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RASSF1AMethylation Status and BRAF V600E Immunohistochemical Expression in Odontogenic Lesions

Open Journal of Pathology 2020年第3期10卷 93-107页

作者： Chatchaphan Udompatanakorn Naomi Yada kou matsuo Division of Oral Pathology Department of Health Promotion Kyushu Dental University Kitakyushu Japan Department of Oral Surgery and Oral Medicine Faculty of Dentistry Srinakharinwirot University Bangkok Thailand

Background: The etiology and pathogenesis of odontogenic lesions remain to be determined. Previous studies have identified epigenetic and genetic alterations that may be relevant to lesions progression and development. Hypermethylation of the Ras association domain family protein 1A (RASSF1A) has been observed in a variety of human cancers. However, the methylation status of RASSF1A in odontogenic lesions remains unknown. Thus, the aim of this study was to investigate the prevalence of RASSFA promoter hypermethylation and v-raf murine sarcoma viral oncogene homolog B V600E mutant (BRAF V600E) expression as well as the correlations between these alterations and clinicopathological features of patients with odontogenic lesions. Methods: We subjected 66 formalin-fixed, paraffin-embedded odontogenic lesions [ameloblastoma (AM), 21;ameloblastic carcinoma (AC), 6;odontogenic keratocyst (OKC), 19;and dentigerous cyst (DC), 20] to methylation-specific polymerase chain reaction to determine RASSF1A hypermethylation and immunohistochemistry to detect BRAF V600E protein expression. Results: We observed RASSF1A hypermethylation in 20% (4/20;methylation could not be detected in one lesion), 100% (6/6), 26.3% (5/19), and 5% (1/20) of AM, AC, OKC, and DC samples, respectively. RASSF1A methylation was significantly more frequently observed in AC relative to AM, OKC, and DC (p Conclusions: Concomitant RASSF1A methylation and positive BRAF V600E expression are commonly observed in AC, which may contribute to AC tumorigenesis.

关键词： Odontogenic Lesions DNA Methylation RASSF1A Immunohistochemistry BRAF V600E

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Primary Neuroendocrine Carcinoma Combined with Squamous Cell Carcinoma of the Soft Palate: A Case Report and Review of Literature

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Open Journal of Stomatology 2018年第3期8卷 90-99页

作者： Chatchaphan Udompatanakorn Naomi Yada Ayataka Ishikawa Ikuya Miyamoto Yukiko Sato kou matsuo Division of Oral Pathology Department of Health Promotion Kyushu Dental University Kitakyushu Japan Department of Pathology Saitama Cancer Center Saitama Japan Department of Oral and Maxillofacial Reconstructive Surgery School of Dentistry Iwate Medical University Morioka Japan Division of Pathology Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan

Background: Neuroendocrine carcinomas (NECs) are rare neoplasms that widely occur in various organs. They are heterogeneous and vary from low to high grade malignant. NEC presenting with a squamous cell carcinoma (SCC) component is referred to as a composite tumor. Thus far, few cases of this composite tumor in the oral cavity have been reported in the literature;thus, the histogenesis remains unclear. ase Presentation: We encountered a rare case of a primary NEC combined with SCC, occurring at the soft palate in a 59-year-old man. A resected specimen of the tumor was composed of two components: NEC and SCC. The NEC area contained small round to oval atypical cells arranged in nests with a glandular-like-pattern, hyperchromatic molded nuclei, a high nuclear-to-cytoplasmic ratio, and a scant eosinophilic cytoplasm. The SCC area was composed of non-keratotic, dysplastic oval to spindle-shaped squamous cells with indistinct cell borders and large nuclei that were hyperchromatic and pleomorphic. Immunohistochemically, the tumor cells of the NEC component were positive for chromagranin A, synaptophysin, CD56, and p16, whereas those of the SCC component were positive for 34βE12, p63, and p16. Conclusion: In consideration of the morphological and immunohistochemical results, the final diagnosis was a primary NEC combined with SCC of the soft palate.

关键词： Oral Cavity Neuroendocrine Carcinoma Squamous Cell Carcinoma Combined Tumor

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Friction Characteristics Between Marine Clay and Construction Materials

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Journal of Ocean University of China 2024年第2期23卷 427-437页

作者： kou Hailei HUANG Jiaming CHENG Yang College of Engineering Ocean University of ChinaQingdao 266100China Fourth Division Organization Department of the CPC Qingdao Municipal CommitteeQingdao 266100China

Structure-soil interface friction characteristics is of importance to investigate the interaction between engineering structures and soils,especially for offshore *** interface friction behavior between marine clay and structural materials with different roughness was studied in this paper by using 3D optical scanning tests,a modified direct shear device and numerical *** between the surface roughness of structures,water content and interface friction angle were presented by model *** increase of water contents decreased the interface friction *** interfaces with different roughness,the interface friction angles will be smaller than that of the soil when the water content exceeds a certain *** roughness of the interface and the water content of the soil are mutually coupled to influence the coefficient of friction(COF).This paper proposed a Finite Element Method(FEM)to simulate the interface direct shear tests of structures with different *** surface models with different roughness are established based on the structure data obtained by 3D *** Coupled Eulerian-Lagrangian(CEL)approach was employed to analyse soils sheared by irregular *** interface behavior for interfaces with different roughness under cyclic shear stresses was analyzed by FEM.

关键词： marine clay construction material interface friction behavior surface roughness Finite Element Method

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A modified smoothed particle hydrodynamics method considering residual stress for simulating failure and its application in layered rock mass

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Journal of Mountain Science 2024年第6期21卷 2091-2112页

作者： XIA Chengzhi SHI Zhenming kou Huanjia Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China

Residual strength is an indispensable factor in evaluating rock fracture,yet the current Smoothed Particle Hydrodynamics(SPH)framework rarely considers its influence when simulating *** improved cracking strategy considering residual stress in the base bond SPH method was proposed to simulate failures in layered rocks and slopes and verified by experimental results and other simulation methods(i.e.,the discrete element method).Modified Mohr–Coulomb failure criterion was applied to distinguish the mixed failure of tensile and *** fracture markψwas introduced to improve the kernel function after tensile damage,and the calculation of residual stress after the damage was derived after shear *** simulations were carried out to evaluate its performance under different stress and scale conditions and to verify its effectiveness in realistically reproducing crack initiation and propagation and coalescence,even fracture and *** results indicate that the improved cracking strategy precisely captures the fracture and failure pattern in layered rocks and rock *** residual stress of brittle tock is correctly captured by the improved SPH *** improved SPH method that considers residual strength shows an approximately 13%improvement in accuracy for the safety factor of anti-dip layered slopes compared to the method that does not consider residual strength,as validated against analytical *** infer that the improved SPH method is effective and shows promise for applications to continuous and discontinuous rock masses.

关键词： Smoothed particle hydrodynamics Cracking strategy Residual stress Layered rock Crack propagation

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Methylation and Expression Status of SOCS1 and SOCS3 in Oral Lichen Planus

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Open Journal of Stomatology 2018年第5期8卷 168-181页

作者： Kurara Yoshimura Naomi Yada kou matsuo Hisako Hikiji Daigo Yoshiga Manabu Habu Masaaki Sasaguri Kazuhiro Tominaga Department of Science of Physical Functions Division of Oral and Maxillofacial Surgery Kyushu Dental University Kitakyushu Japan Department of Health Promotion Division of Oral Pathology Kyushu Dental University Kitakyushu Japan School of Oral Health Sciences Kyushu Dental University Kitakyushu Kitakyushu Japan

Oral lichen planus (OLP) is a disease of unknown etiology affecting oral mucosa by mediated chronic inflammation and is classified as a potentially malignant oral disorder. SOCS1 and SOCS3 in the SOCS family have been identified as negative regulators of the cytokine-activated JAK/STAT pathway responsible for inflammatory reaction. The DNA methylation in the promoter regions of SOCS1 and SOCS3 have been reported to correlate with carcinogenesis. In this study, we performed methylation-specific PCR (MSP) to investigate the methylation status of the promoter regions in SOCS1 and SOCS3 genes using biopsy samples from OLP and oral squamous cell carcinoma (OSCC) patients. SOCS1 was methylated in 14/29 (48.3%) cases with OLP and 7/15 (46.7%) cases with OSCC. At the same time, SOCS3 was methylated in 25/29 (86.2%) cases with OLP and 11/15 (73.3%) cases with OSCC. We didn’t recognize any DNA methylation in SOCS1 or SOCS3 genes from the exfoliated cytological specimens of normal buccal mucosa. Furthermore, mRNA expression level was analyzed using real-time RT-PCR method to evaluate the correlation with DNA methylation status. DNA methylation status of SOCS1 seemed not to affect the expression level of SOCS1 mRNA. At the same time, DNA methylation status of SOCS3 was negatively correlated with the expression level of SOCS3 mRNA (p < 0.05). We posit frequent methylation of the SOCS3 gene promoter, theoretically resulting in the increase of cytokines expression, might be associated with the etiological mechanism of OLP.

关键词： Oral Lichen Planus SOCS3 SOCS1 Methylation

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Estimating the production of dark photons withηdecay in high-energy collisions

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Chinese Physics C 2024年第10期48卷 150-156页

作者： Wei kou Xurong Chen Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Southern Center for Nuclear Science Theory Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

We propose searching for dark photon signals in the decay channel of η mesons,specifically through the leptonic decay(A'→e^(+)e^(-)(μ^(+)μ^(-)))observable in photon-photon interactions during ultra-peripheral heavy-ion *** estimate the total cross-section for dark photon production in ultra-peripheral PbPb collisions at current and future hadron *** findings support the potential for detecting dark photon signals at the LHC,HighLuminosity LHC,High-Energy LHC,and Future Circular Collider.

关键词： dark photon ηdecay ultra-peripheral collision lead-lead collision

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Spatial Heterogeneity of Embedded Water Consumption from the Perspective of Virtual Water Surplus and Deficit in the Yellow River Basin,China

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Chinese Geographical Science 2024年第2期34卷 311-326页

作者： MA Weijing LI Xiangjie kou Jingwen LI Chengyi College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065China School of Economics and Management Ningxia UniversityYinchuan 750021China

Virtual water trade(VWT)provides a new perspective for alleviating water crisis and has thus attracted widespread ***,the heterogeneity of virtual water trade inside and outside the river basin and its influencing factors remains further *** this study,for better investigating the pattern and heterogeneity of virtual water trade inside and outside provincial regions along the Yellow River Basin in 2015 using the input-output model(MRIO),we proposed two new concepts,i.e.,virtual water surplus and virtual water deficit,and then used the Logarithmic Mean Divisia Index(LMDI)model to identify the inherent mechanism of the imbalance of virtual water trade between provincial regions along the Yellow River Basin and the other four regions in *** results show that:1)in provincial regions along the Yellow River Basin,the less developed the economy was,the larger the contribution of the agricultural sector in virtual water trade,while the smaller the contribution of the industrial sector.2)Due to the large output of agricultural products,the upstream and midstream provincial regions of the Yellow River Basin had a virtual water surplus,with a net outflow of virtual water of 2.7×10^(8) m^(3) and 0.9×10^(8) m^(3),respectively.3)provincial regions along the Yellow River Basin were in a virtual water deficit with the rest of China,and the decisive factor was the active degree of trade with the *** study would be beneficial to illuminate the trade-related water use issues in provincial regions along the Yellow River Basin,which has farreaching practical signific-ance for alleviating water scarcity.

关键词： virtual water trade(VWT) input-output model(MRIO) virtual water surplus virtual water deficit Yellow River Basin,China

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Highly Flexible Graphene-Film-Based Rectenna for Wireless Energy Harvesting

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Energy & Environmental Materials 2024年第2期7卷 320-325页

作者： Jingwei Zhang Yuchao Wang Rongguo Song Zongkui kou Daping He Hubei Engineering Research Center of RF-Microwave Technology and Application School of ScienceWuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Herein,we report the design,fabrication,and performance of two wireless energy harvesting devices based on highly flexible graphene macroscopic films(FGMFs).We first demonstrate that benefiting from the high conductivity of up to 1×10^(6)S m^(-1)and good resistive stability of FGMFs even under extensive bending,the FGMFs-based rectifying circuit(GRC)exhibits good flexibility and RF-to-DC efficiency of 53%at 2.1 ***,we further expand the application of FGMFs to a flexible wideband monopole rectenna and a 2.45 GHz wearable rectenna for harvesting wireless *** wideband rectenna at various bending conditions produces a maximum conversion efficiency of 52%,46%,and 44%at the 5th Generation(5G)2.1 GHz,Industrial Long-Term Evolution(LTE)2.3 GHz,and Scientific Medical(ISM)2.45 GHz,respectively.A 2.45 GHz GRC is optimized and integrated with an AMC-backed wearable *** proposed 2.45 GHz wearable rectenna shows a maximum conversion efficiency of 55.7%.All the results indicate that the highly flexible graphene-film-based rectennas have great potential as a wireless power supplier for smart Internet of Things(loT)applications.

关键词： flexible rectennas highly flexible graphene-based films wireless energy harvesting

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An air combat maneuver pattern extraction based on time series segmentation and clustering analysis

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Defence Technology（防务技术） 2024年第6期36卷 149-162页

作者： Zhifei Xi Yingxin kou Zhanwu Li Yue Lv You Li Air Force Engineering University No.1 Baling RoadBaqiao DistrictXi'anShaanxi ProvinceChina

Target maneuver recognition is a prerequisite for air combat situation awareness,trajectory prediction,threat assessment and maneuver *** get rid of the dependence of the current target maneuver recognition method on empirical criteria and sample data,and automatically and adaptively complete the task of extracting the target maneuver pattern,in this paper,an air combat maneuver pattern extraction based on time series segmentation and clustering analysis is proposed by combining autoencoder,G-G clustering algorithm and the selective ensemble clustering analysis ***,the autoencoder is used to extract key features of maneuvering trajectory to remove the impacts of redundant variables and reduce the data dimension;Then,taking the time information into account,the segmentation of Maneuver characteristic time series is realized with the improved FSTS-AEGG algorithm,and a large number of maneuver primitives are extracted;Finally,the maneuver primitives are grouped into some categories by using the selective ensemble multiple time series clustering algorithm,which can prove that each class represents a maneuver *** maneuver pattern extraction method is applied to small scale air combat trajectory and can recognize and correctly partition at least 71.3%of maneuver actions,indicating that the method is effective and satisfies the requirements for engineering *** addition,this method can provide data support for various target maneuvering recognition methods proposed in the literature,greatly reduce the workload and improve the recognition accuracy.

关键词： Maneuver pattern extraction Data mining Fuzzy segmentation Selective ensemble clustering

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Heterogeneous data-driven aerodynamic modeling based on physical feature embedding

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Chinese Journal of Aeronautics 2024年第3期37卷 1-6页

作者： Weiwei ZHANG Xuhao PENG Jiaqing kou Xu WANG School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Institute of Aerodynamics RWTH Aachen UniversityAachen 52062Germany

Aerodynamic surrogate modeling mostly relies only on integrated loads data obtained from simulation or experiment,while neglecting and wasting the valuable distributed physical information on the *** make full use of both integrated and distributed loads,a modeling paradigm,called the heterogeneous data-driven aerodynamic modeling,is *** essential concept is to incorporate the physical information of distributed loads as additional constraints within the end-to-end aerodynamic *** heterogenous data,a novel and easily applicable physical feature embedding modeling framework is *** framework extracts lowdimensional physical features from pressure distribution and then effectively enhances the modeling of the integrated loads via feature *** proposed framework can be coupled with multiple feature extraction methods,and the well-performed generalization capabilities over different airfoils are verified through a transonic *** with traditional direct modeling,the proposed framework can reduce testing errors by almost 50%.Given the same prediction accuracy,it can save more than half of the training ***,the visualization analysis has revealed a significant correlation between the discovered low-dimensional physical features and the heterogeneous aerodynamic loads,which shows the interpretability and credibility of the superior performance offered by the proposed deep learning framework.

关键词： Transonic flow Data-driven modeling Feature embedding Heterogenous data Feature visualization

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