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Biosynthetic scaffolds for partial meniscal loss:A systematic review from animal models to clinical practice

Bioactive Materials 2021年第11期6卷 3782-3800页

作者： F.Veronesi B.Di Matteo N.D.Vitale G.Filardo A.Visani e.kon M.Fini Complex Structure of Surgical Sciences and Technologies IRCCS Istituto Ortopedico RizzoliBolognaItaly Humanitas University Department of Biomedical SciencesVia Rita Levi Montalcini 420090Pieve EmanueleMilanItaly IRCCS Humanitas Research Hospital Via Manzoni 5620089RozzanoMilanItaly Applied and Translational Research Center IRCCS Istituto Ortopedico RizzoliBolognaItaly Orthopaedic and Traumatology Unit Ospedale Regionale di LuganoEOCLuganoSwitzerland Faculty of Biomedical Sciences Universit`a della Svizzera ItalianaLuganoSwitzerland First Moscow State Medical University-Sechenov University Bol’shaya Pirogovskaya Ulitsa19c1119146MoscowRussia

Acute or degenerative meniscus tears are the most common knee *** provides symptomatic relief and functional recovery only in the short-to mid-term follow-up but significantly increases the risk of *** this reason,preserving the meniscus is key,although it remains a *** transplants present many disadvantages,so during the last 20 years preclinical and clinical research focused on developing and investigating meniscal *** aim of this systematic review was to collect and evaluate all the available evidence on biosynthetic scaffolds for meniscus regeneration both in vivo and in clinical *** databases were searched:46 in vivo preclinical studies and 30 clinical ones were *** natural,15 synthetic,and 15 hybrid scaffolds were studied in *** them,only 2 were translated into clinic:the Collagen Meniscus Implant,used in 11 studies,and the polyurethane-based scaffold Actifit®,applied in 19 *** positive outcomes were described in the short-to mid-term,the number of concurrent procedures and the lack of randomized trials are the major limitations of the available clinical *** in vivo studies also combined the use of cells or growth factors,but these augmentation strategies have not been applied in the clinical practice *** solutions offer a significant but incomplete clinical improvement,and the regeneration potential is still *** upon the overall positive results of these“old”technologies to address partial meniscal loss,further innovation is urgently needed in this field to provide patients better joint sparing treatment options.

关键词： Meniscal scaffold Meniscectomy Osteoarthritis Regenerative medicine Collagen Polyurethane

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The Problem of Rehospitalisation for Heart Failure at the Cardiology Department of the Hôpital National Ignace Deen

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World Journal of Cardiovascular Diseases 2024年第9期14卷 539-546页

作者： Samoura Sana Bah Mamadou Bassirou Soumaoro Morlaye Samoura Aly koné Alpha Sylla Ibrahima Sory Samoura Sekouba Barry Ibrahim Sory Balde elhadj Yaya Balde Mamadou Dadhi Hopital Sino-Guineen Conakry Guinea Hopital National Ignace Deen Conakry Guinea Hopital de Lamiti Sino-Guineenne Conakry Guinea

Introduction: Despite current therapeutic advances, heart failure in sub-Saharan Africa remains a common, serious and costly disease, particularly due to rehospitalizations. The objective of this work was to determine the proportion of rehospitalizations for heart failure and to identify etiological factors. Methodology: This was a retrospective descriptive study with a duration of 8 months from April 1 to November 30, 2021. This study included all patients rehospitalized in the department for Heart Failure and who agreed to participate in our study. Results: During the period of our study, 437 patients were hospitalized in the HF department, among which we collected 126 cases of rehospitalization for HF with a frequency of 28.83%. The mean age of our patients was 46.32 ± 18.98 years with the extremes of 15 to 84 years. The most affected age group was between 35 and 44 years old in 24 cases, i.e. a frequency of 19%. We observed a female predominance of 64 cases, i.e. a frequency of 50.8% compared to 62 cases, i.e. a frequency of 49.2% with a sex ratio (M/F) equal to 0.96. 98 cases of our patients, i.e. a frequency of 77.8%, were mutual insurance companies who felt they had the necessary support from those around them. In our sample, the underlying heart disease was mainly represented by valvular heart disease in 59 cases, followed by hypertensive heart disease in 42 cases with the respective frequencies of 46.82% and 33.33%. The majority of our patients were rehospitalized (1 - 3) times after a first episode of HF flare-up in 117 cases or 92.9%. Irregularity at control and therapeutic break were the most common decompensation factors with frequencies of 75.8% and 74.2% respectively. The majority of our patients were rehospitalized (1 - 3) times after a first episode of HF flare-up in 117 cases or 92.9%. Irregularity at control and therapeutic break were the most common decompensation factors with frequencies of 75.8% and 74.2% respectively. Conclusion: It appears in

关键词： Heart Failure Rehospitalisation Valvular Heart Disease

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基质辅助自体软骨细胞移植治疗髌股关节软骨损伤——髌骨与滑车损伤修复疗效对比

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中国骨科临床与基础研究杂志 2015年第1期7卷 60-60页

作者： Filardo G kon e Andriolo L 沈洪园章莹

由于自身愈合能力有限，软骨损伤修复一直以来都具有临床挑战性。膝关节软骨损伤患病率高，尤以髌股关节软骨损伤最为多见。基质辅助自体软骨细胞移植（matrix-assisted autologous chondrocyte transplantation，MACT）中期随访显示出... 详细信息

由于自身愈合能力有限，软骨损伤修复一直以来都具有临床挑战性。膝关节软骨损伤患病率高，尤以髌股关节软骨损伤最为多见。基质辅助自体软骨细胞移植（matrix-assisted autologous chondrocyte transplantation，MACT）中期随访显示出良好疗效，但对于不同患者及不同损伤类型，治疗结果各异。本研究的目的在于对同一手术团队采取同一术式治疗的髌股关节软骨缺损的中期疗效进行前瞻性队列研究，明确髌骨和滑车软骨缺损治疗后是否存在临床愈合结果的差异。

关键词：自体软骨细胞移植膝关节软骨损伤骨损伤修复移植治疗中期疗效基质辅助滑车髌骨

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epidemiological and Clinical Profile and Immediate Outcome of Neonates Transferred from the Maternity Unit to the Neonatology Unit of the CSReF in Commune V of Bamako District, Mali

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Open Journal of Pediatrics 2024年第3期14卷 547-557页

作者： Maimouna Kante Ya Traoré Balilé Harber Beydari Mamadou Traoré Issiaka koné Diéneba Sacko Maimouna Haidara Korotoumou Bamba Assitan Farota Abdoulaye Kassogué Mohamed Diarra Dramane Touré Abdoul Salam Diarra Leyla Maïga Dicko Fatoumata Paediatric Ward CSR&#233f CV Bamako Mali Paediatric Ward of Nianankoro Fomba Hospital S&#233gou Mali Paediatric Ward of Kalaban CoroCSReF Bamako Mali Pediatric Department of the Mopti Reference Health Center Mopti Mali National Centre for Scientific and Technological Research Bamako Mali Paediatrics Department Mohamed VI Perinatal Clinic Bamako Mali Department of Paediatrics Gabriel Tour&#233 University Hospital Bamako Mali

Introduction: Neonatal mortality remains a major public health concern. According to the World Health Organisation (WHO), the number of newborns dying each year has fallen from 5 million in 1990 to 2.4 million in 2019. The aim of our study was to describe the main morbid conditions and their lethality in newborns admitted to the paediatric ward of the CSReF in Commune V. Methodology: We conducted a 12-month prospective descriptive and analytical study from August 2020 to July 2021. Results: During the 12 months of the study, out of 2654 neonates admitted to hospital, 216 met our inclusion criteria, i.e. 8%. Newborns admitted in the first few hours of life represented 99.54% of cases. Full-term newborns accounted for 65.74% of the total. Forty-eight percent of newborns had hypothermia on admission. The most common diagnosis was asphyxia in 55.56% of cases, followed by neonatal infection in 27.78% and prematurity in 10.65%. Death was recorded in 22.2% of cases. Asphyxia was the main cause of neonatal death, followed by prematurity in our context. Conclusion: Improving the prognosis of newborn babies will require a thorough understanding of neonatal pathologies and the implementation of a pre- and perinatal prevention policy.

关键词： Newborns Morbidity Mortality

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ear Cholesteatoma Surgery in South Sahara: Our experience in Bamako

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第4期13卷 293-303页

作者： Kassim Diarra Oumou Coulibaly Yaya Dembele Nfaly konaté Sidibe Youssouf Saydi Ag Mohamed Harouna Sanogo Abraham Diarra Ibrahim Fofana Moussa Bourama Keita Youssouf Traore Fatogoma Issa koné Boubacary Guindo Siaka Soumaoro Doumbia Kadidiatou Singare Mohamed Amadou Keita ORLCCF Department Gabriel Toure University Hospital Bamako Mali ORLCCF Unit Kati Army Polyclinics Kati Mali eNT-CCF Department CHU Luxembourg Bamako Mali ORLCCF Service of the Reference Center of Commune VI Sogoniko Bamako Mali

In Mali, cholesteatoma surgery remains a challenge due to the limited number of otological practitioners, and the low socio-economic level of patients reflecting the difficulties in performing CT or MRI for post-operative follow-up. We therefore initiated this work with the objective of analyzing, through a broad bibliographic review, the clinical, paraclinical, topographical, therapeutic and progressive aspects of a series of ear cholesteatoma. Materials and Method: This was a retrospective and prospective, descriptive study that took place in the eNT and head and neck surgery department of the Gabriel Touré University Hospital over 36 months from November 2020 to October 2023. These were patients admitted to the department for chronic cholestematous otitis media. Result: In total, we collected 34 files of patients admitted for cholesteatoma. This represented 9% of cases compared to all otological surgeries carried out during the same period, i.e. 362 cases. The average age of our patients was 35.31 years, with extremes ranging from 7 years to 80 years, there were 24 men and 10 women, i.e. a M/F ratio of 2.4. The average time to diagnosis was 7 years. The main functional signs were dominated by chronic fetid purulent otorrhea associated with hypoacusis in 94.6% of cases. One case of meningeal complication and three cases of cerebral empyema were reported. Clinically, a postero-superior and marginal tympanic perforation was observed in 53%, a retraction pocket in 5.9%, the sentinel polyp in 9%, and a non-marginal tympanic perforation in 32%. Pure-tone audiometry performed preoperatively for all patients showed conductive hearing loss in 83%. In 82% of cases we created a recess with the creation of a mini box. An ossiculoplasty was performed immediately with fragments of cartilage. The postoperative course found the disappearance of otorrhea (88.23%), the persistence of otorrhea in one case, two cases of facial paralysis, and one case of tinnitus. We did not identify

关键词： Cholesteatoma CT TTO TTF

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Increasing the detail of european land use/cover data by combining heterogeneous data sets

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International Journal of Digital earth 2020年第5期13卷 602-626页

作者： konštantín Rosina Filipe Batista e Silva Pilar Vizcaino Mario Marín Herrera Sérgio Freire Marcello Schiavina european Commission Joint Research Centre(JRC)IspraItaly

Data on land use and land cover(LULC)are a vital input for policy-relevant research,such as modelling of the human population,socioeconomic activities,transportation,environment,and their *** europe,CORINe Land Cover has been the only data set covering the entire continent consistently,but with rather limited spatial *** data sets have provided much better detail,but either have covered only a fraction of europe(*** Atlas)or have been thematically restricted(*** High Resolution Layers).In this study,we processed and combined diverse LULC data to create a harmonised,ready-to-use map covering 41 *** doing so,we increased the spatial detail(from 25 to one hectare)and the thematic detail(by seven additional LULC classes)compared to the CORINe Land ***,we decomposed the class‘Industrial and commercial units’into‘Production facilities’,‘Commercial/service facilities’and‘Public facilities’using machine learning to exploit a large database of points of *** overall accuracy of this thematic breakdown was 74%,despite the confusion between the production and commercial land uses,often attributable to noisy training data or mixed land *** learnt from this exercise are discussed,and further research direction is proposed.

关键词： Data fusion land use land cover machine learning points of interest

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PRePARATION OF ULTRAFINe MONODISPeRSe SILVeR CHLORIDe PARTICLeS IN NON-IONIC ReVeRSeD MICeLLeS

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Chinese Chemical Letters 1995年第12期6卷 1095-1098页

作者： Fang Qiong TANG Junichi TANABe Takeshi KAWAI Kijiro kon-NO Institute of Photographic Chemistry Academia SinicaBeijing 100101 Department of Industrial Chemistry Science University of Tokyo1-3 KagurazakaShinjukuTokyo 162Japan

The ultrafine particles of silver chloride (AgCl) were obtained by mixing two separately prepared reversed micelle systems both containing a non-ionic surfactant,cyclohexane and an aqueous solution of either silver nitrate (AgNO3) or potassium chloride (KCl). The size distribution of spherical AgCl particles depended on the solubility behavior of aqueous electrolytes in surfactant solution. The NMR, near infrared,light-scattering, X-ray, UV spectroscopy and TeM (transmission electron microscopy) were used to examine the relationship between the size of particles and the states of solubilized water or reversed micelles. In the solubilized regions, it was found that three states of water were related to the formation of reversed and swollen micelles or W/O microemulsions. i.e, monodisperse particles were formed in reversed micelle and swollen micelle systems, whereas in W/O microemulsion system the particles became polydisperse.

关键词： R?

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Metrology for sub-Rayleigh-length target positioning in ～1022W/cm2 laser-plasma experiments

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High Power Laser Science and engineering 2024年第3期 95-110页

作者： e.A.Vishnyakov A.Sagisaka K.Ogura T.Zh.esirkepov B.Gonzalez-Izquierdo C.D.Armstrong T.A.Pikuz S.A.Pikuz W.Yan T.M.Jeong S.Singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.Velyhan T.Hayakawa Y.Fukuda J.K.Koga M.Ishino K.kondo Y.Miyasaka A.kon M.Nishikino Y.V.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kumar J.Nejdl D.Margarone P.V.Sasorov S.Weber M.Kando H.Kiriyama Y.Kato,G.Korn K.kondo S.V.Bulanov T.Kawachi A.S.Pirozhkov eLI Beamlines Facility The Extreme Light Infrastructure ERIC Kansai Institute for Photon Science (KPSI) Central Laser Facility Rutherford Appleton LaboratorySTFC Institute for Open and Transdisciplinary Research Initiatives Osaka University HB11 energy Holdings Key Laboratory for Laser Plasmas (Ministry of education) School of Physics and AstronomyShanghai Jiao Tong University Collaborative Innovation Center of IFSA Shanghai Jiao Tong University Institute of Plasma Physics ASCR FZU±Institute of Physics ASCR Czech Technical University in Prague Institute of Laser engineering Osaka University Institute of Physics National Academy of Sciences of Ukraine ISTeQ AR

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a～1022W/cm2laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy （i.e.,around half of the short Rayleigh length）and show that several diagnostics （in particular,3ωreflection and on-axis hard X-rays） can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast （it requires 10±20 laser shots） and does not rely on the coincidence of low-power and high-power focal planes.

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γ-酮醛清道夫水杨胺对尿毒症Apoe-/-小鼠动脉粥样硬化的作用

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西安交通大学学报（医学版） 2020年第1期41卷 47-52页

作者：申燕陈胜男赵艳 VALeNTINA kon 西安交通大学第一附属医院肾内科陕西西安710061 西安交通大学第一附属医院心血管内科陕西西安710061 美国范德堡大学医学中心儿科肾脏与高血压系田纳西纳什维尔37232

目的观察γ-酮醛清道夫水杨胺(salicylamine,SAM)对尿毒症Apoe-/-小鼠动脉粥样硬化(atherosclerosis,AS)及其表型的影响。方法Apoe-/-小鼠通过5/6肾切除术建立尿毒症模型,对照组仅行假手术。实验动物分为对照组、尿毒症组及尿毒症SAM干... 详细信息

目的观察γ-酮醛清道夫水杨胺(salicylamine,SAM)对尿毒症Apoe-/-小鼠动脉粥样硬化(atherosclerosis,AS)及其表型的影响。方法Apoe-/-小鼠通过5/6肾切除术建立尿毒症模型,对照组仅行假手术。实验动物分为对照组、尿毒症组及尿毒症SAM干预组,分别以SAM或安慰剂干预6周。干预结束后检测体质量、血压、血脂、肾功能、血清SAM浓度、主动脉AS斑块面积及斑块组分。结果与对照组相比,尿毒症组主动脉AS病变面积明显增大,AS斑块组分中坏死面积增大,巨噬细胞含量增多,胶原含量减少。SAM干预6周,尿毒症小鼠AS损伤面积、AS斑块中坏死面积及巨噬细胞含量减少,胶原含量增加,但不影响体质量、血压、血脂和肾功能,未发生药物蓄积和毒性作用。结论SAM能减轻尿毒症Apoe-/-小鼠加速发展的AS病变并使斑块的稳定性增加,这些作用不依赖于对血压、血脂或肾功能的影响,同时不引起药物蓄积及毒性作用。

关键词： γ-酮醛清道夫水杨胺尿毒症 Apoe-/-小鼠动脉粥样硬化水杨胺(salicylamine)

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Otological Injuries Observed in Head and Neck Trauma in a Second-Line Hospital

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International Journal of Otolaryngology and Head & Neck Surgery 2022年第3期11卷 119-125页

作者： Ghislaine Neuilly Ngniée Tafo koné Fatogoma Issa Samaké Djibril Timbo Samba Karim Keita Mohamed Reference Health Center of Commune I of Bamako (CSReF) Bamako Mali University Hospital (CHU) Gabriel Touré Bamako Mali Reference Health Center of Commune V of Bamako (CSReF) Bamako Mali

Otological injuries are common during cervicofacial trauma. The aim of this study is to describe the epidemiological characteristics and to map otological injuries during head and neck trauma. This was an observational, descriptive, prospective study conducted at the eNT unit of the Referral Health Center Hospital in Mali from January 2017 to September 2018. Patients with middle and/or inner ear injuries due to trauma were included. The prevalence of otologic injuries was 34.54% of cases. The mean age was 25 years and the sex ratio was 1.11. Students accounted for 42.10%. The mechanism of occurrence was an intentional assault in 68.42% of the cases followed by road traffic accidents (15.79%). The most common functional signs were hearing loss (68.42%), tinnitus (57.89%), and facial paralysis in 5.26%. Otoscopy showed tympanic perforation (47.83%), otorrhagia (21.05%) and otoliquorrhea (5.26%). Rock fractures with osteodural breach (10.53%) and pneumencephaly were found on a CT scan of the rock. The evolution was marked by the regression of the facial paralysis and the healing of the tympanum in 45.45% of the cases. Sequelae persisted in the form of sensorineural deafness (17%). The otological lesions observed during cervicofacial trauma are varied. The challenges in our context are felt at three levels: the improvement of the technical platform, the long-term follow-up of patients, and the cost of care in terms of equipment. These lesions are responsible for disabling deafness, a source of difficulty in social and school integration.

关键词： Otological Lesions Trauma Sequelae Hearing Loss Disability

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