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Ex vivo liver resection and auto-transplantation and special systemic therapy in perihilar cholangiocarcinoma treatment

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 635-640页

作者： konstantin y tchilikidi Department of Surgery with Postgraduate Education Altai State Medical UniversityBarnaul 656031Russia

This editorial contains comments on the article“Systematic sequential therapy for ex vivo liver resection and autotransplantation:A case report and review of li-terature”in the recent issue of World Journal of Gastrointestinal *** points out the actuality and importance of the article and focuses primarily on the role and place of ex vivo liver resection and autotransplantation(ELRAT)and systemic therapy,underlying molecular mechanisms for targeted therapy in perihilar cho-langiocarcinoma(pCCA)*** is a tough malignancy with a high proportion of advanced disease at the time of *** only curative option is radical *** excision and reconstruction become extremely com-plicated and not always could be performed even in localized *** the other hand,ELRAT takes its place among surgical options for carefully selected pCCA *** advanced disease,systemic therapy becomes a viable option to prolong *** editorial describes current possibilities in chemotherapy and reveals underlying mechanisms and projections in targeted therapy with ki-nase inhibitors and immunotherapy in both palliative and adjuvant ***-broblast grow factor and fibroblast grow factor receptor,human epidermal grow-th factor receptor 2,isocitrate dehydrogenase,and protein kinase cAMP activated catalytic subunit alpha(PRKACA)and beta(PRKACB)pathways have been ac-tively investigated in CCA in last *** agents were introduced and approved by the Food and Drug *** all demonstrated mean-ingful activity in CCA patients with no global change in *** is why every successfully treated patient counts,especially those with advanced *** conclusion,pCCA is still hard to treat due to late diagnosis and extremely complicated surgical *** also brings some hope,but it could be performed in very carefully selected *** disease requires systemic anticancer treatment,which is supposed to be indivi

关键词： Perihilar cholangiocarcinoma Klatskin’tumor Ex vivo liver resection and autotransplantation Chemotherapy Immunotherapy Targeted therapy

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Actuality and underlying mechanisms of systemic immuneinflammation index and geriatric nutritional risk index prognostic value in hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 260-265页

作者： konstantin y tchilikidi Department of Surgery with Postgraduate Education Altai State Medical UniversityBarnaul 656031Russia

This editorial contains comments on the article“Correlation between preoperative systemic immune inflammation index,nutritional risk index,and prognosis of radical resection of liver cancer”in a recent issue of the World Journal of Gastrointestinal *** pointed out the actuality and importance of the article and focused primarily on the underlying mechanisms making the systemic immuneinflammation index(SII)and geriatric nutritional risk index(GNRI)prediction features *** are few publications on both SII and GNRI together in hepatocellular carcinoma(HCC)and patient prognosis after radical *** release cytokines,chemokines,and enzymes,degrade extracellular matrix,reduce cell adhesion,and create conditions for tumor cell *** promote the adhesion of tumor cells to endothelial cells,through physical *** results in the migration of tumor ***-angiogenic factors from platelets enhance tumor angiogenesis to meet tumor cell supply *** can form a protective film on the surface of tumor *** allows avoiding blood flow damage as well as immune system *** also induces the epithelial-mesenchymal transformation of tumor cells that is critical for *** SII is also associated with macro-and microvascular invasion and increased numbers of circulating tumor cells.A high GNRI was associated with significantly better progression-free and overall *** patients are a very special population that requires increased *** and GNRI have significant survival prediction value in both palliative treatment and radical surgery *** underlying mechanisms of their possible predictive properties lie in the field of essential cancer *** features provide tumor nutrition,growth,and distribution throughout the body,such as vascular *** the other hand,they are tied to the possibility of patients to resist tumor progression and development of complications in bot

关键词： Systemic immune-inflammation index Geriatric nutritional risk index Radical surgery Transarterial chemoembolization Hepatocellular carcinoma Prognosis

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Liver graft preservation methods during cold ischemia phase and normothermic machine perfusion

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World Journal of Gastrointestinal Surgery 2019年第3期11卷 126-142页

作者： konstantin y tchilikidi Department of Surgery Altai State Medical University

The growing demand for donor organs requires measures to expand donor *** include extended criteria donors, such as elderly people, steatotic livers,donation after cardiac death, etc. Static cold storage to reduce metabolic requirements developed by Collins in late 1960 s is the mainstay and the golden standard for donated organ protection. Hypothermic machine perfusion provides dynamic organ preservation at 4°C with protracted infusion of metabolic substrates to the graft during the ex vivo period. It has been used instead of static cold storage or after it as short perfusion in transplant center. Normothermic machine perfusion(NMP) delivers oxygen, and nutrition at physiological temperature mimicking regular environment in order to support cellular function. This would minimize effects of ischemia/reperfusion ***, NMP may help to estimate graft functionality before implantation into a recipient. Clinical studies demonstrated at least its non-inferiority or better outcomes vs static cold storage. Regular grafts donated after brain death could be safely preserved with convenient static cold storage. Except for prolonged ischemia time where hypothermic machine perfusion started in transplant center could be estimated to provide possible positive reconditioning effect. Use of hypothermic machine perfusion in regular donation instead of static cold storage or in extended criteria donors requires further investigation. Multicenter randomized clinical trial supposed to be completed in December 2021. Extended criteria donors need additional measures for graft storage and assessment until its implantation. NMP is actively evaluating promising method for this *** studies are necessary for precise estimation and confirmation to issue clinical practice recommendations.

关键词： Liver graft preservation Graft preservation solutions Static cold storage Hypothermic machine perfusion Normothermic machine perfusion Ischemia-reperfusion injury Marginal grafts Donation after cardiac death Extended criteria donors Transplant complications

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Robotic surgery in living liver donors and liver recipients

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 123-127页

作者： konstantin Semash Department of Mini-Invasive Surgery National Children’s Medical CenterTashkent 100171Uzbekistan

There have been nearly 60 years since Thomas Starzl’s first liver *** this period,advancements in medical technology have progressively enabled the adoption of new methods for *** these innovations,robotic surgery has emerged in recent decades and is gradually being integrated into transplant *** hepatectomy and liver implantation represent significant advancements in the field of transplant *** precision and minimally invasive nature of robotic surgery offer substantial benefits for both living donors and *** living donors,robotic hepatectomy reduces postoperative pain,minimizes scarring,and accelerates *** liver recipients,robotic liver implantation enhances surgical accuracy,leading to better graft positioning and vascular *** systems provide more precise and maneuverable control of instruments,allowing surgeons to perform complex procedures with greater accuracy and reduced risk to *** review encompasses publications on minimally invasive donor liver surgery,with a specific focus on robotic liver resection in transplantation,and aims to summarize current knowledge and the development status of robotic surgery in liver transplantation,focusing on liver resection in donors and graft implantation in recipients.

关键词： Liver transplantation Robotic surgery Robotic liver resection Robotic hepatectomy Robotic liver implantation

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Consideration of the influence of supports in modeling the electromagnetic fields of 25 kV traction networks under emergency conditions

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Global Energy Interconnection 2024年第4期7卷 528-540页

作者： konstantin Suslov Andrey Kryukov Ekaterina Voronina Pavel Ilyushin Department of Hydropower and Renewable Energy National Research UniversityMoscow Power Engineering InstituteMoscow 11250Russia Department of Power Supply and Electrical Engineering Irkutsk National Research Technical UniversityIrkutsk 664074Russia Department of Transport Electric Power Irkutsk State Transport UniversityIrkutsk 664074Russia Department of Research on the Relationship between Energy and the Economy Energy Research Institute of the Russian Academy of SciencesMoscow 117186Russia

Single-phase 25 kV traction networks of electrified alternating current(AC)railways create electromagnetic fields(EMFs)with significant levels of *** most intense magnetic fields occur when short circuits exist between the contact wire and rails or *** the short duration of exposure,they can adversely affect electronic devices and induce significant voltages in adjacent power lines,which is dangerous for operating *** numerous investigations have focused on modeling the EMF of traction networks and power lines,the challenge of determining the three-dimensional electromagnetic fields near metal supports during the flow of a short-circuit current through them is yet to be *** this case,the field has a complex spatial structure that significantly complicates the calculations of *** study proposes a methodology,algorithms,software,and digital models for determining the EMF in the described emergency *** the modeling process,the objects being studied were represented by segments of thin wires to analyze the distribution of the electric charge and calculate the intensities of the electric and magnetic *** approach was implemented in the Fazonord software,and the modeling results show a substantial increase in EMF levels close to the support,with a noticeable decrease in the levels as the distance from it *** procedure implemented in the commercial software Fazonord is universal and can be used to determine electromagnetic fields at any electrical power facility that includes live parts of limited *** on the proposed procedure,the EMF near the supports of overhead power lines and traction networks of various designs could be determined,the EMF levels at substations can be calculated,and the influence of metal structures located near traction networks,such as pedestrian crossings at railway stations,can be considered.

关键词： Power supply systems AC railways Emergency conditions Electromagnetic fields near supports Modeling Electromagnetic safety

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The Disintegration of a Floating Ferrofluid Layer into an Ordered Drop System in a Vertical Magnetic Field

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Fluid Dynamics & Materials Processing 2024年第10期20卷 2205-2218页

作者： Christina Khokhryakova konstantin Kostarev Irina Mizeva Laboratory of Dispersed System Dynamics Institute of Continuous Media Mechanics UrB RASPerm614018Russia Laboratory of Hydrodynamical Stability Institute of Continuous Media Mechanics UrB RASPerm614018Russia Laboratory of Turbulence Institute of Continuous Media Mechanics UrB RASPerm614018Russia

Magnetic fluids,also known as ferrofluids,are versatile functional materials with a wide range of *** applications span from industrial uses such as vacuum seals,actuators,and acoustic devices to medical uses,including serving as contrast agents for magnetic resonance imaging(MRI),delivering medications to specific locations within the body,and magnetic hyperthermia for cancer *** use of a non-wettable immiscible liquid substrate to support a layer of magnetic fluid opens up new possibilities for studying various fluid flows and related instabilities in multi-phase systems with both a free surface and an *** presence of two deformable boundaries within a ferrofluid layer significantly reduces the critical magnetic field strength required to transform the layer into an organized system of drops or polygonal figures evolving according to the intensity,frequency and direction of the considered magnetic *** paper experimentally investigates this problem by assuming a uniform magnetic field perpendicular to the *** specific subject has not been previously explored *** critical magnetic field intensity required to destabilize the ferrofluid layer is determined based on the layer’s thickness and the fluid’s initial magnetic *** is demonstrated that the critical magnetic field strength needed to disrupt the initially continuous ferrofluid layer increases with the layer’s ***,an increase in the ferrofluid’s magnetic susceptibility results in a decrease in the critical magnetic field *** emerging droplet structures are analyzed in terms of the number of drops,their size,and the periodicity of their *** number of droplets formed depends on the initial thickness of the layer,the presence or absence of a stable rupture in the upper layer,and the rate at which the magnetic field strength is increased to the critical value.A characteristic viscous time is proposed

关键词： Ferrofluid liquid substrate normal field instability ordered droplet structure

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Electroluminescence from pure resonant states in hBN-based vertical tunneling junctions

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Light(Science & Applications) 2024年第8期13卷 1557-1564页

作者： Magdalena Grzeszczyk Kristina Vaklinova Kenji Watanabe Takashi Taniguchi konstantin SNovoselov Maciej Koperski Institute for Functional Intelligent Materials National University of SingaporeSingapore 117544Singapore Research Center for Functional Materials National Institute for Materials ScienceTsukuba 305-0044Japan International Center for Materials Nanoarchitectonics National Institute for Materials ScienceTsukuba 305-0044Japan Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Defect centers in wide-band-gap crystals have garnered interest for their potential in applications among optoelectronic and sensor ***,defects embedded in highly insulating crystals,like diamond,silicon carbide,or aluminum oxide,have been notoriously difficult to excite electrically due to their large internal *** address this challenge,we realized a new paradigm of exciting defects in vertical tunneling junctions based on carbon centers in hexagonal boron nitride(hBN).The rational design of the devices via van der Waals technology enabled us to raise and control optical processes related to defect-to-band and intradefect *** fundamental understanding of the tunneling events was based on the transfer of the electronic wave function amplitude between resonant defect states in hBN to the metallic state in graphene,which leads to dramatic changes in the characteristics of electrons due to different band structures of constituent *** our devices,the decay of electrons via tunneling pathways competed with radiative recombination,resulting in an unprecedented degree of tuneability of carrier dynamics due to the significant sensitivity of the characteristic tunneling times on the thickness and structure of the *** enabled us to achieve a high-efficiency electrical excitation of intradefect transitions,exceeding by several orders of magnitude the efficiency of optical excitation in the sub-band-gap *** work represents a significant advancement towards a universal and scalable platform for electrically driven devices utilizing defect centers in wide-band-gap crystals with properties modulated via activation of different tunneling mechanisms at a level of device engineering.

关键词： carbide tunneling defect

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A Numerical Investigation of the Effect of Boundary Conditions on Acoustic Pressure Distribution in a Sonochemical Reactor Chamber

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1425-1439页

作者： Ivan Sboev Tatyana Lyubimova konstantin Rybkin Michael Kuchinskiy UEC-Aviadvigatel 93 Komsomolsky ProspectPerm614990Russia Laboratory of Computing Hydrodynamic Institute of Continuous Media Mechanics UB RASPerm614013Russia Laboratory of Interfacial Hydrodynamic Perm State UniversityPerm614068Russia

The intensification of physicochemical processes in the sonochemical reactor chamber is widely used in problems of synthesis,extraction and *** of the most important mechanisms at play in such processes is the acoustic cavitation due to the non-uniform distribution of acoustic pressure in the *** has a strong impact on the surface degradation *** this work,a numerical calculation of the acoustic pressure distribution inside the reactor chamber was performed using COMSOL *** numerical results have revealed the dependence of the structure of the acoustic pressure field on the boundary conditions for various thicknesses of the piezoelectric *** particular,the amplitude of the acoustic pressure is minimal in the case of absorbing boundaries,and the attenuation becomes more significant as the thickness of the piezoelectric transducer *** addition,reflective boundaries play a significant role in the formation and distribution of zones of maximum cavitation activity.

关键词： Ultrasound numerical simulation acoustic pressure field cavitation erosion foil test

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S-,P-stabilized bromoallenes for modular allenylborylation of alkenes

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Science China Chemistry 2024年第1期67卷 360-367页

作者： Jixin Wang Donghao Luo ying Hu Zhili Duan Jianlin yao konstantin Karaghiosoff Jie Li Key Laboratory of Organic Synthesis of Jiangsu Province Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective MedicineCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Department Chemie Ludwig-Maximilians-Universitat MunchenButenandtstr.5-13Haus F81377 MunichGermany State Key Laboratory and Institute of Elemento-Organic Chemistry Haihe Laboratory of Sustainable Chemical TransformationsCollege of ChemistryNankai UniversityTianjin 300071China

Simultaneously forming a carbon-carbon and a carbon-heteroatom bond in a single step through transition metal-catalyzed alkene difunctionalization strategy has emerged as a powerful tool for synthetic organic *** to the uncontrollable reactivity,direct cross-coupling with bromoallenes as the building blocks for the selective allenation and borylation remains *** herein report a new type of S-and P-stabilized bromoallenes for palladium-catalyzed modular allenation and borylation of alkenes to the divergent synthesis of multiply functionalized allenes in a highly regio-and diastereoselective *** reaction features broad substrate scope and wide functional group compatibility,thus providing a straightforward method to install allenyl and boryl groups across *** experiments highlight the crucial importance of S-,P-stabilization for the oxidative insertion of Pd-species into the allenyl-Br *** facile syntheses of bioactive allenic steroids and exocyclic allenes demonstrate the synthetic utility of this protocol.

关键词： alkene difunctionalization olefins bromoallenes allenylborylation palladium

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Investigation of Cavitation in NaCl Solutions in a Sonochemical Reactor Using the Foil Test Method

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Fluid Dynamics & Materials Processing 2024年第5期20卷 1093-1102页

作者： Michael Kuchinskiy Tatyana Lyubimova konstantin Rybkin Anastasiia Sadovnikova Vasiliy Galishevskiy Institute of Continuous Media Mechanics UB RAS Perm614013Russia Faculty of Physics Perm State UniversityPerm614068Russia

Ultrasonic baths and sonochemical reactors are widely used in industrial applications dealing with surface cleaningand chemical synthesis. The processes of erosion, cleaning and structuring of the surface can be typically controlledby changing relevant influential parameters. In particular, in this work, we experimentally investigate theeffect of NaCl concentration (0–5.5 mol/L) on the erosion of an aluminum foil under ultrasonic exposure at afrequency of 28 kHz. Special attention is paid to the determination of cavitation zones and their visualizationusing heat maps. It is found that at low NaCl concentration (0.3 mol/L), the foil destruction rate is higher thanin distilled water. At higher concentrations of salt, cavitation takes place mainly in the upper part of the container.

关键词： Ultrasound NaCl solution foil test cavitation activity

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