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generation of oxidants and their role in the metabolism of oxygen in the survivability of filarial parasite Setaria digitata in cattle:a possible intervention strategy

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Infectious Diseases Research 2023年第1期4卷 23-27页

作者： Kochukunju Pillai Jayakumar kottayath g nevin Department of Biochemistry PMS College of Dental Science and ResearchThiruvananthapuram 695028India Centre for Bioactive Substances from Marine Organisms Kerala University of Fisheries and Ocean StudiesKerala 682506India Department of Marine Biosciences Faculty of Ocean Science and TechnologyKerala University of Fisheries and Ocean StudiesKerala 682506India

Background:The goal of the current study was to identify the potential therapeutic targets by analyzing the production of oxidants and their effects on the antioxidant system of Setaria digitata,a filarial worm that was collected from the peritoneal cavity of recently butchered ***:*** was collected and the mitochondria-like particles(MLP),somatic isolates and the post-nuclear fraction were prepared for *** radical intensity and the antioxidant enzyme activity in these fractions were *** effect of diethylcarbamazine(DEC),Q0,omeprazole,and L-methyl arginine on NOS production in the worm was also ***:Experiments showed that coelomic fluid and whole worm showed significant levels of Nitric oxide compared to other *** cytosol of the worm showed higher NOS activity than *** dismutase and nitric oxide(NO)levels were found to be higher in MLP fraction of the *** was also found that DEC did not have any effect on the prevention of NO,while Q0,omeprazole,and L-methyl arginine treatment showed a decrease in NO production ***:The results showed that by using the existing drugs we could reduce the propagation of *** by inhibiting the production of NO.

关键词： Setaria digitata mitochondria-like particles nitric oxide L-methyl arginine

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