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Quantitative analysis of cyclooxygenase 2 in the posterior longitudinal ligament of cervical spondylotic myelopathy

Chinese Medical Journal 2011年第16期124卷 2480-2484页

作者： SONG Hong-xing Michael Scarpatetti Wolfgang Kreil SHEN Hui-liang koppany bodo Birgit Ebner Heribert Schrottner Michael Mokry Department of Orthopaedics Xuanwu Hospital Capital MedicalUniversity Beijing 100053 China Institute of Pathology Medical University of Graz 8036 Graz Austria Department of Neurosurgery Medical University of Graz 8036 Graz Austria Center for Medical Research Medical University of Graz 8010Graz Austria

Background Cervical spondylotic myelopathy （CSM）, in part, results from degeneration of the posterior longitudinal ligament （PLL）, which mechanically compresses the spinal cord. Much research was done on the ossification of PLL, but not concerning the non-ossifying degeneration of cervical PLL. The degeneration of cervical PLL may be related to inflammation. The aim of this study was to elucidate the pathological features of the PLL and the role of cyclooxygenase 2 （COX-2） in the degeneration of the PLL in CSM. Methods A total of 23 PLL specimens were collected during surgery from patients with CSM for the histological and immunohistochemical （type II collagen and Ki-67） study. For the control group 14 cervical PLL autopsy specimens were investigated in the same manner, mRNA expression of COX-2 was quantitatively measured by real-time reverse transcription-polymerase chain reaction （RT-PCR） from 18 PLL specimens of patients with CSM and 18 PLL specimens of autopsy cases. Immunohistochemistry was used to evaluate the cellular location of COX-2 in PLL. Results A distinct amount of fibrotic area, chondrometaplastic tissue and calcification were found in the PLL of the patient group, compared with the control group. Type II collagen was apparent around chondrometaplastic cells. Ki-67 positive reaction was less than 5%. A COX-2 positive reaction was found in 9 of the patient specimens （39.1%） in which the COX-2 was released from vascular endothelial cells in the PLL. However, such reactions were not found in the control group. Real-time PCR showed that the mRNA expression level of COX-2 in the patient group was significantly higher than that in the control group （P〈0.01）. Conclusions Chondrometaplastic tissue producing type II collagen was identified as the most predominant pathological feature in the degenerative PLL. The higher expression of COX-2 might be related to degeneration of the PLL in CSM.

关键词： posterior longitudinal ligament cyclooxygenase 2 immunohistochemistry polymerase chain reaction

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Metabolic characterization of selected probiotic consortia during gluten and wheat bread simulated digestion

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Food Science and Human Wellness 2024年

作者： Mirco Vacca Giuseppe Celano Olga Nikoloudaki bodo Speckmann Francesco Maria Calabrese Marco Gobbetti Maria de Angelis Faculty of Science and Technology， Free University of Bozen Evonik Operations GmbH Department of Soil Plant and Food Sciences， University of Bari Aldo Moro

While exerting their metabolic activities in the gastrointestinal milieu， probiotics impact the host well-being by boosting immunity， treating metabolic disorders， and modulating microbiota and metabolome. Due to the high incidence of gluten-based disorders， the present work aims to deeply explore the metabolism of two selected microbial consortia (MCs) during gluten digestion under simulated gastrointestinal conditions. Featured by high protease and peptidase activity， both MCs accounted for different lactic acid bacteria and Bacillus strains that were combined with two commercial protease enzymes. Gluten substrates were used as purified extracts， white and whole wheat breads. Control samples， instead， relied onto the microbial enzyme lack. Twenty-four hours of simulated digestion were sufficient to completely hydrolyze gluten in one of the two MC-containing experimental sets， and the relative 48 h-digested extract did not alter the cytokine expression in duodenal biopsies from celiac disease (CeD) patients. When digested samples were assayed for antioxidant and phytase activities， microbial enzymes demonstrated to significantly improve both ABTS and DPPH values and to decrease the phytic acid concentration. The inspection of the free amino acid profiles allowed for distinguishing the two MCs， whereas the detection of a heterogeneous panel of volatile organic compounds supported the presence/activity of microbial enzymes without statistically significant differences between MCs. As functional contribution， digested extracts with MCs also proved to reduce the inflammatory cytokine concentrations in cell lines exposed to lipopolysaccharide trigger. Therefore， in line with studies exploring novel adjuvant therapies， the present innovative probiotic consortium featured by high gluten-hydrolyzing metabolism also showed the capability to improve various parameters usually found to be altered in patients affected by gluten-based disorders or CeD.

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Long-term vegetation development on a wildfire slope in Innerzwain(Styria,Austria)

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Journal of Forestry Research 2014年第1期25卷 103-111页

作者： bodo Malowerschnig Oliver Sass Karl-Franzens-University Graz Department of Geography and Regional Science

Forest fires in mountainous areas can cause severe defores-tation which can potentially trigger secondary natural hazards like debris falls and avalanches. We documented an extreme case study for the range of possible post-fire land cover （LC） dynamics. We investigated a 15-ha, steep （10°-65°） burnt slope in Styria （Austria） at elevation of 760-1130 m, which burned in 1946 and has not fully recovered to date. Seven 8-class legend LC maps were produced （1954, 1966, 1973, 1982, 1998, 2004, 2009） and integrated in a vector-based GIS, mainly by on-screen interpretation of aerial photos. Our aim was to clarify how post-wildfire LC dynamics take place on a severely damaged, steep slope and to give a basic projection of the future vegetation recovery process. The pre-fire Pinus sylvestrisstands have been mainly replaced by Picea abies and Larix decidua. Regeneration proceeded mainly from the base of the slope upwards. All tree species together still cover no more than 40% of the slope after more than 60 years of recovery, while grassland communities and rock/debris areas have expanded. Multitemporal analysis showed a slow but steady increase in woodland cover. Degraded rock/debris areas, however, expanded as well because soil erosion and related debris flows remained active. Slope angle （with a threshold value of approx. 35-40°） seemed to control whether erosion or regeneration prevailed. According to a simple extrapolation, the slope will not reach its former condition before 2070. This extreme disturbance window of more than 120 years is owed to the steepness of the slope and to the shallow soils on dolomitic bedrock that were severely damaged by the fire. The neglect of any game fencing is a further factor slowing regeneration.

关键词： wildfire landcover change temperate forest aerial photos,soil degradation vegetation development

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Reactive pathways toward parasitic release of singlet oxygen in metal-air batteries

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npj Computational Materials 2021年第1期7卷 1135-1142页

作者： Adriano Pierini Sergio Brutti Enrico bodo Department of Chemistry University of Rome“La Sapienza”RomeItaly GISEL—Centro di Riferimento Nazionale per i Sistemi di Accumulo Elettrochimico di Energia FirenzeItaly

The superoxide disproportionation reaction is a key step in the chemistry of aprotic metal oxygen batteries that controls the peroxide formation upon discharge and opens the way for singlet oxygen *** we clarify the energy landscape of the disproportionation of superoxide in aprotic media catalyzed by group 1A *** analysis is based on ab initio multireference computational methods and unveils the competition between the expected reactive path leading to peroxide and an unexpected reaction channel that involves the reduction of the alkaline *** channels lead to the release of triplet and singlet O_(2).The existence of this reduction channel not only facilitates singlet oxygen release but leads to a reactive neutral solvated species that can onset parasitic chemistries due to their well-known reducing ***,we show that the application of moderate overpotentials makes both these channels accessible in aprotic batteries.

关键词： properties release singlet

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Radial variations in xylem sap flux in a temperate red pine plantation forest

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Ecological Processes 2021年第1期10卷 328-336页

作者： Alanna V.bodo M.Altaf Arain School of Earth Environment and SocietyMcMaster UniversityHamiltonONCanada McMaster Centre for Climate Change HamiltonONCanada

Background:Scaling sap flux measurements to whole-tree water use or stand-level transpiration is often done using measurements conducted at a single point in the sapwood of the tree and has the potential to cause significant *** studies have shown that much of this uncertainty is related to(i)measurement of sapwood area and(ii)variations in sap flow at different depths within the tree ***:This study measured sap flux density at three depth intervals in the sapwood of 88-year-old red pine(Pinus resinosa)trees to more accurately estimate water-use at the tree-and stand-level in a plantation forest near Lake Erie in Southern Ontario,*** showed that most of the water transport(65%)occurred in the outermost sapwood,while only 26%and 9%of water was transported in the middle and innermost depths of sapwood,***:These results suggest that failing to consider radial variations in sap flux density within trees can lead to an overestimation of transpiration by as much as 81%,which may cause large uncertainties in water budgets at the ecosystem and catchment *** study will help to improve our understanding of water use dynamics and reduce uncertainties in sap flow measurements in the temperate pine forest ecosystems in the Great Lakes region and help in protecting these forests in the face of climate change.

关键词： Sap flow Transpiration Water use Red pine Temperate forest Great Lakes region

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Effects of variable retention harvesting on canopy transpiration in a red pine plantation forest

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Ecological Processes 2022年第1期11卷 374-385页

作者： Alanna V.bodo M.Altaf Arain School of Earth Environment and SocietyMcMaster University1280 Main Street WestHamiltonON L8S 4K1Canada McMaster Centre for Climate Change McMaster University1280 Main Street WestHamiltonON L8S 4K1Canada

Background:Variable Retention Harvesting(VRH)is a forest management practice applied to enhance forest growth,improve biodiversity,preserve ecosystem function and provide economic revenue from harvested *** are many different forms and compositions in which VRH is applied in forest *** this study,the impacts of four different VRH treatments on transpiration were evaluated in an 83-year-old red pine(Pinus Pinus resinosa)plantation forest in the Great Lakes region in *** VRH treatments included 55%aggregated crown retention(55A),55%dispersed crown retention(55D),33%aggregated crown retention(33A),33%dispersed crown retention(33D)and unharvested control(CN)*** VRH treatments were implemented in 1-ha plots in the winter of 2014,while sap flow measurements were conducted from 2018 to ***:Study results showed that tree-level transpiration was highest among trees in the 55D treatment,followed by 33D,55A,33A and CN *** found that photosynthetically active radiation(PAR)and vapor pressure deficit(VPD)were major controls or drivers of transpiration in all VRH *** study suggests that dispersed or distributed retention of 55%basal area(55D)is the ideal forest management technique to enhance transpiration and forest ***:This study will help researchers,forest managers and decision-makers to improve their understanding of water cycling in forest ecosystem and adopt the best forest management regimes to enhance forest growth,health and resiliency to climate change.

关键词： Variable Retention Harvesting Forest management Transpiration Sap flow Red pine Great Lakes region

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Association between Placental Malaria and Severe Pre-Eclampsia in Two University Hospitals of Yaounde City

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1488-1511页

作者： Ayissi Gregory Astrid Ruth Ndolo Kondo Ndoumba Afouba Alice Noa Ndoua Claude Cyrille Essiben Félix Meka Esther Belinga Etienne Metogo Junie Engo Engo Samuel Désiré bodo Edmond Lemaire Tchente Nguefack Charlotte Foumane Pascal Mboudou Emile Télésphore Department of Obstetrics and Gynecology Faculty of Medicine and Biomedicals Sciences University of Yaound I Yaounde Cameroon Department of Obstetrics and Gynecology Faculty of Medicine and Pharmaceuticals Sciences University of Douala Douala Cameroon Department of Morphological and Anatomo-Pathological Sciences Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon. Department of Morphological and Anatomo-Pathological Sciences Faculty of Medicine and Biomedicals Sciences University of Yaound I Yaounde Cameroon

Context: Pre-eclampsia and placental malaria, are two diseases that share pathophysiological similarities, such as placental ischemia, endothelial dysfunction and production of pro-inflammatory cytokines. Objective: The objective of our study was to investigate the association between placental malaria lesions and severe pre-eclampsia. Methodology: We conducted a prospective analytical cross-sectional study in two University Hospitals in the city of Yaounde (Yaounde Central Hospital and the Gynaecological Obstetrics and Paediatrics Hospital), and in the laboratory of the Centre Pasteur in Yaounde over an eight-month period (1st January 2021 – 1st September 2021). All patients with pre-eclampsia diagnosed according to the criteria of the International Society for the Study of Hypertension (ISSHP) and free of chronic metabolic or infectious pathology were included in this study. The patients were divided into two groups: group 1 (mild pre-eclampsia) and group 2: severe pre-eclampsia. Socio-demographic, clinical and histopathological characteristics specific to pre-eclampsia and placental malaria were investigated. Statistical analysis was performed with SPSS 23.0 software, Chi 2 was used to compare categorical variables, Student t-test was used to compare means, and logistic regression was used to assess the association between placental malaria lesions and PES. Results: The mean age of our study population was 29.93 ± 7.36 years versus 28.28 ± 7.18 years in patients with mild and severe pre-eclampsia respectively. Pre-eclampsia placental lesions (accelerated villous maturation, infarction) were significantly greater in patients with severe pre-eclampsia (p Conclusion: Placental malaria lesions were significantly associated with severe pre-eclampsia and increased the risk of developing severe pre-eclampsia placental lesions by a factor of 10.

关键词： Mild Pre-Eclampsia Severe Pre-Eclampsia Malaria Placental Lesions Association

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Symmetry Adapted Block Diagonalisation in Equivariant Steady State Bifurcation Problems and its Numerical Application

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数学进展 1991年第4期 455-487页

作者： Peter Stork,bodo Werner Institut fur Angewandte Mathematik der Universitat Hamburg Bundesstr.55 D-2000 Hamburg 13 Federal Republic of Germany Institut fur Angewandte Mathematik der Universitat Hamburg Bundesstr.55 D-2000 Hamburg 13 Federal Republic of Germany

Considering steady state bifurcation of single parameter r-equivariant systemswhere Γ is a compact Lie group acting on X via a faithful orthogonal representation, we simultaneously block-diagonalise all jacobians of g along a solution path with respect to symmetry adapted subspaces and apply bifurcation groups to reduce symmetry breaking bifurcation points to simple bifurcation points. In generical situations this algorithm allows for numerically stable use of continuation methods and steady state bifurcation point detection and computation. The large scale decrease of computing efforts is demonstrated at computing the equilibria of a hexagonal lattice dome with 21 degrees of freedom, we present a great variety of solution arcs with symmetry from full D6 down to Z2 symmetry.

关键词： Symmetry Adapted Block Diagonalisation in Equivariant Steady State Bifurcation Problems and its Numerical Application

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Unconventional bound states in the continuum from metamaterial-induced electron acoustic waves

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Advanced Photonics 2023年第5期5卷 77-85页

作者： Wenhui Wang Antonio Günzler bodo D.Wilts Ullrich Steiner Matthias Saba University of Fribourg Adolphe Merkle InstituteFribourgSwitzerland University of Salzburg Department of Chemistry and Physics of MaterialsSalzburgAustria

Photonic bound states in the continuum(BICs)are spatially localized modes with infinitely long lifetimes,which exist within a radiation continuum at discrete energy *** states have been explored in various systems,including photonic and phononic crystal slabs,metasurfaces,waveguides,and integrated *** and availability of the BICs are important aspects for fully taming the BICs toward practical ***,we propose a generic mechanism to realize BICs that exist by first principles free of fine parameter tuning based on non-Maxwellian double-net metamaterials(DNMs).An ideal warm hydrodynamic double plasma(HDP)fluid model provides a homogenized description of DNMs and explains the robustness of the BICs found *** the HDP model,these are standing wave formations made of electron acoustic waves(EAWs),which are pure charge oscillations with vanishing electromagnetic *** BICs have various advantages,such as(i)frequency-comb-like collection of BICs free from normal resonances;(ii)robustness to symmetry-breaking perturbations and formation of quasi-BICs with an ultrahigh Q-factor even if subject to disorder;and(iii)giving rise to subwavelength microcavity resonators hosting quasi-BIC modes with an ultrahigh Q-factor.

关键词： bound states in the continuum double-net metamaterial metamaterial electron acoustic wave hydrodynamical plasma

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Quantifying the refractive index dispersion of a pigmented biological tissue using Jamin–Lebedeff interference microscopy

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Light(Science & Applications) 2013年第1期2卷 58-63页

作者： Doekele G Stavenga Hein L Leertouwer bodo D Wilts Computational Physics Zernike Institute for Advanced MaterialsUniversity of GroningenNL-9747 AG GroningenThe Netherlands

Jamin–Lebedeff polarizing interference microscopy is a classical method for determining the refractive index and thickness of transparent ***,we extend the application of this method to pigmented,absorbing biological tissues,based on a theoretical derivation using Jones *** novel method is applied to the wings of the American Rubyspot damselfly,Hetaerina *** membranes in the red-colored parts of the damselfly’s wings,with a thickness of 2.5 μm,contain a pigment with maximal absorption at 490 nm and a peak absorbance coefficient of 0.7 μm^(-1).The high pigment density causes a considerable and anomalous dispersion of the refractive *** result can be quantitatively understood from the pigment absorbance spectrum by applying the Kramers–Kronig dispersion *** of the spectral dependence of the refractive index and the absorption are valuable for gaining quantitative insight into how the material properties of animal tissues influence coloration.

关键词： absorption chitin insect wings Jones calculus Kramers–Kronig relations

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