use. This suggests that individuals adapted to the exoskeleton support and maintained altered muscle control, even without the exoskeleton. Conclusion: This study demonstrates that passive exoskeletons significantly reduce lumbar muscle activity during lifting tasks, and that this altered muscle control persists after exoskeleton removal. These findings contribute to the understanding of the risks and benefits of passive exoskeletons, potentially aiding their development and informing their use in the prevention and treatment of low back pain.

关键词： Passive Exoskeleton Low Back Pain Muscle Activity Adaptation

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Disturbed passage of jejunal limb near esophageal hiatus after overlapped esophagojejunostomy following laparoscopic total gastrectomy

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1285-1296页

作者： Hirokazu Noshiro Keiichiro okuyama Yukie Yoda Department of Surgery Saga University Faculty of MedicineSaga 849-8501Japan Department of Surgery Saga UniversitySaga 849-8501Japan

BACKGROUND Overlapped esophagojejunostomy(OEJ) is a secure purely laparoscopic reconstruction after laparoscopic total gastrectomy(LTG). However, long-term surgical results have not been documented *** In this paper, we report unusual patients who manifested jejunal limb stricture near the esophageal hiatus without anastomotic stenosis during long-term observation after *** From April 2009 until May 2020, we retrospectively reviewed 211 patients underwent LTG following by OEJ for gastric carcinoma and took a standard surveillance program. We aimed to characterize a novel complicated disorder observed in these patients to assist treatment and *** Five patients(2.4%) had unusual jejunal limb stricture after LTG and OEJ,occurring at a mean of 10 mo after initial radical LTG. All five patients had disturbed oral intake and marked weight loss, and two had aspiration *** diagnostic modalities and intraoperative findings in each patient revealed an intact anastomosis, bent or tortuous jejunal limb resulting from loose fibrous adhesions on the left crus at the esophageal hiatus and no cancer recurrence. All five patients were successfully treated by reoperation for adhesiolysis, division of the left crus and rearrangement of the jejunal *** Disturbed passage through the jejunal limb near the hiatus can occur after some types of OEJ following LTG. We speculate that it may result from a short remnant esophagus, excessive mobilization of the jejunal limb that permits bending or tortuosity and adhesions on the left crus at the hiatus. Prevention for this complication is possible during the original LTG procedure.

关键词： Laparoscopic total gastrectomy Overlapped esophagojejunostomy Anastomotic stenosis Adhesiolysis Gastric carcinoma

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Rotation,Translation and Scale Invariant Sign Word Recognition Using Deep Learning

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Computer Systems Science & Engineering 2023年第3期44卷 2521-2536页

作者： Abu Saleh Musa Miah Jungpil Shin Md.Al Mehedi Hasan Md Abdur Rahim Yuichi okuyama School of Computer Science and Engineering The University of AizuAizuwakamatsuFukushima965-8580Japan Department of Computer Science and Engineering Pabna University of Science and TechnologyPabnaBangladesh

Communication between people with disabilities and people who do not understand sign language is a growing social need and can be a tedious *** of the main functions of sign language is to communicate with each other through hand *** of hand gestures has become an important challenge for the recognition of sign *** are many existing models that can produce a good accuracy,but if the model test with rotated or translated images,they may face some difficulties to make good performance *** resolve these challenges of hand gesture recognition,we proposed a Rotation,Translation and Scale-invariant sign word recognition system using a convolu-tional neural network(CNN).We have followed three steps in our work:rotated,translated and scaled(RTS)version dataset generation,gesture segmentation,and sign word ***,we have enlarged a benchmark dataset of 20 sign words by making different amounts of Rotation,Translation and Scale of the ori-ginal images to create the RTS version *** we have applied the gesture segmentation *** segmentation consists of three levels,i)Otsu Thresholding with YCbCr,ii)Morphological analysis:dilation through opening morphology and iii)Watershed ***,our designed CNN model has been trained to classify the hand gesture as well as the sign *** model has been evaluated using the twenty sign word dataset,five sign word dataset and the RTS version of these *** achieved 99.30%accuracy from the twenty sign word dataset evaluation,99.10%accuracy from the RTS version of the twenty sign word evolution,100%accuracy from thefive sign word dataset evaluation,and 98.00%accuracy from the RTS versionfive sign word dataset ***,the influence of our model exists in competitive results with state-of-the-art methods in sign word recognition.

关键词： Sign word recognition convolution neural network(cnn) rotation translation and scaling(rts) otsu segmentation

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Discontinuous-Galerkin-Based Analysis of Traffic Flow Model Connected with Multi-Agent Traffic Model

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Computer Modeling in Engineering & Sciences 2021年第9期128卷 949-965页

作者： Rina okuyama Naoto Mitsume Hideki Fujii Hideaki Uchida The University of Tokyo 7-3-1 HongoBunkyo-kuTokyo113-8656Japan University of Tsukuba 1-1-1 TennodaiTsukuba CityIbaraki305-8577Japan

As the number of automobiles continues to increase year after year,the associated problem of traffic congestion has become a serious societal *** to mitigate this problem have considered methods for optimizing traffic volumes in wide-area road networks,and traffic-flow simulation has become a focus of interest as a technique for advance characterization of such *** of models commonly used for traffic-flow simulations include microscopic models based on discrete vehicle representations,macroscopic models that describe entire traffic-flow systems in terms of average vehicle densities and velocities,and mesoscopic models and hybrid(or multiscale)models incorporating both microscopic and macroscopic *** traffic-flow simulations are designed to model traffic systems under a variety of conditions,their underlyingmodelsmust be capable of rapidly capturing the consequences of minor variations in operating *** other words,the computation speed of macroscopic models and the precise representation of microscopic models are needed ***,in this study we propose a multiscale model that combines a microscopic model—for detailed analysis of subregions containing traffic congestion bottlenecks or other localized phenomena of interest-with a macroscopic model enabling simulation of wide target areas at a modest computational *** addition,to ensure analytical stability with robustness in the presence of discontinuities,we discretize our macroscopic model using a discontinuous Galerkin finite element method(DGFEM),while to conjoin microscopic and macroscopic models,we use a generating/absorbing sponge layer,a technique widely used for numerical analysis of long-wavelength phenomena in shallow water,to enable traffic-flow simulations with stable input and output regions.

关键词： Discontinuous Galerkin finite element method multiscale modeling traffic flow

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Influence of Housing and Urban Development on Debris Flow Flooding and Deposition

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Journal of Mountain Science 2013年第2期10卷 273-280页

作者： Kana NAKATANI Yuki okuyama Yuji HASEGAWA Yoshifumi SATOFUKA Takahisa MIZUYAMA Graduate School of Agriculture Kyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto City606-8502Japan National Institute for Land and Infrastructure Management AsahiTsukuba CityIbaraki305-0804Japan Civil Engineering Research Laboratory 904-1 TohigashiTsukuba CityIbaraki300-2633Japan Department of Civil Engineering Ritsumeikan University1-1-1 Noji-higashiKusatsu CityShiga525-8577Japan

Debris flows form deposits when they reach an alluvial fan until they eventually ***,houses located in the alluvial fan might affect the debris flow flooding and deposition *** previous studies have considered the effects of houses on debris flow flooding and *** study conducted model experiments and numerical simulations using the Kanako2D debris flow simulator to determine the influence of houses on debris flow flooding and *** model experiments showed that when houses are present,the debris flow spreads widely in the cross direction immediately upstream of the houses,especially when the flow discharge is large or the grain size is *** located in the alluvial fan also influence the deposition *** presence of houses led to flooding and deposition damage in some places and reduced the damage in *** simulation also demonstrated the influence of *** the model experiment and the simulation showed that houses change the flooding and deposition areas.

关键词：沉积过程泥石流洪水城市发展住房模型实验冲积扇可能影响

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基于转录组测序和网络药理学探究青蒿琥酯干预U87和U251脑胶质瘤细胞的药效差异机制

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药学学报 2023年第6期58卷 1475-1483页

作者：李涛毛霞张彦琼林娜 SATO Takashi MIZUNO Koji okuyama Katsuki 黄丰云南中医药大学中药学院云南昆明650500 中国中医科学院中药研究所北京100700 东京药科大学生物化学系东京都八王子市192-0392

青蒿琥酯具有干预脑胶质瘤的潜能,但其药理作用机制尚不明确。本研究首先基于U87和U251两种人源脑胶质瘤细胞,探究青蒿琥酯对细胞活性、增殖和凋亡的影响,发现青蒿琥酯对U87细胞活性和增殖能力的抑制作用强于对U251细胞;Hoechst和TUNEL... 详细信息

青蒿琥酯具有干预脑胶质瘤的潜能,但其药理作用机制尚不明确。本研究首先基于U87和U251两种人源脑胶质瘤细胞,探究青蒿琥酯对细胞活性、增殖和凋亡的影响,发现青蒿琥酯对U87细胞活性和增殖能力的抑制作用强于对U251细胞;Hoechst和TUNEL细胞凋亡染色实验也发现,青蒿琥酯可以显著促进U87细胞的凋亡(P <0.05),而仅大剂量的青蒿琥酯可促进U251细胞的凋亡(P <0.01)。接着,利用青蒿琥酯处理前后的U87和U251细胞裂解液,通过转录组测序检测和差异数据分析,分别获得青蒿琥酯敏感性和非敏感性细胞株的差异基因集以及青蒿琥酯效应相关基因集,旨在挖掘青蒿琥酯对两类细胞敏感性不一的分子机制。通过构建上述各对比组差异基因互作网络和计算网络拓扑特征值,筛选药效相关的关键网络靶标;生物功能富集分析结果表明,上述关键网络靶标显著富集于多条与脑胶质瘤病理环节相关的信号通路,其中,与细胞凋亡相关的转录激活因子4 (ATF4)-DNA损伤诱导转录因子3 (DDIT3)-聚腺苷二磷酸核糖聚合酶1 (PARP1)信号轴的富集显著性最高。分子对接结果也表明,青蒿琥酯与ATF4和DDIT3均具有较好的结合能力。本研究初步揭示了青蒿琥酯干预U87脑胶质瘤细胞的潜能与其抑制肿瘤细胞内异常活化的ATF4-DDIT3-PARP1信号轴,进而诱导细胞凋亡有关;同时也表明了PARP1可能是U251细胞对青蒿琥酯产生耐药的重要靶标。相关结果为青蒿琥酯治疗脑胶质瘤,以及解决脑胶质瘤治疗药物耐药的现状提供了新的实验依据。

关键词：青蒿琥酯脑胶质瘤转录组测序网络药理学药理机制

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Leakage behavior and distortion of the hysteresis loop in ferroelectric thin films

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Science China(Technological Sciences) 1997年第2期40卷 126-134页

作者：郑立荣林成鲁许华平邹世昌 Masanori okuyama Shanghai Institute of Metallurgy Chinese Academy of Sciences Shanghai 200050 China Department of Electrical Engineering Faculty of Engineering SciencesOsaka UniversityOsaka 560Japan

Leakage behavior and distortion of the polarization hysteresis loop in ferroelectric thin films are analyzed by applying a totally depleted asymmetric back-to-back Schottky model, with the Pt/Pb(Zr, Ti)O3/Pt ( Pt/ PZT/Pt) sandwich structural thin film capacitor as an example. Some interesting phenomena resulting from the asymmetric interfaces, such as the leakage current level, the flat-band voltage, the disclosure of the hysteresis loop, and the change in the remanent polarization and coercive field, as well as the vertical drift of the polarization hysteresis loop, are discussed in detail. The calculated results are also verified with experiments.

关键词： ferroelectric thin film Schottky barrier leakage hysteresis loop.

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基于DNA甲基化测序技术研究青蒿琥酯干预脑胶质瘤的分子机制

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中草药 2023年第6期54卷 1814-1824页

作者：闫向英毛霞李涛 Koji Mizuno Katsuki okuyama 林娜张彦琼 Takashi Sato 中国中医科学院中药研究所北京100700 东京药科大学生物化学系东京192-0392

目的探究青蒿琥酯干预胶质母细胞瘤(glioblastoma,GBM)的药效及其潜在分子机制。方法采用Cell TiterBlue检测青蒿琥酯对U87和U2512种人源胶质母细胞瘤细胞活性和增殖的影响;流式细胞术检测青蒿琥酯对2种细胞周期的调节作用;采用q RT-PCR... 详细信息

目的探究青蒿琥酯干预胶质母细胞瘤(glioblastoma,GBM)的药效及其潜在分子机制。方法采用Cell TiterBlue检测青蒿琥酯对U87和U2512种人源胶质母细胞瘤细胞活性和增殖的影响;流式细胞术检测青蒿琥酯对2种细胞周期的调节作用;采用q RT-PCR和Western blotting检测青蒿琥酯对2种细胞自噬水平的影响。采用DNA甲基化联合网络药理学从表观遗传学层面研究青蒿琥酯干预GBM的靶标基因,并建立蛋白质-蛋白质相互作用网络,通过计算网络中各节点的网络拓扑特征值,筛选出青蒿琥酯干预GBM的核心靶点并进行生物功能富集分析;采用AutoDock v4.2.6和Auto Dock Vina v1.2.0软件开展分子对接虚拟计算,考察青蒿琥酯与其候选关键靶点的结合能力,并采用Western blotting验证青蒿琥酯对2种脑胶质瘤细胞中关键靶点表达的影响。结果青蒿琥酯可显著抑制U87细胞的活性和增殖(P<0.05、0.01、0.001),而对U251细胞的药效不显著;高剂量青蒿琥酯可影响2种细胞周期分布;高剂量青蒿琥酯可显著提高U87细胞中3种自噬标志分子[自噬关键分子酵母Atg6同系物(ATG6 autophagy related 6 homolog,Beclin1)、泛素结合蛋白(ubiquitin-binding protein,p62)、微管相关蛋白1轻链3(microtubule-associated protein 1 light chain 3,LC3)]的m RNA表达水平(P<0.001),而仅高剂量青蒿琥酯升高U251细胞中p62的m RNA表达水平(P<0.05);低、中、高剂量青蒿琥酯可显著提高U87细胞中Beclin1、p62、LC3B蛋白表达水平(P<0.05、0.01),仅中、高剂量青蒿琥酯可以影响U251细胞中Beclin1、p62、LC3B蛋白表达。利用给药前后的U87与U251细胞进行DNA甲基化测序与网络药理学整合分析,在获得青蒿琥酯敏感型和耐药型脑胶质瘤细胞的差异基因集,以及青蒿琥酯干预2种细胞效应基因集的基础上,发现其干预2类脑胶质瘤细胞的关键网络靶标共同参与GBM恶性进展密切相关的血小板衍生生长因子受体α(platelet derived growth factor receptorα,PDGFRA)-大鼠肉瘤基因(rat sarcoma viral oncogene homolog,RAS)-B-Raf原癌基因(B-Raf proto-oncogene,BRAF)-丝裂原活化蛋白激酶激酶(mitogenactivated protein kinase kinase,MEK)-细胞外信号调节激酶(extracellular signal regulated kinase,ERK)通路,且青蒿琥酯与其直接靶标(PDGFRA、BRAF)具有较强的亲和力。Western blotting实验证实青蒿琥酯可以抑制U87和U251细胞中关键靶点PDGFRA和BRAF蛋白的表达(P<0.05、0.01、0.001)。结论青蒿琥酯可能通过靶向调控PDGFRA-RAS-BRAF-MEKERK信号通路,从而抑制GBM细胞的生长和扩散,为青蒿琥酯治疗GBM提供了体外实验依据,也为解决临床抗肿瘤药物的耐药问题提供了新思路和新方法。

关键词：青蒿琥酯胶质母细胞瘤 DNA甲基化分析耐药 PDGFRA-RAS-BRAF-MEK-ERK信号通路

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Improving Effect of Acetic Acid Bacteria (Gluconacetobacter hansenii GK-1) on sIgA and Physical Conditions in Healthy People: Double-Blinded Placebo-Controlled Study

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Food and Nutrition Sciences 2022年第6期13卷 541-557页

作者： Soyogu Yamashita Mariko Oe Mamoru Kimura Yohei okuyama Satoshi Seino Daichi Kajiyama Ryosuke Matsuoka Yasunobu Masuda Keiichi Tsukinoki R&D Division Kewpie Corporation Tokyo Japan Kanagawa Dental University Kanagawa Japan

It is known that the consumption of bacteria such as lactobacilli and bifidobacteria has beneficial effects on human immune function. Most of them are Gram-positive bacteria, and there are few reports on Gram-negative bacteria. In this study, we evaluated the effects of intake of Gluconacetobacter hansenii GK-1 (GK-1), Gram-negative acetic acid bacteria, for 12 weeks on physical condition and immune indices. We conducted a randomized, double-blind, placebo-controlled, parallel-group study in 100 healthy adults. The subjects were randomized into the GK-1 and the placebo groups. The diary-administered physical condition survey was conducted during the study period. The evaluation of salivary sIgA levels, NK-cell activity, and serum IFN-γ levels and quality of life survey was conducted before, in 6 weeks, and 12 weeks after the start of ingestion. Based on the physical condition survey, the cumulative onset-days of symptoms were significantly suppressed in the GK-1 group compared to the placebo group regarding the evaluation of 13 symptoms related to immunity, every 3 weeks. Additionally, salivary sIgA levels per hour were significantly increased in the GK-1 group compared with the placebo group at 6 and 12 weeks. Despite no significant differences in the NK-cell activity, serum IFN-γ levels or quality of life survey between the groups. Serum IFN-γ levels in the GK-1 group were significantly elevated at 12 weeks after the start of ingestion compared with those before ingestion. In conclusion, intake of GK-1 was shown to increase salivary sIgA levels and improve physical condition. This suggested that oral intake of GK-1 may help maintain the immune system.

关键词： Acetic Acid Bacteria Gram-Negative Bacteria Gluconacetobacter hansenii GK-1 (GK-1) Functional Food Immune

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Design, Synthesis, Crystal Structure and Photophysical Properties of New Oxadiazole Extended Viologen Fluorophore

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Crystal Structure Theory and Applications 2021年第2期10卷 27-37页

作者： Tetsuji Moriguchi Masataka okuyama Venkataprasad Jalli Department of Applied Chemistry Faculty of Engineering Kyushu Institute of Technology 1-1 Sensui-cho Tobata-ku Kitakyushu Japan Sankar Foundation Research and Development Division Visakhapatnam Andhra Pradesh India

Viologens (N,N'-dimethyl-4,4-bipyridinium) are advanced functional materials, found important applications in electrochromic devices, molecular machines, organic batteries, and carbohydrate oxidation catalysts in alkaline fuel. In this article, we investigated the design, synthesis and photophysical properties of N,N'-dimethyl-2,5-Bis(pyridinium)oxadiazole 4 and its precursor 2,5- Bis(pyridine)oxadiazole 2. The crystal structure and photophysical properties of viologen 4 and precursor 2 have been determined. The viologen molecule 4 crystallized in monoclinic form, space group P21/n with four molecules in unit cell. Precursor molecule 2 also crystalized in monoclinic form, space group C2/c with four molecules in unit cell. From X-rd data, we found three cations in the molecular structure of viologen molecule 4, which is unusual in viologens. In the three-dimensional molecular packing diagram of molecule 4, the three cations and iodate anions are stabilized by C···C, C···I, N···I, N···H, H···I, N—H···I and C—H···I. The dihedral angle between planes having oxadiazole and two benzene rings are 5°and 8°, suggesting the molecule 4 is a slightly strained one. The molecular structure of precursor molecule 2 stabilized by C···C and N···H short contacts between the molecules. The molecule 4 displayed strong absorbance at 315 nm and emissions between 390 - 410 nm.

关键词： Oxadiazole Extended Methyl Viologen Bipyridine Oxadiazole Crystal Struc-ture Pyridine-4-Carboxy Aldehyde Isonicotinic Acid Hydrazide Fluorescence

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