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Acetylsalicylic acid for metal stent in malignant distal common bile duct obstruction:A randomized controlled trial

Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 493-499页

作者： Jin Ho Choi Kyong Joo Lee Woo Hyun Paik Namyoung Park Jung Won Chun Sang Hyub Lee Ji kon Ryu Yong-Tae Kim Department of Internal Medicine Liver Research InstituteSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University Wonju College of MedicineWonjuKorea

Background:Endoscopic biliary drainage is the treatment of choice for patients with malignant distal common bile duct ***-expandable metal stents have clinical advantages including an increased duration of patency that may be prolonged by acetylsalicylic acid(ASA)*** aim of this study was to investigate whether ASA had a positive effect on the patency of self-expandable metal stents compared with ***:This prospective,multicenter,double-blinded,and randomized placebo-controlled trial was conducted from October 2017 to May 2020 in *** who underwent palliative endoscopic biliary drainage with self-expandable metal stents for malignant distal bile duct obstruction were enrolled,and allocated to ASA treatment or *** study outcomes were the rate of stent dysfunction at 6 months,duration of stent patency,risk factors for stent dysfunction,and any adverse ***:Interim analysis included 24 and 28 patients in the ASA and placebo groups,*** was no significant difference between the ASA and placebo groups in stent dysfunction(25.0%vs.20.7%,P=0.761)or the duration of stent patency(150.97±10.55 vs.158.07±8.70 days,P=0.497).Six patients experienced suspected ASA-related adverse events,and there was one lethal ***:ASA did not prolong stent *** study was terminated early because of the possibility of serious adverse events related to ASA treatment of these patients receiving palliative care.

关键词： Endoscopic retrograde cholangiopancreatography Self expandable metallic stents Randomized controlled trial Acetylsalicylic acid

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Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma

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Genes & Diseases 2022年第6期9卷 1727-1741页

作者： Nattawan Suwannakul Napat Armartmuntree Raynoo Thanan Kaoru Midorikawa Tetsuo kon Shinji Oikawa Hatasu Kobayashi Ning Ma Shosuke Kawanishi Mariko Murata Department of Environmental and Molecular Medicine Mie University Graduate School of MedicineTsuMie 514-8507Japan Department of Biochemistry Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Laboratory of Functional Genomics Graduate School of BioscienceNagahama Institute of Bioscience and TechnologyNagahamaShiga 526-0829Japan Graduate School of Health Science Suzuka University of Medical ScienceSuzukaMie 513-8670Japan Faculty of Pharmaceutical Sciences Suzuka University of Medical ScienceSuzukaMie 513-8670Japan

Alterations in cellular metabolism may contribute to tumor proliferation and *** of the facilitative glucose transporter(GLUT)plays a key role in promoting ***5 mediates modulation of fructose utilization,and its overexpression has been associated with poor prognosis in several ***,its metabolic regulation remains poorly ***,we demonstrated elevated GLUT5 expression in human cholangiocarcinoma(CCA),using RNA sequencing data from samples of human tissues and cell lines,as compared to normal liver tissues or a cholangiocyte cell *** exhibiting highexpression of GLUT5 showed increased rates of cell proliferation and ATP production,particularly in a fructose-supplemented *** contrast,GLUT5 silencing attenuated cell proliferation,ATP production,cell migration/invasion,and improved epithelialemesenchymal transition(EMT)***,fructose consumption increased tumor growth in a nude mouse xenograft model,and GLUT5 silencing suppressed growth,supporting the tumor-inhibitory effect of GLUT5 ***,in the metabolic pathways of fructolysis-Warburg effect,the expression levels of relative downstream genes,including ketohexokinase(KHK),aldolase B(ALDOB),lactate dehydrogenase A(LDHA),and monocarboxylate transporter 4(MCT4),as well as hypoxia-inducible factor 1 alpha(HIF1A),were altered in a GLUT5 expression-dependent *** together,these findings indicate that GLUT5 could be a potential target for CCA therapeutic approach via metabolic regulation.

关键词： Cholangiocarcinoma Fructose Glucose transporter 5 Metabolic regulation Warburg effect

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SNOMED CT: A Clinical Terminology but Also a Formal Ontology

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Journal of Biosciences and Medicines 2023年第11期11卷 326-333页

作者： Constant Joseph koné Michel Babri Jean Marie Rodrigues Félix Houphouë t-Boigny National Polytechnic Institute Yamoussoukro Cote d’Ivoire University Jean Monnet Saint Etienne France

Context and Objective: Over the past few decades, terminologies developed for clinical descriptions have been increasingly used as key resources for knowledge management, data integration, and decision support to the extent that today they have become essential in the biomedical and health field. Among these clinical terminologies, some may possess the characteristics of one or several types of representation. This is the case for the Systematized Nomenclature of Human and Veterinary Medicine—Clinical Terms (SNOMED CT), which is both a clinical medical terminology and a formal ontology based on the principles of semantic web. Methods: We present and discuss, on one hand, the compliance of SNOMED CT with the requirements of a reference clinical terminology and, on the other hand, the specifications of the features and constructions of descriptive of SNOMED CT. Results: We demonstrate the consistency of the reference clinical terminology SNOMED CT with the principles stated in James J. Cimino’s desiderata and we also show that SNOMED CT contains an ontology based on the EL profile of OWL2 with some simplifications. Conclusions: The duality of SNOMED CT shown is crucial for understanding the versatility, depth, and scope in the health field.

关键词： SNOMED CT Clinical Terminology Ontology OWL2

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Analysis of Social Networks among Students in Abidjan City

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Open Journal of Applied Sciences 2022年第8期12卷 1339-1351页

作者： Aliou Bamba Aladji Kamagaté Moussa Koivogui Douatia koné Direction de la Recherche et de l’Innovation Technologique (DRIT) Ecole Supérieure Africaine des TIC (ESATIC) Blvd Marseille Abidjan Cote d’Ivoire Wireless Acoustics Environment & Expert Systems (WAVES) iMEC Department of Information Technology Ghent University Ghent Belgium Département de Mathématiques Physique et Chimie Université Péléforo Gon Coulibaly (UPGC) Korhogo C&ocirc te d’Ivoire Agence Nationale de la Recherche (ANR) Paris France

This paper investigates the social networks usage by students in Abidjan city, Côte d’Ivoire. We focus on a descriptive or quantitative analysis to understand the motivations and how students make use of internet and social networks. More than six hundred forms were distributed to persons we have deemed as students. In return, we received more than 93% of the forms that have been processed. The study highlights the materials and the digital platforms that students used the most. The majority of the respondents reported to have access to the social networks in their mobile phones, with WhatsApp leading this application ranking, followed by Instagram, Facebook, YouTube, and Tik Tok. The survey shows that two third of our respondents are aged from 19 to 25 years old and almost half of the respondents spend daily 2 to 5 hours on digital platforms. The investigation also reveals that the main online activities are the e-commerce, chatting, information, and entertainment. The paper addresses also the online harassment of the students and it shows that more than one tenth of them have been victims of cyber-bullying. This study might be useful for governments, institutions, academia, individuals and professionals in order to communicate efficiently with a given population for a better use of social networks and to prevent students from harassment.

关键词： Social Network Social Media Applications Network Structure View Status Structure View Statistics Digital Platforms Online Harassment

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Analysis of Students’ Preferences and Engagement with Mobile Games: A Study of Game Assets and Colour Impact

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Open Journal of Applied Sciences 2023年第12期13卷 2211-2222页

作者： Venance Saho Zoh Tiémoman koné Yao konan Informatique et Sciences du Numérique Université Virtuelle de C&#244te d’Ivoire Abidjan C&#244te d’Ivoire

Mobile games are gaining in popularity among students, although the factors driving engagement remain poorly understood. This study, conducted among 378 students studying for a Bachelor’s degree in Computer and Digital Sciences at the Université Virtuelle de Côte d’Ivoire, explores the influence of game assets and colours on player engagement. Using an online questionnaire, the study identified students’ gaming preferences and their perception of colours. The results show that the key elements most favoured by students are graphics, sound design, the game system, narrative, interactivity and accessibility. What’s more, colour plays a decisive role in their preferences and commitment to educational mobile games.

关键词： Engagement Game Assets Colour Mobile Games

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Feasibility of Scanopelvimetry in the Medical Imaging Department of the University Hospital of Point “G”.

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Open Journal of Medical Imaging 2022年第3期12卷 157-164页

作者： Abdoulaye koné Moussa konaté Youssouf koné Moussa Traore Youssouf Diawara Ibrahima Coulibaly Ouncoumba Diarra fatoumata Kalapo Amadou Doumbia Kassim Sidibe Cheick Oumar Touré Oumar Aba Ata Mody A. Camara Mamadou Sima Coulibaly Salia Mahamadou Diallo Adama Diaman Keita Siaka Sidibé Faculty of Medicine and Odontostomatology Bamako Mali Medical Imaging Department of the University Hospital of Point G Bamako Mali Radiology Department of the Jacques Boutard Hospital Saint-Yrieix-la-Perche France Medical Imaging Department of GABRIEL TOURE Hospital Bamako Mali Radiology Department of CSREF Commune III Bamako Mali Medical Imaging Service Health Center of Ref Commune VI Bamako Mali DCSSA Kati Mali Medical Imaging Service Health Center of Ref Commune IV Bamako Mali Medical Imaging Service of the Mali Hospital Bamako Mali. Surgery of Gynecology-Obstetrics CHU Point G Bamako Mali Medical Imaging Department CHU BSS Kati Mali

Purpose: The purpose of our study was to describe the technique of scanopelvimetry used in the radiology department of the Point G University Hospital, to specify the indications of scanopelvimetry in the department and to evaluate the cost of radiopelvimetry. Patients and Method: This was a prospective, cross-sectional study that took place over a 12-month period from January 1 to December 31, 2018. It focused on pregnant women in whom scanopelvimetry was performed in the medical imaging department of Point G University Hospital during the study period. Results: Out of 8615 CT examinations performed in the radiology department, we collected 65 cases of scanopelvimetry, i.e., 0.7% of the CT examinations. Primigravida and paucigravida dominated the study (40% each). In 60% of the pregnant women the height was less than 150 cm. The most frequent indication for CT scanning was clinical pelvic narrowing (50%). In 80% of the cases, the scanopelvimetry was performed after 37 weeks of amenorrhea. A predominance of narrowing of the superior strait was noted (40%). 4.6% of the pregnant women had a Magnin index of less than 20. CT scanopelvimetry is a feasible examination in our context but the level of demand is low because of the high cost of the examination (49500 fca). Conclusion: In light of the results obtained, we can say that CT pelvimetry allows us to predict the probable route of delivery and thus we can reduce the risk of fetomaternal morbidity and mortality to improve maternal and child health.

关键词： Scanopelvimetry Prognosis Magnin Index Delivery

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热带草原棕榈树的空间格局及其时间变异性

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Journal of Plant Ecology 2022年第5期15卷 1049-1064页

作者： Amara Sidiki Traoré Kouadio Ignace Kouassi Moussa koné Jacques Gignoux Sébastien Barot UFR des Sciences de la Nature UniversitéNANGUI ABROGOUACentre de Recherche en EcologieStation d'Ecologie de LamtoAbidjanCote d'Ivoire Institute of Ecology and Environmental Sciences Paris Sorbonne UniversiteUniversitéde ParisUPECCNRSINRAIRDParisFrance

物种的空间分布和关联可以提供林分的基本信息及动态。然而,由于树木的空间分布和关联依赖于不同尺度下的环境因子,要弄清环境异质性和植物间相互作用的影响,需要选择合适的空间模型进行分析。本研究分析了同一热带草原棕榈树的种群空... 详细信息

物种的空间分布和关联可以提供林分的基本信息及动态。然而,由于树木的空间分布和关联依赖于不同尺度下的环境因子,要弄清环境异质性和植物间相互作用的影响,需要选择合适的空间模型进行分析。本研究分析了同一热带草原棕榈树的种群空间分布,并假设这些分布在20年内发生了变化。为了消除大规模环境异质性的影响,采用异质性泊松零模型下的非均质L-函数。研究结果发现:(ⅰ)与20年前不同,稀树草原地区的成年树种呈规则分布而非聚集分布:(ⅱ)虽然幼苗和幼树的空间分布总是呈聚集状,但聚集区域面积(强度)在减少:(ⅲ)除幼树期,其它阶段均与富养斑块无关联,这也与20年前不同;(ⅳ)没有两个研究地点在结构上有特别的差异,只是雌性棕榈树在空间上与保护区的整叶幼苗有关联,而在乡村,它们在空间上是相互独立的。我们的研究证明,空间分布发生了部分变化,同时对空间异质性的管理也更加完善,模拟结果也更精确。

关键词：空间异质性棕榈树异质性泊松零模型空间分布空间关联 Lamto保护区

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Update on acute myeloid leukemia stem cells:New discoveries and therapeutic opportunities

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World Journal of Stem Cells 2016年第10期8卷 316-331页

作者： Maximilian Stahl Tae kon Kim Amer M Zeidan Section of Hematology Department of Internal MedicineYale School of Medicine

The existence of cancer stem cells has been wellestablished in acute myeloid leukemia. Initial proof of the existence of leukemia stem cells(LSCs) was accomplished by functional studies in xenograft models making use of the key features shared with normal hematopoietic stem cells(HSCs) such as the capacity of self-renewal and the ability to initiate and sustain growth of progenitors in vivo. Significant progress has also been made in identifying the phenotype and signaling pathways specific for LSCs. Therapeutically, a multitude of drugs targeting LSCs are in different phases of preclinical and clinical development. This review focuses on recent discoveries which have advanced our understanding of LSC biology and provided rational targets for development of novel therapeutic agents. One of the major challenges is how to target the selfrenewal pathways of LSCs without affecting normal HSCs significantly therefore providing an acceptable therapeutic window. Important issues pertinent to the successful design and conduct of clinical trials evaluating drugs targeting LSCs will be discussed as well.

关键词： Leukemia stem cells Cancer stem cells Acute myeloid leukemia Stem cell niche Xenotransplantation Plerixafor NF-kB C-X-C chemokine receptor type 4

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Methyl Orange removal by a novel PEI-AuNPs-hemin nanocomposite

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Journal of Environmental Sciences 2017年第3期29卷 278-283页

作者： Weiwen Hu Xuehua Yu Qiong Hu Jinming kon Lianzhi Li Xueji Zhan School of Environmental and Biological Engineering Nanjing University of Science&TechnologyNanjing 210094China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical EngineeringLiaocheng UniversityLiaocheng 252000China Chemistry Department College of Arts and SciencesUniversity of South FloridaFL 33620-4202USA

A novel poly（ethyleneimine）/Au nanoparticles/hemin nanocomposite （PEI-AuNPs-Hemin） acting for Methyl Orange （MO） removal has been synthesized. PEI-AuNPs was prepared firstly and it was then linked to heroin through the coupling between carboxyl groups in hemin and amino groups in PEI without the activation of carboxyl groups. The high reactivity and stability of AuNPs contributed greatly in the formation of the amido bonds in the nanocomposite. Fourier transform infrared spectroscopy, transmission electron microscopy and UV-visible spectroscopy were used to characterize the PEI-AuNPs-Hemin. Results show that PEI-AuNPs-Hemin has strong adsorption for MO. Adsorption and degradation experiments were carried out at different pHs, nanocomposite concentrations and UV irradiation times. Removal of MO in acidic solutions was more effective than in basic solutions. The real-time study showed that the MO degradation with the nanocom- posite under UV irradiation was a fast process. In addition, the photocatalytic degradation mechanism was proposed. The study suggests that the PEI-AuNPs-Hemin may have promising applications in environmental monitoring and protection.

关键词： Poly(ethyleneimine)HeroinAu nanoparticleNanocompositeMethyl Orange removal

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Experimental symmetric private information retrieval with measurement-device-independent quantum network

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Light(Science & Applications) 2022年第10期11卷 2399-2405页

作者： Chao Wang Wen Yu kon Hong Jie Ng Charles C.-W.Lim Department of Electrical&Computer Engineering National University of SingaporeSingaporeSingapore Centre for Quantum Technologies National University of SingaporeSingaporeSingapore

Secure information retrieval is an essential task in today's highly digitised *** some applications,it may be necessary that user query's privacy and database content's security are *** these settings,symmetric private information retrieval(SPIR)could be employed,but its implementation is known to be demanding,requiring a private key-exchange network as the base ***,we report for the first time a realisation of provably-secure SPIR supported by a quantum-secure key-exchange *** SPIR scheme looks at biometric security,offering secure retrieval of 582-byte fingerprint files from a database with 800 *** experimental results clearly demonstrate the feasibility of SPIR with quantum secure communications,thereby opening up new possibilities in secure distributed data storage and cloud computinq over the future Quantum Internet.

关键词： database network quantum

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