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Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5723-5731页

作者： Akihiro Yoshihara kota Nishihama Chisa Inoue Yuko Okano Kazuhito Eguchi Soichiro Tanaka Kanako Maki Valeria Fridman D'Alessandro Atsuro Takeshita Taro Yasuma Mei Uemura Toshinari suzuki Esteban C Gabazza Yutaka Yano Department of Diabetes and Endocrinology Japan Community Health care Organization Yokkaichi Hazu Medical CenterYokkaichi 510-0016MieJapan Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie UniversityTsu 514-8507MieJapan Department of Immunology Faculty and Graduate School of MedicineMie UniversityTsu 514-8507MieJapan Department of Immunology and Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan

BACKGROUND Ectopic adrenocorticotropic hormone(ACTH)-secreting neuroendocrine tumors are rare *** with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor *** and coagulopathies have been reported as the cause of ***,detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been *** SUMMARY A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric *** analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol *** enhanced computed tomography(CT)scan revealed a 3-cm tumor in the pancreatic *** cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTHsecreting pancreatic neuroendocrine *** Ki-67 index was 40%.She was transferred to Mie University Hospital for surgical *** patient was diagnosed with urinary tract infection,cytomegalovirus hepatitis,esophageal candidiasis,pulmonary infiltrates suspicious for Pneumocystis carinii pneumonia,peripheral deep vein thrombosis,pulmonary embolism,and disseminated intravascular *** multiple organ infections and thromboses responded well to antimicrobial and anticoagulant *** studies disclosed a pancreatic tumor and a metastatic lesion in the liver,whereas somatostatin receptor scintigraphy showed negative findings,suggesting the primary and metastatic tumors were poorly differentiated.A CT scan before admission showed no metastatic liver lesion,suggesting that the pancreatic tumor was rapidly *** of surgery,antitumor chemotherapy was *** patient was transferred to another hospital to initiate ***,she died four months later due to the rapidly progressive *** ACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor ***

关键词： Neuroendocrine tumors Cushing's syndrome Ectopic adrenocorticotropic hormone syndrome Pneumocystis pneumonia Pulmonary embolism Infections Case report

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Magnetic properties of soft layer/FePt-MgO exchange coupled composite perpendicular recording media

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Chinese Physics B 2008年第10期17卷 3907-3909页

作者：阴津华 Takao suzuki 潘礼庆 Department of Physics University of Science and Technology Beijing Information Storage Materials Laboratory Toyota Technological Institute

The magnetic properties of exchange coupled composite （ECC） media that are composed of perpendicular magnetic recording media FePt MgO and two kinds of soft layers have been studied by using an x-ray diffractometer, a polar Kerr magneto-optical system （PMOKE） and a vibrating sample magnetometer （VSM）. The results show that ECC media can reduce the coercivities of perpendicular magnetic recording media FePt-MgO. The ECC media with granular-type soft layers have weaker exchange couplings between magnetic grains and the magnetization process, for ECC media of this kind mainly follow the Stoner Wohlfarth model.

关键词： exchange coupled composite media perpendicular magnetic recording media magnetic properties

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The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

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Cellular & Molecular Immunology 2011年第4期8卷 305-314页

作者： Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi kota Ishizawa Mei He Takaya suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku Department of Regional Cooperation for Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Advanced Preventive Medicine for Infectious Disease Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Respiratory Medicine Japanese Red-Cross Ishinomaki HospitalIshinomakiMiyagiJapan Department of Infection Control and Laboratory Diagnostics Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Clinical Microbiology with Epidemiological Research&Management and Analysis of Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityChiyoda-kuTokyoJapan Graduate School of Pharmaceutical Sciences Kyoto UniversityKyotoJapan

Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host ***,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of *** studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung ***,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain *** this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model ***,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing ***,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface *** findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of *** CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death.

关键词： CXCL12 CXCR4 lipopolysaccharides lung injury neutrophils

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Uncertainty in solid precipitation and snow depth prediction for Siberia using the Noah and Noah-MP land surface models

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Frontiers of Earth Science 2018年第4期12卷 672-682页

作者： Kazuyoshi suzuki Milija ZUPANSKI Institute of Arctic Climate and Environment Change Research (IACE) Japan Agency for Marine-Earth Science and Technology (JAMSTEC)Yokohama236-0001Japan Cooperative Institute for Research in the Atmosphere Colorado State UniversityFort CollinsCO 80523-1375USA

In this study, we investigate the uncertainties associated with land surface processes in an ensemble predication context. Specifically, we compare the uncertainties produced by a coupled atmosphere–land modeling system with two different land surface models, the Noah- MP land surface model (LSM) and the Noah LSM, by using the Maximum Likelihood Ensemble Filter (MLEF) data assimilation system as a platform for ensemble prediction. We carried out 24-hour prediction simulations in Siberia with 32 ensemble members beginning at 00:00 UTC on 5 March 2013. We then compared the model prediction uncertainty of snow depth and solid precipitation with observation-based research products and evaluated the standard deviation of the ensemble spread. The prediction skill and ensemble spread exhibited high positive correlation for both LSMs, indicating a realistic uncertainty estimation. The inclusion of a multiple snowlayer model in the Noah-MP LSM was beneficial for reducing the uncertainties of snow depth and snow depth change compared to the Noah LSM, but the uncertainty in daily solid precipitation showed minimal difference between the two LSMs. The impact of LSM choice in reducing temperature uncertainty was limited to surface layers of the atmosphere. In summary, we found that the more sophisticated Noah-MP LSM reduces uncertainties associated with land surface processes compared to the Noah LSM. Thus, using prediction models with improved skill implies improved predictability and greater certainty of prediction.

关键词： ensemble simulation land-atmosphere interaction ensemble spread vertical temperature snow prediction

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A Partial Order in the Knot Table Ⅱ

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Acta Mathematica Sinica,English Series 2008年第11期24卷 1801-1816页

作者： Teruaki KITANO Masaaki suzuki Department of Information Systems Science Faculty of Engineering Soka University 1-236 Tangi-cho Hachioji-city Tokyo 192-8577 Japan Department of Mathematics Akita University 1-1 Tegata-Gakuenmachi Akita 010-8502 Japan

A partial order on the set of the prime knots can be defined by the existence of a surjective homomorphism between knot groups. In the previous paper, we determined the partial order in the knot table. In this paper, we prove that 31 and 41 are minimal elements. Further, we study which surjection a pair of a periodic knot and its quotient knot induces, and which surjection a degree one map can induce.

关键词： knot partial order surjective homomorphism period degree one map

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Periostin in cerebrovascular disease

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Neural Regeneration Research 2020年第1期15卷 63-64页

作者： Fumihiro Kawakita Hidenori suzuki Department of Neurosurgery Mie University Graduate School of Medicine

Cerebrovascular diseases,which include ischemic and hemorrhagic strokes,remain serious conditions with high mortality and disability worldwide(He et al.,2018).Ischemic stroke accounts for around 80%of all strokes(He et al.,2018).Hemorrhagic stroke consisting of intracerebral hemorrhage and subarachnoid hemorrhage(SAH)occurs less frequently but may cause poorer outcomes than ischemic stroke(Ji et al.,2017;Luo et al.,2018).It is also well known that aneurysmal SAH may have delayed cerebral ischemia(DCI):thus aneurysmal SAH has both characteristics of hemorrhagic and ischemic strokes(Kanamaru et al.,2019).In spite of enormous efforts to improve outcomes,no conclusive treatment exists thus far,once stroke is completed.

关键词： al. hemorrhagic mortality

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Edge detection based multi-material interface extraction on industrial CT volumes

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Science China(Information Sciences) 2013年第9期56卷 74-82页

作者： OHTAKE Yutaka suzuki Hiromasa Research Center for Advanced Science and Technology The University of Tokyo

X-ray CT scanning is recently becoming a popular technology for industrial applications as well as medical ones. Since the geometrical accuracy is often important for industrial applications, more precise methods for processing CT volumes are required. This paper proposes a method for extracting the multimaterial interfaces on CT volumes obtained by industrial CT scanners. Instead of extracting isosurfaces we detect edge-points, at which the norm of the volume gradient takes a local maximum in the gradient direction, and then interpolate the points as the material interfaces represented by the zero-level of compounded implicit functions. In order to achieve a robust material-identification, multilabel graph-cut is utilized in our method. Using edge-points, we can reduce the inaccuracy caused by CT scanning artifacts.

关键词： CT volume multi-material interface segmentation edge extraction

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Potential therapeutic molecular targets for blood-brain barrier disruption after subarachnoid hemorrhage

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Neural Regeneration Research 2019年第7期14卷 1138-1143页

作者： Hideki Kanamaru Hidenori suzuki Department of Neurosurgery Mie University Graduate School of Medicine

Aneurysmal subarachnoid hemorrhage remains serious hemorrhagic stroke with high morbidities and *** rupture causes arterial bleeding-induced mechanical brain tissue injuries and elevated intracranial pressure,followed by global cerebral ***-subarachnoid hemorrhage ischemia,tissue injuries as well as extravasated blood components and the breakdown products activate microglia,astrocytes and Toll-like receptor 4,and disrupt blood-brain barrier associated with the induction of many inflammatory and other *** blood-brain barrier is disrupted,brain tissues are directly exposed to harmful blood contents and immune cells,which aggravate brain injuries ***-brain barrier disruption after subarachnoid hemorrhage may be developed by a variety of mechanisms including endothelial cell apoptosis and disruption of tight junction *** molecules and pathways have been reported to disrupt the blood-brain barrier after subarachnoid hemorrhage,but the exact mechanisms remain *** independent and/or interconnected signaling pathways may be involved in blood-brain barrier disruption after subarachnoid *** review provides recent understandings of the mechanisms and the potential therapeutic targets of blood-brain barrier disruption after subarachnoid hemorrhage.

关键词： blood-brain barrier early brain injury endothelial cell subarachnoid hemorrhage tight junction inflammation matricellular protein Toll-like receptor 4 TLR4

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Numerical Investigation on Super-cooled Large Droplet Icing of Fan Rotor Blade in Jet Engine

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Journal of Thermal Science 2014年第5期23卷 432-437页

作者： Keisuke Isobe Masaya suzuki Makoto Yamamoto Graduate School of Mechanical Engineering Tokyo University of Science6-3-1 NiijukuKatsushika-kuTokyo125-8585Japan Aviation Program Group Japan Aerospace Exploration Agency(JAXA)7-44-1 Jindaiji Higashi-machiChofu-shiTokyo182-8522Japan Department of Mechanical Engineering Tokyo University of Science6-3-1 NiijukuKatsushika-kuTokyo125-8585Japan

Icing(or ice accretion) is a phenomenon in which super-cooled water droplets impinge and accrete on a *** is well known that ice accretion on blades and vanes leads to performance degradation and has caused severe *** various anti-icing and deicing systems have been developed,such accidents still ***,it is important to clarify the phenomenon of ice accretion on an aircraft and in a jet ***,flight tests for ice accretion are very expensive,and in the wind tunnel it is difficult to reproduce all climate conditions where ice accretion can ***,it is expected that computational fluid dynamics(CFD),which can estimate ice accretion in various climate conditions,will be a useful way to predict and understand the ice accretion *** the other hand,although the icing caused by super-cooled large droplets(SLD) is very dangerous,the numerical method has not been established *** is why SLD icing is characterized by splash and bounce phenomena of droplets and they are very complex in *** the present study,we develop an ice accretion code considering the splash and bounce phenomena to predict SLD icing,and the code is applied to a fan rotor *** numerical results with and without the SLD icing model are *** this study,the influence of the SLD icing model is numerically clarified.

关键词： Ice Accretion Fan Rotor Blade Super-cooled Large Droplet Multi-physics Simulation

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Effects of uniaxial compressive strain on the electronic- transport properties of zigzag carbon nanotubes

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Nano Research 2016年第5期9卷 1267-1275页

作者： Masato Ohnishi Ken suzuki Hideo Miura Fracture and Reliability Research Institute Graduate School of Engineering Tohoku University Sendai 980-8579 Japan

Recently, substantial attention has been paid to the strain sensitivity of the carbon nanotubes＇（CNTs＇） electronic properties. In this study, the relationships between the geometric structures and electronic states of zigzag CNTs under uniaxial compressive strain were investigated. We found that different factors dominate the electronic states of zigzag CNTs depending on the strain regions： the initial stage of the strain loading, which lasts until column-buckling deformation begins, and the strain regions corresponding to column- and shell-buckling deformations. Because shell-buckling deformation significantly increases the re-orbital angle, the angle between the π orbital axis vectors of adjacent atoms, strong localization of the density of states （LDOS） occurs in the buckled area. We also analyzed the current able to pass through deformed CNTs using a tight-binding-based Green＇s function approach and determined that the current can be significantly suppressed by applying uniaxial compressive strain. Our method of predicting the electronic state of a deformed CNT based on the π-orbital angle is expected to be useful for predicting the electronic properties of CNT-based electronic devices and sensors.

关键词： carbon nanotube strain buckling deformation Green's function method electronic-transport property

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