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The 26th IAHR Symposium on Hydraulic Machinery and Systems

作者： Y X Xiao 1 D G Sun 2 Z W Wang 1 J Zhang 1 and G Y Peng 3 1 State Key Laboratory of Hydroscience and Engineering & Department of Thermal Engineering Tsinghua University Haidian District Beijing 100084 China.2 Hangzhou Resource Power Equipment Co.Ltd.Hangzhou 311241 China.3 Department of Mechanical Engineering College of Engineering Nihon University koriyama fukushima 963-8642 Japan

The unsteady flow within the entire flow passage of a pump-turbine with misaligned guide vanes （MGV） device under the rated speed was simulated using the Reynolds-averaged Navier-Stokes equations together with the k-ω based SST turbulence *** kinds of MGV arrangement of different opening angles were chosen to analyse the influence of MGV on the pressure pulsation in the flow passages of spiral case,stay vanes,guide vanes,rotating runner blades and draft *** characteristics of the dominant frequency of the unsteady flows in different flow parts under different misaligned guide vane arrangement/openings and the hydraulic performance of the pump-turbine were investigated at the turbine operating *** computation result shows that the MGV can decrease the peak-to-peak amplitude of the pressure fluctuation in the whole flow passage except the rotating runner *** low frequencies and the influence of Rotor Stator Interaction （RSI） in the entire flow passage vary with the arrangement/openings of MGV.

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Efficacy of long-term rifaximin treatment for hepatic encephalopathy in the Japanese

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World Journal of Hepatology 2019年第6期11卷 531-541页

作者： Shinya Nishida Koichi Hamada Noriyuki Nishino Daizo fukushima Ryota Koyanagi Yoshinori Horikawa Yoshiki Shiwa Satoshi Saitoh Department of Gastroenterology Shin-Yurigaoka General HospitalKawasaki 215-0026Japan Department of Gastroenterology Southern-Tohoku General HospitalKoriyama 963-8563Japan Department of Minimally Invasive Surgical and Medical Oncology Fukushima Medical UniversityFukushima 960-1295Japan Department of Hepatology Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Hepatic encephalopathy(HE)is a complication of liver cirrhosis and can result in neuropsychological and neuromuscular dysfunctions in ***,an antibiotic,has been reported to decrease the occurrence of overt HE and also improve cognitive function in studies from Europe and the United States of *** is not enough evidence of the relationship between the long-term use of rifaximin and its clinical effects in the *** To determine the clinical effects of long-term rifaximin therapy in decompensated liver cirrhosis patients,with overt HE or *** In this single-center retrospective observational cohort study,we reviewed the data of 38 patients who had taken rifaximin at the dose of 1200 mg/d for more than 24 *** primary outcome measured was the efficacy of long-term rifaximin use,and secondary outcome measured was the safety of its long-term use as determined by its influence on portosystemic shunts as well as Escherichia coli-related ***,we compared the prognosis between the rifaximin group and control cases,matched for hepatic elasticity assessed by magnetic resonance ela-stography,age,and Child-Pugh *** Of the 38 patients included in the study,12(31.6%)had overt HE,27(71.1%)had complications of esophageal varices,and 9(23.7%)had hepatocellular carcinoma(HCC).The control group was matched for age,Child-Pugh classification,liver stiffness,and presence of *** median of serum ammonia level before treatment was 104μg/dL(59-297),and 2 wk after treatment,it significantly decreased to 85μg/dL(34-153)(P=0.002).A significantly low value of 80.5μg/dL(44-150)was maintained 24 wk after *** long-term use of rifaximin did not cause a decline in liver *** occurred in 2 patients,who improved with the administration of probiotics,and there were no cases of aborted rifaximin therapy owing to adverse *** patients with Child C,the survival was short,but there

关键词： Hepatic encephalopathy Rifaximin Hepatic cirrhosis Spontaneous portosystemic shunt Magnetic resonance elastography Child-Pugh classification

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