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SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2463-2466页

作者： Fabian Zech Stefanie Weber Hanna Dietenberger Linyun Zhang Sabrina Noettger Meta Volcic Tim Bergner Clarissa Read konstantin M.J.Sparrer Thomas F.E.Barth Frank Kirchhoff Institute of Molecular Virology Ulm University Medical CenterUlmGermany Institute of Pathology Ulm UniversityUlmGermany Central Facility for Electron Microscopy Ulm UniversityUlmGermany

Dear Editor Effective vaccines and some antiviral agents against SARS-CoV-2,the causative agent of coronavirus disease 2019(COVID-19),have been ***,additional therapeutics are needed since emerging SARS-CoV-2 variants evade immunity induced by vaccination or previous infection and are resistant to therapeutic antibodies and fusion inhibitors.^(1)In addition,many patients experience prolonged post-acute sequelae of SARS-CoV-2.

关键词： ACE2 immunity acute

Development of an Autonomous Flight Control System for Small Size Unmanned Helicopter Based on Dynamical Model

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Journal of Shanghai Jiaotong university(Science) 2007年第6期12卷 744-752页

作者：王赓 Kondak konstantin Marek Musial 盛焕烨吕恬生 Hommel Günter Dept. of Computer Sci. & Eng. Shanghai Jiaotong Univ. Dept. of Computer Sci. & Electronics Technische Univ. Eng. Training Center Shanghai Jiaotong Univ.

It is devoted to the development of an autonomous flight control system for small size unmanned helicopter based on dynamical model. At first, the mathematical model of a small size helicopter is described. After that simple but effective MTCV control algorithm was proposed. The whole flight control algorithm is composed of two parts: orientation controller based on the model for rotation dynamics and a robust position controller for a double integrator. The MTCV block is also used to achieve translation velocity control. To demonstrate the performance of the presented algorithm, simulation results and results achieved in real flight experiments were presented.

关键词： unmanned helicopter dynamical model flight control unmanned aerial vehicle (UAV)

Comprehensive Automation of Microprocessor Protection Relay Terminals Operated on AC Railways

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Journal of Applied Mathematics and Physics 2022年第2期10卷 491-503页

作者： Vostrikov Maksim Viktorovich Daneev Aleksey Vasilyevich Menaker konstantin Vladimirovich Sizykh Viktor Nikolaevich Zabaikalsk Rail Transport Institute A Branch of Irkutsk State Transport University Chita Russia Irkutsk State Transport University Irkutsk Russia

The article discusses the possibility of a potential reduction in the number of operations of microprocessor relay protection of feeders of the contact network of AC railways TsZA-27.5-FKS (FTS) for unknown reasons. Real statistics on the number of microprocessor relay protection operations at the Buryatskaya traction substation are presented, simulation of the real train situation (in accordance with the regime maps of the throughput capacity of the sections of the Trans-Baikal railway) was carried out in the specialized software complex “KORTES”. Based on the results of the analysis of simulation modeling, the process of forming a unified template of settings using neural network technologies is considered, which characterizes only this specific regular train situation. To protect objects in the event of pre-emergency and emergency modes of operation of the traction power supply system, a variant of changing the standard operation algorithm of the TsZA-27.5-FKS (FTS) terminal by introducing additional blocks for calculating the predictive functions of current and voltage has been proposed.

关键词： Automated System Microprocessor Relay Protection Devices Feeder Traction Substation

Small Ubiquitin-Like Modifier Conjugating Enzyme with Active Site Mutation Acts as Dominant Negative Inhibitor of SUMO Conjugation in Arabidopsis

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Journal of Integrative Plant Biology 2013年第1期55卷 75-82页

作者： konstantin Tomanov Christian Hardtke Ruchika Budhiraja Rebecca Hermkes George Coupland Andreas Bachmair Department of Biochemistry and Cell Biology Max F. Perutz Laboratories Center for Molecular Biology University of Vienna Department of Plant Molecular Biology University of Lausanne Department of Plant Developmental Biology Max Planck Institute for Plant Breeding Research

Small ubiquitin-like modifier （SUMO） conjugation affects a broad range of processes in plants, including growth, flower initiation, pathogen defense, and responses to abiotic stress. Here, we investigate in vivo and in vitro a SUMO conjugating enzyme with a Cys to Ser change in the active site, and show that it has a dominant negative effect. In planta expression significantly perturbs normal development, leading to growth retardation, early flowering and gene expression changes. We suggest that the mutant protein can serve as a probe to investigate sumoylation, also in plants for which poor genetic infrastructure precludes analysis via loss-of-function mutants.

关键词： Agroinfection conjugating enzyme dominant-negative active site mutation small ubiquitin-like modifier conjugation small ubiquitin-like modifier.

Septic arthritis of the hand: From etiopathogenesis to surgical treatment

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World Journal of Orthopedics 2022年第11期13卷 993-1005页

作者： konstantin V Lipatov Arthur Asatryan George Melkonyan Aleksandr D Kazantcev Ekaterina I Solov’eva Irina V Gorbacheva Alexander S Vorotyntsev Andrey Y Emelyanov General Surgery Department Institute of Clinical Medicine named after N.V.SklifosovskySechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia General Surgery Department State Budgetary Institution“City Clinical Hospital named after S.S.Yudin of Moscow Healthcare Department”Moscow 115142Russia General Surgery Department The Hospital for War Veterans N3Moscow 129336Russia General Surgery Department I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia

BACKGROUND Septic arthritis of the hand,which is the second most common after damage of the knee joint,remains one of the leading causes of temporary *** inflammation can cause dysfunction of the joint,and in the most severe cases,the need for amputation of the finger may *** results of their treatment today,especially from a functional point of view,cannot be considered *** surgical treatment is extremely important in septic arthritis of the hand,as it helps to prevent cartilage destruction and the development of *** To explore the features of the course of septic arthritis of the hand as well as approaches to surgical treatment and its results,depending on the nature of the damage to the articular *** The results of the treatment of 170 patients with septic arthritis of the hand,which were treated in the period of 2020-2021,were *** of the interphalangeal and metacarpophalangeal joints(MCP)of fingers 1,2,and 3 was more often noted in 147(81.6%)*** most common cause of arthritis was a penetrating injury as a result of household trauma(101,59.4%),animal bite(30,17.6%),and clenched fist injury(15,8.8%).Septic arthritis with contiguous osteomyelitis was observed in 98(54.4%)*** treatment was completed with drainage and irrigation of the *** mobilization was used to restore *** patients with osteomyelitis,it was aimed at the formation of *** was not ***-term results of treatment were assessed in 142(83.5%)patients within 1 mo to 12 mo after discharge from the hospital[the median was 7 mo(IQR:4-9)].RESULTS The most commonly isolated organism was Staphylococcus aureus(35.3%).The median treatment delay in patients without osteomyelitis was 5 d(IQR:4-7);for septic arthritis with contiguous osteomyelitis,it was 14 d(IQR:5-21).Radiography for osteomyelitis within 2 wk was uninformative:41.2%of diagnoses.A single surgical treatment was

关键词： Septic arthritis Osteomyelitis Hand Surgical treatment Neoarthrosis

Plasma treatment for enhancement of the sorption capacity of carbon fabric

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Plasma Science and Technology 2021年第12期23卷 150-160页

作者： IIya ZADIRIEV Elena KRALKINA Vladimir SAMOILOV Victoria ELCHANINOVA Valentina GORINA Ilya IVANENKO konstantin VAVILIN Alexander NIKONOV Physical Electronics Department Faculty of PhysicsLomonosov Moscow State University119991 MoscowRussia Research Institute for Graphite-Based Structural Materials‘Nllgrafit’ 1524 MoscowRussia

In this work we carried out an experimental investigation into enhancement of the sorption capacity of carbon fabric using plasma treatment *** fabric is based on viscose fiber and is hydrophobic by *** of the fabric sorption capacity is required for its application in *** this purpose,two plasma treatment methods were considered,*** nonequilibrium radiofrequency(RF)discharge and a vacuum RF plasma source with an external magnetic *** treated by atmospheric discharge demonstrated aging effects during the first week after *** sorption capacity of samples treated by the RF plasma source was stable over the same period and reached values as high as *** of the beam created by the vacuum RF plasma source were analyzed and dependences of the fabric sorption capacity and specific surface area on plasma treatment time were *** found that sorption capacity reached its maximum value after 30 min of treatment and did not change significantly if processing was continued,while the specific surface area reached its maximum after 3 min of treatment and quickly decreased after *** was found that the micropore structure of the fabric remained almost the same during plasma *** volume of mesopores in a unit of the fabric mass(specific volume)doubled during the first 5 min of treatment and returned to initial values after 30 min of *** sorption capacity continued to increase even when the specific surface area decreased after reaching its peak *** indicates the important role of surface functional groups formed on carbon fibers during plasma *** is consistent with the results of x-ray photoelectron spectroscopy analysis showing changes in surface oxidation during plasma treatment.

关键词： carbon fabric sorption plasma treatment radiofrequency

Simulation-based mastery learning in gastrointestinal endoscopy training

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World Journal of Gastrointestinal Endoscopy 2022年第9期14卷 512-523页

作者： Hasan Maulahela Nagita Gianty Annisa Tiffany konstantin Ari Fahrial Syam Roy Soetikno Department of Internal Medicine Gastroenterology DivisionFaculty of Medicine University of Indonesia-Cipto Mangunkusumo General Central National HospitalJakarta 10430Indonesia Tiffany konstantin Faculty of MedicineUniversity of IndonesiaJakarta 10430Indonesia

Simulation-based mastery learning(SBML)is an emerging form of competencybased training that has been proposed as the next standard method for procedural task training,including that in gastr-ointestinal *** basic gastrointestinal endoscopy training relies on the number of procedures performed,and it has been criticized for its lack of objective standards that result in variable skills among trainees and its association with patient safety ***,incorporating simulators into a competency-based curriculum seems ideal for gastrointestinal endoscopy *** curriculum for SBML in gastrointestinal endoscopy is currently being developed and has promising potential to translate into the clinical *** the present apprenticeship model of“see one,do one,teach one,”SBML integrates a competency-based curriculum with specific learning objectives alongside simulation-based *** allows trainees to practice essential skills repeatedly,receive feedback from experts,and gradually develop their abilities to achieve ***,trainees and trainers need to understand the learning targets of the program so that trainees can focus their learning on the necessary skills and trainers can provide structured feedback based on the expected *** addition to learning targets,an assessment plan is essential to provide trainees with future directions for their improvement and ensure patient safety by issuing a passing ***,the SBML program should be planned and managed by a specific team and conducted within a developed and tested *** review discusses the current state of gastr-ointestinal endoscopy training and the role of SBML in that field.

关键词： Simulation training Education Endoscopy Mastery learning Competency-based education Curriculum

Altitude-dependent distribution of 137Cs in the environment:a case study of Aragats massif, Armenia

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Acta Geochimica 2020年第1期39卷 127-138页

作者： konstantin Pyuskyulyan Stephen P.LaMont Vovik Atoyan Olga Belyaeva Nona Movsisyan Armen Saghatelyan Armenian Nuclear Power Plant MetsamorArmenia Nuclear and Radiochemistry Los Alamos National LaboratoryLos AlamosUSA Radioecology Department Center for Ecological-Noosphere StudiesNAS RA.YerevanArmenia

This paper considers the distribution of technogenic 137Cs and naturally occurring radionuclides:238 U,232 Th and40 R concentrations in soils and 137Cs in atmospheric dry depositions by altitudinal belts of the Aragats mountain massif,Republic of *** soil samples were collected at altitudes from 1000 to 3200 *** the determination of geochemical variability,two soil sampling campaigns were *** dry depositions were sampled from five stations at1100-3200 m collected onto organic fiber filters between June and December 2016.137Cs activity was measured using a high-purity Germanium detector coupled to a multichannel analyzer(Canberra).Results indicated that specific activity of 137Cs in soils at 1000 m is495-528 Bq m^-2,andat3200 mis10,500-11,470 Bq m^-*** correlation observed for 137Cs versus naturally occurring radionuclides,which varies in distribution by *** activities of 137Cs in dry atmospheric depositions varies from 1.06 at 846 m to2.37 Bq m^-2 per quarter at 3200 m and increases as the altitude *** of 137Cs in soil and dry atmospheric deposition correlated significantly,and 137Cs activity in soils and atmospheric dry depositions decrease as the absolute altitude *** 50-year effective dose from exposure to 137Cs fallout varies with altitude from 0.007 to 1.42 m Sv.

关键词： 137Cs Distribution by altitude Naturally occurring radionuclides Topsoil Dry atmospheric depositions Gamma radiation Mountain regions

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土石坝竖向排水的渗流控制(英文)

岩土工程学报 2008年第11期30卷 1657-1660页

作者： Abdelkader Djehiche konstantin Kotchev L.G.C.U. Amar Telidji University Laghouat 03000 Laghouat Algeria Potyteehniea Sofia Bulgaria

水流通过坝体和坝基时存在压力和梯度,这在大坝工程设计中已视为重要因素。但是,在土石坝设计时往往会遇到抵御不利大坝安全因素的排水系统的选型和设计问题。目前,很多工程中虽存在一些效果不错的排水系统,但其缺乏渗流和浸润线位置的... 详细信息

水流通过坝体和坝基时存在压力和梯度,这在大坝工程设计中已视为重要因素。但是,在土石坝设计时往往会遇到抵御不利大坝安全因素的排水系统的选型和设计问题。目前,很多工程中虽存在一些效果不错的排水系统,但其缺乏渗流和浸润线位置的控制,可能会对工程安全产生威胁,或使渗流控制措施达不到经济有效的目的。为此,本文基于均质土坝实验研究取得的成果,研究出在竖向排水体中的渗流量的控制方法,采用这种方法可以对土石坝进行更好的管理。

关键词：渗流土石坝竖向排水排水体位置流量