检索结果-南通市图书馆

The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

引用

Cellular & Molecular Immunology 2011年第4期8卷 305-314页

作者： Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi kota ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku Department of Regional Cooperation for Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Advanced Preventive Medicine for Infectious Disease Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Respiratory Medicine Japanese Red-Cross Ishinomaki HospitalIshinomakiMiyagiJapan Department of Infection Control and Laboratory Diagnostics Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Clinical Microbiology with Epidemiological Research&Management and Analysis of Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityChiyoda-kuTokyoJapan Graduate School of Pharmaceutical Sciences Kyoto UniversityKyotoJapan

Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host ***,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of *** studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung ***,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain *** this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model ***,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing ***,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface *** findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of *** CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death.

关键词： CXCL12 CXCR4 lipopolysaccharides lung injury neutrophils

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Japanese Sign Language Recognition by Combining Joint Skeleton-Based Handcrafted and Pixel-Based Deep Learning Features with Machine Learning Classification

引用

Computer Modeling in Engineering & Sciences 2024年第6期139卷 2605-2625页

作者： Jungpil Shin Md.Al Mehedi Hasan Abu Saleh Musa Miah kota Suzuki Koki Hirooka School of Computer Science and Engineering The University of AizuAizuwakamatsu965-8580Japan Department of Computer Science&Engineering Rajshahi University of Engineering&TechnologyRajshahi6204Bangladesh

Sign language recognition is vital for enhancing communication accessibility among the Deaf and hard-of-hearing *** Japan,approximately 360,000 individualswith hearing and speech disabilities rely on Japanese Sign Language(JSL)for ***,existing JSL recognition systems have faced significant performance limitations due to inherent *** response to these challenges,we present a novel JSL recognition system that employs a strategic fusion approach,combining joint skeleton-based handcrafted features and pixel-based deep learning *** system incorporates two distinct streams:the first stream extracts crucial handcrafted features,emphasizing the capture of hand and body movements within JSL ***,a deep learning-based transfer learning stream captures hierarchical representations of JSL gestures in the second ***,we concatenated the critical information of the first stream and the hierarchy of the second stream features to produce the multiple levels of the fusion features,aiming to create a comprehensive representation of the JSL *** reducing the dimensionality of the feature,a feature selection approach and a kernel-based support vector machine(SVM)were used for the *** assess the effectiveness of our approach,we conducted extensive experiments on our Lab JSL dataset and a publicly available Arabic sign language(ArSL)*** results unequivocally demonstrate that our fusion approach significantly enhances JSL recognition accuracy and robustness compared to individual feature sets or traditional recognition methods.

关键词： Japanese Sign Language(JSL) hand gesture recognition geometric feature distance feature angle feature GoogleNet

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advancements in the diagnosis and treatment of acral melanoma

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 106-122页

作者： Ahmad ALHASKAWI Sohaib Hasan Abdullah EZZI Yanzhao DONG Haiying ZHOU Zewei WANG Jingtian LAI Chengjun YAO Vishnu Goutham kota Mohamed Hasan Abdulla Hasan ABDULLA Hui LU Department of Orthopedics the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China Department of Orthopaedics Third Xiangya HospitalCentral South UniversityChangsha410013China Zhejiang University School of Medicine Hangzhou310058China Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare Zhejiang UniversityHangzhou310058China

Acral melanoma(AM)is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate,largely due to the inconspicuous nature of early-stage lesions,which can lead to late *** of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas,early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities,including clinical examination,dermoscopy,histopathology,molecular testing,radiological imaging,and blood *** surgery is the preferred method of treatment for AM,other therapeutic options may be employed based on the stage and underlying etiology of the *** checkpoint inhibitors,molecular targeted therapy,radiotherapy,chemotherapy,and oncolytic virotherapy represent promising advanced treatment options for *** this review,we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM,highlighting the importance of early detection and the prompt,individualized management of this challenging disease.

关键词： Acral melanoma Acral lentiginous melanoma Acral nevus Cutaneous malignant melanoma Dermoscopy Oncolytic virotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fine 3D control of THz emission in air with dual femtosecond laser pre-pulses at tunnelling ionisation regime

引用

Light(Advanced Manufacturing) 2024年第3期5卷 62-74页

作者： Hsin-Hui Huang Takeshi Nagashima kota Kumagai Yoshio Hayasaki Saulius Juodkazis Vladimir T.Tikhonchuk Koji Hatanaka Optical Sciences Centre ARC Training Centre in Surface Engineering for Advanced Materials(SEAM)School of ScienceSwinburne University of TechnologyHawthornVictoria 3122Australia Faculty of Science and Engineering Setsunan University17-8 Ikeda-NakamachiNeyagawaOsaka572-8508Japan Center for Optical Research and Education(CORE) Utsunomiya University7-1-2 YotoUtsunomiya 321-8585Japan WRH Program International Research Frontiers Initiative(IRFI)Tokyo Institute of Technology Nagatsuta-choMidori-kuYokohamaKanagawa 226-8503 Japan Laser Research Center Physics FacultyVilnius UniversitySauletekio Ave.1010223 VilniusLithuania Centre Lasers Intenses et Applications Universite de Bordeaux351Cours de la Liberation33405 Talence cedexFrance Extreme Light Infrastructure ERIC ELI Beamlines FacilityZa Radnicic 83525241 Dolni BřežanyCzech Republic Organization for Research Strategy and Development Okayama Univ.1-1-1 Tsushima-nakaKita-kuOkayama 700-8530Japan

Emission of THz radiation from air breakdown at focused ultra-short fs-laser pulses(800 nm/35 fs)was investigated for the 3D spatio-temporal control where two pre-pulses are used before the *** laser pulse induced air breakdown forms a~120μm-long focal volume generate shockwaves which deliver a denser air into the focal region of the main pulse for enhanced generation of THz radiation at 0.1-2.5 THz spectral *** intensity of 162 pre-and main-pulses was at the tunnelling ionisation intensities(1-3)×10 W/cm and corresponded to sub-critical(transparent)plasma formation in *** analysis of THz radiation revealed that orientation of the air density gradients generated by pre-pulses and their time-position locations defined the ellipticity of the generated THz electrical *** rotational component of electric current is the origin of THz radiation.

关键词： THz radiation Femtosecond laser induced breakdown Air breakdown spatio-temporal control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prediction of wall deposition behaviour in a pilot-scale spray dryer using deposition correlations for pipe flows

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 301-312页

作者： kota K. LANGRISH T.A.G. School of Chemical and Biomolecular Engineering University of Sydney Sydney Australia

The particle deposition behaviour of skim milk, water and maltodextrin in the conical section of a pilot-scale spray dryer was predicted using simple correlations for particle depositions in pipes. The predicted particle deposition fluxes of these materials were then compared with the measured deposition fluxes. The predicted particle deposition regimes of the spray dryer were expected to be in the diffusional and mixed (diffusional and inertial) regimes, but the experimental results suggested that the particle deposition was mainly in the inertial regime. Therefore, using the pipe correlations for predicting deposition in a pilot-scale spray dryer suggests that they do not sufficiently represent the actual deposition behaviour. This outcome indicates that a further study of particle flow patterns needs to be carried out using numerical simulations (computational fluid dynamics, CFD) in view of the additional geometrical complexity of the spray dryer.

关键词： Spray dryer Pipe correlations Particle deposition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

肢端黑色素瘤的诊断和治疗进展（英文）

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期 106-123页

作者： Ahmad ALHASKAWI Sohaib Hasan Abdullah EZZI 董延钊周海英王泽伟来经天姚成俊 Vishnu Goutham kota Mohamed Hasan Abdulla Hasan ABDULLA 卢荟浙江大学医学院附属第一医院骨科中南大学湘雅三医院骨科浙江大学医学院阿里巴巴-浙江大学未来数字医疗联合研究中心

肢端黑色素瘤（AM）是深色皮肤患者中最常见的黑色素瘤组织学亚型，常伴有更差的预后和高死亡率，主要原因为早期病变的不典型特征导致诊断延误。由于AM的临床和组织病理学特征与其他形式的皮肤黑色素瘤相近，其早期检测需要综合各种诊... 详细信息

肢端黑色素瘤（AM）是深色皮肤患者中最常见的黑色素瘤组织学亚型，常伴有更差的预后和高死亡率，主要原因为早期病变的不典型特征导致诊断延误。由于AM的临床和组织病理学特征与其他形式的皮肤黑色素瘤相近，其早期检测需要综合各种诊断模式的多学科方法，包括临床检查、皮肤镜检查、组织病理学检查、分子检测、放射学成像和血液检测。虽然手术是AM的首选治疗方法，但是根据疾病的分期和潜在病因，也可以采用其他治疗方案。免疫检查点抑制剂、分子靶向治疗、放疗、化疗和溶瘤病毒治疗在AM治疗上具有应用前景。在本文中，我们概述了AM诊断和治疗方法的最新进展，强调了早期发现和及时、个性化管理在这一具有挑战性疾病诊疗上的重要性。

关键词：肢端黑色素瘤肢端雀斑样黑色素瘤肢端痣皮肤恶性黑色素瘤皮肤镜检查溶瘤病毒治疗

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Influence of Diffuser on Aerodynamic Noise of a Forward Curved Fan

引用

Journal of Thermal Science 2013年第5期22卷 433-438页

作者： Soichi SASAKI kota SUZUKI Yuta Onomichi Hidechito Hayashi Division of System Science Graduate School of Engineering Nagasaki University1-14 Bunkyo-machi Nagasaki 852-8521 Japan Department of Advanced Engineering Graduate School of Engineering Nagasaki University1-14 Bunkyo-machi Nagasaki 852-8521 Japan

In order to clarify the influence of a diffuser on the charactersfics of a forward curved fan, the influence of the bare ratio and the outlet angle on the characteristics of the fan were measured through an experiment performed with an actual fan as well as through a numerical simulation, respectively. The mechanism of the discrete fre- quency noise generated by the separated flow of the diffuser was analyzed. The optimized bare ratio was ap- proximately 17%. The flow separated inside of the diffuser generated discrete frequency noise owing to the inter- action between the reversed flow from the diffuser and the impeller rotating at the blade passing frequency. The diffuser outlet angle influenced the pressure ratio more than that by the bare ratio. Furthermore, it was confirmed that restraining the separation in the diffuser effectively decreases the fan noise.

关键词： Pressure Drop Fan Aerodynamic Noise Internal Flow Separation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prediction of return of spontaneous circulation in outof-hospital cardiac arrest with non-shockable initial rhythm using point-of-care testing: a retrospective observational study

引用

World Journal of Emergency Medicine 2023年第2期14卷 89-95页

作者： kota Shinada Hiroyuki Koami Ayaka Matsuoka Yuichiro Sakamoto Department of Emergency and Critical Care Medicine Faculty of MedicineSaga UniversitySaga CitySaga Prefecture 849-8501Japan Division of Translational Research in Intensive Care Medicine Faculty of MedicineSaga UniversitySaga CitySaga Prefecture 849-8501Japan

BACKGROUND:Out-of-hospital cardiac arrest(OHCA) is a public health concern, and many studies have been conducted on return of spontaneous circulation(ROSC) and its prognostic *** thromboelastometry(ROTEM?), a point-of-care testing(POCT) method, has been useful for predicting ROSC in patients with OHCA, but very few studies have focused on patients with non-shockable rhythm. We examined whether the parameters of POCT could predict ROSC in patients with OHCA and accompanying non-shockable ***:This is a single-center, retrospective observational study. Complete blood count,blood gas, and ROTEM POCT measurements were used. This study included patients with nontraumatic OHCA aged 18 years or older who were transported to the emergency department and evaluated using POCT between January 2013 and December 2021. The patients were divided into the ROSC and non-ROSC groups. Prehospital information and POCT parameters were compared using receiver operating characteristic(ROC) curve analysis, and further logistic regression analysis was ***:Sixty-seven and 135 patients were in the ROSC and non-ROSC groups,respectively. The ROC curves showed a high area under the curve(AUC) for K^(+) of 0.77(95%confidence interval [CI]:0.71–0.83) and EXTEM amplitude 5 min after clotting time(A5) of 0.70(95%CI:0.62–0.77). The odds ratios for ROSC were as follows:female sex 3.67(95%CI:1.67–8.04);K^(+)0.64(95%CI:0.48–0.84);and EXTEM A5 1.03(95%CI:1.01–1.06).CONCLUSION:In OHCA patients with non-shockable rhythm, K^(+) level and the ROTEM parameter EXTEM A5 may be useful in predicting ROSC.

关键词： Rotational thromboelastometry Blood coagulation disorders Extrinsic pathway Potassium

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High accuracy offering attention mechanisms based deep learning approach using CNN/bi-LSTM for sentiment analysis

引用

International Journal of Intelligent Computing and Cybernetics 2022年第1期15卷 61-74页

作者： Venkateswara Rao kota Shyamala Devi Munisamy CSE Vel Tech Rangarajan Dr Sagunthala R&D Institute of Science and TechnologyChennaiIndia CSE Andhra Loyola Institute of Engineering and TechnologyVijayawadaIndia

Purpose-Neural network(NN)-based deep learning(DL)approach is considered for sentiment analysis(SA)by incorporating convolutional neural network(CNN),bi-directional long short-term memory(Bi-LSTM)and attention *** the conventional supervised machine learning natural language processing algorithms,the authors have used unsupervised deep learning ***/methodology/approach-The method presented for sentiment analysis is designed using CNN,Bi-LSTM and the attention ***2vec word embedding is used for natural language processing(NLP).The discussed approach is designed for sentence-level SA which consists of one embedding layer,two convolutional layers with max-pooling,oneLSTMlayer and two fully connected(FC)*** the system training time is 30 ***-The method performance is analyzed using metrics like precision,recall,F1 score,and *** is helped to reduce the complexity and Bi-LSTM is helped to process the long sequence input ***/value-The attention mechanism is adopted to decide the significance of every hidden state and give a weighted sum of all the features fed as input.

关键词： Sentiment analysis NLP Neural networks Bi-LSTM Attention mechanism Word embedding Dropout Fully connected(FC)layer Performance metrics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental Evaluation of a Multistage Reciprocating Evaporative Cooler Performance for Varied Climatic Conditions

引用

Journal of Thermal Science 2023年第4期32卷 1523-1535页

作者： Sampath SURANJAN SALINS S.V.kota REDDY Shiva KUMAR School of Engineering and IT Manipal Academy of Higher EducationDubai CampusDubaiPO 345050UAE Mechanical Engineering Department VIT-AP UniversityAmaravatiAndra Pradesh52223India Department of Mechanical and Manufacturing Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal576104India

Current system focuses on design&construction of a multistage reciprocating evaporative cooling test *** packings that are used will undergo the reciprocating action,powered by the cam follower mechanism maintained at an actual rotation *** dry bulb temperature&humidity values are varied to replicate the varying climatic conditions,and the output parameters such as cooling load,evaporation rate(ER),humidification efficiency(HE),coefficient of performance(COP)are *** results showed that as inlet humidity raises,the performance of system *** the rise in the camshaft speed or packing velocity,there is an upsurge in the performance until a cam speed of 10 r/min or packing velocity of 0.083 m/s and with further increases in the value,overall performance *** system gave a maximum COP,ER,and HE equal to 3.80,73.87%,and 0.53 g/kg respectively.A rise in the inlet air temperature yielded a maximum change in dry bulb temperature of 8.2℃.Overall,results indicated that evaporative cooling is more effective in arid climates than the cold and humid *** quality test is performed to measure CO_(2),Total Volatile Organic Compound(TVOC),and Formaldehyde(HCHO),and it is found that humidified air entering the defined space is of excellent quality.

关键词： multistage humidifier evaporative cooling reciprocating packing humidification efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：