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Probiotics' Preventive Effect on Pediatric Food Allergy: A Meta-analysis of Randomized Controlled Trials

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Chinese Medical Sciences Journal 2014年第3期29卷 144-147页

作者： Xiang-yi kong yi yang jian guan Ren-zhi wang Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To investigate the preventive effect of probiotics on pediatric food allergy. Methods From MEDLINE bibliographical database, we searched and reviewed all randomized controlled trials on the preventive effects of probiotics on pediatric food allergies up to September 2013 and excluded the studies that do not meet inclusion criteria and extracted the data. Meta-analysis for the results of homogenous studies was performed using RevMan 5.0 and the co-effect was pooled by using fixed-effects model of relative risk(RR) ratios. Results Ten trials published between 2007 and 2012 including 2701 cases were included. Meta-analysis based on included data showed that the preventive effect of prenatal and postnatal probiotic supplementation on food allergies was not significant with the RR=0.88(95% CI: 0.76-1.03). Conclusion Present evidences cannot show in unequivocal terms that prenatal and postnatal probiotic supplementation will prevent food allergic diseases.

关键词： probiotics food allergy preventive effect meta-analysis

In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy

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Chinese Journal of Integrative Medicine 2020年第9期26卷 663-669页

作者： WEI Tian-zi wang Hao WU Xue-qing LU yi guan Sheng-hui DONG Feng-quan DONG Chen-le ZHU Gu-li BAO Yu-zhou ZHANG jian wang guan-yu LI Hai-ying Department of Biology Southern University of Science and TechnologyShenzhen(518055)GuangdongChina School of Medicine Southern University of Science and TechnologyShenzhen(518055)GuangdongChina School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SARChina Department of Obstetrics and Gynecology Shenzhen University General HospitalShenzhen(518055)GuangdongChina Clinical Medical Academy Shenzhen UniversityShenzhen(518055)GuangdongChina Department of Cardiology Shenzhen University General HospitalShenzhen(518055)GuangdongChina Department of Obstetrics and Gynecology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou(325000)ZhejiangChina guangdong Provincial Key Laboratory of Computational Science and Material Design Shenzhen(518055)GuangdongChina guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research Shenzhen(518055)GuangdongChina

Objective:To select potential molecules that can target viral spike proteins,which may potentially interrupt the interaction between the human angiotension-converting enzyme 2(ACE2)receptor and viral spike protein by virtual ***:The three-dimensional(3D)-coordinate file of the receptor-binding domain(RBD)-ACE2 complex for searching a suitable docking pocket was firstly downloaded and ***,approximately 15,000 molecular candidates were prepared,including US Food and Drug Administration(FDA)-approved drngs from DrugBank and natural compounds from Traditional Chinese Medicine Systems Pharmacology(TCMSP),for the docking ***,virtual screening was performed and the binding energy in Autodock Vina was ***,the top 20 molecules with high binding energy and their Chinese medicine(CM)herb sources were listed in this ***:It was found that digitoxin,a cardiac glycoside in DrugBank and bisindigotin in TCMSP had the highest docking ***,two of the CM herbs containing the natural compounds that had relatively high binding scores,Forsyfh/ae frucft/s and/saf/d/s racWx,are components of Lianhua Qingwen(莲花清痕),a CM formula reportedly exerting activity against severe acute respiratory syndrome(SARS)-***,raltegravir,an HIV integrase inhibitor,was found to have a relatively high binding ***:A class of compounds,which are from FDA-approved drugs and CM natural compounds,that had high binding energy with RBD of the viral spike *** work provides potential candidates for other researchers to identify inhibitors to prevent SARS-CoV-2 infection,and highlights the importance of CM and integrative application of CM and Western medicine on treating COVID-19.

关键词： COVID-19 SARS-CoV-2 drug repurposing virtual screening Chinese medicine

Waveguide distribution system of the HEPS linac

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Radiation Detection Technology and Methods 2023年第4期7卷 502-513页

作者： Xiang He Jing-Ru Zhang Hua Shi Ou-Zheng Xiao Jing-Dong liu Nan Gan Hao Zeng Xiao-Ping Li guan Shu Feng-Li Zhao Sheng-Chang wang Xin-Peng Ma Cai Meng Da-Yong He Fei Li Dong Dong Zu-Sheng Zhou Jing-yi Li jian-Li wang Bing-Lin Deng Pi-Long Tian Xu-jian wang Hong Song Qi yang Xiang-Cheng kong National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230029China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Zhang jiang Laboratory Shanghai200120China

Purpose The High-Energy Photon Source(HEPS)is a 6 GeV storage ring-based light source under construction in Beijing,*** accelerator consists of a 6 GeV storage ring,a full-energy booster,an S-band normal-conducting 500 MeV linac,and three transport *** the beginning of HEPS,a stable linac is quite important,which needs a qualified waveguide distribution system to transmit microwave power from klystrons to accelerating *** Installation and high-power conditioning of the HEPS linac were performed from February to September *** assembly and conditioning of the waveguide distribution system were completed in April and July,*** design of the waveguide distribution system began in 2018 and was finalized at the end of 2020 after multiple *** Owing to careful design,fabrication,and assembly preparation,the assembly and conditioning of the system proceeded smoothly and considerable time was *** The entire process from the design to the ultimate realization of the system is introduced in detail in this *** measurement results were obtained for some waveguide components.

关键词： HEPS linac Waveguide distribution system System design Assembly and commissioning High-power conditioning

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左侧额骨罕见海绵状血管瘤1例报告

基础医学与临床 2014年第8期34卷 1091-1093页

作者：孔祥溢刘阳关健杨义王任直中国医学科学院北京协和医学院北京协和医院神经外科北京100730

原发性骨内海绵状血管瘤十分罕见,发生在颅骨者更少。本病兼有良、恶性肿瘤特点,及时的诊断及科学的治疗对预后至关重要。本文报道1例该病患者,并给予手术处理,以期为神经外科医师提供借鉴。

关键词：海绵状血管瘤额骨病例报告

Infection,pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile,adult and aged Syrian hamsters

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Cellular & Molecular Immunology 2022年第12期19卷 1392-1399页

作者： Lunzhi Yuan Huachen Zhu Peiwen Chen Ming Zhou jian Ma Xuan liu Kun Wu Rirong Chen Qiwei liu Huan Yu Lifeng Li Jia wang Yali Zhang Shengxiang Ge Quan Yuan Qiyi Tang Tong Cheng yi guan Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiamenFujianChina State Key Laboratory of Emerging Infectious Diseases School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina guangdong-Hong kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases Joint Institute of Virology(STU/HKU)Shantou UniversityShantouGuangdongChina EKIH Pathogen Research Institute Futian DistrictShenzhenGuangdongChina Department of Microbiology Howard University College of MedicineWashingtonDCUSA

The new predominant circulating SARS-CoV-2 variant,Omicron,can robustly escape current vaccines and neutralizing *** Omicron has been reported to have milder replication and disease manifestations than some earlier variants,its pathogenicity in different age groups has not been well ***,we report that the SARS-CoV-2 Omicron BA.1 sublineage causes elevated infection and lung pathogenesis in juvenile and aged hamsters,with more body weight loss,respiratory tract viral burden,and lung injury in these hamsters than in adult *** hamsters show a reduced interferon response against Omicron BA.1 infection,whereas aged hamsters show excessive proinflammatory cytokine expression,delayed viral clearance,and aggravated lung *** inhaled IFN-α2b treatment suppresses Omicron BA.1 infection and lung pathogenesis in juvenile and adult ***,the data suggest that the diverse patterns of the innate immune response affect the disease outcomes of Omicron BA.1 infection in different age groups.

关键词： SARS-CoV-2 Omicron Lung pathology Innate immune response Interferon treatment

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei liu yi-Peng Jing Gang wang Hao-Tong Zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-ying Huo Lei Jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin Xiao kong Xu kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li guang-Wei Li Hai-Ning Li jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao liu Gen-Rong liu guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-yin Shen Huo-Ming Shi Jing Song yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang jian wang Jia-Ning wang jian-Ling wang jian-Ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua yang Hai-Feng yang Hui-Qin yang Ming yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu Yue Huang guang-Cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei Jia Fang-Jun Lu Xiang Ma Lian Tao Wei Zhang Li Chen Li-Ming Song Ti-Pei Li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du Min-Xue Fu guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua jiang Wei-Chun jiang Jing Jin Yong-Jie Jin Ling-Da kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li Wei Li Xian Li Xiao-Bo Li Xu-Fang Li yang-Guo Li Zheng-Wei Li Xiao-Hua Liang Jing-Yuan Liao Bai-Sheng liu Guo-Qing liu Hong-Wei liu Xiao-Jing liu yi-Nong liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng yi Nang jian-yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-ying Song Liang Sun ying Tan You-Li Tuo Chen wang Guo-Feng wang Juan wang Ling-Jun wang Weng-Shuai wang Yu-Sa wang Xiang-yang Wen Bai-yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-Lin Xiong He Xu Jia-Wei yang Sheng yang Yan-Ji yang yi-Jung yang Qi-Bin yi Qian-Qing yin Yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-Zhao Zhang yi Zhang yi-Fei Zhang Yong-Jie Zhang Yuan-Hang Zhang Yue Zhang Zhao Zhang Zhi Zhang Zi-Liang Zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-guang Zheng Deng-Ke Zhou jian-Feng Zhou Yu-Xuan Zhu Ren-Lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

氧化应激在急性脑缺血病程中的分子生物学作用

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中国医学科学院学报 2016年第2期38卷 222-227页

作者：孔祥溢关健王任直中国医学科学院北京协和医学院北京协和医院神经外科北京100730

急性脑缺血的发生过程非常复杂,涉及到包括自由基过剩在内的多种病理机制。细胞内自由基产生和清除的失衡被称为氧化应激。急性脑缺血发生后,活性氧自由基通过与多种生物分子的相互作用,不可逆转地改变或毁损细胞脂质、蛋白质及核酸的功... 详细信息

急性脑缺血的发生过程非常复杂,涉及到包括自由基过剩在内的多种病理机制。细胞内自由基产生和清除的失衡被称为氧化应激。急性脑缺血发生后,活性氧自由基通过与多种生物分子的相互作用,不可逆转地改变或毁损细胞脂质、蛋白质及核酸的功能,启动异常细胞信号转导通路。氧化应激的详细分子生物学特性及如何针对氧化应激进行急性脑缺血的神经保护仍需进一步探究。

关键词：急性脑缺血氧化应激自由基脑卒中

Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1369-1376页

作者： Lunzhi Yuan Huachen Zhu Ming Zhou jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che liu Huan Yu Yali Zhang Jia wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan yixin Chen Qiyi Tang Honglin Chen Tong Cheng yi guan Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiamenP.R.China State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongP.R.China Joint Institute of Virology(Shantou University and The University of Hong kong) Guangdong-Hongkong Joint Laboratory of Emerging Infectious DiseasesShantou UniversityShantouP.R.China Department of Microbiology Howard University College of MedicineWashingtonDCUSA Research Unit of Frontier Technology of Structural Vaccinology Chinese Academy of Medical SciencesXiamenFujianChina

Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung *** experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with ***,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and *** contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung *** obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender.

关键词： pathogenesis lung infection