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Dendritic spine degeneration:a primary mechanism in the aging process

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neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto nicolini Andrea Judith vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(InCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto nacional de Medicina Genómica(InMEGEn) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in liv.n. beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and ev.n.includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a liv.n. organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

MODELInG THE KnOWLEDGE CREATIOn PROCESS OF GRADUATE RESEARCH

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Journal of Systems Science and Systems Engineering 2018年第6期27卷 790-809页

作者： J. Sun J. Tian v.n. Huynh Y. nakamori School of Knowledge Science Japan Advanced lnstitute of Science and Technology lshikawa Japan School of Computer Science and Technology Wuhan University of Technology Wuhan China

Graduate students who are beginning academic research want to learn how to create and verify new knowledge in their research. Their supervisors, on the other hand, are seeking appropriate research environments including effective research guidance methods. In order to meet these demands, this paper proposes a knowledge creation model that supports the objectives of both graduate students and their supervisors. This is an academic knowledge creation model for individuals supported by a group and its origin can be traced back to a famous organizational knowledge creation model. Since this type of model is constructed from empirical knowledge, it is not easy to prove its objective significance. But, this paper tries to show the effectiv.n.ss of the proposed model as an initial stage of model validation based on a questionnaire survey of students in a graduate school in China.

关键词： Knowledge creation model graduate students research ability research environment

Dynamic verification of newton's Law and the Principal Limits in Measuring Intermediate-Range Forces

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Chinese Physics Letters 1991年第12期8卷 607-610页

作者： Kolosnitsyn n.I. LUO Jun Melnikov v.n. Huaxhong University of Science and Technology Wuhan 430074

According to the controversial results of recent experiments for fifth force,we present a clasaiEcation of all poasibk types of theories leading to non-newtonian *** theoretical analysis shows that if the interaction potential differs from the newton's law the interactions of macro-and micro-bodies are in gen-eral dis£*** calculation also shows that Long's result can be improved by several orders if the new method proposed is used.

关键词： newtonian orders interaction

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Adv.n.ed Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular ev.n.s,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prev.n. central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relev.n. role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

多年冻土地区金刚石矿的环境问题——以Yakutia西北部Anabar矿为例(英文)

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冰川冻土 2004年第S1期26卷 257-262页

作者： v.n. Makarov Permafrost Institute Siberian Branch of Russian Academy of Sciences Yakutsk 677010 Russia

Placer diamond mining in the Anabar area involves various operations that cause long-term (nearly a quarter of a century) environmental impacts. The long history of mining activities, the technology used to mine the placers, as well as the poor assimilative capacity of the natural systems can result in serious environmental impacts in the area. The primary geochemical processes in the diamond-bearing area are affected by the occurrence of permafrost and relict ice, the lengthy duration of ice cover in water bodies, and the widespread development of cryogenic processes. This promotes physical migration of contaminants, cryogenic metamorphization of waters, and long-term accumulation of organic contaminants in low-temperature, reduction and sedimentation barriers. In this paper, some environmental and geochemical effects of diamond mining in the Arctic area are discussed.

关键词： geoenvironmental diamond mining permafrost water hydrogeochemical anomalies concentrations

A Semi-Analytical Approach to Green＇s Functions for Problems in Multiply-Connected Regions on a Spherical Surface

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Journal of Mathematics and System Science 2013年第12期3卷 597-601页

作者： v.n. Borodin Computational Science Program Middle Tennessee State University Murfreesboro TN USA

This work aims at potential fields generated by point sources in conductive perforated fragments of spherical shells. Such fields are interpreted as profiles of Green＇s functions of relev.n. boundary-value problems stated in multiply-connected regions for Laplace equation written in geographical coordinates. Those are efficiently computed by a modification of the method of functional equations, with closed analytical forms preliminary obtained for Green＇s functions for the corresponding simply-connected regions.

关键词： Green's function Laplace equation spherical coordinates surfaces with apertures.

Enhancing interfacial Li+transport and dielectric properties in poly(ethylene oxide)-based all-solid electrolytes via inactive g-C_(3)n_(4)nanosheets filler incorporation

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Journal of Materials Science & Technology 2024年第16期183卷 184-192页

作者： Zhixuan Li Weijian Zhang Yue Chen Qiaoquan Lin Long Zhang Jianming Tao Oleg v.kolosov Jiaxin Li Yingbin Lin Zhigao Huang College of Physics and Energy Fujian Normal UniversityFujian Provincial Key Laboratory of Quantum Manipulation and New Energy MaterialsFuzhou 350117China Fujian Prov.n.ial Engineering Technical Research Centre of Solar-Energy Conversion and Stored Energy Fuzhou 350117China Fujian Prov.n.ial Collaborative Innovation Centre for Adv.n.ed High-Field Superconducting Materials and Engineering Fuzhou 350117China Physics Department Lancaster UniversityLancaster LA14YBUK The Faraday Institution Quad OneBecquerel AvenueHarwell CampusDidcotOX110RAUK

The adv.n.ement of all-solid-state Li metal batteries(ASSLMBs)faces a major challenge in the growth of lithium dendrites on the anode-electrolyte *** this study,we propose a dual-filler approach using poly(ethylene oxide)(PEO)-based solid polymer electrolytes(SPEs)that combine Li_(1.4)Al_(0.4)Ti_(1.6)(PO_(4))_(3)(LATP)ion-conductive particles with graphitic carbon nitride(g-C_(3)n_(4))*** through sec-ond harmonic resonance enhanced electrostatic force microscopy and critical current density(CCD)tests reveal that the g-C_(3)n_(4)additives form nano-capacitors at the SPE-lithium interface,effectively reducing sudden changes in current *** distribution of relaxation time constant(DRT)measurements confirms that the g-C_(3)n_(4)filler suppresses uncontrolled Li dendrite growth,effectively mitigating battery aging caused by anode interfacial ***,X-ray photoelectron spectroscopy(XPS)anal-ysis indicates that the nitrogen-containing organic groups in g-C_(3)n_(4)are reduced to form a stable interfa-cial layer with lithium *** a result of these enhancements,the electrolyte demonstrates remarkable interfacial stability in Li/Li symmetrical cells at 0.65 mA/cm2 and delivers promising performance in assembled Li-LiFePO4 batteries,achiev.n. a reversible capacity of 121.6 mAh/g at 1 C after 200 *** findings highlight the potential of dual-filler PEO-based SPEs for promoting interfacial lithium-ion transport in all-solid-state Li metal batteries.

关键词： Lithium metal anode Lithium dendrite Dielectric force microscopy All-solid-state electrolyte Lithium ion batteries

Experimental and numerical investigation of controlled disturbances development from two sources in supersonic boundary layer

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Adv.n.es in Aerodynamics 2019年第1期1卷 288-300页

作者： G.L.kolosov A.D.Kosinov A.n.Semenov A.A.Yatskikh Khristianovich Institute of Theoretical and Applied Mechanics SB RAS Novosibirsk 630090Russia

The paper presents the experimental results and the results of direct numerical simulation of the development and interaction of two wave trains from two point sources of controlled disturbances in a supersonic boundary layer on a flat plate with an incident flow Mach number of *** were located parallel to the leading edge of the *** the introduction of controlled disturbances into the boundary layer,the normal component of the mass flow rate was varied in the *** the experiment,periodic glow discharges at a frequency of 20 kHz were *** both cases,the disturbances sources worked *** flow rate pulsations were measured and recorded in sections,parallel to the leading edge of the model,near the maximum of disturbances along the boundary *** the experiment,a constanttemperature hot-wire anemometer was *** performing a discrete Fourier transform,the spatial distributions of disturbances,the beta-spectra were determined,and the wave characteristics of the development of disturbances downstream were *** addition,direct numerical simulation of the downstream development of disturbances from a single source was *** work presents a comparison of experimental and theoretical calculated *** paper discusses the effects inherent in the interaction of unstable traveling controlled disturbances from two sources operating synchronously.

关键词： :DnS Computational modeling Supersonic boundary layer Compressibility Discharge Flat plate Hot-wire anemometer Instability Turbulence