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Serum Omega-6/Omega-3 Ratio and Risk Markers for Cardiovascular Disease in an Industrial Population of Delhi

Food and Nutrition Sciences 2013年第9期4卷 94-97页

作者： Ruby Gupta Ramakrishnan Lakshmy Ransi Ann Abraham kolli srinath reddy Panniyammakal Jeemon Dorairaj Prabhakaran Center for Chronic Disease Control New Delhi India Center for Chronic Disease Control New Delhi India Public Health Foundation of India New Delhi India Department of Cardiac Biochemistry AIIMS New Delhi India Public Health Foundation of India New Delhi India South Asia Network for Chronic Disease New Delhi India Center for Chronic Disease Control New Delhi India

High omega-6/omega-3 ratio intake promotes development of many chronic diseases. Secondary prevention studies though have demonstrated a decline in progression of many such diseases after reducing the intake, specific biochemical indices of cardiovascular disease risk markers have not been evaluated. We have evaluated the circulating levels of omega-6/omega-3 ratio and its effect on cardiovascular risk markers in India. Present study was conducted in industrial setting where employees were randomly selected. Data on their demographic characteristics were collected using pre-tested questionnaire. Fasting blood samples were collected from all the participants. Serum was separated and stored at-80℃ till the time of analysis. Lipids were estimated using standard kits. Fatty acids in serum were estimated by Gas chromatography. The identified Omega-3 fatty acid included were 18:3 (Alpha-linolenic acid), 20:5 (Eicosapentenoic acid) & 22:6 (Docosahexenoic acid). Among omega-6 included were 18:2 (linoleic acid), 18:3 (gamma-linolenic acid) & 20:4 (Arachidonic acid). Complete data was available for 176 participants (89% males and 11% females) with mean age of 47.23 ± 6.00 years. The bmi of the participants was 24.88 ±3.43 Kg/m2 and waist circumference was 91.50 ±9.56 cm. The median of omega-6/omega-3 ratio in the study population was 36.69 (range: 6.21 -?183.69). The levels of total cholesterol, triglycerides, ldl-cholesterol and cholesterol/hdl ratio and apo B correlated significantly with omega-6/3 ratio. There was no correlation observed with hsCRP and LDL-particle size. A direct relationship of omega-6/ omega-3 ratio with dyslipidemia was observed in our study.

关键词： Omega Fatty Acids Dyslipidemia Omega 6/3 Ratio CHD hs CRP

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Association of obesity with hypertension and type 2 diabetes mellitus in India:A meta-analysis of observational studies

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World Journal of Diabetes 2018年第1期9卷 40-52页

作者： Giridhara R Babu GVS Murthy Yamuna Ana Prital Patel R Deepa Sara E Benjamin-Neelon Sanjay Kinra K srinath reddy Public Health Foundation of India IIPH-HBangalore CampusSIHFW PremisesBeside Leprosy HospitalBangalore 560023India Indian Institute of Public Health-Hyderabad Plot#1A.N.V.ArcadeAmar Co-op SocietyKavuri HillsMadhapurHyderabad 500033India London School of Hygiene and Tropical Medicine London WC1E 7HTUnited Kingdom Indian School of Business Hyderabad 500111India Johns Hopkins Bloomberg School of Public Health BaltimoreMD 21205United States Department of Non-Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine and University College London HospitalLondon WC1E 7HTUnited Kingdom Public Health Foundation of India ISID Campus4 Institutional Area Vasant KunjNew Delhi 110070India

AIM To perform a meta-analysis of the association of obesity with hypertension and type 2 diabetes mellitus(T2DM) in India among adults. METHODS To conduct meta-analysis, we performed comprehensive, electronic literature search in the PubM ed, CINAHL Plus, and Google Scholar. We restricted the analysis to studies with documentation of some measure of obesity namely; body mass index, waist-hip ratio, waist circumference and diagnosis of hypertension or diagnosis of T2DM. By obtaining summary estimates of all included studies, the meta-analysis was performed using both RevM an version 5 and "metan" command STATA version 11. Heterogeneity was measured by I^2 statistic. Funnel plot analysis has been done to assess the study publication *** Of the 956 studies screened, 18 met the eligibility criteria. The pooled odds ratio between obesity and hypertension was 3.82(95%CI: 3.39 to 4.25). The heterogeneity around this estimate(I^2 statistic) was 0%, indicating low variability. The pooled odds ratio from the included studies showed a statistically significant association between obesity and T2DM(OR = 1.14, 95%CI: 1.04 to 1.24) with a high degree of *** Despite methodological differences, obesity showed significant, potentially plausible association with hypertension and T2DM in studies conducted in India. Being a modifiable risk factor, our study informs setting policy priority and intervention efforts to prevent debilitating complications.

关键词： Obesity Meta-analysis Hypertension Type 2 diabetes mellitus

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