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Geoscience Frontiers 2024年第4期15卷 411-426页

作者： Aifeng Liu Muhammad Imran abdelmohsen A.Nassani Rima H.Binsaeed Khalid Zaman International Business School Shaanxi Normal UniversityXi’anChina Department of Economics The University of HaripurHaripur Khyber Pakhtunkhwa 22620Pakistan Department of Management College of Business AdministrationKing Saud UniversityP.O.Box 71115Riyadh 11587Saudi Arabia

Standards for Low-Carbon Energy Portfolios(LC-EPS)mandate that a certain percentage of a region's electricity generation originate from zero-or low-emissions *** 1995Q1 through 2020Q4,the study used the ARDL-Bounds testing technique to estimate coefficient parameters,Granger causality to draw causal inferences,and variance decomposition analysis to anticipate the factors that will have the greatest impact on carbon emissions in the US *** power significantly impacts carbon emissions,as seen by an inverted U-shaped environmental Kuznets curve,whereas long-term impact of innovation leads to lower *** the other hand,exports of sophisticated technology reduce carbon *** growth has a discernible effect on carbon emissions,nuclear power,innovation,and environmentally friendly ***-tech exports will likely impact carbon emissions most,followed by a demand for nuclear power,innovation,economic expansion,and sustainable finance for the next ten *** results give policymakers helpful insight into how the US economy may reduce carbon emissions and fight climate change via renewable energy and green finance.

关键词： Nuclear energy demand High technology exports Innovation Economic growth Green finance USA

Contribution of hydro energy production,economic complexity and technological innovation in achieving an environmentally sustainable Asia

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Geoscience Frontiers 2024年第5期15卷 515-528页

作者： Farah Rana Bilal Hussain abdelmohsen A.Nassani Ayesha Hussain Mohamed Haffar Syed Asif Ali Naqvi Department of Economics Government College UniversityFaisalabadPakistan Government Graduate College Gojra Toba Tek SinghPakistan Department of Management College of Business AdministrationKing Saud UniversityP.O.Box 71115Riyadh 11587Saudi Arabia Department of Home Economics Government College Women University FaisalabadPakistan Department of Management Birmingham Business SchoolUniversity of BirminghamUnited Kingdom

The impact of hydro energy production,economic complexity,urbanization,technological innovation and financial development on environmental sustainability between 1995 and 2017 is examined for a panel of thirteen Asian economies using two environmental proxies—their ecological footprint and CO_(2)*** non-parametric Driscoll-Kraay standard error method and the Dumitrescu-Hurlin panel causality test are applied to the *** findings show that hydro energy production and technological innovation have a significant negative impact on the environment,thus promoting environmental *** complexity significantly lowers environmental sustainability while the non-linear effect of economic complexity favors environmental sustainability;this confirms the existence of an economic-complexity-based inverted-U-shaped environmental Kuznets curve ***,urbanization and financial development significantly decrease environmental *** results of our study confirm the feedback causality between hydro energy production and carbon dioxide *** recommend expansionary policies regarding hydro energy production that are beneficial for substituting fossil fuel *** paves a path towards environmental sustainability in this era of global boiling.

关键词： Hydro energy production Environmental sustainability Global boiling Economic complexity Asian countries Panel corrected standard error

Does nuclear energy reduce carbon emissions despite using fuels and chemicals?Transition to clean energy and finance for green solutions

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Geoscience Frontiers 2024年第4期15卷 359-371页

作者： Muhammad Imran Khalid Zaman abdelmohsen A.Nassani Gheorghița Dinca˘ Haroon ur Rashid Khan Mohamed Haffar Department of Economics The University of HaripurHaripur Khyber Pakhtunkhwa 22620Pakistan Department of Management College of Business AdministrationKing Saud UniversityP.O.Box 71115Riyadh 11587Saudi Arabia Finance and Accounting Department Transilvania University of BrașovRomania Faculty of Business The University of Wollongong in DubaiDubai 20183United Arab Emirates Department of Management Birmingham Business SchoolUniversity of BirminghamBirminghamUnited Kingdom

Green power conversion is the shift away from traditional fuels towards clean energy sources such as nuclear power plants,hydroelectric dams,wind farms,and solar *** research examines the impact of clean energy demand and green financing on reducing carbon emissions in 29 economies in Europe and Asia from 2007 to *** study used a two-step differenced GMM estimator for the available data set spanning 2007 to *** study found that rising demand for nuclear power helps to achieve a carbon-neutral agenda,but insufficient funding for renewable energy leads to higher carbon *** research suggests increasing investment in nuclear energy and green financing can improve regional environmental *** study found a causal link between fuel imports,nuclear power and regional *** also determined that fuel imports,chemical use,green financing and the need for nuclear energy will likely impact regional environmental *** research recommends allocating more resources toward innovation to boost energy efficiency and expanding investment in renewable and nuclear energy production industries via green *** study also highlights the need to encourage the development of renewable energy sources to cut carbon emissions and establish a sustainable society.

关键词： Nuclear energy Renewable energy Green financing Fuel imports Chemical use Differenced GMM estimator

Molecular biology techniques for the surgeon

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World Journal of Surgical Procedures 2012年第2期2卷 5-15页

作者： Gopal Kowdley Subramanya Srikantan kotb abdelmohsen Myriam Gorospe Javeed Khan Department of Surgery St Agnes Hospital Baltimore MD 21229 United States Laboratory of Molecular Biology and Immunology National Institute on Aging NIH Baltimore MD 21224 United States

New technologies are constantly being introduced into the medical and surgical fields. These technologies come in the form of newer medicines, imaging methods and prognostic tools, among others, and allow clinicians to make more rational and informed decisions on the care of their patients. Many of these technologies utilize advanced techniques which are at the forefront of many research fields and represent a transition of bench advances into the clinical realm. This review will highlight four technologies that are at the forefront in the treatment of oncology patients treated by surgeons on a daily basis. Circulating tumor cells, microarray analysis, proteomic studies and rapid sequencing technologies will be highlighted. These technologies will be reviewed and their potential use in the care o surgical patients will be discussed.

关键词： Methods Molecular diagnostic techniques Medical oncology General surgery MT

Optimized Predictive Framework for Healthcare Through Deep Learning

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Computers, Materials & Continua 2021年第5期67卷 2463-2480页

作者： Yasir Shahzad Huma Javed Haleem Farman Jamil Ahmad Bilal Jan abdelmohsen A.Nassani Department of Computer Science University of PeshawarPeshawar25120Pakistan Department of Computer Science Islamia College PeshawarPeshawar25120Pakistan Department of Computer Science FATA UniversityKohat26100Pakistan Department of Management College of Business AdministrationKing Saud UniversityRiyadhSaudi Arabia

Smart healthcare integrates an advanced wave of information technology using smart devices to collect health-related medical science *** data usually exist in unstructured,noisy,incomplete,and heterogeneous *** these limitations remains an open challenge in deep learning to classify health *** this paper,a long short-term memory(LSTM)based health condition prediction framework is proposed to rectify imbalanced and noisy data and transform it into a useful form to predict accurate health *** imbalanced and scarce data is normalized through coding to gain consistency for accurate results using synthetic minority oversampling *** proposed model is optimized and ne-tuned in an end to end manner to select ideal parameters using tree parzen estimator to build a probabilistic *** patient’s medication is pigeonholed to plot the diabetic condition’s risk factor through an algorithm to classify blood glucose metrics using a modern surveillance error grid *** proposed model can efciently train,validate,and test noisy data by obtaining consistent results around 90%over the state of the art machine and deep learning techniques and overcoming the insufciency in training data through transfer *** overall results of the proposed model are further tested with secondary datasets to verify model sustainability.

关键词： Recurrent neural network long short-term memory deep learning Bayesian optimization surveillance error grid hyperparameter

Bio-Inspired Computational Methods for the Polio Virus Epidemic Model

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Computers, Materials & Continua 2022年第8期72卷 2357-2374页

作者： Fatimah Abdulrahman Alrawajeh F.M.Allehiany Ali Raza Shaimaa A.M.abdelmohsen Tahir Nawaz Cheema Muhammad Rafiq Muhammad Mohsin Department of Mathematics Faculty of Science CollegeImam Abdulrahman Bin Faisal University(IAU)Dammam31441Saudi Arabia Department of Mathematical Sciences College of Applied SciencesUmm Al-Qura UniversityP.O.Box 715Makkah21955Saudi Arabia Department of Mathematics Govt.Maulana Zafar Ali Khan Graduate College Wazirabad52000Punjab Higher Education Department(PHED)Lahore54000Pakistan Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia Department of Mathematics University of GujratGujrat50700Pakistan Department of Mathematics Faculty of SciencesUniversity of Central PunjabLahore54600Pakistan Department of Mathematics Technische Universitat Chemnitz6209111Germany

In 2021,most of the developing countries are fighting polio,and parents are concerned with the disabling of their *** transmits from person to person,which can infect the spinal cord,and paralyzes the parts of the body within a matter of *** to the World Health Organization(WHO),18 million currently healthy people could have been paralyzed by the virus during 1988–*** all countries but Pakistan,Afghanistan,and a fewmore have been declared *** mathematical modeling of poliovirus is studied in the population by categorizing it as susceptible individuals(S),exposed individuals(E),infected individuals(I),and recovered individuals(R).In this study,we study the fundamental properties such as positivity and boundedness of the *** also rigorously study the model’s stability and equilibria with or without *** numerical study,we design the Euler,Runge–Kutta,and nonstandard finite difference ***,the standard techniques are time-dependent and fail to present the results for an extended *** nonstandard finite difference method works well to study disease dynamics for a long time without any ***,the results of different methods are compared to prove their effectiveness.

关键词： Poliovirus modeling stability results computational methods

Amphiphilic AIEgen-polymer aggregates:Design,self-assembly and biomedical applications

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Aggregate

Aggregate 2022年第1期3卷 75-92页

作者： Shoupeng Cao Jingxin Shao Loai K.E.A.abdelmohsen Jan C.M.van Hest Bio-Organic Chemistry Institute for Complex Molecular SystemsEindhoven University of TechnologyEindhovenThe Netherlands

Aggregation-induced emission(AIE)is a phenomenon in which fluorescence is enhanced rather than quenched upon molecular *** fluorogens(AIEgens)are flexible,conjugated systems that are limited in their dynamics when assembled,which improves their fluorescent *** intriguing feature has been incorporated in many different molecular assemblies and has been extended to nanoparticles composed of amphiphilic polymer building *** integration of the fascinating AIE design principle with versatile polymer chemistry opens up new frontiers to approach and solve intrinsic obstacles of conventional fluorescent materials in nanoscience,including the aggregation-caused quenching ***,this integration has drawn significant attention from the nanomedicine community,due to the additional advantages of nanoparticles comprising AIEgenic molecules,such as emission brightness and fluorescence *** this regard,a range of AIEgenic amphiphilic polymers have been developed,displaying enhanced emission in the self-assembly/aggregated *** assemblies are regarded as attractive nanomaterials with inherent fluorescence,which display promising features in a biomedical context,for instance in biosensing,cell/tissue imaging and tracking,as well as(photo)*** this review,we describe recent strategies for the design and synthesis of novel types of AIEgenic amphiphilic polymers via facile approaches including direct conjugation to natural/synthetic polymers,polymerization,post-polymerization and supramolecular host−guest *** self-assembly behavior and biomedical potential will be discussed.

关键词： aggregation-induced emission amphiphilic polymers biomedical applications nanomotors supramolecular self-assembly

Uncoupling tumor necrosis factor-αand interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p/MALAT-1/H19 circuit

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BIOCELL 2022年第3期46卷 769-783页

作者： RAGHDA A.SOLIMAN RANA A.YOUNESS TAMER M.MANIE EMAD KHALLAF MOHAMED EL-SHAZLY MONA abdelmohsen HEBA HANDOUSSA MOHAMED Z.GAD Pharmaceutical Biology Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt School of Life and Medical Sciences University of Hertfordshire Hosted by Global Academic FoundationNew Administrative Capital11578Egypt Breast Surgery Department National Cancer InstituteCairo UniversityCairoEgypt General Surgery Department Faculty of MedicineCairo UniversityCairoEgypt Department of Phytochemistry National Research CentreGiza12622Egypt Biochemistry Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt

Triple Negative Breast Cancer(TNBC)immunotherapy has recently shown promising ***,some TNBC patients presented with *** of the reasons was attributed to the excessive release of cytokines at the tumor microenvironment(TME)such as Tumor necrosis factor alpha(TNF-α)and Interleukin-10(IL-10).Fine regulation of these cytokines’levels via non-coding RNAs(ncRNAs)might alleviate the immune quiescent nature of TME at TNBC ***,the extrapolation of ncRNAs as therapeutic tools is highly ***,disentanglement the nature for the isolation of natural compounds that could modulate the ncRNAs and their respective targets is an applicable translational therapeutic ***,this study aimed to targeting the chief immune suppressive cytokines at the TME(TNF-αand IL-10)via ncRNAs and to examine the effects of Rosemary aerial parts extract on the expression levels of these ncRNAs in *** revealed miR-17-5p as a dual regulator of TNF-αand ***,an intricate interaction has been shown between miR-17-5p and the oncogenic lncRNAs:MALAT1 and *** down of MALAT1 and/or H19 caused an induction in miR-17-5p and reduction in TNF-αand IL-10 expression ***-17-5p was found to be down-regulated,while TNF-α,IL-10,MALAT1 and H19 were up-regulated in BC *** expression of miR-17-5p in MDA-MB-231 cells reduced TNF-α,IL-10,MALAT1 and H19 expression levels,as well as several BC *** a translational approach,ursolic acid(UA)isolated from rosemary induced the expression of miR-17-5p,MALAT1 and decreased H19 expression *** conclusion,this study suggests miR-17-5p as a tumor suppressor and an immune-activator miRNA in BC through tuning up the immunological targets TNF-α,IL-10 at the TME and the oncological mediators MALAT1 and H19 lncRNAs.

关键词： Breast cancer Tumor microenvironment Cytokines TNF-α IL-10 miR-17-5p MALAT1 H19 lncRNAs miRNA Ursolic acid

A Paucity of Detection of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Nucleic Acids in the Vaginal Secretions and the Urine of Some Naturally Infected Dromedary Camels

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Open Journal of Veterinary Medicine 2021年第12期11卷 327-335页

作者： Maged Gomaa Hemida Ali M. Ali abdelmohsen Alnaeem Department of Microbiology College of Veterinary Medicine King Faisal University Al-Hasa Saudi Arabia Department of Virology Faculty of Veterinary Medicine Kafrelsheikh University Kafrelsheikh Egypt Department of Biological Sciences College of Science King Faisal University Al-Hasa Saudi Arabia Department of Botany and Microbiology Faculty of Science Minia University Minia Egypt Department of Clinical Sciences College of Veterinary Medicine King Faisal University Al-Hasa Saudi Arabia

The dromedary camels play some critical roles in the evolution and transmission cycle of the MERS-CoV. There are no current available vaccines or antiviral medications to do prevention or to treat humans against the virus, respectively. Few studies reported the course of the MERS-CoV infection in dromedary camels under both the experiment and natural infection approaches. The curve of the viral particle, as well as its nucleic acids in nasal secretions of the dromedary camels, was reported in more details. However, MERS-CoV shedding in some other secretions such as vaginal secretions still understudied. The main goal of the current study was to check the possibility of MERS-CoV shedding of the MERS-CoV through the vaginal mucous membranes of some female camels. To achieve these goals, we conducted molecular surveillance on one dromedary camel herd in eastern Saudi Arabia. We collected the following swabs per each animal (nasal, rectal, and vaginal) as well as urine samples during the period from Jan 2020-April 2020. Testing of MERS-CoV nucleic acid (NA) was conducted in these swabs by the real-time PCR kits. Our results are showing that (47%, 21%, 0%, and 0%) of the (nasal, rectal, and vaginal) swabs, as well as the urine, were positive, respectively. All the tested vaginal swabs were negative. This may suggest the absence of MERS-CoV shedding in the female genital tract and urine samples despite the detection of the viral NA in the nasal swabs. This study is showing for the first time the failure of detection of the MERS-CoV in the vaginal secretions of some naturally infected dromedary camels. This result is enriching our understanding of the MERS-CoV shedding in various body secretions and excretions.

关键词： MERS-CoV rt-RT-PCR Dromedary Camels Nasal Swabs Rectal Swabs Vaginal Swabs Urine

Current and novel modalities for management of chronic hepatitis B infection

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World Journal of Hepatology 2023年第5期15卷 585-608页

作者： Iman Ibrahim Salama Samia M Sami Somaia I Salama Ghada A Abdel-Latif Fatma A Shaaban Walaa A Fouad Aida M abdelmohsen Hala M Raslan Department of Community Medicine Research National Research CentreGiza 12411DokkiEgypt Department of Child Health National Research CentreGiza 12411DokkiEgypt Department of Internal Medicine National Research CentreGiza 12411DokkiEgypt

Over 296 million people are estimated to have chronic hepatitis B viral infection(CHB),and it poses unique challenges for *** is the result of hepatitis B virus(HBV)-specific immune tolerance and the presence of covalently closed circular DNA as mini chromosome inside the nucleus and the integrated *** hepatitis B core-related antigen is the best surrogate marker for intrahepatic covalently closed circular *** HBV“cure”is the durable loss of hepatitis B surface antigen(HBsAg),with or without HBsAg seroconversion and undetectable serum HBV DNA after completing a course of *** currently approved therapies are nucleos(t)ide analogues,interferon-alpha,and *** these therapies,functional cure can be achieved in<10%of CHB *** variation to HBV or the host immune system that disrupts the interaction between them can lead to reactivation of *** therapies may allow efficient control of *** include direct acting antivirals and *** of the viral antigen load is a crucial factor for success of immune-based *** therapy may lead to modulation of the host immune *** may enhance/restore innate immunity against HBV(as toll-like-receptors and cytosolic retinoic acid inducible geneⅠagonist).Others may induce adaptive immunity as checkpoint inhibitors,therapeutic HBV vaccines including protein(HBsAg/pre S and hepatitis B core antigen),monoclonal or bispecific antibodies and genetically engineered T cells to generate chimeric antigen receptor-T or T-cell receptor-T cells and HBV-specific T cells to restore T cell function to efficiently clear *** therapy may successfully overcome immune tolerance and lead to HBV control and *** approaches carry the risk of overshooting immune responses causing uncontrolled liver *** safety of any new curative therapies should be measured in relation to the excellent safety of currently appro

关键词： immunity infection overcome