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Clinical significance of monocyte-derived dendritic cell activation in patients with acute coronary syndrome

World Journal of Cardiovascular Diseases 2012年第2期2卷 74-81页

作者： Yasue Takahashi Kazunori Shimada Katsuhiko Sumiyoshi Takashi Kiyanagi Makoto Hiki kosuke fukao Kuniaki Hirose Rie Matsumori Hiromichi Ohsaka Atsumi Kume Tetsuro Miyazaki Hiroaki Miyajima Isao Nagaoka Hiroyuki Daida Department of Cardiovascular Medicine Juntendo University School of Medicine Tokyo Japan Department of Host Defense and Biochemical Research Juntendo University Graduate School of Medicine Tokyo Japan Division of Cell Biology Juntendo University Graduate School of Medicine Tokyo Japan

Background: Acute coronary syndrome (ACS) is an amplified state of inflammation and immune reaction. Dendritic cells (DCs) expressing various Toll-like receptors (TLRs) have been observed in atherosclerotic lesions, however, the clinical significance of DCs in pathogenesis of ACS has not been completely investigated. Methods: Ten patients with ACS and 10 patients with stable angina pectoris (SAP) were enrolled in this study. Monocyte-derived DCs were generated from CD14+ cells by culturing with granulocyte macrophage colony-stimulating factor and interleukin (IL)-4 for 6 days. Expression of cell surface CD86 and CD83 were measured by flowcytometry. Expression of genes, including CD86, CD83, CCL19, CCR7, TLR2, TLR4, TLR5, TLR8, and TLR9, were measured by real-time PCR. Plasma IL-6 and tumor necrosis factor (TNF)-α levels were also measured. Results: The number of CD86+CD83+DCs in the ACS group was significantly higher than that in the SAP group (P P P +CD83+ cells and plasma levels of IL-6 (P = 0.88, P +CD83+ cells TNF-α levels (r = 0.78, P < 0.0001). Conclusions: These results demonstrated that mono-cyte-derived DCs are activated in patients with ACS, suggesting that activated DCs may play an important role in the pathogenesis of ACS.

关键词： Acute Coronary Syndrome (ACS) Dendritic Cells (DCs) Toll-Like Receptors (TLRs)

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Clinical and prognostic features in asymptomatic and symptomatic patients with arteriosclerosis obliterans

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World Journal of Cardiovascular Diseases 2012年第1期2卷 1-7页

作者： Hiromichi Ohsaka Kazunori Shimada kosuke fukao Eiryu Sai Yoshifumi Fukushima Hiroshi Masuda Kuniaki Hirose Takuma Yoshihara Rie Matsumori Makoto Hiki Takashi Kiyanagi Atsumi Kume Haruyo Yamashita Tetsuro Miyazaki Hiroyuki Daida 不详

Background: Patients with arteriosclerosis obliterans (ASO) often have co-existing atherosclerotic diseases. The purpose of this study was to examine the clinical features of patients with ASO, including the overlap of atherosclerotic risk factors, characteristics of car-diovascular events, and clinical prognosis. Method: We enrolled 205 consecutive patients who had ankle brachial index (ABI) of ?0.9 between January 2008 and December 2009. Fontaine (F) classification and clinical background were evaluated and clinical events including mortality and major adverse cardiocerebro-vascular events (MACCEs) were determined. Results: There was a high prevalence of each risk factor. Sixty- five percent of subjects had three or more of the four overlapping risk factors, including hypertension, dia- betes, dyslipidemia, and smoking. After a maximum follow-up of 800 days, the incidence of MACCEs and mortality was 46% and 10%, respectively. We divided the patients into two groups according to the presence of ASO symptoms (F1 and F2-4) and compared the incidence of events. The incidence of MACCEs and mortality in the F2-4 group was significantly higher than that in the F1 group (P = 0.048, P = 0.044, respectively). After excluding lower extremity revascularization, coronary artery disease was a common cause of MACCEs, and the mortality rates after MACCEs increased in a stepwise manner according to F classification severity (P = 0.028). Conclusion: Patients with ASO had overlapping coronary risk factors and a high incidence rate of cardiovascular events. The incidence of coronary events was common, especially in symptomatic patients, and the mortality rates after MACCEs were high in accordance with F classification severity.

关键词： Arteriosclerosis Obliterans Fontaine Classification Risk Factor Mortality Cardiocerebrovascular Event

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Clinical and prognostic features in asymptomatic and symptomatic patients with arteriosclerosis obliterans

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World Journal of Cardiovascular Diseases（心血管病） 2012年第1期

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