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The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

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Cellular & Molecular Immunology 2011年第4期8卷 305-314页

作者： Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi kota ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku Department of Regional Cooperation for Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Advanced Preventive Medicine for Infectious Disease Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Respiratory Medicine Japanese Red-Cross Ishinomaki HospitalIshinomakiMiyagiJapan Department of Infection Control and Laboratory Diagnostics Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Clinical Microbiology with Epidemiological Research&Management and Analysis of Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityChiyoda-kuTokyoJapan Graduate School of Pharmaceutical Sciences Kyoto UniversityKyotoJapan

Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host ***,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of *** studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung ***,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain *** this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model ***,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing ***,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface *** findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of *** CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death.

关键词： CXCL12 CXCR4 lipopolysaccharides lung injury neutrophils

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Prediction of wall deposition behaviour in a pilot-scale spray dryer using deposition correlations for pipe flows

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 301-312页

作者： kota K. LANGRISH T.A.G. School of Chemical and Biomolecular Engineering University of Sydney Sydney Australia

The particle deposition behaviour of skim milk, water and maltodextrin in the conical section of a pilot-scale spray dryer was predicted using simple correlations for particle depositions in pipes. The predicted particle deposition fluxes of these materials were then compared with the measured deposition fluxes. The predicted particle deposition regimes of the spray dryer were expected to be in the diffusional and mixed (diffusional and inertial) regimes, but the experimental results suggested that the particle deposition was mainly in the inertial regime. Therefore, using the pipe correlations for predicting deposition in a pilot-scale spray dryer suggests that they do not sufficiently represent the actual deposition behaviour. This outcome indicates that a further study of particle flow patterns needs to be carried out using numerical simulations (computational fluid dynamics, CFD) in view of the additional geometrical complexity of the spray dryer.

关键词： Spray dryer Pipe correlations Particle deposition

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Influence of Diffuser on Aerodynamic Noise of a Forward Curved Fan

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Journal of Thermal Science 2013年第5期22卷 433-438页

作者： Soichi SASAKI kota SUZUKI Yuta Onomichi Hidechito Hayashi Division of System Science Graduate School of Engineering Nagasaki University1-14 Bunkyo-machi Nagasaki 852-8521 Japan Department of Advanced Engineering Graduate School of Engineering Nagasaki University1-14 Bunkyo-machi Nagasaki 852-8521 Japan

In order to clarify the influence of a diffuser on the charactersfics of a forward curved fan, the influence of the bare ratio and the outlet angle on the characteristics of the fan were measured through an experiment performed with an actual fan as well as through a numerical simulation, respectively. The mechanism of the discrete fre- quency noise generated by the separated flow of the diffuser was analyzed. The optimized bare ratio was ap- proximately 17%. The flow separated inside of the diffuser generated discrete frequency noise owing to the inter- action between the reversed flow from the diffuser and the impeller rotating at the blade passing frequency. The diffuser outlet angle influenced the pressure ratio more than that by the bare ratio. Furthermore, it was confirmed that restraining the separation in the diffuser effectively decreases the fan noise.

关键词： Pressure Drop Fan Aerodynamic Noise Internal Flow Separation

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Recent trends on energy-efficient solar dryers for food and agricultural products drying:a review

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Waste Disposal and Sustainable Energy 2024年第3期6卷 335-353页

作者： Kavati Venkateswarlu S.V.kota Reddy Mechanical Engineering School of Engineering and the Built EnvironmentJEDS CampusUniversity of NamibiaPrivate Bag 3624OngwedivaOshakati RegionNamibia School of Mechanical Engineering(SMEC) VIT-AP UniversityAmaravatiAndhra Pradesh522237India

The energy efficiency enhancement of solar dryers has attracted the attention of researchers worldwide because of the need for energy storage in solar drying applications,which arises primarily from the irregular nature of solar energy that leads to improper drying which will reduce the quality of the products being *** work comprehensively reviews the state-of-the-art research carried out on solar dryers for energy efficiency enhancement using various alternative strategies,including hybrid solar dryers that use auxiliary heating sources,such as electric heaters or biomass heaters,solar-assisted heat pump dryer,use of desiccant materials,and heat storage systems that use both sensible and latent heat *** advent of phase change materials(PCM),such as thermally and chemically stable PCMs,for long-term storage,bio-degradable and bio-compatible PCM materials to alleviate the negative environmental impact of conventional PCMs is also *** performance parameters considered for evaluating dryers include the maximum temperature attained inside the drying chamber,drying time and efficiency,specific moisture extraction rate(SMER),energy and exergy efficiency and CO_(2) mitigation *** factors considered to analyze the PCMs application in solar dryers include cost and sustainability of PCMs,and both energy and exergy analyses of dryers using *** gaps in current knowledge and future scope for further improvement of solar dryers are also elucidated.

关键词： Agricultural and food products Desiccant materials Hybrid dryers Phase change material Solar-assisted heat pump dryers Thermal energy storage

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Prediction of return of spontaneous circulation in outof-hospital cardiac arrest with non-shockable initial rhythm using point-of-care testing: a retrospective observational study

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World Journal of Emergency Medicine 2023年第2期14卷 89-95页

作者： kota Shinada Hiroyuki Koami Ayaka Matsuoka Yuichiro Sakamoto Department of Emergency and Critical Care Medicine Faculty of MedicineSaga UniversitySaga CitySaga Prefecture 849-8501Japan Division of Translational Research in Intensive Care Medicine Faculty of MedicineSaga UniversitySaga CitySaga Prefecture 849-8501Japan

BACKGROUND:Out-of-hospital cardiac arrest(OHCA) is a public health concern, and many studies have been conducted on return of spontaneous circulation(ROSC) and its prognostic *** thromboelastometry(ROTEM?), a point-of-care testing(POCT) method, has been useful for predicting ROSC in patients with OHCA, but very few studies have focused on patients with non-shockable rhythm. We examined whether the parameters of POCT could predict ROSC in patients with OHCA and accompanying non-shockable ***:This is a single-center, retrospective observational study. Complete blood count,blood gas, and ROTEM POCT measurements were used. This study included patients with nontraumatic OHCA aged 18 years or older who were transported to the emergency department and evaluated using POCT between January 2013 and December 2021. The patients were divided into the ROSC and non-ROSC groups. Prehospital information and POCT parameters were compared using receiver operating characteristic(ROC) curve analysis, and further logistic regression analysis was ***:Sixty-seven and 135 patients were in the ROSC and non-ROSC groups,respectively. The ROC curves showed a high area under the curve(AUC) for K^(+) of 0.77(95%confidence interval [CI]:0.71–0.83) and EXTEM amplitude 5 min after clotting time(A5) of 0.70(95%CI:0.62–0.77). The odds ratios for ROSC were as follows:female sex 3.67(95%CI:1.67–8.04);K^(+)0.64(95%CI:0.48–0.84);and EXTEM A5 1.03(95%CI:1.01–1.06).CONCLUSION:In OHCA patients with non-shockable rhythm, K^(+) level and the ROTEM parameter EXTEM A5 may be useful in predicting ROSC.

关键词： Rotational thromboelastometry Blood coagulation disorders Extrinsic pathway Potassium

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Experimental Evaluation of a Multistage Reciprocating Evaporative Cooler Performance for Varied Climatic Conditions

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Journal of Thermal Science 2023年第4期32卷 1523-1535页

作者： Sampath SURANJAN SALINS S.V.kota REDDY Shiva KUMAR School of Engineering and IT Manipal Academy of Higher EducationDubai CampusDubaiPO 345050UAE Mechanical Engineering Department VIT-AP UniversityAmaravatiAndra Pradesh52223India Department of Mechanical and Manufacturing Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal576104India

Current system focuses on design&construction of a multistage reciprocating evaporative cooling test *** packings that are used will undergo the reciprocating action,powered by the cam follower mechanism maintained at an actual rotation *** dry bulb temperature&humidity values are varied to replicate the varying climatic conditions,and the output parameters such as cooling load,evaporation rate(ER),humidification efficiency(HE),coefficient of performance(COP)are *** results showed that as inlet humidity raises,the performance of system *** the rise in the camshaft speed or packing velocity,there is an upsurge in the performance until a cam speed of 10 r/min or packing velocity of 0.083 m/s and with further increases in the value,overall performance *** system gave a maximum COP,ER,and HE equal to 3.80,73.87%,and 0.53 g/kg respectively.A rise in the inlet air temperature yielded a maximum change in dry bulb temperature of 8.2℃.Overall,results indicated that evaporative cooling is more effective in arid climates than the cold and humid *** quality test is performed to measure CO_(2),Total Volatile Organic Compound(TVOC),and Formaldehyde(HCHO),and it is found that humidified air entering the defined space is of excellent quality.

关键词： multistage humidifier evaporative cooling reciprocating packing humidification efficiency

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Characterization of microstructure and wear behavior of nickel modified Zn-27%Al alloy casting

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China Foundry 2024年第6期21卷 693-701页

作者： Anusha Raj kota Ramesh Gopalan Babu Rao Jinugu Surendarnath Sundaramoorthy Department of Metallurgical and Materials Engineering Rajiv Gandhi University of Knowledge Technologies-R K Valley CampusKadapaAndhra PradeshIndia Department of Metallurgical Engineering AU College of Engineering-Andhra UniversityVisakhapatnamAndhra PradeshIndia Department of Mechanical Engineering DVR&Dr.HS MIC College of Technology(A)VijayawadaAndhra PradeshIndia

Improvement of mechanical and tribological behaviors of zinc-based die cast alloy is necessary for bearing applications,and chemical modification is found to be a good *** modification of Zn-27wt.%Al alloy was carried out with 1%,2%and 3%nickel through casting route,and its effect on microstructure,hardness,and dry sliding wear behavior was *** refinement of dendritic microstructure is observed along with a transformation from rosette to near rounded morphology with the increase in nickel content of base *** 1%nickel modification,an aluminum-rich Al_(3)Ni intermetallic compound of string type forms in inter dendritic region,while with 2%and 3%nickel modifications,a nickel-rich AlNi3 intermetallic compound of lath/plate type is formed within the intra dendritic *** of the base alloy is improved through grain boundary strengthening at a lower concentration of nickel,and particulate strengthening and spinodal decomposition are the reason for increase in hardness of the alloy with a higher content of *** of friction and wear rate of base alloy is decreased with increasing nickel *** surface is characterized by delamination,smearing and *** wear mechanism is transferred from adhesion to abrasive via oxide film formation with an increase in amount of nickel.

关键词： ZA alloy nickel modifications microstructure dry sliding wear hardness

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High accuracy offering attention mechanisms based deep learning approach using CNN/bi-LSTM for sentiment analysis

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International Journal of Intelligent Computing and Cybernetics 2022年第1期15卷 61-74页

作者： Venkateswara Rao kota Shyamala Devi Munisamy CSE Vel Tech Rangarajan Dr Sagunthala R&D Institute of Science and TechnologyChennaiIndia CSE Andhra Loyola Institute of Engineering and TechnologyVijayawadaIndia

Purpose-Neural network(NN)-based deep learning(DL)approach is considered for sentiment analysis(SA)by incorporating convolutional neural network(CNN),bi-directional long short-term memory(Bi-LSTM)and attention *** the conventional supervised machine learning natural language processing algorithms,the authors have used unsupervised deep learning ***/methodology/approach-The method presented for sentiment analysis is designed using CNN,Bi-LSTM and the attention ***2vec word embedding is used for natural language processing(NLP).The discussed approach is designed for sentence-level SA which consists of one embedding layer,two convolutional layers with max-pooling,oneLSTMlayer and two fully connected(FC)*** the system training time is 30 ***-The method performance is analyzed using metrics like precision,recall,F1 score,and *** is helped to reduce the complexity and Bi-LSTM is helped to process the long sequence input ***/value-The attention mechanism is adopted to decide the significance of every hidden state and give a weighted sum of all the features fed as input.

关键词： Sentiment analysis NLP Neural networks Bi-LSTM Attention mechanism Word embedding Dropout Fully connected(FC)layer Performance metrics

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Derivation of Optimal Rotor Topologies for Consequent-Pole PMSM by ON/OFF Method

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CES Transactions on Electrical Machines and Systems 2021年第4期5卷 301-310页

作者： Zhen Sun kota Watanebe Xiaozhuo Xu the Graduate School of Engineering Muroran Institute of TechnologyMuroran 050-8585Japan the School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo 454000China

Consequent-pole permanent magnet synchronous machines(CP-PMSMs)have attracted considerable interest as a means of reducing manufacturing costs through a marked reduction in the volume of permanent magnet required to meet a particular torque *** this paper,novel rotor topologies for a CP-PMSM are derived to unlock the full design space *** ON/OFF method is introduced to manage the laminated steel material distribution over the rotor region,high average torque and low torque ripple are the objects of rotor design,and the immune algorithm is used to search for the optimal material distribution for the formulated *** than 9000 different rotor topologies are created and evaluated within 12 hours by this *** optimal topologies under different design strategy are presented,and performance of these topologies are *** analysis results show that the proposed methodology can deliver novel rotor topologies for the CP-PMSM with surprising torque quality since the torque ripple is suppressed to a low level with no average torque sacrifice.

关键词： Consequent-pole Immune algorithm Permanent magnet synchronous machines Topology optimization

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Community spaces in the minds of traditional craftsmen in a pottery villase in Japan

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Frontiers of Architectural Research 2015年第4期4卷 253-262页

作者： kota Maruya Sampei Yamashita Tadashi Uchiyama Department of Tourism Rikkvo University 1-2-26 Kitano Niiza-shi Saitama 352-8558 Japan Department of Civil Engineering Kyushu Sangyo University 2-3-1 Matsukadai Higashi-ku Fukuoka813-8503 Japan Center for Landscape Research t(yushu Sangyo University 2-3-1 Matsukadai Higashi-ku Fukuoka813-8503 Japan

At present, the planning for the conservation or development of Japanese traditional crafts is based on administrative districts or water catchment areas. However, the conservation of Japanese traditions relies not only on the access to relevant natural resources but also on artisans＇ ability to manufacture crafts in specific environments. The perspectives of artisans on their work environments have a significant influence on traditional crafts. In this study, we aimed to investigate the changes in natural resource use in a vilage recognized for Koishiwara-yaki-style pottery. We employed a questionnaire and conducted interview surveys to collect data on the perceptions of the artisans working in the said viliage. The findings were as follows. 1 ） The area commonly resarded by the artisans as their place for pottery was identified. The identification of areas that are significant to local tradition can serve as a vital contribution to spatial planning. 2） The birth place of the local ceramics tradition in a local water catchment area was regarded as critically important in the preservation of the traditions of the viilage. 3） Several potters emphasized the value of their work environment to ver administrative support because of the histoHcal connection between the place and their traditions. Highlighting this connection can attract historical and cultural tourism to this area.

关键词： Recognized area Cultural landscape Modernization Traditional craft nat-ural resource

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