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Stem cell treatment improves post stroke neurological outcomes:a comparative study in male and female rats

Stroke & Vascular Neurology 2021年第4期6卷 519-527,I0005-I0010页

作者： koteswara rao nalamolu Bharath Chelluboina Casimir A Fornal Siva Reddy Challa David M Pinson David Z Wang Jeffrey D Klopfenstein Krishna Kumar Veeravalli Cancer Biology and Pharmacology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Pharmaceutical and Biomedical Sciences California Health Sciences UniversityClovisCaliforniaUSA Neurological Surgery University of Wisconsin-MadisonMadisonWisconsinUSA Health Sciences Education College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology Barrow Neurological InstitutePhoenixArizonaUSA Neurosurgery College of MedicineUniversity of IllinoisPeoriaIllinoisUSA OSF HealthCare Illinois Neurological Institute PeoriaIllinoisUSA Pediatrics College of MedicineUniversity of IllinoisPeoriaIllinoisUSA

Background and purpose The therapeutic potential of different stem cells for ischaemic stroke treatment is intriguing and somewhat *** results from our laboratory have demonstrated the potential benefits of human umbilical cord blood-derived mesenchymal stem cells(MSC)in a rodent stroke *** hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females,despite any apparent sex differences in post stroke brain *** Transient focal cerebral ischaemia was induced in adult Sprague-Dawley rats by occlusion of the middle cerebral *** the procedure,male and female rats of the untreated group were euthanised 1 day after reperfusion and their brains were used to estimate the resulting infarct volume and tissue *** groups of stroke-induced male and female rats were treated with MSC or vehicle and were subsequently subjected to a battery of standard neurological/neurobehavioral tests(Modified Neurological Severity Score assessment,adhesive tape removal,beam walk and rotarod).The tests were administered at regular intervals(at days 1,3,5,7 and 14)after reperfusion to determine the time course of neurological and functional recovery after *** The infarct volume and extent of swelling of the ischaemic brain were similar in males and *** similar pathological stroke lesions,the clinical manifestations of stroke were more pronounced in males than females,as indicated by the neurological scores and other *** treatment significantly improved the recovery of sensory and motor function in both sexes,and it demonstrated efficacy in both moderate stroke(females)and severe stroke(males).Conclusions Despite sex differences in the severity of post stroke outcomes,MSC treatment promoted the recovery of sensory and motor function in male and female rats,suggesting that it may be a promising treatment for stroke.

关键词： neurological female rats

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Post-stroke mRNA expression profile of MMPs:effect of genetic deletion of MMP-12

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Stroke & Vascular Neurology 2018年第3期3卷 153-159页

作者： koteswara rao nalamolu Bharath Chelluboina Ian B Magruder Diane N Fru Adithya Mohandass Ishwarya Venkatesh Jeffrey D Klopfenstein David M Pinson Krishna M Boini Krishna Kumar Veeravalli Department of Cancer Biology and Pharmacology University of Illinois College of MedicinePeoriaIllinoisUSA Department of Neurosurgery University of Illinois College of MedicinePeoriaIllinoisUSA Comprehensive Stroke Center Illinois Neurological InstituteOSF HealthCare SystemSaint Francis Medical CenterPeoriaIllinoisUSA Department of Pathology University of Illinois College of MedicinePeoriaIllinoisUSA Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTexasUSA Department of Neurology University of Illinois College of MedicinePeoriaIllinoisUSA

background and purpose Recent reports from our laboratory demonstrated the post-ischaemic expression profile of various matrix metalloproteinases(MMPs)in rats and the detrimental role of MMP-12 in post-stroke brain *** hypothesise that the post-stroke dysregulation of MMPs is similar across species and that genetic deletion of MMP-12 would not affect the post-stroke expression of other *** tested our hypothesis by determining the pre-ischaemic and post-ischaemic expression profile of MMPs in wild-type and MMP-12 knockout *** Focal cerebral ischaemia was induced in wildtype and MMP-12 knockout mice by middle cerebral artery occlusion procedure by insertion of a monofilament *** hour after ischaemia,reperfusion was initiated by removing the *** day after reperfusion,ischaemic brain tissues from various groups of mice were collected,and total RNA was isolated and subjected to cDNA synthesis followed by PCR *** Although the post-stroke expression profile of MMPs in the ischaemic brain of mice is different from rats,there is a clear species similarity in the expression of MMP-12,which was found to be predominantly upregulated in both ***,the post-stroke induction or inhibition of various MMPs in MMP-12 knockout mice is different from their respective expression profile in wild-type ***,the brain mRNA expression profile of various MMPs in MMP-12 knockout mice under normal conditions is also different to their expression in wild-type *** In the ischaemic brain,MMP-12 upregulates several fold higher than any other *** derived with the genetic deletion of MMP-12 are constitutive and have altered MMP expression profile both under normal and ischaemic conditions.

关键词： MMPs removing hypothesis

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Prevalence of shifted Rayleigh filter for passive surveillance in underwater

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International Journal of Intelligent Computing and Cybernetics 2022年第1期15卷 110-123页

作者： Guduru Naga Divya Sanagapallea koteswara rao Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationGunturIndia

Purpose-From many decades,bearings-only tracking(BOT)is the interested problem for *** utilises nonlinear filtering methods for state estimation as there is only information about the target,*** is a nonlinear *** measurement bearing is tangentially related to the target state *** are many nonlinear filtering algorithms developed so far in the ***/methodology/approach-In this research work,the recently developed nonlinear filtering algorithm,*** Rayleigh filter(SRF),is applied to ***-The SRF is tested for two-dimensional BOT against various *** simulation results emphasise that the SRF performs well when compared to the standard nonlinear filtering algorithm,unscented Kalman filter(UKF).Originality/value-SRF utilises the nonlinearities present in the bearing measurement through the use of moment *** SRF is able to produce the solution in highly noisy environment,long ranges and high dimension tracking.

关键词： Stochastic signal processing Shifted Rayleigh filter State estimation Underwater surveillance

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Improved sliding-mode control for tracking global maximum power of triple-series-parallel ladder photovoltaic arrays under uneven shadowing

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Clean Energy 2024年第5期8卷 54-72页

作者： Rama koteswara rao Alla Kandipati Rajani Ravindranath Tagore Yadlapalli EEE Department RVR&JC College of EngineeringGunturAndhra Pradesh-522019India EEE Department Vignan’s Lara Institute of Technology&ScienceGunturAndhra Pradesh-522213India

This paper presents an innovative way to enhance the performance of photovoltaic(PV)arrays under uneven shadowing *** study focuses on a triple-series–parallel ladder configuration to exploit the benefits of increased power generation while ad-dressing the challenges associated with uneven *** proposed methodology focuses on the implementation of improved sliding-mode control technique for efficient global maximum power point ***-mode control is known for its robustness in the presence of uncertainties and disturbances,making it suitable for dynamic and complex systems such as PV *** work employs a comprehensive simulation framework to comment on the performance of the suggested improved sliding-mode control strategy in uneven shadowing *** analysis has been done to show the better effectiveness of the suggested method than the traditional control *** results demonstrate a remarkable enhancement in the tracking accuracy of the global maximum power point,leading to enhanced energy-harvesting capabilities under challenging environmental ***,the proposed approach exhibits robustness and adaptability in mitigating the effect of shading on the PV array,thereby increasing overall system *** research contributes valuable insights into the development of advanced control strategies for PV arrays,particularly in the context of triple-series–parallel ladder configurations operating under uneven shadowing *** short narrow shading conditions,the improved sliding-mode control method tracks the maximum power better compared with perturb&observe at 20.68%,incremental-conductance at 68.78%,fuzzy incremental-conductance at 19.8%,and constant-velocity sliding-mode control at 1.25%.The improved sliding-mode control method has 60%less chattering than constant-velocity sliding-mode control under shading conditions.

关键词： improved sliding-mode control PV array global maximum power point series-parallel boost converter

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A novel monocrystalline PV array configuration for enhancing the maximum power under partial shading conditions

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Clean Energy 2023年第4期7卷 783-794页

作者： Sarayu Vunnam M.Vanithasri Rama koteswara rao Alla Research Scholar Department of Electrical EngineeringAnnamalai UniversityAnnamalai NagarChidambaramTamilnadu-608002India Assistant Professor Department of Electrical and Electronics EngineeringRVR&JC College of EngineeringGunturAndhra Pradesh-522019India Associate Professor Department of Electrical EngineeringAnnamalai UniversityAnnamalai NagarChidambaramTamilnadu-608002India Associate Professor Department of Electrical and Electronics EngineeringRVR&JC College of EngineeringGunturAndhra Pradesh-522019India

Solar photovoltaic(PV)systems have gained importance as a promising renewable energy source in recent *** arrays are prone to variable irradiance levels under partial shading conditions due to non-uniform *** a result,there will be a decrease in the amount of power produced and hotspots will *** overcome these issues,it is essential to select an appropriate PV material and a suitable array *** obtain the maximum output power from a PV array under partial shading conditions,this paper suggests a novel triple-series–parallel ladder topology with monocrystalline PV *** short and wide,long and wide,short and narrow,long and narrow,middle and diagonal shading situations,a 6×6-sized array has been considered and compared with other existing configurations such as total cross-tied,bridge-link,honeycomb,series–parallel and series–parallel *** proposed configuration has an optimal number of cross ties to produce maximum *** has 4 cross ties fewer than a honeycomb,3 cross ties fewer than a bridge link,16 cross ties fewer than a total cross-tied and 7 cross ties fewer than series–parallel cross-tied *** proposed configuration has an improvement in power of 0.1%to 20%compared with other configurations under the considered shading scenarios.

关键词： monocrystalline PV material photo voltaic array series–parallel cross-tied,triple-series–parallel ladder topology

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Measure of nonlinearity for underwater target tracking using hull-mounted sensor

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International Journal of Intelligent Computing and Cybernetics 2022年第3期15卷 333-344页

作者： B.Omkar Lakshmi Jagan S.koteswara rao Department of Electrical and Electronics Engineering Koneru Lakshmaiah Education FoundationGunturIndia Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationGunturIndia

Purpose-Doppler-Bearing Tracking(DBT)is commonly used in target tracking applications for the underwater environment using the Hull-Mounted Sensor(HMS).It is an important and challenging problem in an underwater ***/methodology/approach-The system nonlinearity in an underwater environment increases due to several reasons such as the type of measurements taken,the speeds of target and observer,environmental conditions,number of sensors considered for measurements and so *** of nonlinearity(DoNL)for these problems are analyzed using a proposed measure of nonlinearity(MoNL)for state ***-In this research,the authors analyzed MoNL for state estimation and computed the conditional MoNL(normalized)using different filtering algorithms where measurements are obtained from a single sensor array(***).MoNL is implemented to find out the system nonlinearity for different filtering algorithms and identified how much nonlinear the system is,that is,to measure nonlinearity of a ***/value-Algorithms are evaluated for various scenarios with different angles on the target bow(ATB)in Monte-Carlo *** of root mean squared(RMS)errors in position and velocity is carried out to assess the state estimation accuracy using MATLAB.

关键词： Nonlinear filtering Statistical signal processing Underwater target tracking Estimation theory Hull-mounted sensor

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Group Ⅱ-Ⅵ semiconductor quantum dot heterojunction photodiode for mid wave infrared detection

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Optoelectronics Letters 2020年第4期16卷 290-292页

作者： Abhijit Chatterjee Atul Abhale Naresh Pendyala KSR koteswara rao Space Applications Centre ISRO Sensors Development AreaAhmedabad 380015India Department of Physics Indian Institute of ScienceBangalore 560012India

In this article we report the development of 10×10 photodiode array by realizing heterojunction between mercury cadmium telluride(HgCdTe)quantum dot(diameter^14 nm)and silicon responsive in mid wave infrared(MWIR)range(=3-5μm)at room *** of this optical sensor has been evaluated experimentally and Detectivity of 1.6×10^8 cm/■W has been achieved at spectral wavelength of 3.μgm at 300 *** work ascertains the compatibility of chemically synthesized HgCdTe quantum dots with commercially available direct injection type readout integrated circuits(ROIC)for the development of low cost large format MWIR focal plane array(FPA).

关键词： heterojunction temperature. quantum

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Pervasive underwater passive target tracking for the computation of standard deviation solution in a 3D environment

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International Journal of Intelligent Computing and Cybernetics 2021年第4期14卷 580-597页

作者： M.Kavitha Lakshmi S.koteswara rao Kodukula Subrahmanyam Computer Science and Engineering Koneru Lakshmaiah Education FoundationGunturIndia Electronics and Communications Engineering Koneru Lakshmaiah Education FoundationGunturIndiaand

Purpose-Nowadays advancement in acoustic technology can be explored with marine *** purpose of the paper is pervasive computing underwater target tracking has aroused military and civilian interest as a key component of ocean *** many pervasive techniques are currently found in the literature,there is little published research on the effectiveness of these paradigms in the target tracking ***/methodology/approach-The unscented Kalman filter(UKF)provides good results for bearing and elevation angles only *** methodology and mathematical modeling are carried out and used to analyze the performance of the filter based on the Monte Carlo ***-Due to the intricacy of maritime surroundings,tracking underwater targets using acoustic signals,without knowing the range parameter is *** intention is to find out the solution in terms of standard deviation in a three-dimensional(3D)***/value-A new method is found for the acceptance criteria for range,course,speed and pitch based on the standard deviation for bearing and elevation 3D target tracking using the unscented Kalman filter covariance *** the Monte Carlo simulation,several scenarios are used and the results are shown.

关键词： Unscented Kalman filter Underwater target tracking Acceptance criteria Three-dimensional target tracking Standard deviation

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High-Velocity Projectile Impact Behaviour of Friction Stir Welded AA7075 Thick Plates

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Defence Technology（防务技术） 2023年第11期29卷 153-163页

作者： R.Praveen S.R.koteswara rao G.Selvakumar R.Damodaram Department of Robotics and Automation Karpaga Vinayaga College of Engineering and TechnologyChengalpattu603308TamilNaduIndia Department of Mechanical Engineering Sri Sivasubramaniya Nadar College of EngineeringChennai603110TamilNaduIndia

In this study, high velocity impact behaviour of friction stir welded AA7075-T651 25 mm thick plates were investigated using a 7.62 mm × 51 mm lead core and 7.62 mm × 39 mm steel core projectiles. Prior to ballistic trails, mechanical and metallurgical properties of friction stir welded AA 7075-T651 25 mm thick plates were studied. Microstructural and hardness studies revealed that friction stir welds constituted three distinct regions namely Weld Nugget(WN), Thermo-Mechanically Affected Zone(TMAZ) and Heat Affected Zone(HAZ). Base Material(BM) and all three weld regions were ballistically tested as per military standard NIJ.0108.01 using lead and steel core bullets at maximum permissible velocities of 830 ± 20 and 700 ± 30 m/s, respectively. It has been found that base material(AA7075-T651)and all three weld regions of 25 mm thick plates were able to resist perforation by both types of projectiles used. However depth of penetration has been found to increase from BM to WN, HAZ and TMAZ for both types of projectiles. In all cases steel core projectiles caused higher depth of penetration compared to those caused by lead core projectiles. TMAZs of the friction stir welds were found to be the weakest zone. The fracture that occurred in the base material was spall fragmentation indicating brittle failure, whereas all zones of friction stir welded AA7075-T651 targets with a front petalling, indicating ductile failure. The post-ballistic tested samples showed no significant change in the microstructure of the BM and WN. On the other hand, TMAZ and HAZ showed severe grain deformation in the direction of projectile penetration, and the formation of adiabatic shear bands(ASB). This work showed that 25 mm thick friction stir welded AA7075-T651 joints responded well to ballistic impact loads, making them a good choice for light combat vehicles.

关键词： Aluminum alloy Thick plate Friction stir welding Ballistic performance Depth of penetration

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Stiffness of a 3-degree of freedom translational parallel kinematic machine

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Frontiers of Mechanical Engineering 2014年第3期9卷 233-241页

作者： S. SHANKAR GANESH A.B. koteswara rao Department of Mechanical Engineering Gayatri Vidya Parishad College of Engineering Visakhapatnam 530048 India

In this paper, a typical 3-degree of freedom （3- DOF） translational parallel kinematic machine （PKM） is studied and analyzed whose tool platform has only translations along X-, Y- and Z-axes. It consists of three limbs, each of which have arm and forearm with prismatic- revolute-revolute-revolute （PRRR）joints. Inverse kine- matics analysis is carried out to find the slider coordinates and joint angles for a given position of tool platform. Stiffness modeling is done based on the compliance matrices of arm and forearm of each limb. Using the stiffness modeling the variations of minimum and max- imum translational stiffness in the workspaee are analyzed. For various architectural parameters of the 3-DOF PKM the tendency of variations on the minimum and maximum stiffness over the entire workspace is studied; and also the deflections of the tool platform along X, Y, and Z directions with respect to various forces are presented.

关键词： 3-DOF translational PKM inverse kine-matics stiffness modeling translational stiffness

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