检索结果-南通市图书馆

Phylogenetic placement and diet of homalopsid snake Miralia alternans (Ruess,1833)

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2022年第5期43卷 734-737页

作者： Ibuki Fukuyama Tomonori Kodama koshiro eto Masafumi Matsui Mohamad Yazid Hossman Kanto Nishikawa Graduate School of Human and Environmental Studies Kyoto UniversityYoshida-NihonmatsuSakyoKyoto 606-8501Japan Graduate School of Science Kyoto UniversityKitashirakawa-OiwakeSakyoKyoto 606-8502Japan Kitakyushu Museum of Natural History&Human History Higashida 2-4-1YahatahigashiKitakyushuFukuoka 805-0071Japan Research Developmentand Innovation DivisionForest Department SarawakKuchingSarawak 93250Malaysia Graduate School of Global Environmental Studies Kyoto UniversityYoshida-HonmachiSakyoKyoto 606-8501Japan

DEAR EDITOR,Miralia alternans(Ruess,1833)is distributed in Borneo,Sumatra,and Java in Southeast *** species is morphologically similar to Raclitia indica,a monotypic genus known from Peninsular ***,we collected a juvenile specimen of *** from Borneo,and report on its coloration in life and first prey item recovered from the *** also explored the phylogenetic position of the genus using molecular phylogenetic analysis of mitochondrial DNA(mtDNA)gene cytochrome b(cyt b)and nuclear gene prolactin receptor(PRLR),confirming *** as sister to ***,with the two genera exhibiting relatively high genetic divergence in cyt b(13.0%-13.1%).

关键词： EDIT fir Java

Lower Concentrations of Glucose or Insulin Decrease the Risk of Various Types of Cancer in the Long-Lived Ames Dwarf Mouse by Increasing the Expression of p27Kip1, a Cell-Cycle Repressor Protein

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

American Journal of Molecular Biology 2020年第3期10卷 148-164页

作者： Isao eto Department of Nutrition Sciences (DNS) and Nutrition Obesity Research Center (NORC) University of Alabama at Birmingham Birmingham AL USA

Introduction. The molecular biological mechanism of the increased incidence of the various types of cancer in obesity or type 2 diabetes in rodents or humans has largely been resolved in recent years. By contrast, the molecular biological mechanism of the decreased, not increased, incidence of the various types of cancer in the homozygous long-lived Ames dwarf mice still remains unresolved. Objective. The first objective of the present study was to investigate whether the decrease in the incidence of cancer in the homozygous long-lived Ames dwarf mice is due to the increase, not decrease, in the expression of p27Kip1, a cell cycle repressor protein. The second objective was to investigate whether the decrease in the incidence of cancer in the homozygous long-lived Ames dwarf mice is due to the decrease, not increase, in the levels of glucose or insulin. Methods. To achieve these objectives, we first performed western immunoblot analysis of the hepatic expression of p27Kip1 protein. We then performed, using a human breast cancer cell line in vitro, the luciferase reporter plasmid assay to determine whether the translation initiation activity of the p27Kip1 mRNA is increased when the concentrations of either glucose or insulin are decreased. Results and Conclusion. The results of the first objective indicated that the hepatic expression of p27Kip1 protein was up-regulated in the homozygous long-lived Ames dwarf mice as expected. We also found that the lower concentrat

关键词： Cancer Glucose Insulin Caloric Restriction Long-Lived Ames Dwarf Mouse p27Kip1 Cell-Cycle Repressor Protein

Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第29期17卷 3459-3464页

作者： Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Nobuyuki Ehira Hiroaki Yamato Kazunori eto Kanako Kubota Masahiro Asaka Department of Gastroenterology Hokkaido University Graduate School of MedicineKita 15Nishi 7Kita-kuSapporo060-8638Japan Department of Surgical pathology Hokkaido University HospitalKita 14Nishi 5Kita-kuSapporo060-8638Japan

Schwannomas are peripheral nerve tumors that are typically solitary and *** diagnosis is largely based on surgically resected ***,a number of case reports have indicated that retroperitoneal schwannomas could be diagnosed with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).We report the diagnosis of three cases of schwannoma using *** were two males and one female,ages 22,40,and 46 years,respectively,all of whom were *** findings showed well-circumscribed round ***,as the tumors could not be diagnosed using these findings alone,EUS-FNA was ***-eosin staining of the resulting tissue fragments revealed bland spindle cells with nuclear *** was no disparity in nuclear *** revealed S-100 protein positivity and all cases were diagnosed as ***-67 indexes were 3%-15%,2%-3%,and 3%,*** case showed any signs of *** most schwannomas are benign tumors and seldom become malignant,we observed these patients without *** tumors demonstrated no enlargement and no change in *** are almost always benign and can be observed following diagnosis by EUS-FNA.

关键词： Schwannoma Endoscopic ultrasonography Fine-needle aspiration Retroperitoneal tumor S100 proteins Ki-67 index

Diverse Voices and Democratic Policymaking： What Causes Japan＇s Nuclear Phase-Out Plan to Fail？

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journalism and Mass Communication 2016年第6期6卷 330-349页

作者： Mikiko eto Hosei University Tokyo Japan

The nuclear disaster at Fukushima has raised questions about the nature of democratic policymaking in Japan. Focusing on nuclear policymaking post-Fukushima, this paper considers ways in which the diversity of public opinion can be connected with legislative processes. The disaster forced the government to rethink existing nuclear policies. To infuse public voices into government policy, the Democratic Party of Japan （DPJ） government introduced a new method of public participation called ＂national debates＂, comprising a series of public hearings, mass public comments, and deliberative polling. The government also attached importance to anti-nuclear rallies and opinion polls conducted by the media. The national debates highlighted that the majority of Japanese people supported a nuclear-free society; as a result, the government drafted a new energy plan to phase out nuclear power by 2039. Owing to both domestic and international opposition, the plan failed to become law. Progress was also impeded by the public＇s contradictory demands. However, this paper posits that inefficient legislative deliberation was the main factor behind the policy failure. The Japanese case suggests that effective legislative deliberation is crucial to assessing and coordinating numerous divergent public voices.

关键词： public debates contradictory demands democracy nuclear policy Fukushima Japan

Expression of p27(Kip1), a Cyclin-Dependent Kinase Inhibitor, in Human Peripheral Blood Mononuclear Cells Is Inversely Associated with Potential Carcinogenic Risk in Obese Type 2 Diabetic Individuals Relative to Lean Normal Controls

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Molecular Biology 2014年第3期4卷 114-128页

作者： Isao eto Department of Nutrition Sciences University of Alabama at Birmingham Birmingham USA

Introduction: The consensus report issued jointly by the American Diabetes Association and the American Cancer Society stated that “type 2 diabetes and cancer share many risk factors, but potential biologic links between the two diseases are incompletely understood”. Interestingly, however, a recent report suggested that the expression of p27(Kip1), a cell cycle repressor protein, in the rodent liver was inversely associated with potential carcinogenic risk in the genetic rodent models of diabetic obesity. p27 is a cyclin-dependent kinase inhibitor that, when down-regulated, allows the progression of the cell cycle from G1 to S phase, thereby increasing the risk of developing cancer. Objective: The objective of the study described below was to extend the results of the recent report on the expression of p27 in the livers of obese, diabetic rodents to the humans and investigate whether the expression of p27 in the human peripheral blood mononuclear cells (PBMCs) might also be inversely associated with potential carcinogenic risk in obese type 2 diabetic individuals relative to the lean normal controls. Methods: Western immunoblot analysis was performed to evaluate the expression of p27 and the two most relevant upstream molecular signaling pathways of the expression of p27, namely 4E-BP1 and MNK1, in human PBMCs obtained from obese type 2 diabetic individuals relative to the lean normal controls. Results: First, expression of p27 in human PBMCs was significantly down-regulated in obese type 2 diabetic individuals relative to the lean normal controls. Secondly, expression of p27 in human PBMCs was also significantly down-regulated in obese type 2 diabetic African Americans relative even to the obese type 2 diabetic Caucasian Americans. Conclusions: Expression of p27 in human PBMCs was inversely associated with potential carcinogenic risk in obese type 2 diabetes relative to the lean normal controls.

关键词： Zucker Rats Liver Kidney Diabetic Nephropathy 4E-BP1 MNK1 eIF4E

Expression of p27Kip1, A Cell Cycle Repressor Protein with Dual Roles for Both Cancer Prevention and Promotion, Is Regulated Primarily at the Level of Unusual p27Kip1 mRNA—A Short Concept Proposal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Molecular Biology 2018年第3期8卷 186-193页

作者： Isao eto Department of Nutrition Sciences University of Alabama at Birmingham Birmingham AL USA Webb Nutrition Sciences Building University Boulevard Birmingham AL USA

The p27Kip1 is a cell cycle repressor protein that regulates primarily the cell cycle transition from G1 to S phase and hence the DNA replication is in the S phase and cell division in the M phase. Expression of p27Kip1 protein has dual roles for both cancer prevention and promotion. For example, numerous nutritional and chemopreventive anti-cancer agents specifically increase the expression of p27Kip1 protein without directly affecting the expression of any other cell cycle regulatory proteins. On the other hand, pro-cancer agents (like glucose, insulin and other growth factors frequently seen in obesity and/or diabetes) specifically decrease the expression of p27Kip1 protein without directly affecting the expression of any other cell cycle regulatory proteins. Unlike expression of any other cell cycle regulatory proteins, expression of p27Kip1 protein is very unusual. The mRNA of p27Kip1 has a very long and unusual 5’-untranslated region (from -575 to -1 in human). It appears that the 5’-untranslated region of p27Kip1 mRNA forms two alternative secondary structures. One increases the expression of p27Kip1 protein when anti-cancer agents are added and another decrease the expression of p27K1p1 when pro-cancer agents are added. For this short concept proposal, Dr. Albert Einstein’s “visualized thought experiments (German: Gedanken experiment)” were used as a fundamental tool for understanding how either anti- or pro-cancer agents bring the primary structure of the 5’-untranslated region of p27Kip1 mRNA into two alternative secondary structures, thereby either increasing or decreasing, respectively, the translation initiation of p27Kip1 protein.

关键词： p27Kip1 Cell Cycle Repressor Protein Cancer Prevention Anti-Cancer Agents Cancer Promotion Pro-Cancer Agents p27Kip1 mRNA 5-Prime-Untranslated Region Translation Initiation 5-Prime Cap Upstream Open Reading Frame Internal Ribosome Entry Site

Higher Concentrations of Glucose or Insulin Increase the Risk of Various Types of Cancer in Obesity or Type 2 Diabetes by Decreasing the Expression of p27Kip1, a Cell Cycle Repressor Protein

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Molecular Biology 2020年第1期10卷 1-11页

作者： Isao eto Department of Nutrition Sciences Nutrition Obesity Research Center University of Alabama at Birmingham Birmingham AL USA

Research Aims: Obesity and type 2 diabetes are known to be associated with increased risk of various types of cancer. However, the molecular biological mechanism of how the risk of cancer is increased in obesity or type 2 diabetes is not known. The aim this research is to investigate if the decreased expression of p27Kip1, a cell cycle repressor protein, plays a central role in this mechanism. Research Methods, Previous Studies and Theoretical Backgrounds: It is well known that the expression of p27Kip1 is increased by numerous nutritional or chemopreventive anti-cancer agents. But it has never been known that the expression of p27Kip1 could be decreased, rather than increased, and the risk of cancer could be increased, rather than decreased. This problem was solved recently and this new analytical method was used in this study. Results: 1) The expression of p27Kip1 was indeed significantly decreased in human obese type 2 diabetic individuals relative to the lean normal controls. 2) The expression of p27Kip1 was also significantly decreased in genetically obese rodents relative to the lean normal controls. Additionally, in obese rodents, the concentrations of glucose or insulin were significantly increased relative to the lean normal controls. 3) Using human cells cultured in vitro it was found that the increased concentrations of glucose or insulin decrease the expression of p27Kip1. Conclusions: These results suggest that higher concentrations of glucose or insulin increase the risk of various types of cancer in obesity or type 2 diabetes by decreasing the expression of p27Kip1.

关键词： Obesity Type 2 Diabetes Cancer p27Kip1 mRNA Translation Initiation 5’-Untranslated Region (5’UTR) 5’-End Cap of p27Kip1 mRNA Upstream Open Reading Frame (uORF) Internal Ribosome Entry Site (IRES)

Varicella-zoster virus-associated meningitis,encephalitis,and myelitis with sporadic skin blisters:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第2期10卷 717-724页

作者： Ken Takami Tsuneaki Kenzaka Ayako Kumabe Megumi Fukuzawa Yoko eto Shun Nakata Katsuhiro Shinohara Kazunori Endo Department of Internal Medicine Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 652-0032HyogoJapan Department of Neurology Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan Department of Dermatology Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan Emergency Department Sainokuni Higashiomiya Medical CenterSaitama 331-8577SaitamaJapan

BACKGROUND Varicella-zoster virus(VZV)generally causes chickenpox at first infection in childhood and then establishes latent infection in the dorsal root ganglia of the spinal cord or other *** reactivation owing to an impaired immune system causes inflammation along spinal nerves from the affected spinal segment,leading to skin manifestations(herpes zoster).Viremia and subsequent hematogenous transmission and nerve axonal transport of the virus may lead to meningitis,encephalitis,and *** such case is described in this *** SUMMARY A 64-year-old man presented with dysuria,pyrexia,and progressive disturbance in *** had signs of meningeal irritation,and cerebrospinal fluid(CSF)analysis revealed marked pleocytosis with mononuclear predominance and a CSF/serum glucose ratio of *** magnetic resonance imaging revealed hyperintense areas in the frontal *** had four isolated blisters with papules and halos on his right chest,right lumbar region,and left scapular *** giant cells were detected using the Tzanck *** epidermal cells with intranuclear inclusion bodies and ballooning degeneration were present on skin *** VZV antibody titers suggested previous infection,and the CSF tested positive for *** developed paraplegia,decreased temperature perception in the legs,urinary retention,and fecal *** patient was diagnosed with meningitis,encephalitis,and myelitis and was treated with acyclovir for 23 days and prednisolone for 14 *** gradual improvement,the urinary retention and gait disturbances persisted as *** VZV reactivation should be considered in differential diagnoses of patients with sporadic blisters and unexplained central nervous system symptoms.

关键词： Varicella-zoster virus Encephalitis Meningitis Myelitis Central nervous system Case report

Fetal stem cell transplantation: Past, present, and future

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2014年第4期6卷 404-420页

作者： Tetsuya Ishii Koji eto Office of Health and Safety Hokkaido UniversityKita-kuSapporo 060-0808HokkaidoJapan Center for iPS Cell Research and Application Kyoto UniversityShogoin YoshidaSakyo-kuKyoto 606-8507Japan

Since 1928, human fetal tissues and stem cells have been used worldwide to treat various conditions. Although the transplantation of the fetal midbrain substantia nigra and dopaminergic neurons in patients suffering from Parkinson's disease is particularly noteworthy, the history of other types of grafts, such as those of the fetal liver, thymus, and pancreas, should be addressed as there are many lessons to be learnt for future stem cell transplantation. This report describes previous practices and complications that led to current clinical trials of isolated fetal stem cells and embryonic stem(ES) cells. Moreover, strategies for transplantation are considered, with a particular focus on donor cells, cell processing, and the therapeutic cell niche, in addition to ethical issues associated with fetal origin. With the advent of autologous induced pluripotent stem cells and ES cells, clinical dependence on fetal transplantation is expected to gradually decline due to lasting ethical controversies, despite landmark achievements.

关键词： Fetal tissue Fetal stem cells Fetus,Embryonic stem cells Transplantation Clinical trials