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科技情报开发与经济 2010年第26期20卷 194-196页

作者：陈雪女福建师范大学协和学院福建福州350108

简要介绍了精益生产方式在中国的应用现状,阐述了培养精益人才的意义,探讨了适合中国企业的精益人才培养的方法。

关键词：精益生产精益人才人员培训

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快速和中等生长速度猪种的日粮维生素B需求

国外畜牧学：猪与禽 2009年第4期29卷 5-9页

作者：汪力 T. S. Stahly n. H. Williams 美国衣阿华州立大学动物科学系

本研究利用来自2个猪品系的10组(每组5头同窝仔猪)试验猪,测定5种B族维生素(核黄素、烟酸、泛酸、维生素B12和叶酸)的日粮水平对体重9～28kg的高和中等瘦肉系仔猪生长的影响。所有试验仔猪均采用单只圈养,并进行早期隔离断奶,以便能够... 详细信息

本研究利用来自2个猪品系的10组(每组5头同窝仔猪)试验猪,测定5种B族维生素(核黄素、烟酸、泛酸、维生素B12和叶酸)的日粮水平对体重9～28kg的高和中等瘦肉系仔猪生长的影响。所有试验仔猪均采用单只圈养,并进行早期隔离断奶,以便能够使其发挥出瘦肉生长潜力。基因日粮所提供的5种测试维生素生物的总体和估测生物可利用率分别相当于体重5～10kg仔猪的nRC(1998)估测需求量的100%和70%。当体重为9±0.9kg时,给每窝内的各头仔猪分别喂给添加了生物可利用率相当于nRC(1998)需求量的0%、100%、200%、300%或400%的5种测试维生素的基础日粮。结果表明,与中等瘦肉系猪相比,高瘦肉系猪消耗的饲料少(PnRC需求量的470%以上)显著高于中等瘦肉率试验猪(270%)(PnRC(1998)的估测值,尤其是高瘦肉系的猪种。对这些维生素较高的需求与较高的日粮能量摄入量或较高的机体能量沉积量无关,但很可能是由于主要的代谢通路发生改变所致。

关键词： B族维生素瘦肉系猪

长链多不饱和脂肪酸喂养的早产儿的身体组分:一项前瞻性随机对照研究

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 60-61页

作者： Groh-Wargo S. Jacobs J. Auestad n. 宁亮 Case Western reserve University School of Medicine Department of Pediatrics 2500 MetroHealth Drive Cleveland OH 44109 CanadaDr.

The objective of this study was to evaluate growth and body composition of premature infants who were fed formulas with arachidonic acid (ARA; 20:4n6) and docosahexaenoic acid (DHA; 22:6n3) to 1 y of gestation-corrected age (CA). Preterm infants (750- 1800 g birth weight and nal age) were assigned within 72 h of first enteral feeding to one of three formulas: control (n = 22), DHA+ ARA from fish/fungal oil [DHA+ ARA(FF); n = 20], or DHA+ ARA from egg/fish oil [DHA+ ARA(EF); n = 18]. Human milk feeding was allowed on the basis of the mother’s choice. Infants were fed breastmilk and/or preterm formulas with or without 0.26% DHA and 0.42% ARA to term CA followed by breast milk or postdischarge preterm formulas with or without 0.16% DHA and 0.42% ARA to 12 mo CA. Body composition was measured by dual-energy x-ray absorptiometry. There were no significant differences among the three study groups at any time point in weight, length, or head circumference. Bone mineral content and bone mineral density did not differ among groups. At 12mo CA, infants who were fed DHA+ ARA-supplemented formulas had significantly greater lean body mass (p nd significantly less fat mass (p n infants who were fed the unsupplemented control formula. The DHA+ ARA-supplemented formulas supported normal growth and bone mineralization in premature infants who were born at.n. Preterm formulas that had DHA+ ARA at the levels and ratios in this study and were fed to 1 y CA led to increased lean body mass and reduced fatmass by 1 y of age.

关键词：不饱和脂肪酸骨矿物质含量骨矿物质密度花生四烯酸出生后母乳喂养头围吸收分析法

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新芝加哥学派城市研究特点与计划

中国名城 2017年第5期31卷 10-17页

作者：特里n.克拉克吴军娄缤元谢思琦唐婧美国芝加哥大学社会学系北京市委党校(北京行政学院)社会学教研部浙江大学人文学院浙江省城市治理研究中心(杭州国际城市学研究中心) 北京城市学院公共管理学部北京市委党校

洛杉矶学派Michael Dear(2001)对传统芝加哥学派的城市研究提出了很多评论,通过整合关于城市如何运作、强调文化与政治等更宽广的理论视角来拓展这些讨论。纽约学派的研究更倾向于阶层分析、生产、不平等、二元劳动力市场和其他相关议题... 详细信息

洛杉矶学派Michael Dear(2001)对传统芝加哥学派的城市研究提出了很多评论,通过整合关于城市如何运作、强调文化与政治等更宽广的理论视角来拓展这些讨论。纽约学派的研究更倾向于阶层分析、生产、不平等、二元劳动力市场和其他相关议题,而且主要采用马克思主义分析视角。洛杉矶学派的学者们通常更个人主义、主观主义以及强调消费导向;其中还有一些比较后现代主义。芝加哥是美国天主教人口数量最多的城市,他们重视个人关系、大家庭(extended families)、邻里和民族传统(ethnic tradition)。这反过来引导芝加哥的研究者们更强调文化与政治的影响作用,因为亚文化的不同让城市社区呈现出了很大差异。另外,本文总结了新芝加哥学派城市研究的七个重点。

关键词：文化邻里政治天主教芝加哥

多囊卵巢综合征妇女的血清瘦素水平与肥胖参数相关,但与高胰岛素血症无关

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 45-46页

作者： Erturk E. Kuru n. Savci V. 高雪莲

To examine serum leptin concentrations in obese and lean patients with polycystic ovary syndrome (PCOS) to assess whether the changes in leptin levels are due to obesity or hormonal alterations. Controlled clinical study. Academic research environment. Obese and lean women with PCOS. Blood samples were collected before and after food consumption. Serum leptin and insulin levels. Serum leptin concentrations were significantly correlated with body mass index (r = 0.649) and also with HOMA (r = 0.535). However, after controlling for body mass index in a partial correlation analysis, no significant correlation was found between serum leptin levels and HOMA or hyperinsulinemia. While lean patients with PCOS had a significant correlation between leptin concentrations and obesity parameters, they did not show any significant correlation with insulin resistance parameters. Although leptin concentrations in women with PCOS correlate with insulin resistance/hyperinsulinemia, this is related only to obesity.

关键词：多囊卵巢综合征高胰岛素血症血清瘦素水平胰岛素抵抗参数相关肥胖型瘦素浓度血样检测激素水平变化指数和

IDEnTIFICATIOn OF THREE SnPs In THE PORCInE MYOSTATIn GEnE(MSTn)

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IDENTIFICATION OF THREE SNPs IN THE PORCINE MYOSTATIN GENE(M...

The common pentanucleotide polymorphism of the 3’-untranslated region of the leptin receptor gene is associated with obesity in Saudi females

第六届动物遗传学讨论会

作者： Y. L. Jiang n. Li G.Plastow Z. L. Liu X. X. Hu C. X. Wu national Laboratories for Agrobiotechnology PIC International Group Fyfield WickAbingdonOxonOX13 5NAUK College of Animal Science and Technology Shandong Agricultural University Taian 271018 China

Thirteen pairs of primers were designed for the entire porcine MSTn gene to enable PCR amplification for the detection of single nucleotide polymorphisms (SnPs) by a PCR-SSCP approach. Altogether 96.5% (1089/1128) of the encoding regions and 971 bp of the non-coding regions were screened. A total of three polymorphisms were identified with PCR-SSCP. They were located in the promoter, intron one and exon three regions of the gene. These polymorphisms were then confirmed to be point mutations (T-A transversion, G - A transition and C - T transition respectively) by sequencing. Allele frequencies were determined for all three SnPs in several different pig breed populations. The polymorphisms were found to be rare in Western breeds, but much more common in Chinese breeds. Whether they have any relationship with the marked difference in lean meat mass between Western and Chinese breeds requires further study.

关键词： MSTn SnP SSCP Meat mass Pig

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Health 2013年第2期5卷 285-291页

作者： Maha H. Daghestani Mazin H. Daghestani Pinar T. Ozand Ahmed R. Al-Himaidi Mamoon H. Daghestani nadia A. Aleisa Hana H. Hakami Abdelmoneim Eldali Ali n. Al-odaib Biostatistics Epidemiology & Scientific Computing (MBC-03) King Faisal Specialist Hospital and Research Center Riyadh KSA Department of Genetics King Faisal Specialist Hospital and Research Center Riyadh KSA Department of Obstetrics & Gynecology Umm-Al-Qura University Makkah KSA Department of Surgery King Abdulaziz Medical City National Guard Health Affairs Jeddah KSA Department of Zoology Center for Scientific and Medical Female Colleges King Saud University Riyadh KSA Department of Zoology Science College King Saud University Riyadh KSA Duzen Laboratories Istanbul Turkey

Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. Leptin receptor (LEPR) gene has been intensively evaluated in the search of variants that could be related to obesity. The results of most of these studies have been controversial. We investigated the effects of leptin receptor gene 3’-untranslated region (3’-UTR) polymorphism on phenotype, metabolic parameters and anthropometric measurements of obese Saudi females. 122 healthy women aged 19 to 36 years. The subjects were divided into 3 groups according to their body mass index BMI;lean (BMI 18 - 24), overweight (BMI 25 - 29) and obese (BMI ≥ 30). There were 13 homozygotes and 34 heterozygotes for the 3’-UTR insertion allele amongst all 122 women. The results of this study show that the allele frequency of the insertion allele (I) of 3’UTR was significantly higher in overweight (35.3) and obese females (32.2) compared to the frequency in lean females (15.6). The insertion allele was associated with increased BMI in obese groups. The results obtained from this study indicated that in the obese subjects most variable values increased in I/I homozygote but the significant high value recorded among BMI (40.9 ± 7.11 kg/m2, P = 0.042). Our findings indicated that, the obesity in Saudi females is influenced by alteration in the leptin receptor gene 3’-UTR polymorphism.

关键词： Pentanucleotide Polymorphism Leptin Obesity Saudi Females

Too Sweet/Too Fatty Food Consumption: Determinants among Secondary School Pupils in the City of Bobo-Dioulasso (Burkina Faso)

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Open Journal of Pediatrics 2018年第2期8卷 126-133页

作者： Té né Marceline Yamé ogo Mireille Marie Dé borah Tapsoba Aimé e Senkaye-Lagom Kissou Bazoumana Coulibali Issiaka Sombié Carole Gilberte Kyelem Alassane Ilboudo Omar Guira Djingri Lankoandé Abraham Bagbila Marina Birba Macaire Sampawindé Oué draogo Youssouf Joseph Drabo CHU SouroSanon Bobo-Dioulasso Burkina Faso InSSA University Nazi Boni Bobo-Dioulasso Burkina Faso UFR-SDS University Joseph Ki Zerbo Ouagadougou Burkina Faso

Introduction: nutrition, particularly when too sweet or too fatty, is a major determinant of chronic diseases. This study aims to determine the frequency and associate factors of the excessive consumption of sweet drinks and fried food among secondary school pupils. Methods: It is cross-sectional study which was conducted from March to April 2016 among 1st, 4th and 7th form pupils of public and private schools in the city of Bobo-Dioulasso. nutritional investigation methods consisted in a reminder of the last 24 hours associated with a questionnaire on food consumption frequency. Excessive consumption of sweet drinks was defined as a consumption of more than 3 sweet drinks (soda) or sugary juice per day (~33 cl × 3);and excessive consumption of fried food as a consumption of more than 1 intake of fried food per day. results: In total, 1993 pupils were interviewed. The mean age was 17.5 ± 3.6 years and sex-ratio 0.7. Excessive consumption of sweet drinks and fried food was recorded in 12.7% (n = 253) and 28.2% (n = 561) of pupils, respectively. The factors associated with excessive consumption of sweet drinks were: sex/female, sedentarily, desire to gain weight, lean or normal corpulence of the mother and breakfast intake;those associated with excessive consumption of fried food were: sex/female, being in 1st or 4th form, physical exercise practice and breakfast intake. But the fact to attend a private secondary school, to have a mother of normal corpulence and a concordance between self-image and actual weight status, were protective against excessive consumption of fried foods. Conclusion: This study has displayed prominently the fact that eating too sweet and too fatty concerned respectively 1/10 and 3/10 of pupils in the city of Bobo-Dioulasso. The main modifiable factors of these eating habits included the level of education, the composition of breakfast and the influence of mothers. An intervention program in the form of a Communication for Continuous Behaviora

关键词： Too Sweet/Too Fatty Food Consumption Young Subject Pupils

在高盐喂食的肥胖大鼠中n-乙酰基-丝氨酸-天门冬氨酰-赖氨酸-脯氨酸的肾保护作用

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中华高血压杂志 2019年第4期27卷 398-398页

作者： Maheshwari M Romero CA Monu SR Kumar n Liao TD Peterson EL Carretero OA 不详

肥胖是一个公共卫生问题,与盐敏感性高血压、肾脏炎症和纤维化有关。n-乙酰基-丝氨酸-天门冬氨酰-赖氨酸-脯氨酸(n-acetyl-seryl-aspartyl-lysyl-proline,Ac-SDKP)是一种具有抗炎和抗纤维化特性的四肽。然而,它在预防肥胖患者肾脏损害... 详细信息

肥胖是一个公共卫生问题,与盐敏感性高血压、肾脏炎症和纤维化有关。n-乙酰基-丝氨酸-天门冬氨酰-赖氨酸-脯氨酸(n-acetyl-seryl-aspartyl-lysyl-proline,Ac-SDKP)是一种具有抗炎和抗纤维化特性的四肽。然而,它在预防肥胖患者肾脏损害中的作用尚不清楚。本研究假设肥胖Zucke( Zucker obese, ZO)大鼠在高盐喂食下可出现肾损害、炎症、纤维化.并可通过Ac-SDKP治疗得以预防。方法:Zucker瘦型(Zucker lean, ZL)大鼠和ZO大鼠(8周)接受Ac-SDKP[ 1.6 mg/(kg·d)]治疗,同时维持正常盐(0.4%)或高盐(4%)喂食8周后.对收缩压、蛋白尿、肾脏炎症和肾纤维化进行评估。

关键词：肥胖大鼠脯氨酸赖氨酸天门冬丝氨酸肾保护作用喂食高盐

Learning,memory and hippocampal LTP in genetically obese rodents

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中国病理生理杂志 2001年第8期 65-65页

作者： Y.Oomura S.Aou X.LI n.Hori D.Armstrong C.Phelix B.Smith M.J.Wayner K.Sasaki T.Shiraishi Division of Life Sciences University of Texas at San Antonio San Antonio TX Department of Physiology Faculty of Medicine Kyushu University Fukuoka Department of Physiology Faculty of Medicine Kyushu University Fukuoka Division of Life Sciences University of Texas at San Antonio San Antonio TX Bioinform School of Engineering Toyama University Toyama Department of neurophysiology Tokai University Medical School Ishihara Japan

We have found that leptin, at physiological concentrations of 10-12 mol/L, facilitates learning and memory and LTP maintenance in Wistar rats. To explore the role of leptin recepors in learning, memory and synaptic plasticity, experiments were carried out using Zucker rats (Z), db/db mice (db), and ob/ob mice(ob). The former two have defects in leptin receptors and the latter cannot produce normal leptin. Unlike the effects observed in normal rats, high or low frequency stimulation of Schaffer collateral-CA1 synapses in hippocampal slices prepared from Z, db and ob animals failed to induce the learning and memory relevant long-term potentiation or depression in CA1 neurons. However, LTP in ob CA1 synapses was facilitated by leptin at 10-12 mol/L concentration. Moreover, the paired-pulse facilitation of CA1 synaptic potentials and intracellularly recorded postsynaptic responses to the neurotransmitters AMPA, nMDA and GABA, applied electrophoretically to the apical dendrites of CA1 neurons, were approximately the same compared to the control lean animals. In addition, unlike the second messenger responses observed in Wistar rats, calmodulin kinase Ⅱ activity in the CA1 area of Z and db animals was not activated after tetanic stimulation of the Schaffer collaterals. It has been shown that all three strains, Z, db and ob display impaired spatial learning and memory when tested in the Morris water maze. The results of these experiments indicate a close relationship between spatial learning and memory, facilitation of LTP, and calmodulin kinase Ⅱ　activity.

关键词： LTP Learning,memory and hippocampal LTP in genetically obese rodents