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现代装饰 2012年第10期 60-67页

作者： Kois Stelios Patsiaourras Nikos Marielina Stavrou Filippos Manolas konstantinos giannakis Vagelis Patepakis 谢作标

UneaPiu是一些世界顶尖时尚品牌如“香奈儿”、“汤姆福特”、“约翰加利亚诺”以厦“蓝色情人”等在希腊的独家特许零售商。此项目是希腊米科诺斯岛上的首家UneaPiu精品店。米科诺斯岛隶属于基克拉迪群岛，此群岛因其居民典雅和热情凹... 详细信息

UneaPiu是一些世界顶尖时尚品牌如“香奈儿”、“汤姆福特”、“约翰加利亚诺”以厦“蓝色情人”等在希腊的独家特许零售商。此项目是希腊米科诺斯岛上的首家UneaPiu精品店。米科诺斯岛隶属于基克拉迪群岛，此群岛因其居民典雅和热情凹溢的生活格调而闻名于世。数不清的立方体建筑物、清一色的白色外墙、曲曲折折贯穿首府Chora的蜿蜒小路,漂亮的教堂以殛迷人的风车等等，描绘出了一幅极富希腊特色和地中海风情的壮美画面。

关键词：精品店希腊时尚品牌生活格调零售商建筑物立方体地中海

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Diffusion-weighted MR imaging of normal and abnorma scrotum： preliminary results

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Asian Journal of Andrology 2012年第4期14卷 649-654页

作者： Athina C Tsili Maria I Argyropoulou Dimitrios giannakis Stavros Tsampalas Nikolaos Sofikitis konstantinos Tsampoulas Department of Clinical Radiology University Hospital of Ioannina Ioannina 45500 Greece Department of Urology University Hospital of Ioannina Ioannina 45500 Greece

Magnetic resonance （MR） imaging of the scrotum represents an important supplemental diagnostic tool in the evaluation of scrotal diseases. Diffusion-weighted （DW） MR imaging is a developing technique, proved to improve tissue characterization. We evaluated the feasibility and diagnostic performance of DW MR imaging in the detection and characterization of scrotal lesions. We retrospectively evaluated 31 scrotal lesions （23 intratesticular and 8 extratesticular） in 26 men. All MR examinations were performed on a 1.5-T unit, using a pelvic-phased array coil. DW sequences were obtained using a single shot, multislice spin echo planar diffusion pulse sequence and a b factor of 0 and 900 s mm-2. The DW MR characteristics and the apparent diffusion coefficient （ADC） values of normal scrotal contents and scrotal diseases were evaluated. Comparison between the ADC values of normal scrotum, benign lesions and scrotal malignancies was performed. The accuracy of conventional sequences, DW images alone and DW imaging combined with conventional images in differentiating benign from malignant scmtal lesions was calculated. The ADC values of testicular malignancies were different from those of normal testis and benign intratesticular lesions, and the ADC values of benign extratesticular lesions from those of normal epididymis （P〈0.05）. The overall accuracy of conventional imaging, DW imaging alone and DW MR combined with conventional sequences in the characterization of intratesticular lesions was 91%, 87% and 100%, respectively. Our findings suggest that DW MR imaging and ADC values may provide valuable information in the diagnosis and characterization of scrotal diseases.

关键词： diagnosis epididymis male genital neoplasms scrotum testicular neoplasms testis

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Apparent diffusion coefficient values of normal testis and variations with age

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Asian Journal of Andrology 2014年第3期16卷 493-497页

作者： Athina C Tsili Dimitrios giannakis Anastasios Sylakos Alexandra Ntorkou Loukas G Astrakas Nikolaos Sofikitis Maria I Argyropoulou Department of Clinical Radiology University of Ioannina Ioannina Greece Department of Urology University of Ioannina Ioannina Greece Department of Medical Physics University of Ioannina Ioannina Greece.

The usefulness of diffusion-weighted magnetic resonance imaging （DWI） in the evaluation of scrotal pathology has recently been reported. A standard reference of normal testicular apparent diffusion coefficient （ADC） values and their variations with age is necessary when interpreting normal testicular anatomy and pathology. We evaluated 147 normal testes using DWI, including 71 testes from 53 men aged 20-39years （group 1）, 67 testes from 42 men aged 40-69 years （group 2） and nine testes from six men older than 70years （group 3）. DWI was performed along the axial plane, using a single shot, multislice spin-echo planar diffusion pulse sequence and b-values of 0 and 900 s mm-2. The mean and standard deviation of the ADC values of normal testicular parenchyma were calculated for each age group separately. Analysis of variance （ANOVA） followed by post hoc analysis （Dunnett T3） was used for statistical purposes. The ADC values （x 10-3 mm2s-1） of normal testicular tissue were different among age groups （group 1：1.08 ± 0.13; group 2：1.15 ±0.15 and group 3：1.31± 0.22）. ANOVA revealed differences in mean ADC among age groups （F= 11.391, P〈 0.001）. Post hoc analysis showed differences between groups 1 and 2 （P= 0.008） and between groups 1 and 3 （P= 0.043）, but not between groups 2 and 3 （P= 0.197）. Our findings suggest that ADC values of normal testicular tissue increase with advancing age.

关键词： age apparent diffusion coefficient (ADC) diffusion-weighted magnetic resonance imaging testis

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A Mechanism for Low Viscosity

A Mechanism for Low Viscosity

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QCD和RHIC物理国际学术研讨会

作者： I. giannakis

＜正＞Because of coherent back scattering effects in a random medium, the RA term of viscosity vanishes, The totally viscosity is considerably suppressed Assuming there are random impurities in QGP （bound states isla...

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Genetic and epigenetic risks of intracytoplasmic sperm injection method

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Asian Journal of Andrology 2006年第6期8卷 643-673页

作者： Ioannis Georgiou Maria Syrrou Nicolaos Pardalidis konstantinos Karakitsios Themis Mantzavinos Nikolaos Giotitsas Dimitrios Loutradis Fotis Dimitriadis Motoaki Saito Ikuo Miyagawa Pavlos Tzoumis Anastasios Sylakos Nikolaos Kanakas Theodoros Moustakareas Dimitrios Baltogiannis Stavros Touloupides Dimitrios giannakis Michael Fatouros Nikolaos Sofikitis Laboratory of Molecular Urology and Genetics of Human Reproduction Department of Urology loannina University School of Medicine loannina 45110 Greece Cytogenetics Unit Laboratory of General Biology Medical School University of loannina loannina 45110 Greece Department of Urology Tottori University School of Medicine Yonago 683 Japan Department of Molecular Pharmacology Tottori University School of Medicine Yonago 683 Japan

Pregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection （ICSI） procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent thatconsequences of the genetic abnormalities underlying male subfertility （or infertility） and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities.

关键词： genetic risks epigenetic risks intracytoplasmic sperm injection testis male infertility

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宽带无线通信中的空时编码

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作者： (美)Georgios B. giannakis[等]

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Effects of phosphodiesterase 5 inhibitors on sperm parameters and fertilizing capacity

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Asian Journal of Andrology 2008年第1期10卷 115-133页

作者： F. Dimitriadis D. giannakis N. Pardalidis K. Zikopoulos E. Paraskevaidis N. Giotitsas V. Kalaboki P.Tsounapi D. Baltogiannis Georgiou M.Saito T.Watanabe I. Miyagawa N.Sofildtis Laboratory of Molecular Urology and Genetics of Human Reproduction Department of Urology Ioannina University School of Medicine Ioannina 45110 Greece Department of Urology Tottori University School of Medicine Yonago 683 Japan

The aim of this review study is to elucidate the effects that phosphodiesterase 5 （PDE5） inhibitors exert on spermatozoa motility, capacitation process and on their ability to fertilize the oocyte. Second messenger systems such as the cAMP/adenylate cyclase （AC） system and the cGMP/guanylate cyclase （GC） system appear to regulate sperm functions. Increased levels of intracytosolic cAMP result in an enhancement of sperm motility and viability. The stimulation of GC by low doses of nitric oxide （NO） leads to an improvement or maintenance of sperm motility, whereas higher concentrations have an adverse effect on sperm parameters. Several in vivo and in vitro studies have been carried out in order to examine whether PDE5 inhibitors affect positively or negatively sperm parameters and sperm fertilizing capacity. The results of these studies are controversial. Some of these studies demonstrate no significant effects of PDE5 inhibitors on the motility, viability, and morphology of spermatozoa collected from men that have been treated with PDE5 inhibitors. On the other hand, several studies demonstrate a positive effect of PDE5 inhibitors on sperm motility both in vivo and in vitro. In vitro studies of sildenafil citrate demonstrate a stimulatory effect on sperm motility with an increase in intracellular cAMP suggesting an inhibitory action of sildenafil citrate on a PDE isoform other than the PDE5. On the other hand, tadalafil＇s actions appear to be associated with the inhibitory effect of this compound on PDE11. In vivo studies in men treated with vardenafil in a daily basis demonstrated a significantly larger total number of spermatozoa per ejaculate, quantitative sperm motility, and qualitative sperm motility; it has been suggested that vardenafil administration enhances the secretory function of the prostate and subsequently increases the qualitative and quantitative motility of spermatozoa. The effect that PDE5 inhibitors exert on sperm parameters may lead to the impr

关键词： sperm fertilizing capacity phosphodiesterase 5 inhibitors spermatozoa testis male infertility

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关于正常成人睾丸MR波谱及其年龄变化的初步观察

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国际医学放射学杂志 2016年第5期 587-587页

作者： A.C.Tsili L.G.Astrakas A.Ntorkou D.giannakis S.Stavrou V.Maliakas 杨学东 Department of Clinical Radiology Medical School University of Ioannina

摘要目的确定正常成人睾丸氢质子MR(1H-MR)波谱及其年龄变化。方法纳入41个正常睾丸的MR资料,包括20～39岁组(组Ⅰ)16个、40～69岁组(组Ⅱ)25个。采用单体素点解析MR波谱序列(PRESS),TR/TE为2 000 ms/25 ms。兴趣容积包括大部分正常睾... 详细信息

摘要目的确定正常成人睾丸氢质子MR(1H-MR)波谱及其年龄变化。方法纳入41个正常睾丸的MR资料,包括20～39岁组(组Ⅰ)16个、40～69岁组(组Ⅱ)25个。采用单体素点解析MR波谱序列(PRESS),TR/TE为2 000 ms/25 ms。兴趣容积包括大部分正常睾丸实质。评价标准化代谢物浓度(即代谢物与肌酸的比值)与年龄的相关性。结果定量测量

关键词：正常成人波谱 MR 睾丸性腺年龄变化

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