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The trade-off between COVID-19 and mental diseases burden during a lockdown: Mathematical modeling of control measures

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Infectious Disease Modelling 2023年第2期8卷 403-414页

作者： Alexei Alexeevich Romanyukha konstantin alexandrovich novikov konstantin konstantinovich Avilov Timofey alexandrovich Nestik Tatiana Evgenevna Sannikova Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences Gubkina str.8Moscow119333Russia Institute of Psychology of the Russian Academy of Sciences Yaroslavskaya str.13Moscow129366Russia

Background:During the COVID-19 pandemic,many countries used lockdowns as a containment *** lockdowns successfully contributed to slowing down the contagion,the related mobility restrictions were reportedly associated with an increased risk of major depressive and anxiety *** aimed to quantify the trade-off between the quality-adjusted life years(QALY)gain due to lower COVID-19 incidence as a result of a lockdown and QALY loss due to lockdown-induced mental ***:We developed an agent-based model of COVID-19 epidemic and coupled mental disorder development in the population of a large *** used data sources on the places of living,studying and working,public health and census *** of mental disorders was based on diathesis-stress *** quantified mental and physical health burden in terms of QALY taking into account major depressive and anxiety disorder episodes,lethal and non-lethal cases of COVID-19,and ***:We evaluated the dynamics of new major depressive disorder(MDD)and anxiety disorder(AD)cases during the period between September 2020 and December 2021 in Moscow,*** found that lockdown imposition increases the daily chances of getting MDD or ADD by a vulnerable person by 16.79%(95%CI[12.36%,21.23%]).The QALY loss associated with COVID-19-induced and lockdown-induced mental disorders was estimated to be 18.93%(95%CI[16.94%,19.73%])of the total QALY loss caused by COVID-19,immunization,and all kinds of mental *** a synthetic“strong”lockdown,it had been shown that QALY loss is minimized when about 70%of the population are ***:The burden associated with mental disorders amounts to a considerable part of COVID-19-related *** findings demonstrate that cost-benefit analysis of mobility restriction should include a forecast of mental disorder development in the population.

关键词： COVID-19 Agent-based model Major depressive and anxiety disorders Quality adjusted life years(QALY) Lockdown strictness Optimal lockdown

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Exploring van der Waals materials with high anisotropy:geometrical and optical approaches

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Light(Science & Applications) 2024年第4期13卷 645-653页

作者： Aleksandr S.Slavich Georgy A.Ermolaev Mikhail K.Tatmyshevskiy Adilet N.Toksumakov Olga G.Matveeva Dmitriy V.Grudinin Kirill V.Voronin Arslan Mazitov konstantin V.Kravtsov Alexander V.Syuy Dmitry M.Tsymbarenko Mikhail S.Mironov Sergey M.novikov Ivan Kruglov Davit A.Ghazaryan Andrey A.Vyshnevyy Aleksey V.Arsenin Valentyn S.Volkov Kostya S.Novoselov Moscow Center for Advanced Studies Kulakova str.20Moscow 123592Russia. Emerging Technologies Research Center XPANCEOInternet CityEmmay TowerDubaiUnited Arab Emirates. Donostia International Physics Center(DIPC) Donostia/San-Sebastián 20018Spain. Institute of Materials Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland. Department of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia. Laboratory of Advanced Functional Materials Yerevan State UniversityYerevan 0025Armenia. National Graphene Institute(NGI) University of ManchesterManchester M139PLUK. Department of Materials Science and Engineering National University of SingaporeSingapore 03-09 EASingapore. Institute for Functional Intelligent Materials National University of Singapore117544 SingaporeSingapore

The emergence of van der Waals(vdW)materials resulted in the discovery of their high optical,mechanical,and electronic anisotropic properties,immediately enabling countless novel phenomena and *** success inspired an intensive search for the highest possible anisotropic properties among vdW ***,the identification of the most promising among the huge family of vdW materials is a challenging quest requiring innovative ***,we suggest an easy-to-use method for such a survey based on the crystallographic geometrical perspective of vdW materials followed by their optical *** our approach,we found As2S3 as a highly anisotropic vdW *** demonstrates high in-plane optical anisotropy that is~20%larger than for rutile and over two times as large as calcite,high refractive index,and transparency in the visible range,overcoming the century-long record set by *** these benefits,As2S3 opens a pathway towards nextgeneration nanophotonics as demonstrated by an ultrathin true zero-order quarter-wave plate that combines classical and the Fabry–Pérot optical phase ***,our approach provides an effective and easy-to-use method to find vdW materials with the utmost anisotropic properties.

关键词： anisotropy anisotropic high

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Using new physics and technology to advance electrostimulated rolling of metals and alloys

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广东有色金属学报 2005年第2期15卷 530-532页

作者： konstantin M. Kli mov Ivan I . novikov Baikov Institute of Metallurgy and Materials Science Russian Academy of Sciences Moscow119991 Russia

Electrostimulated deformation of metals and alloys, using groove or smooth rolling, requires that several important conditions are satisfied. (1) The deformation site must geometrically overlap with the flow of electric current passing through a strip between the rolls; (2) The density of direct or alternating electric current supplied to deformation site must be sufficiently high (of an order of 104-106А/cm^2); (3) An efficient heat removal from the deformation site must be achieved. In general, the temperature of a strip must be within the range of 100-300℃. (4) The electric resistance at the roll-strip interface must be minimized. Our recent studies also indicate that the electrostimulated rolling in the shortcut regime is a further condition for obtaining high quality rolling of metals. In this regime, the rolls are placed in physical contact even in the absence of a strip that ensures an uninterrupted passage of electric current between the rolls.

关键词：金属材料合金物理性能轧制工艺

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Sex differences in cardiovascular control by nitric oxide in normotensive and hypertensive rats

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Health 2010年第8期2卷 897-905页

作者： Oxana Semyachkina-Glushkovskaya Tatyana Anishchenko Sergey Kapralov Roman novikov konstantin Skvorcov Yana Kuznecova Antonina Kuznecova 不详

R Nitric oxide probably plays an important role in mechanisms determining sexual dimorphism in the development of cardiovascular diseases, including hypertension. Because stress together with gender are significant cardiovascular risk factors, we studied the role nitric oxide in car-diovascular regulation in male and female nor-motensive and hypertensive rats under normal and stress conditions. Experiments were per-formed in mongrel normotensive and hyperten-sive (two kidney, one clip) rats of both sexes, weighing 200-250g. The study of mean arterial pressure and heart rate was carried out: 1) under control condition;2) during nitric oxide blo- ckade by NG-nitro-L-arginine-methyl ester (L-NAME, 10 mg/kg, iv) 3) during 60 min immobilization stress and recovery;4) during 60 min immobi-lization stress + L-NAME and recovery. We found that the severity of hypertension in fe-males was lower than in males. We also ob-served that both normotensive and hyperten-sive females demonstrated more favorable pat-tern of cardiovascular responses to stress. At rest, nitric oxide blockade increased the mean arterial pressure and decreased the heart rate more effectively in female normotensive and hypertensive rats than in male groups. During stress, nitric oxide blockade modified the stress- induced cardiovascular responses more sig-nificantly in female normotensive and hyper-tensive rats compared with male groups. Our data show that both normotensive and hyper-tensive females demonstrated the more effec-tive nitric oxide control of cardiovascular activ-ity under normal and especially stress condi-tions than male groups. This male-female dif-ference may be important mechanism respon-sible for greater in females vs. males of cardio-vascular resistance to stress and development of hypertension.

关键词： Nitric Oxide Stress Cardiovascular Stress-Reactivity Sex-Differences

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