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Salivary Duct Carcinoma of the Parotid Gland Definitively Diagnosed by Immunohistochemical Examination of Pulmonary Metastases

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Case Reports in Clinical Medicine 2014年第3期3卷 118-121页

作者： Mei Yonemoto kojiro onizawa Kenji Yamagata Shogo Hasegawa Toru Yanagawa Hiroki Bukawa Department of Oral and Maxillofacial Surgery Faculty of Medicine University of Tsukuba Tsukuba Japan

Salivary duct carcinoma (SDC) is a rare, high-grade, aggressive malignancy, as having a morphologic resemblance to ductal carcinoma of the breast. We present here an atypical SDC of the parotid gland in a 63-year-old man that was diagnosed from immunohistochemical findings. The immunohistochemistry was similar in the parotid lesion and pulmonary metastases in autopsy specimens, but only the latter showed a cribriform pattern and comedolike necrosis. Although the parotid tumor was treated with concurrent chemoradiotherapy and adjuvant chemotherapy for over 21 months, the patient died of respiratory failure caused by advanced pulmonary metastases.

关键词： Salivary Duct Carcinoma (SDC) Immunohistochemistry Parotid Tumor Pulmonary Metastases Autopsy

Parotid lymph node metastasis in a patient with tongue cancer

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Case Reports in Clinical Medicine 2014年第1期3卷 23-27页

作者： Kenji Yamagata Naomi Ishibashi Kanno Hiroyuki Ito Shogo Hasegawa Toru Yanagawa kojiro onizawa Hiroki Bukawa Department of Oral and Maxillofacial Surgery Faculty of Medi-cine University of Tsukuba Tsukuba Japan

Parotid lymph node (LN) metastasis occurs most commonly from cutaneous squamous cell carcinoma (CSCC) of the head and neck, but rarely from oral squamous cell carcinoma (OSCC). Here, we present a rare case of metastasis to the parotid LN in a patient with tongue cancer. Although usual extent of modified radical neck dissection that includes resection of the tail of the parotid gland is below the line of the mandibular angle and the mastoid process was performed, the parotid LN metastasis occurred. The patient was treated with partial parotidectomy and chemoradiotherapy. One year and two months later, there was no evidence of local recurrence, although multiple lung metastases were observed. We also review the literature on parotid LN metastasis from OSCC.

关键词： Oral Squamous Cell Carcinoma (OSCC) Parotid Lymph Node Metastases Tongue Cancer

Evaluation of an oral moisture-checking device for screening dry mouth

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Open Journal of Stomatology 2013年第8期3卷 440-446页

作者： Yosuke Fukushima Tetsuya Yoda Shoichiro Kokabu Ryuichiro Araki Tsubasa Murata Yoshimasa Kitagawa Ken Omura Shuji Toya Kayoko Ito Saori Funayama Hiroshi Iwabuchi Kazuhiro Asano Yutaka Imai Akihide Negishi Satoshi Yokoo Goichi Matsumoto Eiro Kubota Hideki Watanabe Mikio Kusama kojiro onizawa Takuya Goto Seiji Nakamura Ryuichi Nakazawa Kiyoshi Harada Takashi Fujibayashi Community Health Science Center Saitama Medical University Saitama Japan Department of Dentistry and Oral Surgery Tochigi National Hospital Tochigi Japan Department of Oral and Maxillofacial Surgery Division of Medicine Interdisciplinary Graduate School of Medicine and Engi- neering Univer-sity of Yamanashi Kofu and Tamaho Japan Department of Oral and Maxillofacial Surgery Dokkyo Medical University School of Medicine Tochigi Japan Department of Oral and Maxillofacial Surgery Faculty of Medicine Sai-tama Medical University Saitama Japan Department of Oral and Maxillofacial Surgery Institute of Clinical Medicine University of Tsukuba Tsukuba Japan Department of Oral and Maxillofacial Surgery Jichi Medical University Tochigi Japan Department of Oral and Maxillofacial Surgery Kanagawa Dental College Yokosuka Japan Department of Stomatology and Oral Surgery Gunma University Graduate School of Medicine Maebashi Japan Division of Gereatric Dentistry Niigata University Medical & Dental Hospital Niigata Japan Oral and Maxillofacial Surgery Dry Mouth Clinic The Nippon Dental University Niigata Hospital Niigata Japan Oral Diagnosis and Medicine Department of Oral Pathobiological Science Graduate School of Dental Medicine Hokkaido University Sapporo Japan Oral Surgery Department of Oral Restitution Division of Oral Health Sciences Graduate School Tokyo Medical and Dental University Tokyo Japan Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science Kyushu University Fukuoka Japan

Objective: This multicenter clinical study was to assess the clinical usability of an oral moisture-checking device in detecting the dry mouth patients and evaluating the optimal measurement site. Materials and Methods: The study group comprised 250 patients with dry mouth and 241 healthy volunteer subjects at 13 medical centers. This device was used to measure the moisture degrees of the lingual mucosa and the buccal mucosa. Subjective oral dryness, objective oral dryness, and saliva flow rates were also compared between the two groups. For statistical analysis, receiver-operating characteristic analysis was performed to calculate the area under the curve (AUC). Results: The moisture degree of the lingual mucosa was significantly lower in the dry mouth group (27.2 ± 4.9) than that in the healthy group (29.5 ± 3.1, AUC = 0.653). When a lingual mucosa moisture degree of 31.0 or higher was defined as normal, less than 27.0 as dry mouth, and 27.0 to less than 31.0 as borderline zone of dry mouth, both the sensitivity and the specificity for the diagnosis of dry mouth were close to 80%. Conclusion: These results suggest that the oral moisture-checking device is a usable screening device for dry mouth.

关键词： Dry Mouth Oral Moisture-Checking Device ROC Analysis

Proposal of Walking to Prevent a Fall of a Planetary Exploration Legged Rover Using Effect of Loose Soil Caused by a Propagation of Vibration

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Journal of Artificial Intelligence and Technology 2021年第3期1卷 153-165页

作者： Tomohiro Watanabe kojiro Iizuka Graduate School of Engineering and Science Shibaura Institute of TechnologySaitama City 337-8570Japan Department of Systems and Engineering and Science Shibaura Institute of TechnologySaitama City 337-8570Japan

In this study,a walking method that prevents a fall of the planetary exploration-legged rover is *** the proposed walking method,the leg is sunk by giving vibration to the *** posture of the rover is changed to prevent a fall of the rover by sinking the ***,the relationship between the kind of vibration and the subsidence of the leg is *** this experimental result,the leg is shown to be easy to sink to the ground by giving ***,the larger the vibratory force is,the easier the leg sinks to the ***,the legged testbed walks on the loose ground with a slope using the proposed walking *** this experimental result,the testbed is difficult to fall down when it uses the proposed ***,the angle of a slope that the testbed can walk becomes large by using the proposed walking.

关键词： planetary exploration legged rover fall prevention loose ground vibration

近震源地震波波形资料反演震源破裂过程的可靠性分析

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地球物理学报 2005年第1期48卷 124-131页

作者：周仕勇 kojiro Irikura 北京大学地球与空间科学学院北京100871 日本京都大学防灾研究所

用近震源波形资料拟合反演地震的震源破裂过程 ,所包含的一些不确定因素将对反演结果的精度及可靠性产生影响 .文中的数值实验分析了所假定的反演断层模型参数的某些不确定性对反演结果的影响程度 ,并对观测波形的截取长度对反演精度的... 详细信息

用近震源波形资料拟合反演地震的震源破裂过程 ,所包含的一些不确定因素将对反演结果的精度及可靠性产生影响 .文中的数值实验分析了所假定的反演断层模型参数的某些不确定性对反演结果的影响程度 ,并对观测波形的截取长度对反演精度的影响进行了讨论 .结果表明 :(1)近震源地震波形资料能较好地分辨断层浅部的破裂过程 .然而对断层深部的位错分布的约束和反演能力较差 .联合使用近、远场地震波资料进行反演 ,能反演出一个更为完全的整个断层破裂过程的图像 .(2 )用近震源地震波资料反演时 ,反演结果对所假定的反演断层的走向和倾角非常敏感 .断层走向偏离真实值 2°或倾角偏离真实值 5°都会导致一个虚假的反演结果 .(3)反演中所使用的介质速度结构模型的不确定性 ,也会对反演结果产生影响 .

关键词：地球物理观测震源破裂反演近震源地震波

Analysis of lichen substances including triterpenoids by high performance liquid chromatography with a differential refractive index detector and a photodiode array detector

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菌物学报 2011年第6期30卷 944-949页

作者： Hikari SATO kojiro HARA Masashi KOMINE Yoshikazu YAMAMOTO Graduate School of Bioresource Sciences Akita Prefectural University:Shimoshinjo-nakanoAkita 010-0195Japan

A new method for analysis of lichen triterpenoids was established using high performance liquid chromatography with the combination of a differential refractive index detector(RID) and a photodiode array detector(PDA).It is proved that this method was convenient to detect and identify aromatic and aliphatic lichen substances;it enabled quantitative analysis of substances having no or less absorption of ultraviolet rays such as *** addition,they can be measured in high accuracy compared with the TLC method.

关键词：三萜系化合物青苔 RID 菌物学

STING palmitoylation as a therapeutic target

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Cellular & Molecular Immunology 2019年第3期16卷 236-241页

作者： Anne Louise Hansen kojiro Mukai Francisco J.Schopfer Tomohiko Taguchi Christian K.Holm Department of Biomedicine Aarhus University8000 Aarhus CDenmark Laboratory of Organelle Pathophysiology Department of Integrative Life SciencesGraduate School of Life SciencesTohoku UniversitySendai 980-8578 MiyagiJapan Department of Pharmacology and Chemical Biology University of PittsburghPittsburghPA 15213USA

Gain-of-function mutations in the STING-encoding gene TMEM173 are central to the pathology of the autoinflammatory disorder STING-associated vasculopathy with onset in infancy(SAVI).Furthermore,excessive activity of the STING signaling pathway is associated with autoinflammatory diseases,including systemic lupus erythematosus and Aicardi–Goutières syndrome(AGS).Two independent studies recently identified pharmacological inhibitors of ***,both types of compounds are reactive nitrocontaining electrophiles that target STING palmitoylation,a posttranslational modification necessary for STING *** a consequence,the activation of downstream signaling molecules and the induction of type I interferons were *** compounds were effective at ameliorating inflammation in a mouse model of AGS and in blocking the production of type I interferons in primary fibroblasts from SAVI *** mini-review focuses on the roles of palmitoylation in STING activation and signaling and as a pharmaceutical target for drug development.

关键词： STING Palmitoylation Inflammation SAVI Interferonopathies

Isolated pancreatic metastasis from a malignant pleural mesothelioma diagnosed using endoscopic ultrasonography-guided fne needle aspiration biopsy

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 196-198页

作者： Yuki Ishikawa-Kakiya Hirotsugu Maruyama kojiro Tanoue Shusei Fukunaga Yasuaki Nagami Yasuhiro Fujiwara Department of Gastroenterology Osaka City University Graduate School of Medicine1-4-3AsahimachiAbeno-kuOsaka 545-8585Japan

To the Editor:Malignant pleural mesothelioma is a rare and aggressive form of cancer with a poor prognosis [1].Its progression is mainly a direct invasion from the primary lesion,and metastasis to distant regions rarely *** was found that metastasis of malignant pleural mesothelioma may occur in the liver,adrenal glands,and kidneys in autopsy cases [2].

关键词： metastasis pleural needle

Anti-oxidation activity of ethanol extracts from natural thalli of lichens

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菌物学报 2011年第6期30卷 950-954页

作者： kojiro HARA Marie ENDO Hiroko KAWAKAMI Masashi KOMINE Yoshikazu YAMAMOTO Faculty of Bioresource Sciences Akita Prefectural University241-438 Kaidobata-NishiShimoshinjo-NakanoAkita City 010-0195Japan

Screening test on anti-oxidation activity using 1,1-diphenyl-2-picrylhydrazyl(DPPH) was performed for 99 ethanol extracts of 85 species of natural thalli of lichens in order to find novel anti-oxidation *** 17 extracts of natural thalli showed high anti-oxidation *** them,the activities of extracts from Hypogymnia vittata,Peltigera aphthosa,Nephromopsis ornata,Pseudevernia furfuracea,Cladonia vulcani and Peltigera elizabethae were *** of Peltigera *** higher activity than those of other *** ethanol extract of *** had been separated into ethyl acetate-soluble and water-soluble *** anti-oxidative spots were found only in the water-soluble fractions by thin-layer *** compound in the lower spot had the same Rf value,UV spectrum,and color as authentic solorinine that was previously found as a unique quaternary ammonium compound from Peltigera *** now report that the hydrophilic lichen substance,solorinine showed a nearly same anti-oxidation activity(EC50=120?mol/Lol/L) as standard antioxidant Trolox(EC50=150?mol/L).

关键词：青苔 DPPH 菌物学乙醇