检索结果-南通市图书馆

Icaritin Protects Cardiomyocytes from Oxidative Stress-induced Cell Injury Through Akt-Nrf2-HO-1 and Calcium Signaling Pathways

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Icaritin Protects Cardiomyocytes from Oxidative Stress-induc...

A new prognostic histopathologic classification of nasopharyngeal carcinoma

第十四届全国中药和天然药物学术研讨会

作者： Si Wan Lei Guozhen Cui Judy Yuet Wa Chan Sharon Chui Wah Luk Ken Kwok Keung Chan Ronald Adolphus Li Liang Wang Gail B.Mahady George Pak Heng Leung Simon Ming Yuen lee University of Macau The University of Hong kong University of Illinois at Chicago

＜正＞Icaritin,a prenylflavonoid isolated from Herbal Epimedii,is well known for its osteoplastic and anti-tumor ***,we aimed to investigate the protective effects of icaritin against oxidative stress-induced cell injury in H9c2 cardiomyocytes and human embryonic stem cells-derived cardiomyocytes（hESC-CMs）.We found that icaritin pretreatment significantly

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2016年第6期35卷 30-45页

作者： Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-lee Cheah Ming lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Department of Molecular Diagnostics Sun Yat-sen University Cancer Center Department of Pathology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Anatomical and Cellular Pathology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Department of Pathology Singapore General Hospital Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center Department of Pathology Sun Yat-sen University Cancer Center Division of Epidemiology Department of Health Research and PolicyStanford University School of Medicine Health Sciences Practice ExponentInc. Department of Otolaryngology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Clinical Oncology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Division of Radiation Oncology National Cancer CenterSingapore Department of Radiation Oncology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology The Affiliated Hospital of Bengbu Medical College Department of Pathology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology Guangxi Medical University Department of Pathology Hunan Provincial Cancer Hospital Department of Radiation Oncology Sun Yat-sen University Cancer Center Department of Pathology Fujian Provincial Cancer Hospital Department of Pathology The First Affiliated HospitalSun Yat-sen University Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Pathology The Third Affiliated HospitalSun Yat-sen University Department of Experiment Research Sun Yat-sen University Cancer Center Department of Medical Epidemiology and Biostatistics Karolinska Institutet Departments of Mi

Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic *** study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment ***:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from *** efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed *** used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis.

关键词： Nasopharyngeal carcinoma Pathologic classification Prognosis

DISSOCIATION OF THE ACUPUNCTURE EFFECT OF SOMATOSENSORY NEEDLING AND NEEDLING CREDIBILITY ON LOW BACK PAIN PATIENTS USING fMRI

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2014年第3期 221-221页

作者： Kyungmo Park Jeungchan lee Seulgi Eun Abdalla Zein E. Vitaly Napadow Department of Biomedical Engineering Kyung Hee University Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General Hospital

Background: Sham acupuncture as well as real acupuncture, a specific form of needling, is known to reduce low back pain(LBP), but the brain mechanism of placebo effect in sham acupuncture has not been clearly *** devised a novel form of sham acupuncture, so called phantom acupuncture which induces needling credibility without somatosensory *** we aimed to dissociate the brain correlates with somatosensory needling and needling credibility ***: Thirty LBP patients were randomized into the real(REAL, n=15) and phantom acupuncture(PHNT, n=15) *** threshold and LBP intensity(VAS) were measured before and after the fMRI *** the scanning, two steady state pain sessions were scanned before and after acupuncture stimulation(using low-back extension pain-model) and pain intensity(PAIN) induced by the pain model was *** acupuncture session, the REAL group got real acupuncture, while the PHNT group got only the visual stimulation(recorded needling manipulation video) to create needling *** response of heart rate(HR) and skin conductance(SC), and acupuncture sensation were ***: There was greater SC response, acupuncture sensation, signal increase in sensorimotor network(SMN), periaqueductal grey(PAG) and nucleus accumbense(NAC), and greater signal decrease in default mode network(DMN) in the REAL *** increase in vibration detection threshold and decrease in PAIN were *** HR decrease and signal increase in salience network(SLN), as well as the decrease in pressure pain threshold and unpleasantness of PAIN were observed both in the REAL and PHNT *** the PHNT group, decrease in VAS was *** correlation between the change in outcome measure and the change in resting state network connectivity was ***: Physical information processing and placebo/analgesic brain area were involved in somatosensory needling effect, while cognitive processing was rel

关键词： DISSOCIATION OF THE ACUPUNCTURE EFFECT OF SOMATOSENSORY NEEDLING AND NEEDLING CREDIBILITY ON LOW BACK PAIN PATIENTS USING fMRI

香港瘰螈eDNA引物和Taq Man探针的设计与确认

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

动物学杂志 2020年第5期55卷 624-636页

作者：杨泰昌李嘉华张颖刘彦芹袁智勇香港海洋公园环境实验室中国香港香港浸会大学生物系中国香港西南林业大学生物多样性保护学院昆明650224

环境DNA(e DNA)技术是近年来新兴的一种野外水生生物调查方法。本研究旨在设计一组香港瘰螈(Paramesotriton hongkongensis)特异的引物和TaqMan探针并确立此eDNA方法在水样中的实用性,以期进一步调查其野外种群分布。测定11种瘰螈物种... 详细信息

环境DNA(e DNA)技术是近年来新兴的一种野外水生生物调查方法。本研究旨在设计一组香港瘰螈(Paramesotriton hongkongensis)特异的引物和TaqMan探针并确立此eDNA方法在水样中的实用性,以期进一步调查其野外种群分布。测定11种瘰螈物种的线粒体细胞色素b(Cyt b)基因序列,然后使用Primer Express 3.0软件设计引物和TaqMan探针。通过比对NCBI基因库及进行退火温度梯度测试,验证引物和TaqMan探针的特异性。通过测试不同浓度的引物和TaqMan探针,优化q PCR扩增效率。然后检测养殖不同数量香港瘰螈的水缸水体中eDNA,以评估已建立的q PCR方法灵敏度。同时,测定香港瘰螈e DNA降解速度,以估计其在水中的持续时间。实验结果显示,本研究所设计的引物和探针只对香港瘰螈呈阳性扩增,而对同属的其他10个物种均呈阴性。优化的q PCR效率为93.9%、最低检测浓度为10DNA拷贝数。已建立的qPCR方法能灵敏地检测出在养殖1只香港瘰螈24h实验水缸水体的DNA拷贝数为(13.56±3.35)/ml水样。另外,降解实验发现,采用0.45μm孔径滤膜已有效检测香港瘰螈e DNA并能监测15 d。本研究成功设计并建立了一种能在水环境中检测香港瘰螈是否存在的e DNA技术,以期应用于野外考察。

关键词：香港瘰螈环境DNA 线粒体细胞色素b基因 TaqMan qPCR

Uptake of prostate cancer screening and associated factors among Chinese men aged 50 or more: a population-based survey

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2014年第1期11卷 56-63页

作者： Winnie K.W.So Kai Chow Choi Winnie P.Y.Tang Paul C.W.lee Ann T.Y.Shiu Simone S.M.Ho Helen Y.L.Chan Wendy W.T.Lam William B.Goggins Carmen W.H.Chan The Nethersole School of Nursing The Chinese University of Hong Kong Department of Community Medicine The University of Hong Kong The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong

Objective: To investigate the uptake rate of prostate specific antigen(PSA) testing among Hong kong Chinese males aged 50 or above, and identify factors associated with the likelihood of undergoing a PSA ***: A population-based telephone survey was conducted in Hong kong in 2007. The survey covered demographic information, perceived health status, use of complementary therapy, cancer screening behavior, perceived susceptibility to cancer and family history of cancer. Descriptive statistics, percentages and logistic regression analysis were used for data ***: A total of 1,002 men aged 50 or above took part in the study(response rate =67%), and the uptake rate of PSA testing was found to be 10%. Employment status, use of complementary therapy, perceiving regular visits to a doctor as good for health and the recommendations of health professionals were significant factors associated with PSA ***: The uptake rate of PSA testing in the study population was very low. Among all the factors identified, recommendations from health professionals had the strongest association with the uptake of PSA testing, and they should therefore take an active role in educating this population about cancer prevention and detection.

关键词： Prostatic neoplasms early detection of cancer prostate-specific antigen (PSA) population-based survey

在线全文

学校读者我要写书评

暂无评论

中国香港及新加坡推行教育改革的经验与挑战

中国公共政策评论 2013年第1期7卷 166-186页

作者：李晓康哥比纳丹香港中文大学历史系

踏入21世纪,教育改革是中国香港和新加坡的公共政策范畴中相当重要的一环,备受社会大众和不同持份者的关注。通过对两地教育改革发展过程进行的深入分析,不难发现中国香港和新加坡的政府仍然扮演举足轻重的角色,主导当地教育系统的发展... 详细信息

踏入21世纪,教育改革是中国香港和新加坡的公共政策范畴中相当重要的一环,备受社会大众和不同持份者的关注。通过对两地教育改革发展过程进行的深入分析,不难发现中国香港和新加坡的政府仍然扮演举足轻重的角色,主导当地教育系统的发展和变革,藉以配合人力资源和经济发展的需要,并应付全球化所带来的变化和挑战。可是,并非所有教育改革措施都必然会被社会大众所接受,改革推行成功与否,实与教育工作者和其他持份者(stakeholders)对改革措施所抱持的态度有密切关系。本文以中国香港和新加坡的案例说明,推行教育改革的效能在相当程度上受制于政府的能力,亦是建基于社会大众是否信任和支持政府施政的。

关键词：教育改革公共政策新自由主义新公共管理

在线全文

学校读者我要写书评

暂无评论

观察BHH9促进骨折愈合的机制

观察BHH9促进骨折愈合的机制

In-Home Drug Storage by Older Adults

世界针灸学会联合会成立20周年暨世界针灸学术大会

作者： Jeong-Eun Huh Ha-Ru Yanga Yong-Hyeon Baek Do-Young Choi Dong-Suk Park Jae-Dong lee Oriental Medicine Research Center for Bone & Joint Disease Korea Department of Acupuncture & Moxibustion College of Oriental MedicineKyung Hee UniversityKorea

＜正＞目的:骨髓基质干细胞（MSC）对于成骨具有重要作用。骨髓基质干细胞要分化为成骨细胞依赖于分子调控。BHH 9是天然药物黄芪、肉桂、葛根的提取物。该研究的目的是观察 BHH 9促进骨折愈合的机制。方法:2月龄雄性 Sprague-Dawly 大...

＜正＞目的:骨髓基质干细胞（MSC）对于成骨具有重要作用。骨髓基质干细胞要分化为成骨细胞依赖于分子调控。BHH 9是天然药物黄芪、肉桂、葛根的提取物。该研究的目的是观察 BHH 9促进骨折愈合的机制。方法:2月龄雄性 Sprague-Dawly 大鼠单侧股骨骨折造模,在骨折愈合期21天,每日口服 BHH 9（200 毫克/公斤）。对照组,予生理盐水。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Geriatric Medicine 2020年第3期2卷 22-31页

作者： Lori Suet Hang Lo Linda Yin King lee Irene Yuen Fung Wong Yuen Yan Lai Hoi Tong Au Tsz Ying Wong Chui Ping Chueng Wai Lam Shek Choi Yi Wong Hoi Lam Chan Hon Sze Cheuk Nga Hing Mark Shu Ching Wong Wing Yan Cheung The Open University of Hong kong Hong KongChina

Globally,in-home drug-storage compliance is often unsatisfactory,especially among older adults,and can lead to negative health *** study used a cross-sectional and descriptive design to examine inhome drug-storage compliance among older *** sampling was used to recruit 117 older adults in Hong *** in-home drugstorage checklist was used to assess the in-home drug-storage environments(light,temperature,and humidity)and drug-storage methods(drug safety,packaging,information,and expiration)of each older *** findings showed that Hong kong older adults’overall compliance rate in drug storage was 87.25%,and their compliance rate for drug-storage methods(84.59%)was lower than that for drug-storage environments(97.02%).Older adults who were of advanced age,who were less educated or who lived alone demonstrated lower in-home drug-storage *** indicates the need to revise existing health-education strategies to encourage in-home drug-storage *** professionals should assess older adults’drug-storage compliance to identify less compliant subgroups and deliver specific drug-storage support as *** members should also be involved in this process.

关键词： Drug storage Compliance Older adults Home

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于仪器钻进系统的风化花岗岩地层界面识别

北京科技大学学报 2007年第7期29卷 665-669页

作者：谭卓英蔡美峰岳中琦谭国焕李焯芬北京科技大学金属矿山高效开采与安全教育部重点实验室北京100083 香港大学土木工程系

针对香港风化花岗岩场址勘探,在液压旋转钻机上安装钻孔过程监测系统(drilling process monitoring,DPM),对有效轴压力、钻具转速、冲洗压力、钻头位移及穿孔速率进行了实时监测.采用变斜率作为显著性指数,对地层中的主、次界面进行了识... 详细信息

针对香港风化花岗岩场址勘探,在液压旋转钻机上安装钻孔过程监测系统(drilling process monitoring,DPM),对有效轴压力、钻具转速、冲洗压力、钻头位移及穿孔速率进行了实时监测.采用变斜率作为显著性指数,对地层中的主、次界面进行了识别.t检验表明,DPM系统对岩土界面识别的置信度为99%.此外,对穿孔参数在界面处的变化分析表明,这些参数随孔深的变化曲线在界面处存在不同涨落,轴压力和穿孔速率对界面上岩石强度变化的响应度为81.82%.

关键词：仪器钻进系统穿孔参数风化花岗岩界面识别