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Stem cell treatment improves post stroke neurological outcomes:a comparative study in male and female rats

Stroke & Vascular Neurology 2021年第4期6卷 519-527,I0005-I0010页

作者： Koteswara Rao Nalamolu Bharath Chelluboina Casimir A Fornal Siva Reddy Challa David M Pinson David Z Wang Jeffrey D Klopfenstein Krishna Kumar Veeravalli Cancer Biology and Pharmacology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Pharmaceutical and Biomedical Sciences California Health Sciences UniversityClovisCaliforniaUSA Neurological Surgery University of Wisconsin-MadisonMadisonWisconsinUSA Health Sciences Education College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology Barrow Neurological InstitutePhoenixArizonaUSA Neurosurgery College of MedicineUniversity of IllinoisPeoriaIllinoisUSA OSF HealthCare Illinois Neurological Institute PeoriaIllinoisUSA Pediatrics College of MedicineUniversity of IllinoisPeoriaIllinoisUSA

Background and purpose The therapeutic potential of different stem cells for ischaemic stroke treatment is intriguing and somewhat controversial.Recent results from our laboratory have demonstrated the potential benefits of human umbilical cord blood-derived mesenchymal stem cells(MSC)in a rodent stroke model.We hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females,despite any apparent sex differences in post stroke brain injury.Methods Transient focal cerebral ischaemia was induced in adult Sprague-Dawley rats by occlusion of the middle cerebral artery.Following the procedure,male and female rats of the untreated group were euthanised 1 day after reperfusion and their brains were used to estimate the resulting infarct volume and tissue swelling.Additional groups of stroke-induced male and female rats were treated with MSC or vehicle and were subsequently subjected to a battery of standard neurological/neurobehavioral tests(Modified Neurological Severity Score assessment,adhesive tape removal,beam walk and rotarod).The tests were administered at regular intervals(at days 1,3,5,7 and 14)after reperfusion to determine the time course of neurological and functional recovery after stroke.Results The infarct volume and extent of swelling of the ischaemic brain were similar in males and females.Despite similar pathological stroke lesions,the clinical manifestations of stroke were more pronounced in males than females,as indicated by the neurological scores and other tests.MSC treatment significantly improved the recovery of sensory and motor function in both sexes,and it demonstrated efficacy in both moderate stroke(females)and severe stroke(males).Conclusions Despite sex differences in the severity of post stroke outcomes,MSC treatment promoted the recovery of sensory and motor function in male and female rats,suggesting that it may be a promising treatment for stroke.

关键词： neurological female rats

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Post-stroke mRNA expression profile of MMPs:effect of genetic deletion of MMP-12

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Stroke & Vascular Neurology 2018年第3期3卷 153-159页

作者： Koteswara Rao Nalamolu Bharath Chelluboina Ian B Magruder Diane N Fru Adithya Mohandass Ishwarya Venkatesh Jeffrey D Klopfenstein David M Pinson Krishna M Boini Krishna Kumar Veeravalli Department of Cancer Biology and Pharmacology University of Illinois College of MedicinePeoriaIllinoisUSA Department of Neurosurgery University of Illinois College of MedicinePeoriaIllinoisUSA Comprehensive Stroke Center Illinois Neurological InstituteOSF HealthCare SystemSaint Francis Medical CenterPeoriaIllinoisUSA Department of Pathology University of Illinois College of MedicinePeoriaIllinoisUSA Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTexasUSA Department of Neurology University of Illinois College of MedicinePeoriaIllinoisUSA

background and purpose Recent reports from our laboratory demonstrated the post-ischaemic expression profile of various matrix metalloproteinases(MMPs)in rats and the detrimental role of MMP-12 in post-stroke brain damage.We hypothesise that the post-stroke dysregulation of MMPs is similar across species and that genetic deletion of MMP-12 would not affect the post-stroke expression of other MMPs.We tested our hypothesis by determining the pre-ischaemic and post-ischaemic expression profile of MMPs in wild-type and MMP-12 knockout mice.Methods Focal cerebral ischaemia was induced in wildtype and MMP-12 knockout mice by middle cerebral artery occlusion procedure by insertion of a monofilament suture.One hour after ischaemia,reperfusion was initiated by removing the monofilament.One day after reperfusion,ischaemic brain tissues from various groups of mice were collected,and total RNA was isolated and subjected to cDNA synthesis followed by PCR analysis.results Although the post-stroke expression profile of MMPs in the ischaemic brain of mice is different from rats,there is a clear species similarity in the expression of MMP-12,which was found to be predominantly upregulated in both species.Further,the post-stroke induction or inhibition of various MMPs in MMP-12 knockout mice is different from their respective expression profile in wild-type mice.Moreover,the brain mRNA expression profile of various MMPs in MMP-12 knockout mice under normal conditions is also different to their expression in wild-type mice.Conclusions In the ischaemic brain,MMP-12 upregulates several fold higher than any other MMP.Mice derived with the genetic deletion of MMP-12 are constitutive and have altered MMP expression profile both under normal and ischaemic conditions.

关键词： MMPs removing hypothesis

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Prevalence of shifted Rayleigh filter for passive surveillance in underwater

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International Journal of Intelligent Computing and Cybernetics 2022年第1期15卷 110-123页

作者： Guduru Naga Divya Sanagapallea koteswara rao Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationGunturIndia

Purpose-From many decades,bearings-only tracking(BOT)is the interested problem for researchers.This utilises nonlinear filtering methods for state estimation as there is only information about the target,i.***.bearing is a nonlinear measurement.The measurement bearing is tangentially related to the target state vector.There are many nonlinear filtering algorithms developed so far in the literature.Design/methodology/approach-In this research work,the recently developed nonlinear filtering algorithm,i.***.shifted Rayleigh filter(SRF),is applied to BOT.Findings-The SRF is tested for two-dimensional BOT against various scenarios.The simulation results emphasise that the SRF performs well when compared to the standard nonlinear filtering algorithm,unscented Kalman filter(UKF).Originality/value-SRF utilises the nonlinearities present in the bearing measurement through the use of moment matching.The SRF is able to produce the solution in highly noisy environment,long ranges and high dimension tracking.

关键词： Stochastic signal processing Shifted Rayleigh filter State estimation Underwater surveillance

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A novel monocrystalline PV array configuration for enhancing the maximum power under partial shading conditions

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Clean Energy 2023年第4期7卷 783-794页

作者： Sarayu Vunnam M.Vanithasri Rama koteswara rao Alla Research Scholar Department of Electrical EngineeringAnnamalai UniversityAnnamalai NagarChidambaramTamilnadu-608002India Assistant Professor Department of Electrical and Electronics EngineeringRVR&JC College of EngineeringGunturAndhra Pradesh-522019India Associate Professor Department of Electrical EngineeringAnnamalai UniversityAnnamalai NagarChidambaramTamilnadu-608002India Associate Professor Department of Electrical and Electronics EngineeringRVR&JC College of EngineeringGunturAndhra Pradesh-522019India

Solar photovoltaic(PV)systems have gained importance as a promising renewable energy source in recent years.PV arrays are prone to variable irradiance levels under partial shading conditions due to non-uniform shading.As a result,there will be a decrease in the amount of power produced and hotspots will occur.To overcome these issues,it is essential to select an appropriate PV material and a suitable array configuration.To obtain the maximum output power from a PV array under partial shading conditions,this paper suggests a novel triple-series–parallel ladder topology with monocrystalline PV material.Considering short and wide,long and wide,short and narrow,long and narrow,middle and diagonal shading situations,a 6×6-sized array has been considered and compared with other existing configurations such as total cross-tied,bridge-link,honeycomb,series–parallel and series–parallel cross-tied.The proposed configuration has an optimal number of cross ties to produce maximum power.It has 4 cross ties fewer than a honeycomb,3 cross ties fewer than a bridge link,16 cross ties fewer than a total cross-tied and 7 cross ties fewer than series–parallel cross-tied configurations.The proposed configuration has an improvement in power of 0.1%to 20%compared with other configurations under the considered shading scenarios.

关键词： monocrystalline PV material photo voltaic array series–parallel cross-tied,triple-series–parallel ladder topology

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Measure of nonlinearity for underwater target tracking using hull-mounted sensor

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International Journal of Intelligent Computing and Cybernetics 2022年第3期15卷 333-344页

作者： B.Omkar Lakshmi Jagan S.koteswara rao Department of Electrical and Electronics Engineering Koneru Lakshmaiah Education FoundationGunturIndia Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationGunturIndia

Purpose-Doppler-Bearing Tracking(DBT)is commonly used in target tracking applications for the underwater environment using the Hull-Mounted Sensor(HMS).It is an important and challenging problem in an underwater environment.Design/methodology/approach-The system nonlinearity in an underwater environment increases due to several reasons such as the type of measurements taken,the speeds of target and observer,environmental conditions,number of sensors considered for measurements and so on.Degrees of nonlinearity(DoNL)for these problems are analyzed using a proposed measure of nonlinearity(MoNL)for state estimation.Findings-In this research,the authors analyzed MoNL for state estimation and computed the conditional MoNL(normalized)using different filtering algorithms where measurements are obtained from a single sensor array(i.e.HMS).MoNL is implemented to find out the system nonlinearity for different filtering algorithms and identified how much nonlinear the system is,that is,to measure nonlinearity of a problem.Originality/value-Algorithms are evaluated for various scenarios with different angles on the target bow(ATB)in Monte-Carlo simulation.Computation of root mean squared(RMS)errors in position and velocity is carried out to assess the state estimation accuracy using MATLAB.

关键词： Nonlinear filtering Statistical signal processing Underwater target tracking Estimation theory Hull-mounted sensor

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A novel PV array configuration for enhancing maximum power from PV array

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Clean Energy 2022年第6期6卷 817-826页

作者： Dharani Kumar Narne T.A.Ramesh Kumar Rama koteswara rao Alla Department of Electrical Engineering Annamalai UniversityAnnamalai NagarChidambaramTamilnadu-608002India Department of Electrical and Electronics Engineering RVR&JC College of EngineeringGunturAndhra Pradesh-522019India

Partial shading conditions(PSC)are unavoidable and are the main reason for the reduction in power from a photovoltaic(PV)array.With proper arrangement,the impact of PSC can be somewhat mitigated.There are distinct types of configurations,including series,parallel,series-parallel(SP),honeycomb,total cross-tied(TCT),etc.This article presents a novel SP-TCT configuration to maximize output power from PV panels under different shading conditions.The proposed configuration performance has been examined considering a 4×4 PV array under long-narrow and long-wide,short-narrow,short-wide and uniform shading conditions.The results of the proposed configurations are compared with existing configurations in terms of performance measures such as maximum power,fill factor,efficiency and mismatch losses.In all the cases,performance of the proposed configuration is nearer to the TCT configuration performance.The percentage improvement in terms of efficiency for the proposed novel SP-TCT configuration and TCT configuration is nearly 1.6%compared to other methods.

关键词： maximum power shading patterns PV array efficiency

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Design of Multi-Valued Logic Circuit Using Carbon Nano Tube Field Transistors

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Computers, Materials & Continua 2022年第12期73卷 5283-5298页

作者： S.V.Ratankumar L.koteswara rao M.Kiran Kumar Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationAziz NagarHyderabad500075TelanganaIndia Department of Electronics and Communication Engineering RGM College of Engineering and TechnologyNandyal518501Andhra PradeshIndia Department of Electrical and Electronics Engineering Koneru Lakshmaiah Education FoundationVaddeswaramGuntur522502Andhra PradeshIndia

The design of a three-input logic circuit using carbon nanotube field effect transistors(CNTFETs)is presented.Ternary logic must be an exact replacement for dual logic since it performs straightforwardly in digital devices,which is why this design is so popular,and it also reduces chip area,both of which are examples of circuit overheads.The proposed module we have investigated is a triple-logic-based one,based on advanced technology CNTFETs and an emphasis on minimizing delay times at various values,as well as comparisons of the design working with various load capacitances.Comparing the proposed design with the existing design,the delay times was reduced from 66.32 to 16.41 ps,i.e.,a 75.26%reduction.However,the power dissipation was not optimized,and increased by 1.44%compared to the existing adder.The number of transistors was also reduced,and the product of power and delay(P∗D)achieved a value of 0.0498053 fJ.An improvement at 1 V was also achieved.A load capacitance(fF)was measured at different values,and the average delay measured for different values of capacitance had a maximum of 83.60 ps and a minimum of 22.54 ps,with a range of 61.06 ps.The power dissipations ranged from a minimum of 3.38μW to a maximum of 6.49μW.Based on these results,the use of this CNTFET half-adder design in multiple Boolean circuits will be a useful addition to circuit design.

关键词： Carbon nanotube field effect transistor(CNTFET) multivalued logic(MVL) ternary adder Hewlett simulation program with integrated circuit emphasis(HSPICE) chirality(nm) adder

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Pervasive underwater passive target tracking for the computation of standard deviation solution in a 3D environment

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International Journal of Intelligent Computing and Cybernetics 2021年第4期14卷 580-597页

作者： M.Kavitha Lakshmi S.koteswara rao Kodukula Subrahmanyam Computer Science and Engineering Koneru Lakshmaiah Education FoundationGunturIndia Electronics and Communications Engineering Koneru Lakshmaiah Education FoundationGunturIndiaand

Purpose-Nowadays advancement in acoustic technology can be explored with marine assets.The purpose of the paper is pervasive computing underwater target tracking has aroused military and civilian interest as a key component of ocean exploration.While many pervasive techniques are currently found in the literature,there is little published research on the effectiveness of these paradigms in the target tracking context.Design/methodology/approach-The unscented Kalman filter(UKF)provides good results for bearing and elevation angles only tracking.Detailed methodology and mathematical modeling are carried out and used to analyze the performance of the filter based on the Monte Carlo simulation.Findings-Due to the intricacy of maritime surroundings,tracking underwater targets using acoustic signals,without knowing the range parameter is difficult.The intention is to find out the solution in terms of standard deviation in a three-dimensional(3D)space.Originality/value-A new method is found for the acceptance criteria for range,course,speed and pitch based on the standard deviation for bearing and elevation 3D target tracking using the unscented Kalman filter covariance matrix.In the Monte Carlo simulation,several scenarios are used and the results are shown.

关键词： Unscented Kalman filter Underwater target tracking Acceptance criteria Three-dimensional target tracking Standard deviation

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An IoT-based agriculture maintenance using pervasive computing with machine learning technique

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International Journal of Intelligent Computing and Cybernetics 2022年第2期15卷 201-214页

作者： Swathi Kailasam Sampath Dakshina Murthy Achanta P.Rama koteswara rao Ramesh Vatambeti Saikumar Kayam CSE Koneru Lakshmaiah Education FoundationGunturIndia ECE Vignan’s Institute of Information TechnologyVisakhapatnamIndia ECE NRI Institute of TechnologyKrishnaIndia CHRIST(Deemed to be University) BengaluruIndia ECE Koneru Lakshmaiah Education FoundationGunturIndia

Purpose-In cultivation,early harvest offers farmers an opportunity to increase production while decreasing the chances of lower crop production rates,ensuring that the economy remains balanced.The significant reason is to predict the disease in plants and distinguish the type of syndrome with the help of segmentation and random forest optimization classification.In this investigation,the accurate prior phase of crop imagery has been collected from different datasets like cropscience,yesmodes and nelsonwisc.In the current study,the real-time earlier state of crop images has been gathered from numerous data sources similar to crop_science,yes_modes,nelson_wisc dataset.Design/methodology/approach-In this research work,random forest machine learning-based persuasive plants healthcare computing is provided.If proper ecological care is not applied to early harvesting,it can cause diseases in plants,decrease the cropping rate and less production.Until now different methods have been developed for crop analysis at an earlier stage,but it is necessary to implement methods to advanced techniques.So,the detection of plant diseases with the help of threshold segmentation and random forest classification has been involved in this investigation.This implemented design is verified on Python 3.7.8 software for simulation analysis.Findings-In this work,different methods are developed for crops at an earlier stage,but more methods are needed to implement methods with prior stage crop harvesting.Because of this,a disease-finding system has been implemented.The methodologies like“Threshold segmentation”and RFO classifier lends 97.8% identification precision with 99.3%real optimistic rate,and 59.823 peak signal-to-noise(PSNR),0.99894 structure similarity index(SSIM),0.00812 machine squared error(MSE)values are attained.Originality/value-The implemented machine learning design is outperformance methodology,and they are proving good application detection rate.

关键词： Crop harvesting Detection of plant disease RFO Classification Threshold segmentation

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搅拌摩擦焊AA7075-T651铝合金厚板的显微组织和力学性能（英文）

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Transactions of Nonferrous Metals Society of China 2015年第6期25卷 1770-1778页

作者： T.SRINIVASA rao G.MADHUSUDHAN REDDY S.R.koteswara rao Department of Mechanical Engineering Tagore Engineering College Metal Joining Group Defense Metallurgical Research Laboratory Department of Mechanical Engineering SSN College of Engineering

研究厚度为10和16 mm AA7075-T651板的搅拌摩擦焊接过程。通过仔细选择焊接过程参数可获得无缺陷、全渗透焊接样品。两种焊接接头都出现极细的再结晶粒,而10 mm厚板焊接接头的晶粒组织更细。试样的显微组织观察结果表明,焊件热影响区的... 详细信息

研究厚度为10和16 mm AA7075-T651板的搅拌摩擦焊接过程。通过仔细选择焊接过程参数可获得无缺陷、全渗透焊接样品。两种焊接接头都出现极细的再结晶粒,而10 mm厚板焊接接头的晶粒组织更细。试样的显微组织观察结果表明,焊件热影响区的硬度显著降低。16 mm厚合金板焊接接头的硬度降低较大。与16 mm厚合金板相比,10 mm厚合金板焊件具有较优的拉伸性能。在拉伸实验过程中,两种厚度的合金板焊件均在热影响区发生断裂。样品的TEM结果表明,热影响区由沿晶界的宽化无沉积区和晶体内沉淀的部分溶解组成。因此,采用搅拌摩擦焊在AA7075-T651上可制得单道次无缺陷焊件,且10 mm厚合金板焊件表现出较高的焊接效率。

关键词： AA7075-T651铝合金搅拌摩擦焊显微组织力学性能

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