检索结果-南通市图书馆

E2F transcription factors and digestive system malignancies:How much do we know?

World Journal of Gastroenterology 2014年第29期20卷 10212-10216页

作者： konstantinos evangelou Sophia Havaki Athanassios Kotsinas Laboratory Histology-Embryology Medical SchoolNational and Kapodistrian University of Athens

The E2F proteins comprise a family of 8 members that function as transcription factors. They are key targets of the retinoblastoma protein (RB) and were initially divided into groups of activators and repressors. Accumulating data suggest that there is no specific role for each individual E2F member. Instead, each E2F can exert a variety of cellular effects, some of which represent opposing ones. For instance, specific E2Fs can activate transcription and repression, promote or hamper cell proliferation, augment or inhibit apoptosis, all being dependent on the cellular context. This complexity reflects the importance that these transcription factors have on a cell’s fate. Thus, delineating the specific role for each E2F member in specific malignancies, although not easy, is a challenging and continuously pursued task, especially in view of potential E2F targeted therapies. Therefore, several reviews are continuously trying to evaluate available data on E2F status in various malignancies. Such reviews have attempted to reach a consensus, often in the simplistic form of oncogenes or tumor suppressor genes for the E2Fs. However they frequently miss spatial and temporal alterations of these factors during tumor development, which should also be considered in conjunction with the status of the regulatory networks that these factors participate in. In the current ‘‘Letter to the Editor’’, we comment on the flaws, misinterpretations and omissions in one such review article published recently in the World Journal of Gastroenterology regarding the role of E2Fs in digestive system malignancies.

关键词： E2F Hepatocellular carcinoma Pancreatic ductal adenocarcinoma Gastrointestinal tract Digestive system p53 p73 Cancer Apoptosis Proliferation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Iron Phosphate Coating: A Novel Approach to Controlling Pyrite Oxidation

引用

Pedosphere 1997年第2期7卷 103-110页

作者： HUANGXIAO V.P.evangelou NanjingAgriculturalUniversity Nanjing210095（China） UniversityofKentucky LexingtonKY40549（USA）

A novel coating technique was developed for controlling Pyrite oxidation. The technique invo1ved leachingpyrite particles with a solution containing low concentrations of phosphate and hydrogen peroxide. Duringthe leaching process, the iron released from pyrite by hydrogen proxide was precipitated by phosphate as aferric phosphate coating. This coating was shown to be able to effectively prevent Pyrite from oxidation and itcould be established at the expense of only surface portions of Pyrite. The emergence of this technique couldprovide a unique potential route for abating acid mine drainage and reclaiming sulfide-containing degradedmining land.

关键词： acid mine drainage coating pyrite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Combination of Two Control Strategies for Series Hybrid Electric Vehicles

引用

IEEE/CAA Journal of Automatica Sinica 2019年第2期6卷 596-608页

作者： Can Luo Zhen Shen Simos evangelou Gang Xiong Fei-Yue Wang State Key Laboratory for Management and Control of Complex Systems Institute of Automation Chinese Academy of Sciences Cloud Computing Center Chinese Academy of Sciences IEEE Department of Electrical and Electronic Engineering Imperial College London Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation Chinese Academy of Sciences Qingdao Academy of Intelligent Industries

With most countries paying attention to the environment protection, hybrid electric vehicles have become a focus of automobile research and development due to the characteristics of energy saving and low emission. Power follower control strategy(PFCS) and DC-link voltage control strategy are two sorts of control strategies for series hybrid electric vehicles(HEVs). Combining those two control strategies is a new idea for control strategy of series hybrid electric vehicles. By tuning essential parameters which are the defined constants under DClink voltage control and under PFCS, the points of minimum mass of equivalent fuel consumption(EFC) corresponding to a series of variables are marked for worldwide harmonized light vehicles test procedure(WLTP). The fuel economy of series HEVs with the combination control schemes performs better compared with individual control scheme. The results show the effects of the combination control schemes for series HEVs driving in an urban environment.

关键词： DC-Link voltage control power follower control strategy series hybrid electric vehicles tuning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Opening design using bayesian optimization

引用

Virtual Reality & Intelligent Hardware 2023年第6期5卷 550-564页

作者： Nick VITSAS Iordanis evangelou Georgios PAPAIOANNOU Anastasios GKARAVELIS Department of Informatics Athens University of Economics and BusinessGreece

Background Opening design is a major consideration in architectural buildings during early structural layout *** regarding the geometric characteristics of windows,skylights,hatches,etc.,significantly affect the overall energy efficiency,airflow,and appearance of a building both internally and *** In this work,we employ a goal-based,illumination-driven approach to opening design using a Bayesian optimization approach based on Gaussian processes.A method that enables designers to conveniently set lighting intentions in conjunction with the qualitative and quantitative characteristics of the desired openings is *** The parameters are optimized within a cost-minimization framework to calculate geometrically feasible,architecturally admissible,and aesthetically pleasing openings of any desired shape while taking into account the designer′s lighting constraints.

关键词： Inverse geometry Lighting simulation Scene synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of fly ash and sewage sludge application on wheat biomass production,nutrients availability,and soil properties

引用

International Journal of Coal Science & Technology 2014年第2期1卷 221-226页

作者： Christos Tsadilas Vasilios Samaras E.evangelou Sabry M.Shaheen National Agricultural Research Foundation Institute of Soil Mapping and ClassificationLarissaGreece Faculty of Agriculture University of KafrelsheikhKafr El-SheikhEgypt

The influence of fly ash(FA)applied alone and/or with sewage sludge(SS)on wheat(Triticum vulgare)grain yield,biomass production and soil properties was studied in a field *** results showed that both FA and SS significantly increased grain yield and plant *** applied alone increased significantly soil pH and EC while FA applied together with SS did not significantly affect them compared to mono FA *** pH and EC values increased with time in FA and FA-SS *** increased soil organic matter and total N content and SS applied together with FA increased also available soil *** the plant nutrients tested only tissue N concentration was increased significantly in all treatments compared to ***,Zn,Mn,Ni,and Pb at both available and total concentrations are significantly affected.

关键词： Fly ash Sewage sludge By-product of coal combustion Wheat biomass product Soil property

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes

引用

Bone Research 2020年第3期8卷 356-364页

作者： Maria A.Christou Georgios Ntritsos Georgios Markozannes Fotis Koskeridis Spyros N.Nikas David Karasik Douglas P.Kiel Evangelos evangelou Evangelia E.Ntzani Department of Hygiene and Epidemiology Clinical and Molecular Epidemiology UnitSchool of MedicineUniversity of loanninaloanninaGreece Department of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolHinda and Arthur Marcus Institute for Aging ResearchHebrew SeniorLifeand the Broad Institute of MIT&HarvardCambridgeMAUSA Azrieli Faculty of Medicine Bar llan UniversitySafedIsrael Department of Epidemiology and Biostatistics Imperial College LondonLondonUK Department of Health Services Policy and PracticeCenter for Research Synthesis in HealthSchool of Public HealthBrown UniversityProvidenceRlUSA

Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural *** pleiotropy occurs when a single genetic element is associated with more than one *** aimed to identify pleiotropic loci associated with bone mineral density(BMD)and nonbone phenotypes in genome-wide association *** the discovery stage,the NHGRI-EBI Catalog was searched for genome-wide significant associations(P value<5 x 108),excluding bone-related *** was used to identify proxies of the significantly associated single nucleotide polymorphisms(SNPs)(r2=1).We then assessed putative genetic associations of this set of SNPs with femoral neck(FN)and lumbar spine(LS)BMD data from the GEFOS *** variants were claimed at a false discovery rate<1.4x 103 for FN-BMD and<1.5 x 10-3 for *** of these genetic markers was performed among more than 400000 UK Biobank participants of European ancestry with available genetic and heel bone ultrasound *** the discovery stage,72 BMD-related pleiotropic SNPs were identified,and 12 SNPs located in 11 loci on 8 chromosomes were replicated in the UK *** SNPs were associated,in addition to BMD,with 14 different *** pleiotropic associations were exhibited by rs479844(AP5B1,O V O L 1 genes),which was associated with dermatological and allergic diseases,and rs4072037(M U C 1 gene),which was associated with magnesium levels and gastroenterological *** conclusion,12 BMD-related genome-wide significant SNPs showed pleiotropy with nonbone *** associations can deepen the genetic understanding of bone-related diseases by identifying shared biological mechanisms with other diseases or traits.

关键词： magnesium globally Replication

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Active Suspension Systems for Road Vehicles

引用

Engineering 2024年第2期33卷 160-177页

作者： Min Yu Simos Aevangelou Daniele Dini Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK Department of Electrical and Electronic Engineering Imperial College LondonLondon SW72AZUK

Active suspension systems(ASSs)have been proposed and developed for a few decades,and have now once again become a thriving topic in both academia and industry,due to the high demand for driving comfort and safety and the compatibility of ASSs with vehicle electrification and *** review papers on ASSs mainly cover dynamics modeling and robust control;however,the gap between academic research outcomes and industrial application requirements has not yet been bridged,hindering most ASS research knowledge from being transferred to vehicle *** paper comprehensively reviews advances in ASSs for road vehicles,with a focus on hardware structures and control *** particular,state-of-the-art ASSs that have been recently adopted in production cars are discussed in detail,including the representative solutions of Mercedes active body control(ABC)and Audi predictive active suspension;novel concepts that could become alternative candidates are also introduced,including series active variable geometry suspension,and the active wheel-alignment *** with compact structure,small mass increment,low power consumption,high-frequency response,acceptable economic costs,and high reliability are more likely to be adopted by car *** terms of control strategies,the development of future ASSs aims not only to stabilize the chassis attitude and attenuate the chassis vibration,but also to enable ASSs to cooperate with other modules(e.g.,steering and braking)and sensors(e.g.,cameras)within a car,and even with high-level decision-making(e.g.,reference driving speed)in the overall transportation system-strategies that will be compatible with the rapidly developing electric and autonomous vehicles.

关键词： Active suspension Vehicle dynamics Robust control Ride comfort Chassis attitude

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

植物在修复、固定和重建水生、陆生生态系统中的应用

引用

重庆师范大学学报（自然科学版） 2012年第3期29卷 1-3,84-86,I0004,I0005页

作者： Andreas SCHAEFFER 陈忠礼 Mathias EBEL Michael evangelou Henner HOLLERT Martina RO-NICKOLL Burkhard SCHMIDT 袁野 Gottfried LENNARTZ 亚琛工业大学德国亚琛52076 GAIAC生态系统分析与评估研究所德国亚琛52072

植物能够吸收或降解污染物来修复受污染的土壤和水体[1-2],还能固定土壤、泥沙防止侵蚀和污染物从固体介质中释放[3]。众多无机和有机污染物都能被对其有耐性且生物量大的植物有效降解。例如,凤眼莲能吸收和净化来自金矿采掘废水的氰化... 详细信息

植物能够吸收或降解污染物来修复受污染的土壤和水体[1-2],还能固定土壤、泥沙防止侵蚀和污染物从固体介质中释放[3]。众多无机和有机污染物都能被对其有耐性且生物量大的植物有效降解。例如,凤眼莲能吸收和净化来自金矿采掘废水的氰化物,这类废水含各种氰化物以及重金属元素的浓度达到导致生物体产生毒性效应的水平。检测表明氰化物对凤眼莲的半数致死剂量(LC50)为13 mg/L,将经过高浓度氰化物废水驯化后的凤眼莲放在野外小型湿地进行试验,结果显示这类植物对氰化物的降解效率更高。放射性同位素试验发现氰化物分子中的C和N原子经过植物代谢合成天冬酰胺,从而将有毒性的氰化物转化为无毒的产物[4]。尾矿场也可以用植物来修复,一方面植物可以过滤污染物浓度很高的渗滤液,另一方面栽种植物可以固定边坡减少侵蚀。将高覆盖度植被的概念应用在一个尾矿场上,通过种植北美黄杉使其全年都维持较高的蒸腾效率来减少渗滤液。而边坡的固定首先需要在坡面安置固定、菱形的新鲜柳条编织成的笼状网格,其后覆上土壤并喷播能在生长期对固定土壤发挥作用的草本、灌木以及树木种子。这项技术同样适用于河岸侵蚀防护。

关键词：植物修复氰化物废料土壤固定渗滤液减量侵蚀控制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

利用超高场MRI的动脉自旋标记技术评估多发性硬化的皮质区病灶灌注

引用

国际医学放射学杂志 2019年第3期 378-379页

作者：罗嗣频 R.J.Dury Y.Falah P.A.GowlAND N.evangelou M.G.Bright S.T.Francis Sir Peter Mansfield Imaging Centre School of Physics and AstronomyUniversity of NottinghamUniversity Park

摘要目的探讨使用优化的超高场、高空间分辨率、低失真的动脉自旋标记(ASL)MRI测量多发性硬化(MS)皮质区病灶(CL)的血流动力病理学的可行性。方法 12例MS病

关键词：自旋标记 MRI 多发性硬化皮质区

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

与应用口服避孕药相关的自发性冠状动脉夹层:病例报道与文献回顾

引用

世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 42-43页

作者： evangelou D. Letsas K.P. Korantzopoulos P. 刘相飞 Department of Cardiology 'G.Hatzikosta'General Hospital 45001 Ioannina Greece

自发性冠状动脉夹层(SCAD)是急性冠状动脉综合征的一种罕见原因,其病理生理过程非常复杂。本文简要描述1例无传统心血管危险因素的50岁女性患者,因ST段抬高型急性心肌梗死而入院,入院后予溶栓治疗。值得注意的是,该患者在过去10年中口... 详细信息

自发性冠状动脉夹层(SCAD)是急性冠状动脉综合征的一种罕见原因,其病理生理过程非常复杂。本文简要描述1例无传统心血管危险因素的50岁女性患者,因ST段抬高型急性心肌梗死而入院,入院后予溶栓治疗。值得注意的是,该患者在过去10年中口服避孕药。冠状动脉造影示左前降支远端夹层。

关键词：冠状动脉夹层口服避孕药冠状动脉造影前降支急性心肌梗死文献回顾血管危险因素病理生理临床

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：