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Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2679-2688页

作者： Ioannis Lambrou Ioannis Mantzoros Orestis Ioannidis Dimitrios Tatsis Elissavet Anestiadou Vasiliki Bisbinas Manousos-Georgios Pramateftakis Efstathios Kotidis Barbara Driagka Ourania Kerasidou Savvas Symeonidis Stefanos Bitsianis Freideriki Sifaki konstantinos Angelopoulos Haralabos Demetriades Stamatios Angelopoulos Fourth Department of Surgery Medical SchoolAristotle University of ThessalonikiThessaloniki 57010Greece Department of ENT Royal Cornwall Hospitals NHS TrustCornwall TR13LJUnited Kingdom

BACKGROUND Growth hormone(GH)plays a crucial role in wound healing and tissue repair in postoperative *** particular,colonic anastomosis healing following colorectal surgery is impaired by numerous chemotherapy *** To investigate whether GH can improve the healing of a colonic anastomosis following the adverse effects of intraperitoneal administration of 5-fluorouracil(5-FU),bleomycin and *** Eighty Wistar rats underwent laparotomy and a 1 cm-resection of the transverse colon,followed by an end-to-end anastomosis under general *** rats were blindly allocated into four equal groups and administered a different daily intraperitoneal therapeutic regimen for 6 *** control group(A)received normal *** B received chemotherapy with 5-FU(20 mg/kg),bleomycin(4 mg/kg)and cisplatin(0.7 mg/kg).Group C received GH(2 mg/kg),and group D received the aforementioned combination chemotherapy and GH,as *** rats were sacrificed on the 7th postoperative day and the anastomoses were macroscopically and microscop-ically *** weight,bursting pressure,hydroxyproline levels and inflammation markers were *** All rats survived until the day of sacrifice,with no infections or other complications.A decrease in the body weight of group D rats was observed,not statistically significant compared to group A(P=1),but significantly different to groups C(P=0.001)and B(P<0.01).Anastomotic dehiscence rate was not statistically different between the *** pressure was not significantly different between groups A and D(P=1.0),whereas group B had a significantly lower bursting pressure compared to group D(P<0.001).All groups had significantly more adhesions than group ***,as a measurement of collagen deposition,was significantly higher in group D compared to group B(P<0.05),and higher,but not statistically significant,compared to group *** changes in group D were recorded,compared to group A

关键词： Growth hormone Colonic anastomosis Adhesion Bursting pressure Collagen Hydroxyproline Inflammation Neoangiogenesis Chemotherapy

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Burril-Bernard Crohn(1884-1983)and the disease which bears his name

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History & Philosophy of Medicine 2024年第4期6卷 16-23页

作者： Georgios Androutsos konstantinos Laios Pavlos Lytsikas-Sarlis Evangelia Mourellou Constantinos Georgios Zografos Gregory Tsoucalas Marianna Karamanou School of Medicine National and Kapodistrian University of AthensAthens 11527Greece Department of History of Medicine and Medical Ethics School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece Graduate School of Medicine National and Kapodistrian University of AthensAthens 11527Greece Department of the History of Medicine and Medical Deontology School of MedicineUniversity of CreteHeraklion 71003Greece Surgery Department School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece

Background:Crohn’s disease,described by *** Crohn and his colleagues in 1932,continues to be of great research and clinical *** was initially perceived as a distinct condition and it has evolved since into a complex disease,with debates still going regarding its classification and *** though more that 80 years of research have passed,numerous significant questions regarding the disease’s causes and best possible treatment strategies still ***:This article reviews both historical and contemporary perspectives on Crohn’s disease,including its initial description,the research developments that happened in the years to follow,as well as the way it is regarded *** refers to notable contributions from medical figures,such as *** and his colleagues,examines related advances made in medical research and mentions the challenges and the treatment strategies that are still being ***:This article highlights the evolution of Crohn’s disease from a distinct condition to a more heterogeneous ***,it refers to advancements made in medical research,such as the identification of CARD15(NOD2)gene mutations and the role of dysbiosis,and it examines current therapeutic ***:Even though significant progress has been made since the initial description of Chron’s disease,there is no definitive cure,even though it has been determined that genetic and environmental factors are of great *** ongoing research could possibly lead to future discoveries and therefore aid in the discovery of efficient management and treatment of Crohn’s disease.

关键词： regional ileitis granulomatous inflammation endoscopic evaluation historical figures

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Improving the operational stability of perovskite solar cells with cesium-doped graphene oxide interlayer

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Journal of Energy Chemistry 2024年第9期96卷 483-490页

作者： Masaud Almalki Katerina Anagnostou konstantinos Rogdakis Felix T.Eickemeyer Mostafa Othman Minas M.Stylianakis Dimitris Tsikritzis Anwar Q.Alanazi Nikolaos Tzoganakis Lukas Pfeifer Rita Therisod Xiaoliang Mo Christian M.Wolff Aïcha Hessler-Wyser Shaik M.Zakeeruddin Hong Zhang Emmanuel Kymakis Michael Grätzel Laboratory of Photonics and Interfaces École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Electrical and Computer Engineering Hellenic Mediterranean UniversityHeraklionCrete 71410Greece Institute of Electrical and Microengineering(IEM)Photovoltaics and Thin-Film Electronics Laboratory(PV-Lab) École Polytechnique Fédérale de Lausanne(EPFL)Neuchâtel 2000Switzerland Department of Nursing Faculty of Health SciencesHellenic Mediterranean UniversityCrete 71410Greece Centre Interdisciplinaire de Microscopie Electronique École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Future Energy Technology Institute King Abdulaziz City for Science and Technology(KACST)P.O.Box 6086Riyadh 11442Saudi Arabia State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionInstitute of OptoelectronicsDepartment of Materials ScienceFudan UniversityShanghai 200433China

Perovskite solar cells(PSCs)have made great advances in terms of power conversion efficiency(PCE),yet their subpar stability continues to hinder their *** interface between the perovskite layer and the charge-carrier transporting layers plays a crucial role in undermining the stability of *** this work,we propose a strategy to stabilize high-performance PSCs with PCE over 23%by introducing a cesium-doped graphene oxide(GO-Cs)as an interlayer between the perovskite and hole-transporting *** GO-Cs treated PSCs exhibit excellent operational stability with a projected T80(the time where the device PCE reduces to 80%of its initial value)of 2143 h of operation at the maximum powering point under one sun illumination.

关键词： Perovskite solar cells Doped graphene oxide Graphene related material Long-term operational stability

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Circadian rhythm disruption and endocrine-related tumors

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World Journal of Clinical Oncology 2024年第7期15卷 818-834页

作者： Christos Savvidis Efthymia Kallistrou Eleni Kouroglou Sofia Dionysopoulou Georgios Gavriiloglou Dimitra Ragia Vasiliki Tsiama Stella Proikaki konstantinos Belis Ioannis Ilias Department of Endocrinology Hippocration General HospitalAthens GR-11527Greece

This review delved into the intricate relationship between circadian clocks and physiological processes,emphasizing their critical role in maintaining *** by interlocked clock genes,the circadian timekeeping system regulates fundamental processes like the sleep-wake cycle,energy metabolism,immune function,and cell *** central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles,while peripheral tissue clocks are influenced by cues such as feeding *** disruption,linked to modern lifestyle factors like night shift work,correlates with adverse health outcomes,including metabolic syndrome,cardiovascular diseases,infec-tions,and *** explored the molecular mechanisms of circadian clock genes and their impact on metabolic disorders and cancer *** associ-ations between circadian disruption and endocrine tumors,spanning breast,ovarian,testicular,prostate,thyroid,pituitary,and adrenal gland cancers,are *** work is associated with increased breast cancer risk,with PER genes influencing tumor progression and drug *** gene expression correlates with cisplatin resistance in ovarian cancer,while factors like aging and intermittent fasting affect prostate *** review underscored the intricate interplay between circadian rhythms and cancer,involving the regulation of the cell cycle,DNA repair,metabolism,immune function,and the tumor *** advocated for integrating biological timing into clinical consider-ations for personalized healthcare,proposing that understanding these connec-tions could lead to novel therapeutic *** supports circadian rhythm-focused therapies,particularly chronotherapy,for treating endocrine *** review called for further research to uncover detailed connections between circadian clocks and cancer,providing essential insights for targeted *** emphasized the importance of pub

关键词： Circadian rhythm Circadian disruption Shift work CLOCK gene Cancer Endocrine tumors Chronotherapy

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Improving service regularity for high-frequency bus services with rescheduling and bus holding

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第5期8卷 778-794页

作者： konstantinos Gkiotsalitis Centre for Transport Studies Department of Civil EngineeringUniversity of TwenteEnschedeThe Netherlands

In high-frequency bus services,maintaining the service regularity is a critical *** service regularity is directly related to the excessive waiting times(EWT) of passengers at bus *** a regular service,the EWT is minimized resulting in even headways between consecutive buses of the same *** this study,we propose the combined use of rescheduling and bus holding to improve passengers’ excessive waiting *** model the dynamic rescheduling and bus holding problem as an integer nonlinear program(INLP) and we prove its *** model considers the constraints of the original timetable e an issue that is usually neglected from most dynamic control *** the NP-hardness of our mathematical program,we introduce a problem-specific heuristic to explore efficiently the solution *** convergence rate of the proposed heuristic is tested against other solution methods,including simulated annealing with linear cooling,hill climbing and branch and bound with multi-start sequential quadratic *** addition,simulations with the use of actual operational data from a major bus operator in Asia Pacific demonstrate an up to 35% potential EWT improvement for a minor increase of 6% to the travel times of onboard passengers.

关键词： Traffic engineering Rescheduling Bus holding Dynamic control Combinatorial optimization Bus bunching

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Billroth II anastomosis combined with brown anastomosis reduce reflux gastritis in gastric cancer patients

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World Journal of Methodology 2024年第1期14卷 71-79页

作者： Grigorios Christodoulidis Marina Nektaria Kouliou konstantinos Eleftherios Koumarelas konstantinos Argyriou Garyfallia Apostolia Karali konstantinos Tepetes Department of General Surgery University Hospital of LarissaLarissa 41110Greece Department of Gastroenterology University Hospital of LarissaLarissa 41334Greece

BACKGROUND The surgeon performing a distal gastrectomy,has an arsenal of reconstruction techniques at his disposal,Billroth II among *** anastomosis performed during a Billroth II procedure has shown evidence of superiority over typical Billroth II,in terms of survival,with no impact on postoperative morbidity and *** To compare Billroth II vs Billroth II and Braun following distal gastrectomy,regarding their postoperative *** Patients who underwent distal gastrectomy during 2002-2021,were separated into two groups,depending on the surgical technique used(Billroth II:74 patients and Billroth II and Braun:28 patients).The daily output of the nasogastric tube(NGT),the postoperative day that NGT was removed and the day the patient started per os feeding were *** complications were at the same time *** were then statistically *** There was difference in the mean NGT removal day and the mean start feeding *** total postoperative NGT output was lower in Braun group(399.17 mL vs 1102.78 mL)and it was statistically significant(P<0.0001).Mean daily postoperative NGT output was also statistically significantly lower in Braun *** to the postoperative follow up 40 patient experienced bile reflux and alkaline gastritis from the Billroth II group,while 9 patients who underwent Christodoulidis G et *** II and Braun compared with Billroth II WJM https://*** 2 March 20,2024 Volume 14 Issue 1 Billroth II and Braun anastomosis were presented with the same conditions(P<0.05).CONCLUSION There was evidence of superiority of Billroth II and Braun vs typical Billroth II in terms of bile reflux,alkaline gastritis and NGT output.

关键词： Billroth II Billroth II and Braun Reconstruction techniques Gastrectomy Distal gastrectomy

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Spatiotemporal graph queries on geographic databases under a conceptual abstraction scale

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Geo-Spatial Information Science 2014年第2期17卷 110-118页

作者： Panagiotis PARTSINEVELOS konstantinos PAPADAKIS konstantinos MAKANTASIS Laboratory of Geodesy and Geomatics Engineering Department of Mineral Resources EngineeringTechnical University of CreteUniversity CampusChania 73100CreteGreece Department of Electronic and Computer Engineering Technical University of CreteUniversity CampusChania 73100CreteGreece Computer Vision and Decision Support Laboratory Production and Management DepartmentTechnical University of CreteUniversity CampusChania 73100CreteGreece

Visual queries assist non-expert users to extract information from spatial databases in an intuitive and natural approach,making Geographic information systems comprehensive and efficient for a wide range of applications.A common visual means of querying takes the form of drawings or graphs,under which many spatial ambiguity and translation errors *** this study,common query attributes extracted from user graphs such as spatial topology,size,cardinality,and proximity are regarded under a conceptual moderation ***,the system/user may concentrate on various conceptual combinations of ***,time is incorporated to support spatiotemporal queries for changing scenes and moving ***,relative,and absolute scaling is possible according to the data-set and application at *** theoretic approach is implemented under a prototype user interface system,called *** this prototype,a user may extract scene-based relations in an automatically inferred fashion,or include single object-oriented relations when all possible relations seem ***,a natural language description of the query is extracted upon which the user may select the desired query *** on a spatial database demonstrates the concepts of predefined draw objects,scaling relaxation,conceptual abstraction,and scene,object-and textual-oriented transitions that promote query expressiveness and restrain ambiguities.

关键词： visual queries spatial topology spatiotemporal queries graph and sketch queries query by example

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Supporting decision-making processes for selecting fire safety measures for road tunnels

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第3期9卷 473-489页

作者： Panagiotis Ntzeremes konstantinos Kirytopoulos School of Mechanical Engineering National Technical University of AthensAthens 10682Greece

Selecting fires safety measures for road tunnels relies mainly on strict regulatory requirements. However, the choice should also be based on many different criteria and ranking of alternatives should take place. Existing methods exhibit lack in dealing rigorously with measures’ selection amongst different alternatives. This paper contributes to the body of knowledge by proposing a novel method, named EVADE, which aims to incorporate diverse stakeholders’ views and provide a meaningful ranking of *** do so, it estimates the tunnel level of safety taking into account only any standard measures existing. Subsequently, the performance of additional measures is ***, a list of the most significant criteria that are valuable to judge the appropriateness of selected measures is introduced. The relative importance amongst the decision criteria is calculated through the Analytic Hierarchy Process, based on the expert opinion. Sensitivity analysis through Monte Carlo simulation is embedded to allow for a meaningful prioritization of the decision criteria. Thus, the alternatives’ ranking comes as a distribution instead of a single number, providing the decision-maker richer information for selecting the most suitable measure(s) according to the specific tunnel situation. At last, a typical tunnel is examined to showcase the utilization of the method.

关键词： Road tunnel Critical infrastructure Decision-making Quantitative-risk-assessment

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Large solitary retroperitoneal echinococcal cyst:A rare case report

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World Journal of Gastroenterology 2007年第45期13卷 6101-6103页

作者： konstantinos Tepetes Gregory Christodoulidis Michael Spryridakis konstantinos Hatzitheofilou General Surgery Department University Hospital of Larissa Mezourlo Larissa Greece

Echinococcal disease remains a problem within some endemic areas. Echinococcal cysts usually involve the liver and lungs, but any other organ can potentially be involved. Extrahepatic localization is reported in 14%-19% of all cases of abdominal hydatid disease. We report the case of a large echinococcal cyst localized in the lower pelvis. A 28-year-old woman was admitted to a surgical ward with lower abdominal pain and discomfort lasting for a month. Ultrasonography and computed tomography scanning revealed a large retroperitoneal cystic mass (9 cm × 4 cm) in contact with the left ovary and left ureter. There were no cysts in any other location. Serological tests were positive for Echinococcus. The patient was operated on and the entire cyst was excised intact. Histopathological results confirmed the diagnosis of echinococcosis. Antihelminthics were administered postoperatively and the patient was discharged after 6 d, and is now being closely followed up. Total cystectomy when possible represents the treatment of choice for large extrahepatic echinococcal cysts.

关键词： Echinococcus cysts Ultrasonography Extrahepatic location Seropositivity Antihelminthics Total cystectomy

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Effects of glucose-lowering agents on ischemic stroke

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World Journal of Diabetes 2017年第6期8卷 270-277页

作者： konstantinos Avgerinos konstantinos Tziomalos First Propedeutic Department of Internal Medicine Medical SchoolAristotle University of ThessalonikiAHEPA Hospital54636 ThessalonikiGreece

Diabetes mellitus(DM) is a major risk factor for cardiovascular events, including ischemic stroke. Moreover, ischemic stroke appears to be more severe in these patients and to be associated with less favorable outcomes. However, strict glycemic control does not appear to reduce the risk of ischemic stroke. On the other hand, newer glucose-lowering agents(glucagon-like peptide 1 receptor agonists and sodiumglucose cotransporter 2 inhibitors) reduced the risk of cardiovascular events in recent randomized, placebocontrolled trials. Semaglutide also reduced the risk of ischemic stroke. These benefits are independent of glucose lowering and might be due to the favorable effects of these agents on body weight and blood pressure. Pioglitazone also reduced the risk of recurrent stroke in patients with insulin resistance or type 2 DM but the unfavorable safety profile limits its use. In contrast, sulfonylureas and dipeptidyl peptidase 4 inhibitors have a neutral effect on cardiovascular morbidity and might be less attractive options in this high-risk population.

关键词： Antidiabetic treatment Ischemic stroke Cardiovascular events Glucose regulation Neuroprotection

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