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Towards a respondent-preferred k_i-anonymity model

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Frontiers of Information Technology & Electronic Engineering 2015年第9期16卷 720-731页

作者： kok-seng wong Myung Ho KIM School of Computer Science and Engineering Soongsil University School of Software Soongsil University

Recently, privacy concerns about data collection have received an increasing amount of attention. In data collection process, a data collector （an agency） assumed that all respondents would be comfortable with submitting their data if the published data was anonymous. We believe that this assumption is not realistic because the increase in privacy concerns causes some re- spondents to refuse participation or to submit inaccurate data to such agencies. If respondents submit inaccurate data, then the usefulness of the results from analysis of the collected data cannot be guaranteed. Furthermore, we note that the level of anonymity （i.e., k-anonymity） guaranteed by an agency cannot be verified by respondents since they generally do not have access to all of the data that is released. Therefore, we introduce the notion of ki-anonymity, where ki is the level of anonymity preferred by each respondent i. Instead of placing full trust in an agency, our solution increases respondent confidence by allowing each to decide the preferred level of protection. As such, our protocol ensures that respondents achieve their preferred kranonymity during data collection and guarantees that the collected records are genuine and useful for data analysis.

关键词： Anonymous data collection Respondent-preferred privacy protection k-anonymity

Disease Progression, Response to ACEI/ATRA Therapy and Influence of ACE Gene in IgA Nephritis

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Cellular & Molecular Immunology 2007年第3期4卷 227-232页

作者： Keng-Thye Woo Yeow-kok Lau Yi Zhao Fang-E Liu Hwee-Boon Tan Eng-Keng Tan Fook-Chong Stephanie Choong-Meng Chan kok-seng wong Department of Renal Medicine Singapore General Hospital Singapore Clinical Research Singapore General Hospital Singapore Department of Paediatrics The 2nd Hospital Shandong University Jinan Shandong China

Various studies have shown that angiotensin-converting enzyme （ACE） gene insertion/deletion （ID） polymorphism may play a role in the progression to end stage renal failure （ESRF） in patients with IgA nephritis （IgAN）. In this randomized controlled trial, patients were followed up for 5 years to determine their long-term renal outcome to ACEI/ATRA therapy and to ascertain if their ACE gene profile could play a role in determining their response to therapy. Seventy-five patients with IgAN were enlisted. Thirty-seven were on ACEI/ATRA therapy for 62 ± 5 months and thirty-eight were untreated and served as controls. All patients had their ACE gene ID polymorphism genotyped. Compared to controls, treated patients had lower serum creatinine （p 〈 0.001）, lower proteinuria （p 〈 0.002） and fewer numbers progressing to ESRF （p 〈 0.002）. Among patients with genotype II, there were less ESRF in the treatment group when compared to the untreated control group （p 〈 0.02）. The advantage of therapy was not seen in patients with ID or DD genotypes. ACEI/ATRA therapy was found to be effective in retarding disease progression in IgAN with years to ESRF significantly extended in patients at all levels of renal function, including patients whose outcome were ESRF. Genotyping showed better response to therapy only for those with genotype Ⅱ. The common mechanism is probably through lower levels of ACE, glomerular pressure and proteinuria resulting in reduced renal damage and retardation of progression to ESRF. Cellular ＆ Molecular Immunology.

关键词： ACE gene ID polymorphism ACEI/ATRA therapy end-stage renal failure

A retrospective Aliskiren and Losartan study in non-diabetic chronic kidney disease

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World Journal of Nephrology 2013年第4期2卷 129-135页

作者： Keng-Thye Woo Hui-Lin Choong kok-seng wong Han-Kim Tan Marjorie Foo Fook-Chong Stephanie Evan JC Lee Vathsala Anantharaman Grace SL Lee Choong-Meng Chan Department of Renal Medicine Singapore General Hospital Department of Clinical Research Singapore General Hospital Department of Nephrology National University of Singapore

AIM： To assess the effcacy of combined Aliskiren and Losartan vs high dose Losartan and Aliskiren alone in chronic kidney disease （CKD）.METHODS： This is a retrospective study of 143 pa-tients with non-diabetic CKD comparing combined Aliskiren （150 mg/d） with Losartan （100 mg/d） therapy vs High dose Angiotensin receptor blockers （ARB）（Losartan 200 mg/d） and the third group Aliskiren （150 mg/d） alone. This study involved only patient medi-cal records. Entry criteria included those patients who had been treated with the above drugs for at least 36 mo within the 5 years period; other criteria included proteinuria of 1 g or more and or CKD Stage 3 at the start of the 36 mo period. The study utilised primary renal end points of estimated Glomerular Filtration Rate （eGFR）〈 15 mL/min or end stage renal failure. RESULTS： Patients treated with high dose ARB com-pared to the other two treatment groups had signifcantly less proteinuria at the end of 36 mo （ P 〈 0.007）. All 3 groups had signifcant reduction of proteinuria （ P 〈 0.043, P 〈 0.001）. Total urinary protein was signifcantly differ-ent between the 3 groups over the 3-year study period （ P = 0.008）, but not eGFR. The changes in eGFR from baseline to each year were not signifcantly different be-tween the 3 therapeutic groups （ P 〈 0.119）. There were no significant differences in the systolic and diastolic blood pressure between the 3 drug groups throughout the 3 years. The incidence of hyperkalemia （〉 5.5 mmol/L） was 14.2% （7/49） in the Combined Aliskiren and ARB group, 8.7% （4/46） in the Aliskiren alone group and 6.3% （3/48） in the High dose ARB group （ P 〈 0.001）.CONCLUSION： This study in non-diabetic CKD pa-tients showed that Combination therapy with Aliskiren and ARB was effective but was not safe as it was asso-ciated with a high prevalence of hyperkalaemia.

关键词： Aliskiren Chronic kidney disease disease Clinical trial

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi seng Leung Chun Yin Tong Kai Kap wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Feasibility and safety of minimally invasive multivisceral resection for T4b rectal cancer:A 9-year review

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 777-789页

作者： Kai Siang Chan Biquan Liu Ming Ngan Aloysius Tan Kwang Yeong How Kar Yong wong Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND Colorectal cancer is the third most common cancer and the second highest cause of cancer-related mortality *** 5%-10%of patients are diagnosed with locally advanced rectal cancer(LARC)on *** LARC invading into other structures(i.e.T4b),multivisceral resection(MVR)and/or pelvic ex-enteration(PE)remains the only potential curative surgical *** and/or PE is a major and complex surgery with high post-operative *** invasive surgery(MIS)has been shown to improve short-term post-operative outcomes in other gastrointestinal malignancies,but there is little evi-dence on its use in MVR,especially so for robotic *** is a single-center retrospective cohort study from 1st January 2015 to 31st March *** criteria were patients diagnosed with cT4b rectal cancer and underwent MVR,or stage 4 disease with resectable systemic ***-tients who underwent curative MVR for locally recurrent rectal cancer,or me-tachronous rectal cancer were also *** criteria were patients with systemic metastases with non-resectable *** patients planned for elective surgery were enrolled into the standard enhanced recovery after surgery pathway with standard peri-operative management for colorectal *** sur-gery was defined based on technical difficulty of surgery(*** PE,bladder-sparing prostatectomy,pelvic lymph node dissection or need for flap creation).Our primary outcomes were the margin status,and complication ***-gorical values were described as percentages and analysed by the chi-square *** variables were expressed as median(range)and analysed by Mann-Whitney U *** overall survival(OS)and recurrence-free survival(RFS)were analysed using Kaplan-Meier estimates with life table ***-rank test was performed to determine statistical significance between cumulative *** significance was defined as P<*** estimates with li

关键词： Laparoscopy Minimally invasive surgical procedures Multivisceral resection Pelvic Exenteration Rectal neoplasms Robotic surgical procedures

Functional dyspepsia and irritable bowel syndrome,are they different entities and does it matter?

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World Journal of Gastroenterology 2006年第17期12卷 2708-2712页

作者： kok-Ann Gwee Andrew seng Boon Chua Stomach Liver & Bowel Clinic Gleneagles Hospital Singaporeand the Department of MedicineNational University of SingaporeSingapore Ipoh Gastro Centre 31 Lebuh Raya Taman Ipoh Ipoh Garden South31400 IpohPerakMalaysia

A high prevalence of overlap between functional dyspepsia and irritable bowel syndrome has been consistently and universally reported. Recent studies demonstrating shared common pathophysiological disturbances including delayed gastric emptying and visceral hypersensitivity involving more than one region, suggest that these patients have a generalised rather than regional, disorder of the gut. Furthermore, a study of the natural history of dyspepsia suggests that with time, a substantial proportion will evolve into IBS. The recognition of IBS in dyspeptic patients has potentially profound therapeutic importance. It could help to reduce the risk of unnecessary cholecystectomy in IBS patients. The ability to appreciate the extent of involvement could allow us to address the disturbances more comprehensively, and thereby achieve greater patient satisfaction with their treatment.

关键词： Functional dyspepsia Irritable bowel syndrome Common pathophysiology Asian Epidemiology

Dynamic Force Reduction and Heat Transfer Improvement for Horizontal Tubes in Large-Particle Gas-Fluidized Beds

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Journal of Thermal Science 2008年第1期17卷 77-83页

作者： Yusumi Nagahashi John R.Grace kok-seng Lim Yutaka Asako Dept.Mech.Eng. Kochi National College of Technol.KochiJAPAN Professor Dept.Chem.Biological Eng. The University of British ColumbiaVancouverCANADA CSIRO Minerals VictoriaAUSTRALIA Dept.Mech.Eng. Tokyo Metropolitan UniversityTokyoJAPAN

The effects of tube bank configuration on forces and heat transfer were investigated for both two-dimensional and three-dimensional gas fluidized beds. Effective dynamic forces and heat transfer coefficients were measured for several tube bank configurations, and it was found that the average forces are smaller than for a single tube. The heat transfer coefficient can be increased by providing sufficient space for particles to descend around both sides of the tube bank. The results provide useful guidelines for optimizing the configuration of tube banks to achieve high heat transfer coefficients while reducing tube erosion due to dynamic forces.

关键词： fluidized beds forces heat transfer tube arrangement sofid circulation

Composites recycling solutions for the aviation industry

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Science China(Technological Sciences) 2017年第9期60卷 1291-1300页

作者： wong kok RUDD Chris PICKERING Steve LIU XiaoLing Ningbo Nottingham International Academy for the Marine Economy and Technology University of Nottingham Ningbo China Ningbo 315100 China Ningbo Nottingham New Materials Institute University of Nottingham Ningbo China Ningbo 315100 China Division of Materials Mechanics and Structures Faculty of Engineering University of Nottingham Nottingham UK

Ten of thousands of aircraft are expected to retire in the next 20 *** manufacturers are gearing up for a new wave of recycling challenges as these aircrafts contain significant higher amount of carbon fibre reinforced polymer composite,which cannot be recycled by the conventional processes designed for metallic *** manufacturers have been working with the recycling industry to limit unsustainable dismantling that is harmful to the environment and the potential liability risk of re-entry of un-certified salvaged parts back to the aviation *** organised recycling network and procedures have already been set up for the conventional metallic alloys and will soon be required to include the composite *** paper reports the existing aircraft recycling practice and reviews the key recycling technologies for thermoset *** consumptions of these technologies are sought from the literature and are reported in this *** in development of reuse options for the recycled fibre is also included with discussion of their advantages and *** challenge of working with the fluffy fibre is considered and the benefit of fibre alignment is highlighted for encouraging a widespread use of the fibre.

关键词： composite recycling carbon fibre aviation

Basic subgroup and Reid's theorem

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Science China Mathematics 2011年第10期54卷 2249-2251页

作者： NGU Min Hui wong kok Bin wong Peng Choon Institute of Mathematical Sciences University of Malaya

We give conditions under which a torsion-free abelian group is the sum of two basic subgroups.

关键词： torsion-free abelian free abelian basic subgroup pure subgroup