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A Remark on the Courant-Friedrichs-Lewy Condition in Finite Difference Approach to PDE’s

Advances in Applied Mathematics and Mechanics 2014年第5期6卷 693-698页

作者： kosuke abe Nobuyuki Higashimori Masayoshi Kubo Hiroshi Fujiwara Yuusuke Iso Nihon University TokyoJapan Hitotsubashi University KunitachiJapan Graduate School of Informatics Kyoto UniversityKyotoJapan

The Courant-Friedrichs-Lewy condition(The CFL condition)is appeared in the analysis of the finite difference method applied to linear hyperbolic partial differential *** give a remark on the CFL condition from a view point of stability,and we give some numerical experiments which show instability of numerical solutions even under the CFL *** give a mathematical model for rounding errors in order to explain the instability。

关键词： Numerical analysis finite difference scheme stability CFL condition

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New acetogenin katsuurallene from Laurencia saitoi collected from Katsuura, Japan

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Natural Products and Bioprospecting 2022年第1期12卷 121-127页

作者： Yu Minamida Hiroshi Matsuura Takahiro Ishii Miyu Miyagi Yuto Shinjo kosuke Sato Takashi Kamada Yoshihiro Mihara Iwao Togashi Keisuke Sugimoto Tsuyoshi abe Norio Kikuchi Minoru Suzuki Advanced Course of Applied Chemistry National Institute of TechnologyAsahikawa CollegeShunkodai 2-2-1-6AsahikawaHokkaido 071-8142Japan Department of Materials Chemistry National Institute of TechnologyAsahikawa CollageShunkodai 2-2-1-6AsahikawaHokkaido 071-8142Japan Department of Biosciences and Biotechnology Faculty of AgricultureUniversity of the Ryukyus1 SenbaruNishiharaOkinawa 903-0213Japan Department of Materials and Life Science Faculty of Science and TechnologyShizuoka Institute of Science and Technology2200-2 ToyosawaFukuroiShizuoka 437-8555Japan Department of Medicinal Chemistry Faculty of Pharmaceutical SciencesHokkaido University of ScienceMaeda 715-4-1Teine-kuSapporoHokkaido 006-8590Japan The Hokkaido University Museum Hokkaido UniversityN10 W8Kita-kuSapporoHokkaido 060-0810Japan Coastal Branch of Natural History Museum and Institute Chiba123 YoshioKatsuuraChiba 299-5242Japan Department of Life Science Graduate School of Engineering ScienceAkita University1-1 Tegatagakuen-machiAkita 010-8502Japan

We examined the chemical constitution of the red alga Laurencia saitoi Perestenko,collected from Katsuura,Boso Peninsula,Chiba Prefecture,*** specimen produced a new polyhalogenated acetogenin,named katsuural-lene(1),which structure was determined by the spectral methods,along with known diterpene,deoxyparguerol(2)and triterpene,thyrsiferol(3).In this paper we describe the structural elucidation of katsuurallene together with some biological activities.

关键词： Laurencia Rhodomelaceae Acetogenin Triterpene Diterpene Biological activity

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Effect of Aripiprazole on Methamphetamine-Induced Disruption of Latent Inhibition in Rats

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Journal of Behavioral and Brain Science 2011年第3期1卷 167-171页

作者： Hisae Matsuo Hiroshi abe Tetsuya Ikeda kosuke Ebihara Ryuichiro Takeda Toshikazu Nishimori Yasushi Ishida Department of Psychiatry Faculty of Medicine University of Miyazaki 5200 Kihara

Objectives: To elucidate the pharmacological profile of aripiprazole, we examined its ameliorating effect on the methamphetamine-induced disruption of latent inhibition (LI) in rats. Method: The effect was measured using a conditioned emotional response procedure. The conditioned stimulus was a tone (2.8 kHz, 90 dB), and the unconditioned stimulus was a mild foot shock delivered through a floor grid. The conditioning procedure was repeated five times. Results: Methamphetamine-induced (1.0 mg/kg, i.p.) disruption of LI was ameliorated by the administration of haloperidol (0.2 mg/kg, i.p.) and by a moderate dose of aripiprazole (0.3 mg/kg, i.p.) but not by a lower or higher dose (0.1 or 3.0 mg/kg, i.p.) of aripiprazole. However, immunohistochemical examination showed increased levels of c-Fos expression in the shell of the nucleus accumbens after the administration of haloperidol (0.2 mg/kg, i.p.) but not of aripiprazole (0.3 mg/kg, i.p.). Conclusions: It is suggested that aripiprazole has an ameliorating effect on methamphetamine-induced disruption of latent inhibition within only a marginal therapeutic window.

关键词： Aripiprazole Haloperidol Latent Inhibition c-Fos Immunohistochemistry Schizophrenia

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