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银杏叶提取物调控PI3k/AkT信号通路对人脑血管外膜成纤维细胞增殖和凋亡的影响

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中国临床药理学杂志 2024年第11期40卷 1556-1559页

作者：毕晓晨孔晓彬赵娜顾晶晶浙江中医药大学基础医学院实验教学中心浙江杭州310000 浙江中医药大学基础医学院病理与病理生理教研室浙江杭州310000

目的研究银杏叶提取物(GBE)调控磷脂酰肌醇3-激酶(PI3k)/蛋白激酶B(AkT)信号通路对人脑血管外膜成纤维细胞(HBVAFs)增殖和凋亡的影响。方法将HBVAFs分为空白组(正常培养,未做处理)和低、中、高剂量实验组(25、50和100 mg·L^(-1)的GBE处... 详细信息

目的研究银杏叶提取物(GBE)调控磷脂酰肌醇3-激酶(PI3k)/蛋白激酶B(AkT)信号通路对人脑血管外膜成纤维细胞(HBVAFs)增殖和凋亡的影响。方法将HBVAFs分为空白组(正常培养,未做处理)和低、中、高剂量实验组(25、50和100 mg·L^(-1)的GBE处理24 h)及联合组(100 mg·L^(-1)GBE和2 nmol·L^(-1)胰岛素样生长因子-1处理24 h)。用噻唑蓝法检测细胞的增殖情况,用流式细胞仪检测细胞的凋亡情况,用蛋白质印迹法检测细胞磷酸化PI3k(p-PI3k)、PI3k、磷酸化AkT(p-AkT)及AkT蛋白的表达水平。结果低、中、高剂量实验组和联合组、空白组的细胞存活率分别为(66.78±8.21)%、(53.51±7.40)%、(42.33±6.01)%、(75.69±5.87)%和(96.77±12.80)%,细胞凋亡率分别为(24.83±2.47)%、(30.07±3.06)%、(37.02±4.66)%、(16.71±2.11)%和(8.99±0.19)%,p-PI3k/PI3k比值分别为0.75±0.07、0.62±0.06、0.43±0.04、0.72±0.05和0.90±0.09,p-AkT/AkT比值分别为0.70±0.07、0.60±0.06、0.38±0.03、0.69±0.06和0.90±0.09。低、中、高剂量实验组的上述指标与空白组比较,联合组的上述指标与高剂量实验组比较,在统计学上差异均有统计学意义(均Pk/AkT信号通路相关。

关键词：银杏叶提取物磷酸肌醇3激酶/蛋白激酶B信号通路人脑血管外膜成纤维细胞增殖凋亡

Evidence for particle acceleration approaching PeV energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAASO Collaboration Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi W.Bian A.V.Bukevich q.Cao W.Y.Cao Zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen q.H.Chen S.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.Y.Cui S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.q.Dong k.k.Duan J.H.Fan Y.Z.Fan J.Fang J.H.Fang k.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao C.D.Gao q.Gao W.Gao W.k.Gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong q.B.Gou M.H.Gu F.L.Guo X.L.Guo Y.q.Guo Y.Y.Guo Y.A.Han M.Hasan H.H.He H.N.He J.Y.He Y.He Y.k.Hor B.W.Hou C.Hou X.Hou H.B.Hu q.Hu S.C.Hu D.H.Huang T.q.Huang W.J.Huang X.T.Huang X.Y.Huang Y.Huang X.L.Ji H.Y.Jia k.Jia k.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.kang I.karpikov D.kuleshov k.kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li Jian Li Jie Li k.Li S.D.Li W.L.Li W.L.Li X.R.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu J.Liu J.L.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu q.Luo Y.Luo H.k.Lv B.q.Ma L.L.Ma X.H.Ma J.R.Mao Z.Min W.Mitthumsiri H.J.Mu Y.C.Nan A.Neronov L.J.Ou P.Pattarakijwanich Z.Y.Pei J.C.qi M.Y.qi B.q.qiao J.J.qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun q.N.Sun X.N.Sun Z.B.Sun J.Takata P.H.T.Tam q.W.Tang R.Tang Z.B.Tang W.W.Tian C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang J.C.Wang kai Wang kai Wang L.P.Wang L.Y.Wang P.H.Wang R.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu q.W.Wu S.Wu X.F.Wu Y.S.Wu S.q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.Yan J.Z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.J.Yang R.Z.Yang W.X.Yang Y.H.Yao Z.G.Yao L.q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang H.Zhang 不详 key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy of Sciences Moscow 117312Russia Hebei Normal University Shijiazhuang 050024China University of Science and Technology of China Hefei 230026China State key Laboratory of Particle Detection and Electronics China key Laboratory of Dark Matter and Space Astronomy&key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Yunnan UniversityKunming 650091China key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(SNR)W51C and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51C for CRs remains *** on observations conducted with the Large High Altitude Air Shower Observatory(LHAASO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** LHAASO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs.

关键词： UHE c-ray Cosmic rays SNR W51C Star clusters

High-performance carbon fiber/gold/copper composite wires for lightweight electrical cables

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Journal of Materials Science & Technology 2020年第7期42卷 46-53页

作者： Thang q.Tran Jeremy kong Yoong Lee Amutha Chinnappan Nguyen Huu Loc Long T.Tran Dongxiao Ji W.A.D.M.Jayathilaka Vishnu Vijay kumar Seeram Ramakrishna Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1EA-07-05Singapore 117575Singapore Faculty of Mechanical Engineering Ho Chi Minh City University of TechnologyVNUHCM268 Ly Thuong KietDistrict 10Ho Chi Minh City 740400Viet Nam

In this study,we synthesized high-performance Carbon Fiber/Gold/Copper(CF/Au/Cu)composite wires by using a 2-step deposition method via sputtering and *** Au was sputtered on PANbased CFs as a pre-treatment,the wettability and surface reactivity of the CFs were improved,resulting in a homogeneous deposition of Cu on their *** different Cu electrodeposition time,the resulting CF/Au/Cu composite wires could possess a high strength of up to 3.27 GPa(~10 times stronger than copper wires)while their electrical conductivity could be as high as 4.4×10^5 S/cm(~75%of that for copper).More importantly,since the composite wires were lightweight(up to 70%lower than Cu mass density),they are a promising candidate to substitute conventional heavy metal wires in the future electrical applications.

关键词： Carbon fiber Copper composite wires Strength Electrical properties

Adaptive TqWT filter based feature extraction method and its application to detection of repetitive transients

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Science China(Technological Sciences) 2018年第10期61卷 1556-1574页

作者： kong Yun WANG TianYang CHU FuLei Department of Mechanical Engineering Tsinghua University

The local defect in rotating machine always gives rise to repetitive transients in the collected vibration signal. However, the transient signature is prone to be contaminated by strong background noises, thus it is a challenging task to detect the weak transients for machine fault diagnosis. In this paper, a novel adaptive tunable q-factor wavelet transform(TqWT) filter based feature extraction method is proposed to detect repetitive transients. The emerging TqWT possesses distinct advantages over the classical constant-q wavelet transforms, whose q-factor can be tuned to match the oscillatory behavior of different signals, but the parameter selection for TqWT heavily relies on prior knowledge. Within our adaptive TqWT filter algorithm, the automatic optimization techniques for three TqWT parameters are implemented to achieve an optimal TqWT basis that matches the transient components. Specifically, the decomposition level is selected according to a center frequency ratio based stopping criterion, and the q-factor and redundancy are optimized based on the minimum energy-weighted normalized wavelet ***, the adaptive TqWT decomposition can be achieved in a sparse way and result in subband signals at various wavelet ***, the optimum subband signal which carries transient feature information, is identified using a normalized energy to bandwidth ratio index. Finally, the single branch reconstruction signal from the optimum subband is obtained with transient signatures via inverse TqWT, and the frequency of repetitive transients is detected using Hilbert envelope demodulation. It has been verified via numerical simulation that the proposed adaptive TqWT filter based feature extraction method can adaptively select TqWT parameters and the optimum subband for repetitive transient detection without prior knowledge. The proposed method is also applied to faulty bearing vibration signals and its effectiveness is validated.

关键词： tunable q-factor wavelet transform parameter selection energy-weighted normalized wavelet entropy energy to bandwidth ratio transient detection fault diagnosis

Multi-agent Simulation for Strategic Bidding in Electricity Markets Using Reinforcement Learning

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 1051-1065页

作者： Jidong Wang Jiahui Wu Xiangyu kong key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China

In this paper,a theoretical framework of Multiagent Simulation(MAS)is proposed for strategic bidding in electricity markets using reinforcement learning,which consists of two parts:one is a MAS system used to simulate the competitive bidding of the actual electricity market;the other is an adaptive learning strategy bidding system used to provide agents with more intelligent bidding *** ExperienceWeighted Attraction(EWA)reinforcement learning algorithm(RLA)is applied to the MAS model and a new MAS method is presented for strategic bidding in electricity markets using a new Improved EWA(IEWA).From both qualitative and quantitative perspectives,it is compared with three other MAS methods using the Roth-Erev(RE),q-learning and *** results show that the performance of the MAS method using IEWA is proved to be better than the *** four MAS models using four RLAs are built for strategic bidding in electricity *** running the four MAS models,the rationality and correctness of the four MAS methods are verified for strategic bidding in electricity markets using reinforcement learning.

关键词： Electricity market multi-agent simulation reinforcement learning strategic bidding

Effect　of　Ballistic-Type　Hot　Atom　Adsorption　Mechanism　on　the　Phase　Diagram　of　Monomer　Dimer　CO-O2　Surface　Catalytic　Reaction：　A　Monte　Carlo　Simulation

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Chinese Physics Letters 2004年第6期21卷 1171-1174页

作者： M.khalid k.M.khan A.U.qaisrani q.N.Malik DepartmentofPhysics GomalUniversityDeraIsmailKhanPakistan NuclearPhysicsDivision PakistanInstituteofNuclearScienceandTechnology(PINSTECH)P.O.NiloreIslamabadPakistan

We investigate the effect of the ballistic mechanism on the phase diagram using a square surface. While using this mechanism whenever an O2 molecule hits a randomly vacant selected site, the molecule breaks up into atomic form and then executes a ballistic flight. The paths of the two oxygen atoms are taken exactly to be opposite to each other, i. e. anti-parallel, and the ranges of the atoms are taken to be equal, i. e.~they may fly up to 1 or 1.414 or 2 of the atomic spacing from the site of impact. Four cases have been studied on the basis of the range of hot atoms. The range of the hot oxygen atoms executing a ballistic flight might be up to the first nearest neighbourhood (1 atomic spacing from the site of impact), the second nearest neighbourhood (1.414 atomic spacing from the site of impact), the third nearest neighbourhood (2 atomic spacing from the site of impact), known as cases a, b, and c, respectively, while for case d the range of the oxygen atoms executing the ballistic flight might be up to 1 atomic spacing or 1.414 atomic spacing or 2 atomic spacing from the site of impact. The steady reactive window is observed and the continuous transition disappears. As soon as the CO partial pressure departs from zero, the production of CO2 is observed, which clearly verifies the experimental observation.

关键词： Oxygen

云南个旧卡房铜多金属矿床流体包裹体特征及其地质意义

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地球学报 2024年第4期45卷 561-574页

作者：李芬安鹏肖述刚孔志岗余博闫阔刘聿栋昆明理工大学国土资源工程学院云南昆明650093 云南省有色地质局三0八队云南昆明650214

卡房铜多金属矿床位于云南省个旧锡多金属矿集区,作为该区南段典型的铜多金属矿床,其深入的成矿流体性质及成矿物质来源研究尚为薄弱,限制了对该矿床成因的深入认识。本文对产于玄武岩中的似层状铜多金属矿体(主要成矿类型)开展了精细... 详细信息

卡房铜多金属矿床位于云南省个旧锡多金属矿集区,作为该区南段典型的铜多金属矿床,其深入的成矿流体性质及成矿物质来源研究尚为薄弱,限制了对该矿床成因的深入认识。本文对产于玄武岩中的似层状铜多金属矿体(主要成矿类型)开展了精细的野外岩相学、矿物学、C-H-O同位素及流体包裹体原位成分分析。结果显示,流体包裹体主要为气液两相水溶液包裹体,石英流体包裹体均一温度为264.5~330.5℃、盐度w(NaCleq)为16.24%~18.20%、密度为0.853~0.924 g/cm^(3);萤石流体包裹体均一温度为199.8~339.1℃、盐度w(NaCleq)为8.81%~18.88%、密度为0.822~0.955 g/cm^(3);方解石流体包裹体均一温度为112.1~199.4℃、盐度w(NaCleq)为4.96%~10.86%、密度为0.910~1.011 g/cm^(3),表明卡房铜多金属矿床成矿流体具有中低温、中低盐度、低密度特征,且早阶段到晚阶段,成矿温度和流体盐度明显降低。与Cu矿共生的石英δDV-SMOW值为–83.9‰~–78.9‰,δ18OH_(2)O值为4.63‰~12.14‰,方解石δ^(13)CV-PDB值为–7.11‰~0.64‰;同时,石英单个流体包裹体原位分析结果显示流体包裹体富集大离子亲石元素,如Na、k、Rb、Cs、Sr等。这些特征暗示了流体可能来源于与花岗质岩浆有关的热液流体,热液流体上升过程中与围岩碳酸盐岩发生强烈的水-岩反应;该过程可能萃取了玄武岩层中的Cu物质,诱发了Cu的富集并最终成矿。

关键词：成矿流体流体包裹体 C-H-O同位素卡房矿床个旧矿集区

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Complex Velocity Potential for an Ellipse and a Circle in Translation and Rotation

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Communications in Nonlinear Science and Numerical Simulation 1997年第4期2卷 252-257页

作者： R.SUN &A.T.CHWANG (Department of Mechanical Engineering,The University of Hong kong,H.k.) Department of Mechanical Engineering The University of Hong Kong Hong Kong China

This paper investigates the analytical solutions of two- dimensional Neumann- type external boundary- value problem for an ellipse and a circle in complex analysis *** transformation of harmonics between two planes is expanded in Laurent *** circle theorem is extended so as to suitto the system of the ellipse and the circle. By means of Basset’s process,the harmonic expressions of the system are found in the form of recurrence formulae which are suitable for numerical *** complex velocity potential of the system in translation and rotation is represented by the summation of the harmonic expressions.

关键词： velocity potential two bodies

不同海拔花椒叶片-凋落物养分化学计量与重吸收的关系

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生态学杂志 2024年第3期43卷 749-757页

作者：邓雪花喻阳华熊康宁张仕豪孔令伟贵州师范大学喀斯特研究院/国家喀斯特石漠化防治工程技术研究中心贵阳550001

阐明贵州喀斯特高原峡谷区不同海拔顶坛花椒叶片和凋落物化学计量特征与养分重吸收率,有助于掌握养分保存与利用机制。选取531、640、780、871和1097 m共5个海拔的顶坛花椒为对象,采集叶片和凋落物数据,分析其养分含量、化学计量和养分... 详细信息

阐明贵州喀斯特高原峡谷区不同海拔顶坛花椒叶片和凋落物化学计量特征与养分重吸收率,有助于掌握养分保存与利用机制。选取531、640、780、871和1097 m共5个海拔的顶坛花椒为对象,采集叶片和凋落物数据,分析其养分含量、化学计量和养分重吸收率随海拔增加的分异规律,阐明叶片养分重吸收与化学计量之间的内在关联。结果表明:叶片和凋落物有机碳(OC)、全磷(TP)和全铁(TFe)均以海拔780 m为最高,叶片全锰(TMn)、全镁(TMg)和凋落物TMg含量表现出随海拔升高而增加的趋势,叶片和凋落物全氮(TN)、全钾(Tk)、全钙(TCa)未随海拔发生显著分异。叶片和凋落物C∶P、Fe∶Mn、C∶Ca随海拔升高表现出先增加后降低的变化趋势,而叶片和凋落物Ca∶Mg则呈现随海拔升高而降低。叶片养分重吸收率随海拔的分异规律不完全一致,叶片P和k重吸收率以海拔780 m为最高,N、Fe和Mn重吸收率以海拔871 m为最高,海拔1097 m的Ca和Mg重吸收率显著高于其他海拔,而海拔1097 m的P、N和Fe重吸收率则均为负值。冗余分析结果表明,叶片养分重吸收率与化学计量之间具有很强的相关性。

关键词：顶坛花椒化学计量养分重吸收海拔喀斯特石漠化区