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PRePARATION OF ULTRAFINe MONODISPeRSe SILVeR CHLORIDe PARTICLeS IN NON-IONIC ReVeRSeD MICeLLeS

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Chinese Chemical Letters 1995年第12期6卷 1095-1098页

作者： Fang Qiong tanG Junichi tanABe Takeshi KAWAI Kijiro kon-NO Institute of Photographic Chemistry Academia SinicaBeijing 100101 Department of Industrial Chemistry Science University of Tokyo1-3 KagurazakaShinjukuTokyo 162Japan

The ultrafine particles of silver chloride (AgCl) were obtained by mixing two separately prepared reversed micelle systems both containing a non-ionic surfactant,cyclohexane and an aqueous solution of either silver nitrate (AgNO3) or potassium chloride (KCl). The size distribution of spherical AgCl particles depended on the solubility behavior of aqueous electrolytes in surfactant solution. The NMR, near infrared,light-scattering, X-ray, UV spectroscopy and TeM (transmission electron microscopy) were used to examine the relationship between the size of particles and the states of solubilized water or reversed micelles. In the solubilized regions, it was found that three states of water were related to the formation of reversed and swollen micelles or W/O microemulsions. i.e, monodisperse particles were formed in reversed micelle and swollen micelle systems, whereas in W/O microemulsion system the particles became polydisperse.

关键词： R?

Biosynthetic scaffolds for partial meniscal loss:A systematic review from animal models to clinical practice

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Bioactive Materials 2021年第11期6卷 3782-3800页

作者： F.Veronesi B.Di Matteo N.D.Vitale G.Filardo A.Visani e.kon M.Fini Complex Structure of Surgical Sciences and Technologies IRCCS Istituto Ortopedico RizzoliBolognaItaly Humanitas University Department of Biomedical SciencesVia Rita Levi Montalcini 420090Pieve EmanueleMilanItaly IRCCS Humanitas Research Hospital Via Manzoni 5620089RozzanoMilanItaly Applied and Translational Research Center IRCCS Istituto Ortopedico RizzoliBolognaItaly Orthopaedic and Traumatology Unit Ospedale Regionale di LuganoEOCLuganoSwitzerland Faculty of Biomedical Sciences Universit`a della Svizzera ItalianaLuganoSwitzerland First Moscow State Medical University-Sechenov University Bol’shaya Pirogovskaya Ulitsa19c1119146MoscowRussia

Acute or degenerative meniscus tears are the most common knee *** provides symptomatic relief and functional recovery only in the short-to mid-term follow-up but significantly increases the risk of *** this reason,preserving the meniscus is key,although it remains a *** transplants present many disadvantages,so during the last 20 years preclinical and clinical research focused on developing and investigating meniscal *** aim of this systematic review was to collect and evaluate all the available evidence on biosynthetic scaffolds for meniscus regeneration both in vivo and in clinical *** databases were searched:46 in vivo preclinical studies and 30 clinical ones were *** natural,15 synthetic,and 15 hybrid scaffolds were studied in *** them,only 2 were translated into clinic:the Collagen Meniscus Implant,used in 11 studies,and the polyurethane-based scaffold Actifit®,applied in 19 *** positive outcomes were described in the short-to mid-term,the number of concurrent procedures and the lack of randomized trials are the major limitations of the available clinical *** in vivo studies also combined the use of cells or growth factors,but these augmentation strategies have not been applied in the clinical practice *** solutions offer a significant but incomplete clinical improvement,and the regeneration potential is still *** upon the overall positive results of these“old”technologies to address partial meniscal loss,further innovation is urgently needed in this field to provide patients better joint sparing treatment options.

关键词： Meniscal scaffold Meniscectomy Osteoarthritis Regenerative medicine Collagen Polyurethane

γ-酮醛清道夫水杨胺对尿毒症Apoe-/-小鼠动脉粥样硬化的作用

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西安交通大学学报（医学版） 2020年第1期41卷 47-52页

作者：申燕陈胜男赵艳 VALeNTINA kon 西安交通大学第一附属医院肾内科陕西西安710061 西安交通大学第一附属医院心血管内科陕西西安710061 美国范德堡大学医学中心儿科肾脏与高血压系田纳西纳什维尔37232

目的观察γ-酮醛清道夫水杨胺(salicylamine,SAM)对尿毒症Apoe-/-小鼠动脉粥样硬化(atherosclerosis,AS)及其表型的影响。方法Apoe-/-小鼠通过5/6肾切除术建立尿毒症模型,对照组仅行假手术。实验动物分为对照组、尿毒症组及尿毒症SAM干... 详细信息

目的观察γ-酮醛清道夫水杨胺(salicylamine,SAM)对尿毒症Apoe-/-小鼠动脉粥样硬化(atherosclerosis,AS)及其表型的影响。方法Apoe-/-小鼠通过5/6肾切除术建立尿毒症模型,对照组仅行假手术。实验动物分为对照组、尿毒症组及尿毒症SAM干预组,分别以SAM或安慰剂干预6周。干预结束后检测体质量、血压、血脂、肾功能、血清SAM浓度、主动脉AS斑块面积及斑块组分。结果与对照组相比,尿毒症组主动脉AS病变面积明显增大,AS斑块组分中坏死面积增大,巨噬细胞含量增多,胶原含量减少。SAM干预6周,尿毒症小鼠AS损伤面积、AS斑块中坏死面积及巨噬细胞含量减少,胶原含量增加,但不影响体质量、血压、血脂和肾功能,未发生药物蓄积和毒性作用。结论SAM能减轻尿毒症Apoe-/-小鼠加速发展的AS病变并使斑块的稳定性增加,这些作用不依赖于对血压、血脂或肾功能的影响,同时不引起药物蓄积及毒性作用。

关键词： γ-酮醛清道夫水杨胺尿毒症 Apoe-/-小鼠动脉粥样硬化水杨胺(salicylamine)

Otological Injuries Observed in Head and Neck Trauma in a Second-Line Hospital

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International Journal of Otolaryngology and Head & Neck Surgery 2022年第3期11卷 119-125页

作者： Ghislaine Neuilly Ngniée Tafo koné Fatogoma Issa Samaké Djibril Timbo Samba Karim Keita Mohamed Reference Health Center of Commune I of Bamako (CSReF) Bamako Mali University Hospital (CHU) Gabriel Touré Bamako Mali Reference Health Center of Commune V of Bamako (CSReF) Bamako Mali

Otological injuries are common during cervicofacial trauma. The aim of this study is to describe the epidemiological characteristics and to map otological injuries during head and neck trauma. This was an observational, descriptive, prospective study conducted at the eNT unit of the Referral Health Center Hospital in Mali from January 2017 to September 2018. Patients with middle and/or inner ear injuries due to trauma were included. The prevalence of otologic injuries was 34.54% of cases. The mean age was 25 years and the sex ratio was 1.11. Students accounted for 42.10%. The mechanism of occurrence was an intentional assault in 68.42% of the cases followed by road traffic accidents (15.79%). The most common functional signs were hearing loss (68.42%), tinnitus (57.89%), and facial paralysis in 5.26%. Otoscopy showed tympanic perforation (47.83%), otorrhagia (21.05%) and otoliquorrhea (5.26%). Rock fractures with osteodural breach (10.53%) and pneumencephaly were found on a CT scan of the rock. The evolution was marked by the regression of the facial paralysis and the healing of the tympanum in 45.45% of the cases. Sequelae persisted in the form of sensorineural deafness (17%). The otological lesions observed during cervicofacial trauma are varied. The challenges in our context are felt at three levels: the improvement of the technical platform, the long-term follow-up of patients, and the cost of care in terms of equipment. These lesions are responsible for disabling deafness, a source of difficulty in social and school integration.

关键词： Otological Lesions Trauma Sequelae Hearing Loss Disability

Association between preoperative high sensitive troponin I levels and cardiovascular events after hip fracture surgery in the elderly

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Journal of Geriatric Cardiology 2018年第3期15卷 215-221页

作者： Bum Sung Kim Tae-Hoon Kim Jeong-Hwan Oh Chang Hee Kwon Sung Hea Kim Hyun-Joong Kim Heung kon Hwang Sang-Man Chung in-gu Seoul Republic of Korea Department of Orthopedic surgery Konkuk University Medical Center 120-1 Neungdong-ro Hwayang-dong Gwangjin-guSeoulRepublic of Korea

Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery （HFS）. We used high sensitive troponin I （hs-TnI） assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events （MACe） in elderly hip frac^u＇e patients. Method From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry. A total of 262 of these patients underwent HFS and hs-TnI assays. MACe was defined as postoperative all-cause deaths, heart failure （HF）, new-onset atrial fibrillation （AF）, myocardial infarction （MI） and cardiovascular re-hospitalization that occurred within 90 days postoperative. Results Of 262 HFS patients, MACe developed following HFS in 65 （24.8%）. Patients with MACe were older and had higher rates of renal insufficiency, coronary artery disease, prior HF, low left ventricular ejection fraction and use of beta blockers; higher levels of hs-Tnl and N-terminal pro-brain natriuretic peptide （NT-proBNP） and higher revised cardiac risk index. A preoperative hs-TnI≥ 6.5 ng/L was associated with high risk of postoperative HF, new-onset AF and MACe. In multivariable analysis, pre-operative independent predictors for MACe were age 〉 80 years [adjusted hazard ratio （HR）： 1.79, 95% confident interval （CI）： 1.03-3.13, P = 0.04], left ventricular ejection fraction （LVeF）〈 50% （adjusted HR： 3.17, 95% CI： 1.47-5.82, P 〈 0.01） and hs-TnI 〉 6.5 ng/L （adjusted HR： 3.75, 95% CI： 2.09~5.17, P 〈 0.01）. Conclusion In elderly patients with hip fracture who undergo HFS, a preoperative assessment of hs-TnI may help the risk refinement of cardiovascular complications.

关键词： Cardiovascular complication High sensitive troponin I Hip fracture surgery

effect of Herbicides Used in Horticulture (2,4-D, Glyphosate and Nicosulfuron) on Snails <i>Achatina fulica</i>(Bowdich, 1720)

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Journal of Agricultural Chemistry and environment 2021年第4期10卷 402-414页

作者： Aya elichama Désirée Phaceli Mama koné Ardjouma Dembele Jean Florent Haba emile Kouadio Yao Laboratoire de physiologie de pharmacologie et de pharmacopée UFR des Sciences de la Nature Université Nangui Abrogoua Abidjan C&ocirc te d’Ivoire Laboratoire National d’Appui au Développement Agricole (LANADA) Abidjan C&ocirc te d’Ivoire Laboratoire de biodiversité et de gestion durable des écosystèmes UFR des Sciences de la Nature Université Nangui Abrogoua Abidjan C&ocirc te d’Ivoire

2,4-Dichlorophenoxyacetic (2,4-D), glyphosate, and nicosulfuron, because of their modes of action and selectivity, are the most widely used herbicides in Ivorian horticulture. Fuels toxicity was the reason of many debates in the world because of their massive and uncontrolled use. They are frequently blamed for the reduction of soil fertility and terrestrial biodiversity observed in agricultural areas. In view of the debates raised by their toxicities, the use of these herbicides requires the greatest caution and clear information on the real risk incurred by the edaphic fauna by conducting ecotoxicity studies. The present study aims to evaluate the effect of 2,4-D, glyphosate and nicosulfuron herbicides on the growth and reproduction of Achatina fulica snails in microcosm. To do this, we treated each plot on which snail microcosms were placed with 2,4-D, glyphosate or nicosulfuron herbicides according to the manufacturer’s recommendations. The results showed for all the herbicides used, that after 28 days of exposure, the growth of juvenile snails was slowed down. The number of eggs laid per pair was reduced in adult snails. The egg hatchability test revealed a reduction in egg hatchability. In addition, each effect was dependent on the herbicide used. Thus, toxicity was found to be greater according to the following order: nicosulfuron ? glyphosate ? 2,4-D. From the results obtained, we concluded that 2,4-D, glyphosate, and nicosulfuron treatments under field conditions are a potential threat to the sustainability of snail species and therefore to soil life. The intensity of the effect depends on the toxicity of the herbicides used.

关键词： Herbicide effect Growth Reproduction Achatina fulica Microcosm

The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation

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Journal of Molecular Cell Biology 2022年第6期14卷 14-29页

作者： Soonhwa Song Joon Kyu Park Sang Chui Shin Jae-Jin Lee Seung kon Hong In-Kang Song Bokyung Kim eun Joo Song kong-Joo Lee eunice eunKyeong Kim Graduate School of Pharmaceutical Sciences College of PharmacyEwha Womans UniversitySeoul 03760Republic of Korea Biomedical Research Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Technology Support Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Fas-associated factor 1 (FAF1) is a scaffolding protein that plays multiple functions, and dysregulation of FAF1 is associated withmany types of diseases such as cancers. FAF1 contains multiple ubiquitin-related domains (UBA, UBL1, UBL2, UAS, and UBX), eachdomain interacting with a specific partner. In particular, the interaction of UBL1 with heat shock protein 70 (Hsp70) is associatedwith tumor formation, although the molecular understanding remains unknown. In this study, the structural analysis revealed thatHis160 of FAF1 is important for its interaction with Hsp70. The association of Hsp70 with FAF1 is required for the interaction withIQGAP1. FAF1 negatively regulates RhoA activation by FAF1–Hsp70 complex formation, which then interacts with IQGAP1. Thesesteps play a key role in maintaining the stability of cell-to-cell junction. We conclude that FAF1 plays a critical role in the structureand function of adherens junction during tissue homeostasis and morphogenesis by suppressing RhoA activation, which induces theactivation of Rho-associated protein kinase, phosphorylation of myosin light chain, formation of actin stress fiber, and disruptionof adherens junction. In addition, depletion of FAF1 increased collective invasion in a 3D spheroid cell culture. These results provideinsightinto how the FAF1–Hsp70 complex acts as a novelregulator ofthe adherens junction integrity. The complex can be a potentialtherapeutic target to inhibit tumorigenesis and metastasis.

关键词： human Fas-associated factor 1(FAF1) heat shock protein 70(Hsp70) adherens junction RhoA activation IQGAP1 X-ray crystallography FAF1–Hsp70 complex

Analysis of Social Networks among Students in Abidjan City

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Open Journal of Applied Sciences 2022年第8期12卷 1339-1351页

作者： Aliou Bamba Aladji Kamagaté Moussa Koivogui Douatia koné Direction de la Recherche et de l’Innovation Technologique (DRIT) Ecole Supérieure Africaine des TIC (ESATIC) Blvd Marseille Abidjan Cote d’Ivoire Wireless Acoustics Environment & Expert Systems (WAVES) iMEC Department of Information Technology Ghent University Ghent Belgium Département de Mathématiques Physique et Chimie Université Péléforo Gon Coulibaly (UPGC) Korhogo C&ocirc te d’Ivoire Agence Nationale de la Recherche (ANR) Paris France

This paper investigates the social networks usage by students in Abidjan city, Côte d’Ivoire. We focus on a descriptive or quantitative analysis to understand the motivations and how students make use of internet and social networks. More than six hundred forms were distributed to persons we have deemed as students. In return, we received more than 93% of the forms that have been processed. The study highlights the materials and the digital platforms that students used the most. The majority of the respondents reported to have access to the social networks in their mobile phones, with WhatsApp leading this application ranking, followed by Instagram, Facebook, YouTube, and Tik Tok. The survey shows that two third of our respondents are aged from 19 to 25 years old and almost half of the respondents spend daily 2 to 5 hours on digital platforms. The investigation also reveals that the main online activities are the e-commerce, chatting, information, and entertainment. The paper addresses also the online harassment of the students and it shows that more than one tenth of them have been victims of cyber-bullying. This study might be useful for governments, institutions, academia, individuals and professionals in order to communicate efficiently with a given population for a better use of social networks and to prevent students from harassment.

关键词： Social Network Social Media Applications Network Structure View Status Structure View Statistics Digital Platforms Online Harassment

Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer

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World Journal of Gastroenterology 2014年第26期20卷 8545-8557页

作者： Woo Hyun Paik Ji kon Ryu Kyoung-Sin Jeong Jin Myung Park Byeong Jun Song Sang Hyub Lee Yong-Tae Kim Yong Bum Yoon Department of Internal Medicine Inje University Ilsan Paik Hospital Division of Gastroenterology Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine

AIM: To evaluate the anti-tumor effect of clobenpropit, which is a specific H3 antagonist and H4 agonist, in combination with gemcitabine in a pancreatic cancer cell line.

关键词： Clobenpropit epithelial-mesenchymal transition Histamine Histamine receptors Pancreatic neoplasm