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Catheter ablation of persistent atrial fibrillation:The importance of substrate modification

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World Journal of Cardiology 2015年第3期7卷 111-118页

作者： konstantinos P Letsas Michael Efremidis Nikolaos P Sgouros konstantinos Vlachos Dimitrios Asvestas Antonios Sideris Second Department of Cardiology Laboratory of Cardiac ElectrophysiologyEvangelismos General Hospital of Athens

Accumulating data have shown that elimination of atrial fibrillation(AF) sources should be the goal in persistent AF ablation. Pulmonary vein isolation, linear lesions and complex fractionated atrial electrograms(CFAEs) ablation have shown limited efficacy in patients with persistent AF. A combined approach using voltage, CFAEs and dominant frequency(DF) mapping may be helpful for the identification of AF sources and subsequent focal substrate modification. The fibrillatory activity is maintained by intramural reentry centered on fibrotic patches. Voltage mapping may assist in the identification of fibrotic areas. Stable rotors display the higher DF and possibly drive AF. Furthermore, the single rotor is usually consistent with organized AF electrograms without fractionation. It is therefore quite possible that rotors are located at relatively "healthy islands" within the patchy fibrosis. This is supported by the fact that high DF sites have been negatively correlated to the amount of fibrosis. CFAEs are located in areas adjacent to high DF. In conclusion, patchy fibrotic areas displaying the maximum DF along with high organization index and the lower fractionation index are potential targets of ablation. Prospective studies are required to validate the efficacy of substrate modification in left atrial ablation outcomes.

关键词： Ablation Atrial fibrillation Persistent Substrate Dominant frequency

Genetic and epigenetic risks of intracytoplasmic sperm injection method

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Asian Journal of Andrology 2006年第6期8卷 643-673页

作者： Ioannis Georgiou Maria Syrrou Nicolaos Pardalidis konstantinos Karakitsios Themis Mantzavinos Nikolaos Giotitsas Dimitrios Loutradis Fotis Dimitriadis Motoaki Saito Ikuo Miyagawa Pavlos Tzoumis Anastasios Sylakos Nikolaos Kanakas Theodoros Moustakareas Dimitrios Baltogiannis Stavros Touloupides Dimitrios Giannakis Michael Fatouros Nikolaos Sofikitis Laboratory of Molecular Urology and Genetics of Human Reproduction Department of Urology loannina University School of Medicine loannina 45110 Greece Cytogenetics Unit Laboratory of General Biology Medical School University of loannina loannina 45110 Greece Department of Urology Tottori University School of Medicine Yonago 683 Japan Department of Molecular Pharmacology Tottori University School of Medicine Yonago 683 Japan

Pregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection （ICSI） procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent thatconsequences of the genetic abnormalities underlying male subfertility （or infertility） and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities.

关键词： genetic risks epigenetic risks intracytoplasmic sperm injection testis male infertility

Motivation Factors in the Military: Ethical Leadership and Virtue Ethics

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Psychology Research 2020年第8期10卷 293-299页

作者： Evaggelia Kiosi konstantinos M.Karyotakis National and Kapodestrian University of Athens ZografouGreece University of the PeloponneseKalamataGreece Hellenic Police AcademyAthensGreece Technical University of Crete ChaniaGreece Hellenic Police AcademyAthensGreece

This paper focuses on employee motivation factors in military *** the context of the special mission of the military profession,military leadership is approached in an effort to demonstrate the importance and necessity of its ethical dimension in relation to employee *** the motivation factors related to employee personality traits,the paper seeks to demonstrate—through Aristotle’s philosophical reasoning(virtue ethics)—that military virtues have to define each member of the Armed Forces in order to fulfill his/her *** methodology part of this paper uses the method of interview with permanent officers of the Hellenic Armed Forces in order to prove the strong relationship between ethical leadership,virtue ethics,and employee motivation in the military.

关键词： army ethics leadership motivation virtue

Assessment of Impacts and Risks of Air Pollution Applying Two Strategies of Numerical Chemistry Transport Modelling

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Journal of Environmental Protection 2012年第1期3卷 26-40页

作者： Adolf Ebel Dimitris Melas Kostadin Ganev Manjola Banja Ion Sandu Elmar Friese Theodoros Giannaros Hermann J. Jakobs Ioannis Kioutsioukis konstantinos Markakis Michael Memmesheimer Nikolai Miloshev Victor Pescaru Anastasia Poupkou 不详

Assessment of harmful impacts and risks of air pollution in case of accidents as well as of long lasting exposition is an important challenge of chemical transport modeling. Sad confirmation of this statement unexpectedly has come from the nuclear power plant accident in Fukushima which occurred while this paper was finalized. Two strategies to comply with the task of impact and risk assessment in extended regions like Central Europe or the Balkans are described. The first one is characterized by application of a single model system to an extended domain. The other one is based on the combined application of several chemical transport models designed for the use in various sub-domains in the region under consideration. Advantages and disadvantages exist for both approaches. For instance, the single model strategy allows unified and harmonized assessment of risks in a larger region, whereas the combined model strategy may pro-vide faster and locally more specific response in emergency cases. The single model approach is treated exploiting applications of the EURAD model system. The combined model approach is a novel way of joint use of chemical transport model systems developed for the Balkans. The models are described and the accuracy of simulations carried out with them is briefly demonstrated by comparison of simulated and observed concentrations of air pollutants. Applications regarding the search of sources for high pollution events and the assessment of risks through known sources are exem-plarily discussed.

关键词： Air Pollution Chemical Transport Modeling Risk Accidental Release Emergency BALKAN Model System EURAD Model System

Advanced Use of Blockchain for Business and Marketing Improvement

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Management Studies 2020年第6期8卷 466-470页

作者： Panagiotis Gatomatis konstantinos Tsiomos Nikos Bogonikolos University of Patras PatrasGreece Blockchain 2050 BV RotterdamThe Netherlands Aratos Systems BV RijenThe Netherlands

A progressively augmenting demand for trust is observed within the global business environment of 21st *** research sheds light on the disintegration of trust to brands on a global ***,trusted third parties take place to guarantee the trust needed for various business exchanges to take ***,propels in peer-to-peer systems and cryptographic techniques have progressed to a point where transactions of currency,like Bitcoin,indeed esteem as within the case of ownership,property rights,securities,*** be conducted all over the Web with blockchain technology acting as a trust layer injected into the *** technology acts as the missing trust layer in the evolution of the Web.“Blockchain is to trust as the Internet is to information”.It can be regarded as the missing trust layer on Internet *** implications of blockchain technology on business and marketing discipline from various aspects are investigated in this *** can be a favorable instrument that empowers brands and clients alike to bypass middlemen and to fashion concrete business *** enables marketers to obtain reliable data,generate more enhanced analytics,and thus to craft compelling marketing *** a blockchain-based marketing ecosystem,loyalty programs can be fully integrated and *** paper also points the key procedures that marketers need to utilize in order to compete in the rapidly evolving business *** are drawn about the expected direction of business and marketing improvements as affected by these technological advances,resulting to an established perception that Blockchain technologies can profoundly change positively the economy,the society,the political institutions,and scientific activities.

关键词： blockchain business marketing

Patterns of airway involvement in inflammatory bowel diseases

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World Journal of Gastrointestinal Pathophysiology 2014年第4期5卷 560-569页

作者： Ilias Papanikolaou konstantinos Kagouridis Spyros A Papiris Pulmonary Medicine Department Corfu General Hospital 2nd Pulmonary Medicine Department "Attikon" University Hospital Athens Medical School National and Kapodistrian University of Athens 12462 Athens Greece

Extraintestinal manifestations occur commonly in inflammatory bowel diseases(IBD). Pulmonary manifestations(PM) of IBD may be divided in airway disorders, interstitial lung disorders, serositis, pulmonary vasculitis, necrobiotic nodules, drug-induced lung disease, thromboembolic lung disease and enteropulmonary fistulas. Pulmonary involvement may often be asymptomatic and detected solely on the basis of abnormal screening tests. The common embryonic origin of the intestine and the lungs from the primitive foregut, the co-existence of mucosa associated lymphoid tissue in both organs, autoimmunity, smoking and bacterial translocation from the colon to the lungs may all be involved in the pathogenesis of PM in IBD. PM are mainly detected by pulmonary function tests and highresolution computed tomography. This review will focus on the involvement of the airways in the context of IBD, especially stenoses of the large airways, tracheo-bronchitis, bronchiectasis, bronchitis, mucoid impaction, bronchial granulomas, bronchiolitis, bronchiolitis obliterans syndrome and the co-existence of IBD with asthma, chronic obstructive pulmonary disease, sarcoidosis and a1-antitrypsin deficiency.

关键词： Inflammatory bowel diseases Airways Bronchiolitis

Financial Analysis of European Energy Companies

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Macro Management & Public Policies 2019年第2期1卷 29-40页

作者： konstantinos Leventakos Athanasios S.Dagoumas Energy&Environmental Policy Laboratory School of EconomicsBusiness and International StudiesUniversity of PiraeusPiraeus18532Greece

Energy union and climate stands as one of the priorities of the European commission,aiming at the provision of secure,environmentally friendly and affordable *** energy policy over the last two decades have reshaped energy markets challenging the profitability and viability of energy *** latter must prove flexible in their management,including diversification of their portfolio,proceeding on structural unbundling and extending their operations in new markets and *** of the paper is to assess the financial and liquidity performances of key European energy companies over the period *** focus of the analysis concerns liquidity,profitability,operational performance and capital *** analysis is carried out in key energy companies,selected to have an extended geographical *** indicate that gas and oil companies have less risk compared to power companies,attributed mainly to debt *** renewable sector,although underrepresented in the examined sample,implies potential for high *** profitability of power companies is affected by the ownership of assets with low operating costs and by diversification of operations,including regulated network *** European power companies are favored by the derogation of EU regulation,though provision of free emission allowances.

关键词： European energy companies Financial analysis Energy policy

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希腊Linea Piu精品店

现代装饰 2012年第10期 60-67页

作者： Kois Stelios Patsiaourras Nikos Marielina Stavrou Filippos Manolas konstantinos Giannakis Vagelis Patepakis 谢作标

UneaPiu是一些世界顶尖时尚品牌如“香奈儿”、“汤姆福特”、“约翰加利亚诺”以厦“蓝色情人”等在希腊的独家特许零售商。此项目是希腊米科诺斯岛上的首家UneaPiu精品店。米科诺斯岛隶属于基克拉迪群岛，此群岛因其居民典雅和热情凹... 详细信息

UneaPiu是一些世界顶尖时尚品牌如“香奈儿”、“汤姆福特”、“约翰加利亚诺”以厦“蓝色情人”等在希腊的独家特许零售商。此项目是希腊米科诺斯岛上的首家UneaPiu精品店。米科诺斯岛隶属于基克拉迪群岛，此群岛因其居民典雅和热情凹溢的生活格调而闻名于世。数不清的立方体建筑物、清一色的白色外墙、曲曲折折贯穿首府Chora的蜿蜒小路,漂亮的教堂以殛迷人的风车等等，描绘出了一幅极富希腊特色和地中海风情的壮美画面。

关键词：精品店希腊时尚品牌生活格调零售商建筑物立方体地中海

Thickness-based correlations of cortical areas involved in senses, speech and cognitive processes

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World Journal of Neurology 2013年第3期3卷 67-74页

作者： Ioannis Mavridis konstantinos Lontos Sophia Anagnostopoulou Department of Anatomy University of Athens School of Medicine 11527 Athens Greece

AIM: To explore the existence of potential correlations of cortical thickness between different functional brain ***: Our material consisted of 38 formalinfixated human cerebral hemispheres from twenty males and three females, cadaver donors for students' education. We selected the following cortical areas at each hemisphere to examine: supramarginal gyrus(S), angular gyrus(A), area of colors recognition(F), area of names recognition(N), area of auditory attention(H), area of place memory(M), cortex of the superior wall of the calcarine sulcus(V1) and cortex of the inferior wall of the calcarine sulcus(V2). We measured the thickness of each cortical area and statistically analyzed our ***: We found a significant difference of the mean value of the V1(P < 0.05) between right and left hemispheres, as well as very significant correlations(P < 0.001) between the following cortical areas: N and F, A and F, S and F, A and S, A and N, S and N. We also found significant correlations(P < 0.01) between the following areas: S and M, S and H, N and H, as well asbetween the following areas(P < 0.05): V1 and V2, M and F, M and N, A and H. CONCLUSION: Our results suggest that there could be a potentially stronger impact for objects placed in the left inferior quarter of the visual field. Our study revealed several thickness-based correlations among different functional cortical areas. Most of them seem to have a more or less rational explanation.

关键词： Anatomy Cerebral cortex Correlations Cortical thickness Functional areas