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Acta Geologica Sinica(English Edition) 2021年第3期95卷 715-723页

作者： Wieslaw KRZEMIŃSKI Iwona KANIA Wiktoria JORDAN-STASIŁO Herman DE JONG Ewa KRZEMIŃska kornelia skibińska Institute of Biology Pedagogical University of KrakówPodbrzezieKraków 331-054Poland Department of Paleobiology and Evolutionary Biology University of RzeszówZelwerowiczaRzeszów 435–601Poland Naturalis Biodiversity Center DarwinwegCR Leiden 22333Netherlands Institute of Systematics and Evolution of Animals Polish Academy of SciencesSławkowskaKraków 1731-016Poland

Two new fossil subgenera and two new fossil species of the genus Tipula Linnaeus,1758,Tipula(Succinica)berendti *** *** Tipula(Gedanica)adamowiczi *** sp.n.,are described from Baltic amber and compared with other species of Tipula known from the *** two new subgenera and species described herein are an excellent bridge between recent specimens and those preserved in sedimentary rocks,and thus enrich knowledge on the evolution of the family.

关键词： invertebrate paleontology taxonomy craneflies Tipulomorpha Tipula Eocene Lutetian–Priabonian

Flat-footed Females and Missing Males:A New Genus and Species of Pleciofungivoridae(Diptera:Bibionomorpha)Represents the First Record of the Family from Mid-Cretaceous Kachin Amber

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 541-547页

作者： ZHANG Qingqing Wiesław KRZEMINSKI Jan SEVCIK Vladimir BLAGODEROV Agnieszka SOSZYNska kornelia skibiNska Yunnan Key Laboratory for Palaeobiology Institute of PalaeontologyYunnan UniversityKunming 650500China MEC International Joint Laboratory for Palaeobiology and Palaeoenvironment Yunnan UniversityKunming 650500China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China Institute of Systematics and Evolution of Animals Polish Academy of Sciences52551 KrakówPoland University of Ostrava Faculty of ScienceDepartment of Biology and EcologyChittussiho 10CZ-71000 OstravaCzech Republic National Museums Scotland EdinburghUK Natural History Museum LondonUK University of Lodz Faculty of Biology and Environmental ProtectionDepartment of Invertebrate Zoology and HydrobiologyBanacha 12/1690-237ŁódźPoland

A new genus and species,Cretopleciofungivora simpsoni *** ***.,from the extinct family Pleciofungivoridae(Diptera:Bibionomorpha),is discovered in mid-Cretaceous Kachin ***,this family was known only from imprints in sedimentary rocks of the Jurassic and the Lower *** of a representative of Pleciofungivoridae in Kachin amber confirms the presence of the family in the Upper *** new species has a unique structure of fore tarsus,with lobed and extended tarsal segments Ⅱ to Ⅳ,a feature hitherto known only in a few species of extant *** not particularly rare,the new species is currently known only from female *** reasons for this phenomenon,very unusual in Sciaroidea,are briefly discussed,including parthenogenesis as a potentially plausible hypothesis.

关键词： fungus gnats Sciaroidea Upper Cretaceous Burmese amber swollen tarsomeres

The actin-bundling protein Fascin-1 modulates ciliary signalling

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Journal of Molecular Cell Biology 2023年第4期15卷 1-16页

作者： Lena Brücker Stefanie kornelia Becker Vanessa Maissl Gregory Harms Maddy Parsons Helen Louise May-Simera Cilia Cell Biology Institute of Molecular PhysiologyJohannes Gutenberg University Mainz55128 MainzGermany Imaging Core Facility Cell Biology UnitUniversity Medical CentreJohannes Gutenberg University Mainz55101 MainzGermany Randall Centre for Cell and Molecular Biophysics King's College LondonLondon SE11ULUK

Primary cilia are microtubule-based cell organelles important for cellular communication. Since they are involved in the regulation of numerous signalling pathways, defects in cilia development or function are associated with genetic disorders, collectively called ciliopathies. Besides their ciliary functions, recent research has shown that several ciliary proteins are involved in the coordination of the actin cytoskeleton. Although ciliary and actin phenotypes are related, the exact nature of their interconnection remains incompletely understood. Here, we show that the protein BBS6, associated with the ciliopathy Bardet–Biedl syndrome, cooperates with the actin-bundling protein Fascin-1 in regulating filopodia and ciliary signalling. We found that loss of Bbs6 affects filopodia length potentially via attenuated interaction with Fascin-1. Conversely, loss of Fascin-1 leads to a ciliary phenotype, subsequently affecting ciliary Wnt signalling, possibly in collaboration with BBS6. Our data shed light on how ciliary proteins are involved in actin regulations and provide new insight into the involvement of the actin regulator Fascin-1 in ciliogenesis and cilia-associated signalling. Advancing our knowledge of the complex regulations between primary cilia and actin dynamics is important to understand the pathogenic consequences of ciliopathies.

关键词： cilia actin Wnt signalling ciliopathy Bardet–Biedl syndrome filopodia

Rising plasma nociceptin level during development of HCC:A case report

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World Journal of Gastroenterology 2004年第1期10卷 152-154页

作者： AndreaHorvath AnikoFolhoffer PeterLaszloLakatos FerencSzalay JuditHalász GyorgyIllyés ZsuzsaSchaff kornelia Tekes Monika Beatrix Hantos 1~(st) Department of Medicine of Semmelweis University BudapestHungary 2~(nd) Department of Pathology of Semmelweis University BudapestHungary Department of Pharmacodynamics of Semmelweis University BudapestHungary Neurochemical Research Unit of Hungarian Academy of Sciences BudapestHungary

AIM:Although liver cirrhosis is a predisposing factor for hepatocellular carcinoma (HCC),relatively few reports are available on HCC in primary biliary *** plasma nociceptin (N/OFQ) level has been shown in Wilson disease and in patients with acute and chronic pain. METHODS:We report a follow-up case of HCC,which developed in a patient with primary biliary *** tumor appeared 18 years after the diagnosis of PBC and led to death within two *** fetoprotein and serum nociceptin levels were monitored before and during the development of HCC. Nociceptin content was also measured in the tumor tissue. RESULTS:The importance and the curiosity of the presented case was the novel finding of the progressive elevation of plasma nociceptin level up to 17-fold (172 pg/mL) above the baseline (9.2±1.8 pg/mL),parallel with the elevation of alpha fetoprotein (from 13 ng/mL up to 3 480 ng/mL) during tumor *** content was more than 15-fold higher in the neoplastic tissue (0.16 pg/mg) than that in the tumor- free liver tissue samples (0.01 pg/mg) taken during the autopsy. CONCLUSION:Results are in concordance with our previous observation that a very high plasma nociceptin level may be considered as an indicator for hepatocellular carcinoma.

关键词： Carcinoma, Hepatocellular Female Humans Liver Cirrhosis, Biliary Liver Neoplasms Middle Aged Opioid Peptides Tumor Markers, Biological

What have we learned about non-involved psoriatic skin from large-scale expression studies?

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World Journal of Dermatology 2014年第3期3卷 50-57页

作者： Eszter Szlavicz kornelia Szabo Zsuzsanna Bata-Csorgo Lajos Kemeny Marta Szell Department of Dermatology and Allergology University of Szeged H-6720 Szeged Hungary Dermatological Research Group of the Hungarian Academy of Sciences University of Szeged H-6720 Szeged Hungary Department of Medical Genetics the University of Szeged H-6720 Szeged Hungary

Psoriasis is a chronic inflammatory skin disorder; its genetic background has been widely studied in recent decades. Recognition of novel factors contributing to the pathogenesis of this disorder was facilitated by potent molecular biology tools developed during the 1990 s. Large-scale gene expression studies, including differential display and microarray, have been used in experimental dermatology to a great extent; moreover, skin was one of the first organs analyzed using these methods. We performed our first comprehensive gene expression analysis in 2000. With the help of differential display and microarray, we have discovered several novel factors contributing to the inherited susceptibility for psoriasis, including the EDA+ fibronectin splice variant and PRINS. The long non-coding PRINS RNA is expressed at higher levels in non-involved skin compared to healthy and involved psoriatic epidermis and might be a factor contributing cellular stress responses and, specifically, to the development of psoriatic symptoms. This review summarizes the most important results of our large-scale gene expression studies.

关键词： Non-involved psoriatic skin Differential display cDNA microarray EDA+fibronectin isoform PRINS long non-coding RNA mRNA maturation

Size-Resolved Water-Soluble Ionic Composition of Ambient Particles in an Urban Area in Southern Poland

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Journal of Environmental Protection 2013年第4期4卷 371-379页

作者： Wioletta Rogula-Kozlowska Izabela Sowka Barbara Mathews Krzysztof Klejnowski Anna Zwozdziak kornelia Kwiecinska Institute of Environmental Engineering Polish Academy of SciencesZabrzePoland Ecologistics Division Institute of Environmental Protection EngineeringWroclaw University of TechnologyWroclawPoland

The ambient concentrations of PM-related anions (Cl-, NO3-, SO42-) and cations (Na+, NH4+, K+, Ca2+, Mg2+), total and contained in the PM fractions, were investigated in a typical urban area within the Silesian Agglomeration. A DEKATI low pressure impactor (DLPI) was used to sample PM and separate it into 13 fractions. The PM concentrations were determined gravimetrically, the ion content of the PM water extracts—by means of ion chromatography (Herisau Metrohm AG ion chromatograph). In general, sulfate, nitrate, and ammonia had the greatest ambient concentrations. PM1 contained over 60% of the PM-related sulfate and nitrate mass and 90% of the ammonia mass. Also the majority of Na+ and Cl- were bound onto fine particles. Instead, more of the PM-related K+, Ca2+ and Mg2+ mass were in PM2.5-10 than in PM2.5. In the fine particles (sub-fractions of PM1.6) sulfate, nitrate and ammonia occur mainly as (NH4)2SO4 and NH4NO3. In the sub-fractions of PM1.6-10 sulfate and nitrate might also occur as K2SO4, CaSO4, Ca(NO3)2 or NaNO3.

关键词： Ambient Aerosol DEKATI Mass Size Distribution SIA Ammonium Sulfate Ammonium Nitrate Neutralization Ratio Upper Silesia

A Synonymous Polymorphism of APCDD1 Affects Translation Efficacy and is Associated with Androgenic Alopecia

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Journal of Life Sciences 2014年第2期8卷 106-114页

作者： Nikoletta Nagy Katalin Farkas Agnes Kinyo Barbara Fazekas kornelia Szabo Edit Kollar Balazs Sztano Angela Meszes Dora Beke Lajos Kemeny Laszlo Royo Marta Szell Department of Medical Genetics University of Szeged Szeged 6720 Hungary Department of Dermatology andAllergology University ofSzeged Szeged 6720 Hungary Dermatological Research Group Hungarian Academy of Sciences Szeged 6720 Hungary Department of Rhino-Laryngology and Head-Neck Surgery University ofSzeged Szeged 6720 Hungary

The APCDDI （adenomatosis polyposis coli down-regulated 1） gene is an inhibitor of the Wnt signaling pathway, and a rare mutation of this gene has been associated with hereditary hypotrichosis simplex. In this study, the authors aimed to investigate whether common APCDD1 gene polymorphisms contribute to the development of androgenic alopecia. Patients （n = 210） with androgenic alopecia and 98 controls were investigated. SNPs （Single nucleotide polymorphisms） in the coding region of the gene were sequenced. A significant difference in genotype distribution was found for the c. 1781C/T, p.L476L SNP （rs3185480） of the APCDD1 gene. This SNP is located in exon 5 and is associated with a 3.5- and a 2.8-fold increase in risk for the development of androgenic alopecia for homozygote （CI 0.933-13.125; nominal regression P = 0.063） and heterozygote （CI 1.086-7.217; nominal regression P = 0.033） carriers, respectively. These data suggest that the rs3185480 polymorphism contributes to the development of androgenic alopecia. Protein expression experiments revealed that the polymorphism is associated with reduced APCDDI protein abundance. This reduction is likely due to altered codon usage for leucine from a preferred codon （CTC） to a rare codon （CTT）, which might influence translation efficiency and, thus, APCDDI protein level.

关键词： Adenomatosis polyposis coli down-regulated 1 gene hereditary hypotrichosis simplex androgenic alopecia,polymorphism synonymous translation efficacy preferable codon.

Please join us for the 4th New Horizons in Cancer Research Conference

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Cancer Biology & Medicine 2017年第2期 105-105页

作者： Nancy E.Davidson Chi Van Dang kornelia Polyak Hongyang Wang Fred Hutchinson Cancer Center Abramson Cancer Center of University of Pennsylvania Philadelphia Dana Farber Cancer Institute BostonMAUSA

On behalf of the American Association for Cancer Research(AACR),we have the great pleasure to invite you to attend the 4th AACR New Horizons in Cancer Research Conference:Research Propelling Cancer Prevention and Cures,which will be held from November 6-9,2017,in Shanghai,*** year,we are honored that Fudan University will be a partner for the *** outstanding

关键词： AACR MD Ph Please join us for the 4th New Horizons in Cancer Research Conference

Gut microbiota research nexus:One Health relationshipbetween human,animal,and environmental resistomes

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mLife 2023年第4期2卷 350-364页

作者： Yuhao Fu Qingyuan Dou kornelia Smalla Yu Wang Timothy A.Johnson Kristian K.Brandt Zhi Mei Maoyuan Liao Syed A.Hashsham Andreas Schäffer Hauke Smidt Tong Zhang Hui Li Robert Stedtfeld Hongjie Sheng Benli Chai Marko Virta Xin Jiang Fang Wang Yong-Guan Zhu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjingChina University of Chinese Academy of Sciences BeijingChina Julius Kühn Institute(JKI)Federal Research Centre for Cultivated Plants BraunschweigGermany Department of Animal Sciences Purdue UniversityWestLafayetteIndianaUSA Section for Microbial Ecology and Biotechnology Department of Plant and Environmental SciencesUniversity of CopenhagenFrederiksberg CDenmark Sino-Danish Center(SDC) BeijingChina Department of Microbiology University of HelsinkiHelsinkiFinland Department of Plant Soil and MicrobialSciencesCenter for Microbial EcologyMichigan State UniversityMichiganUSA Department of Civil and Environmental Engineering Michigan State UniversityMichiganUSA Institute for Environmental Research RWTH Aachen UniversityAachenGermany Laboratory of Microbiology Wageningen University&ResearchWageningenThe Netherlands Environmental Microbiome Engineering and Biotechnology Laboratory Center for Environmental Engineering ResearchDepartment of Civil EngineeringTheUniversity of Hong KongPokfulamHong KongChina Institute of Agricultural Resources and Environment Jiangsu Academy of Agricultural SciencesNanjingChina KeyLaboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamenChina State Key Laboratory of Urban and Regional Ecology Chinese Academy of SciencesBeijingChina

The emergence and rapid spread of antimicrobial resistance is of global public health *** gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes(ARGs).In this review,we describe the reservoirs of gut ARGs and their dynamics in both animals and humans,use the One Health perspective to track the transmission of ARG-containing bacteria between humans,animals,and the environment,and assess the impact of antimicrobial resistance on human health and socioeconomic *** gut resistome can evolve in an environment subject to various selective pressures,including antibiotic administration and environmental and lifestyle factors(e.g.,diet,age,gender,and living conditions),and interventions through *** to reduce the abundance of clinically relevant antibiotic-resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic *** the help of effective measures taken at the national,local,personal,and intestinal management,it will also result in preventing or minimizing the spread of infectious *** review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.

关键词： antibiotic antimicrobial resistance gut microbiota modulatory strategies One Health

A natural history comparison Check for updates of SOD1-mutant patients with amyotrophic lateral sclerosis between Chinese and German populations

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Translational Neurodegeneration 2021年第4期10卷 551-553页

作者： Lu Tang Johannes Dorst Lu Chen Xiaolu Liu Yan Ma Komelia Günther Sebastian Michels Kathrin Müller Axel Freischmidt Jochen H.Weishaupt Dongsheng Fan Albert C.Ludolph Department of Neurology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases Peking University Third HospitalBeijing 100191China Department of Neurology Ulm University89081 UlmGermany German Center for Neurodegenerative Diseases(DZNE) Ulm Site89081 UlmGermany

Currently,there is no effective treatment for amyotrophic lateral sclerosis(ALS),despite the limited efficacy of riluzole[1]and edaravone[2].SOD1(coding for the Cu/Zn superoxide dismutase)is the second most frequent genetic cause for ALS only after C9orf72 in patients with European ancestry while being the most frequent in Asian ALS populations[3],Multiple therapeutic approaches have targeted SOD1-related ALS,including the antisense oligonucleotide tofersen with promising results in a recent phase I/II trial[4].

关键词： SOD1 patients amyotrophic