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2000全国肿瘤学术大会

作者： Miho Yoshida Yuichi Iino Jun Horiguchi Hiroyuki Takei Yukio koibuchi Fumihiro Ikeda Jun Ninomiya kotaro iijima, ryo ochiai Kazuhiro Uchida Takao Yokoe Yasuo Morisita Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan

＜正＞Objective:To assess recurrence of breast cancer following local excision alone for ductal carcinoma in situ Methods:Eighteen patients who received complete resection for noninvasive ductal carcinoma between 1982 and 1997 were investigated in this *** mean age of the patients was 45（29-78）years *** initial presentation was a clin- ically palpable tumor in 4 patients,nipple discharge in 6,and microcalcification on mammograms in *** with pal-

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Pyridine-Fused Azacorannulene:Fine-Tuning of the Structure and Properties of Nitrogen-Embedded Buckybowls

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Precision Chemistry 2023年第1期1卷 29-33页

作者： Kimihiro Nakamura kotaro ochiai Ayaka Yubuta Dan He Daigo Miyajima Shingo Ito School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371 Center for Emergent Matter Science RIKENWakoSaitama 351-0198Japan College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

Heteroatom-embedded buckybowl molecules provide a fundamental molecular framework that has potential applications in various research ***,selective introduction of heteroatoms into buckybowls is challenging,and thus,studies investigating the effect of introduced heteroatoms have been ***,we report the synthesis of pyridine-fused azacorannulene *** influence of nitrogen atoms introduced into the peripheral positions on the structural,electronic,and optical properties is discussed.

关键词： Azacorannulene Buckybowl Polycyclic Aromatic Molecule 1 3-Dipolar Cycloaddition Azomethine Ylide

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Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1

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World Journal of Hepatology 2017年第36期9卷 1340-1345页

作者： Yoshinori Ozono Kenji Nagata Satoru Hasuike Hisayoshi Iwakiri Kenichi Nakamura Mai Tsuchimochi Yuri Yamada Yuka Takaishi Mitsue Sueta Tadashi Miike Yoshihiro Tahara Shojiro Yamamoto kotaro Shide Tomonori Hidaka Yoko Kubuki Kazunori Kusumoto Toshimasa ochiai Junya Kato Naoto Komada Shuichi Hirono Kazuo Kuroki Masafumi Shigehira Kazuya Shimoda Department of Gastoroenterology and Hematology Faculty of Medicine University of Miyazaki Department of Liver Disease University of Miyazaki Hospital Department of Internal Medicine Koga General Hospital Department of Internal Medicine National Hospital Organization Miyakonojo Medical Center Department of Internal Medicine Hirono Naika Clinic Department of Internal Medicine Kushima Municipal Hospital Department of Internal Medicine Shigehira Clinic

AIM To evaluate the efficacy and safety of a regimen containing sofosbuvir(SOF) and ledipasvir(LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype *** This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazaki prefecture in Japan. Demographic, clinical, virological, and adverse effects(AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger(aged < 75 years) and elderly(aged ≥ 75 years). Virological data and AEs were analyzed by age *** The sustained virological response(SVR) rates at 12 wk after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged < 75 and ≥ 75 years, respectively. Common AEs during therapy were headache, pruritus, constipation, and insomnia. These occurred in fewer than 10% of patients, and their incidence was not significantly different between the younger and elderly groups. Two patients discontinued treatment, one due to a skin eruption and the other due to cerebral bleeding. CONCLUSION Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy.

关键词： Chronic hepatitis C Sofosbuvir Ledipasvir Sustained virological response Direct acting antivirals

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