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The Glob.l Stratotype Section and Point （GSSP） for the b.se of the Holocene Series/Epoch （Quaternary System/Period） in the NGRIP ice core

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Episodes 2008年第2期31卷 264-267页

作者： Mike Walker Sigfus Johnsen Sune Olander Rasmussen Jorgen-Peder Steffensen Trevor Popp Philip Gib.ard Wim Hoek John Lowe John Andrews Svante b.orck Les Cwynar konrad Hughen Peter Kershaw b.rnd Kromer Thomas Litt David J. Lowe Takeshi Nakagawa Rewi Newnham Jakob.Schwander Department of Archaeology and Anthropology University of Wales Lampeter Wales SA48 7ED UK. Centre for Ice and Climatel The Niels b.hr Institute University of Copenhagen Juliane Maries Vej 30 DK2100 Copenhagen Denmark. Stab.e Isotope Lab.ratory Institute of Arctic and Alpine Research University of Colorado Boulder Co 80302 USA. Department of Geography University of Cambridge Downing Place Cambridge CB2 3EN UK. Department-of Physical Geography University of Utrecht Heidelberglaan 2 3508 TC Utrecht The Netherlands. Department of Geography Royal Holloway University of London Egham Surrey TW20 0EX UK. Institute for Arctic and Alpine Research University of Colorado Campus Box 450 Boulder Co 80309 USA. Geob.osphere Science Centre Quaternary Sciences Lund University S/51veg 12 SE-223 62 Lund Sweden. Department of b.ology University of New Brunswick Fredericton New Brunswick Canada E3B 6E1. Department of Marine Chemistry and Geochemistry Woods Hole Oceanographic Institution Woods Hole MA 02543 USA. School of Geography and Environmental Science Monash University Victoria 3800 Australia. Heidelb.rg Academy of Sciences University of Heidelberg 1NF 229 D-69120 Heidelberg Germany. Institute for Palaeontology University of Bonn Nussallee 8 D-53115 Bonn Germany. Department of Earth and Ocean Sciences University of Waikato Private Bag 3105 Hamilton New Zealand. Department of Geography University of Newcastle Newcastle-upon-Tyne NE 1 7RU UK. School of Geography University of Plymouth Drake Circus Plymouth PIA 8AA UK. Climate and Environmental Physics Physics Institute University of Bern Sidlerstrasse 5 CH-3012 Bern Switzerland.

The Greenland ice core from NorthGRIP （NGRIP） contains a proxy climate record across the Pleistocene-Holocene b.undary of unprecedented clarity and resolution. Analysis of an array of physical and chemical parameters within the ice enab.es the b.se of the Holocene, as reflected in the first signs of climatic warming at the end of the Younger Dryas/Greenland Stadial 1 cold phase, to b. located with a high degree of precision.

关键词：地球全新世第四纪地质时代周期

CXCR5^(+)PD-1^(++)CD4^(+)T cells colonize infant intestines early in life and promote b.cell maturation

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Cellular & Molecular Immunology 2023年第2期20卷 201-213页

作者： Ana Jordan-Paiz Glòria Martrus Fenja L.Steinert Max Kaufmann Adrian F.Sageb.el Renée R.C.E.Schreurs Anne Rechtien Martin E.b.umdick Johannes M.Jung Kimb.rly J.Möller Lucy Wegner Cordula Grüttner Laura Richert Roland Thünauer Jennifer Schroeder-Schwarz Johannes b.an Goudoever Teunis b.H.Geijtenb.ek Marcus Altfeld Steven T.Pals Daniel Perez Paul L.Klarenb.ek Christian Tomuschat Guido Sauter Ingo Königs Udo Schumacher Manuel A.Friese Nathaniel Melling konrad Reinshagen Madeleine J.b.nders Department of Virus Immunology Leibniz Institute of VirologyHamburg20251Germany University Medical Center Hamb.rg-Eppendorf Hamburg20246Germany Institute of Neuroimmunology and Multiple Sclerosis Center for Molecular Neurobiology HamburgUniversity Medical Center Hamburg-EppendorfHamburg20251Germany Department of General Visceral and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfHamburg20246Germany Department of Experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdam1105 AZThe Netherlands I.Department of Medicine University Medical Center Hamburg-EppendorfHamburg20246Germany Partner Site Hamb.rg-Lüb.ck-b.rstel-Riems German Center for Infection Research(DZIF)Hamburg20246Germany University of b.rdeaux Institut National de la Santéet de la Recherche MédicaleBordeaux Population Health Research Center UMR1219 and INRIA SISTM TeamBordeaux33000France Institute of Anatomy and Experimental Morphology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pathology Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Rheumatology and Clinical Immunology and Department of Experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1007 MBThe Netherlands Amsterdam Rheumatology&Immunology Center Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatric Surgery University Medical Center Hamburg-EppendorfHamburg20246Germany Institute of Pathology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pediatric Surgery Altona Children’s HospitalHamburg22763Germany III.Department of Medicine University M

Gastrointestinal infections are a major cause for serious clinical complications in *** induction of antib.dy responses b. b.cells is critical for protective immunity against infections and requires CXCR5+PD-1++CD4+T cells(TFH cells).We investigated the ontogeny of CXCR5+PD-1++CD4+T cells in human *** CXCR5+PD-1++CD4+T cells were ab.ent in fetal intestines,CXCR5+PD-1++CD4+T cells increased after b.rth and were ab.ndant in infant intestines,resulting in significant higher numb.rs compared to *** findings were supported b. scRNAseq analyses,showing increased frequencies of CD4+T cells with a TFH gene signature in infant intestines compared to ***-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+T cells with b.cells further demonstrated that infant intestinal TFH cells were ab.e to effectively promote class switching and antib.dy production b. b.*** together,we demonstrate that functional TFH cells are numerous in infant intestines,making them a promising target for oral pediatric vaccine strategies.

关键词： TFH cells b.cells Antib.dies Intestine Pediatrics

霍奇金亚型Richter's综合征：IGVH基因克隆重排及突变分析

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霍奇金亚型Richter's综合征：IGVH基因克隆重排及突变分析

Richter's综合征：IGVH基因克隆重排及突变分析

中华医学会病理学分会2007年学术年会暨第九届全国病理大会

作者：毛峥嵘 Andreas Rosenwald 章锁江周韧 Hans konrad Mueller-Hermelink 浙江大学病理学与法医学研究所病理学与病理生理学系 Pathology Institute Wuerzburg UniversityGermany97080

目的慢性 b.淋巴细胞性白血病(b.cell chronic lymphocytic leukemia,b.CLL)患者发展为高度恶性的大细胞淋巴瘤,称 Richter’s 综合征(Richter’s syndrome)。3-5％b.CLL 转化为弥漫性大 b.细胞淋巴瘤(Diffuse large b.cell lymphoma,DL...

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Richter's综合征：IGVH基因克隆重排及突变分析

中华医学会第11届全国内科学术会议

作者：毛峥嵘章锁江周韧 Andreas Rosenwald Hans konrad Mueller-Hermelink 浙江大学病理学与法医学研究所病理学与病理生理学系 Pathology Institute Wuerzburg University

目的慢性 b.淋巴细胞性白血病(b.cell chronic lymphocytic leukemia,b.CLL)患者发展为高度恶性的大细胞淋巴瘤,称 Richter’s 综合征(Richter’s syndrome)。3～5% b.CLL 转化为主要为弥漫性大 b.细胞淋巴瘤(Diffuse large b.cell lymphoma,DLb.L)又称经典型 Richter’s 综合征：0．5% b.CLL 转化为霍奇金淋巴瘤(Hodgkin lymphoma,HL)称 HL 亚型 Richter’s 综合征。Richter’s 综合征临床预后极差,

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全球PA66汽车安全气囊用纱的市场趋势

国际纺织导报 2004年第S1期32卷 26-26页

作者： b.konrad 秦礼敏高性能聚酰胺公司德国

随着汽车安全气囊采用工业用聚酰胺长丝,人们也越来越关注它在市场中的地位。2003年,产业用聚酰胺的市场需求量为94万t左右(表1)。它的增长率相当稳定,为每年1％-2％。安全气囊的潜力是最大的,年增长率为6％,排名在轮胎之前,轮胎的增长... 详细信息

随着汽车安全气囊采用工业用聚酰胺长丝,人们也越来越关注它在市场中的地位。2003年,产业用聚酰胺的市场需求量为94万t左右(表1)。它的增长率相当稳定,为每年1％-2％。安全气囊的潜力是最大的,年增长率为6％,排名在轮胎之前,轮胎的增长相当迟缓,年增长率仅为1％-2％。与此同时。

关键词：汽车安全气囊年增长率市场趋势市场需求量轮胎长丝聚酰胺工业用 PA66 消费量

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When Lotus Leaves Prevent Metal from Melting一b.omimetic Surfaces for High Temperature Applications

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Journal of b.onic Engineering 2019年第2期16卷 281-290页

作者： Wilfried konrad Jorg Adam Siegfried Konietzko Christoph Neinhuis Technical University of Dresden Institute of BotanyZellescher Weg 20bD-01062 Dresden Germany VDEh-b.trieb.forschungsinstitut Gmb. Sohnstrafie 6540237 DusseldorfGermany Leb.onze Alloys Germany-Hundt&Web.r Gmb.、b.rlenb.cher Strafie 1 57078 SiegenGermany CON-RE A Consulting&RealizationGrafschafter Strafie 1347199 DuisburgGermany

Functional properties of b.ological surfaces have gained increasing interest in the last two decades,especially with regard to wetting and ***,b.ological surfaces of arthropods(Collemb.la)and plants(sacred Lotus)served as models for the principle design of high temperature resistant surfaces used in b.ast furnaces to prevent tuyeres from *** are doub.e-walled,watercooled pipes supplying the b.ast furnace with hot air to keep the reduction and melting process *** failure is mainly caused b. melting of the wall after direct contact with liquid iron,resulting in the partial shut down of the b.ast furnace and huge energy *** a new approach to avoid tuyere failure we developed a new type of tuyere surface with(i)defined cone shaped indentations and(ii)a heat resistant zirconium/corundum coating with"ferrophob.c”properties *** forms with liquid iron of 1500°C a contact angle exceeding 130°.Theoretical considerations indicate that liquid iron infiltrates these indentations only partially if this contact angle and the aperture angle of the cone satisfy an inequality *** heat conductivity of the remaining gas trapped inside the cones is b. five orders of magnitude lower than in copper,the overall heat flow into the tuyere is sub.tantially reduced and the outer walls are much less prone to melting.

关键词： tuyere b.ast furnace b.omimetics liquid iron heat flow

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安全气囊在世界市场上的趋势

国际纺织导报 2004年第4期32卷 70-70页

作者： b.konrad 吴一知李毓陵高性能聚合材料公司（德国）不详

与汽车安全带一样,安全气囊也是一个被动式安全系统,并且对安全气囊的需求已急剧增加.近来,安全气囊正逐渐从被动保护型向积极式安全系统转变.而且,在生产销售中仍占有大量比例,可见其重要性.随之而来的问题是如何降低成本.

关键词：安全气囊织物市场价格生产成本消费者需求量产品质量

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牛磺酸对四氧嘧啶糖尿病家兔血糖、抗氧化的保护作用

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饲料博览 2009年第10期19卷 44-44页

作者： Katarzyna W konrad S Patryk G Marta D Jadwiga b

试验旨在研究探讨牛磺酸对家兔糖尿病的治疗作用。试验在家兔饮水中添加1%的牛磺酸,试验期为3周。以测定下列指标:(1)血清葡萄糖、尿素氮、肌酐酸和羟基自由基(HFR)水平;(2)氧化型谷胱甘肽;(3)尿中白蛋白浓度;(4)肝和肾中HFR水平、GSH/G... 详细信息

试验旨在研究探讨牛磺酸对家兔糖尿病的治疗作用。试验在家兔饮水中添加1%的牛磺酸,试验期为3周。以测定下列指标:(1)血清葡萄糖、尿素氮、肌酐酸和羟基自由基(HFR)水平;(2)氧化型谷胱甘肽;(3)尿中白蛋白浓度;(4)肝和肾中HFR水平、GSH/GSSG比率和过氧化氢酶活性、超氧化物岐化酶、谷胱甘肽代谢酶;(5)肾脏NADPH氧化酶活性;(6)肾脏和肝脏糖原异生比率。同时还测定肾脏的组织学结构。结果表明,糖尿病兔血清葡萄糖水平降低了30%,对肾脏糖原异生作用无显著影响。降低血清尿素氮和肌酐酸浓度,降低了诱发糖尿病兔的GSH/GSSG比率,阻止了羟基自由基在血清、肝脏和肾脏皮层的蓄积。试验结果显示,牛磺酸提高了γ-谷氨酰半胱氨酸合成酶、谷胱甘肽还原酶和过氧化氢酶的活性。而且,牛磺酸刺激了肾脏NADPH的正常活性,减弱了糖尿病兔蛋白尿和肾小球病的发生。由以上结果得出:(1)肾脏糖原异生比率的降低可能由于牛磺酸对低血糖的影响;(2)牛磺酸提高了过氧化氢酶和谷胱甘肽代谢酶的活性是由于牛磺酸具有增强抗氧化的功能;(3)牛磺酸的保护作用可能是源于肾脏NADPH氧化酶活性的减弱。因此,牛磺酸对糖尿病和糖尿病性肾病变具有良好的治疗效果。

关键词：牛磺酸糖尿病氧化应激肾病

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