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Underwater persistent bubble-assisted femtosecond laser ablation for hierarchical micro/nanostructuring

International Journal of Extreme Manufacturing 2020年第1期2卷 135-154页

作者： Dongshi Zhang Bikas Ranjan Takuo tanaka koji Sugioka RIKEN Center for Advanced Photonics 2-1 HirosawaWakoSaitama 351-0198Japan Innovative Photon Manipulation Research Team RIKEN Center for Advanced PhotonicsWakoSaitama 351-0198Japan Metamaterials Laboratory RIKEN Cluster for Pioneering ResearchWakoSaitama 351-0198Japan

In this study,we demonstrate a technique termed underwater persistent bubble assisted femtosecond laser ablation in liquids(UPB-fs-LAL)that can greatly expand the boundaries of surface micro/nanostructuring through laser ablation because of its capability to create concentric circular macrostructures with millimeter-scale tails on silicon ***-tailed macrostructures are composed of layered fan-shaped(central angles of 45°–141°)hierarchical micro/nanostructures,which are produced by fan-shaped beams refracted at the mobile bubble interface(.50°light tilt,referred to as the vertical incident direction)during UPB-fs-LAL line-by-line *** flow generated during UPB-fs-LAL induces bubble *** scanning(e.g.1mms−1)allows a long bubble movement(as long as 2mm),while slow scanning(e.g.0.1mms−1)prevents bubble *** persistent bubbles grow considerably(*** of microns in diameter)due to incubation effects,they become sticky and can cause both gas-phase and liquidphase laser ablation in the central and peripheral regions of the persistent *** generates low/high/ultrahigh spatial frequency laser-induced periodic surface structures(LSFLs/HSFLs/UHSFLs)with periods of 550–900,100–200,40–100 nm,which produce complex hierarchical surface structures.A period of 40 nm,less than 1/25th of the laser wavelength(1030 nm),is the finest laser-induced periodic surface structures(LIPSS)ever created on *** NIR-MIR reflectance/transmittance of fan-shaped hierarchical structures obtained by UPB-fs-LAL at a small line interval(5μm versus 10μm)is extremely low,due to both their extremely high light trapping capacity and absorbance characteristics,which are results of the structures’additional layers and much finer *** the absence of persistent bubbles,only grooves covered with HSFLs with periods larger than 100 nm are produced,illustrating the unique attenuation abilities of laser properties(*** rate,energy,inciden

关键词： hierarchical micro/nanostructures persistent bubble femtosecond laser surface structuring beam refraction fan-shaped microstructure LIPSS

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院内共享的出院小结系统的开发和利用

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医学信息（西安上半月） 2007年第9期20卷 1529-1533页

作者：郭锦秋田中亨治佐藤纯三高田彰吉原博幸大连医科大学学报编辑部中国大连116027 日本熊本大学附属医院医疗情报部日本京都大学附属医院医疗情报部

为了实现出院小结电子化,使医疗信息在院内共享,并与其他医疗机构能进行协同医疗,日本熊本大学附属医院开发了一套独立于医嘱录入系统的出院小结信息系统。该系统采用WEB浏览器的界面,部分数据在患者出院时自动以XML(eXtensible Markup ... 详细信息

为了实现出院小结电子化,使医疗信息在院内共享,并与其他医疗机构能进行协同医疗,日本熊本大学附属医院开发了一套独立于医嘱录入系统的出院小结信息系统。该系统采用WEB浏览器的界面,部分数据在患者出院时自动以XML(eXtensible Markup Language)形式从医院信息系统中输出传入到出院小结系统当中,使出院小结的录入和编辑简单快捷。系统从2001年12月开始运行,至今每天有80-100份出院小结文档储积。无论是临床还是科研都为医务人员提供了极大的方便。

关键词： XML 出院小结医疗信息共享

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Prevention of hepatocellular carcinoma: Focusing on antioxidant therapy

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World Journal of Hepatology 2015年第3期7卷 593-599页

作者： koji Miyanishi Toshifumi Hoki Shingo tanaka Junji Kato Department of Medical Oncology and Hematology Sapporo Medical University School of Medicine

Oxidative stress has been investigated in the context of alcoholic liver injury for many years and shown to be a causal factor of chronic hepatitis C(CHC), nonalcoholic steatohepatitis(NASH), drug-induced liver injury, Wilson's disease, and hemochromatosis. In CHC, it has been demonstrated that oxidative stress plays an important role in hepatocarcinogenesis. In cases with persistent hepatitis due to failure of hepatitis C virus eradication,or chronic liver disease, such as NASH, the treatment of which remains unestablished, it is important to reduce serum alanine aminotransferase levels and prevent liver fibrosis and development of hepatocellular carcinoma. This also suggests the importance of antioxidant therapy. Among treatment options where it would be expected that anti-inflammatory activity plays a role in their confirmed efficacy for chronic hepatitis, iron depletion therapy, glycyrrhizin, ursodeoxycholic acid, Sho-Saiko-To, and vitamin E can all be considered antioxidant therapies. To date, however, the ability of these treatments to prevent cancer has been confirmed only in CHC. Nevertheless, anti-inflammatory and antifibrotic effects have been demonstrated in other liver diseases and these therapies may potentially be effective for cancer prevention.

关键词： Chronic hepatitis Antioxidant therapy Hepatocellular carcinoma Prevention Iron depletiontherapy

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Treating inflammatory bowel disease by adsorptive leucocytapheresis:A desire to treat without drugs

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World Journal of Gastroenterology 2014年第29期20卷 9699-9715页

作者： Abbi R Saniabadi Tomotaka tanaka Toshihide Ohmori koji Sawada Takayuki Yamamoto Hiroyuki Hanai Department of Pharmacology Hamamatsu University School of Medicine Department of Gastroenterology Akitsu Prefectural Hospital Ohmori Gastrointestinal Clinic Ikoma General and Gastroenterological Clinic Inflammatory Bowel Disease Centre Yokkaichi Social Insurance Hospital Hamamatsu South Hospital

Ulcerative colitis and Crohn’s disease are the major phenotypes of the idiopathic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms, impairing function and quality of life. Current medications are aimed at reducing the symptoms or suppressing exacerbations. However, patients require life-long medications, and this can lead to drug dependency, loss of response together with adverse side effects. Indeed, drug side effects become additional morbidity factor in many patients on long-term medications. Nonetheless, the efficacy of anti-tumour necrosis factors (TNF)-α biologics has validated the role of inflammatory cytokines notably TNF-α in the exacerbation of IBD. However, inflammatory cytokines are released by patients’ own cellular elements including myeloid lineage leucocytes, which in patients with IBD are elevated with activation behaviour and prolonged survival. Accordingly, these leucocytes appear logical targets of therapy and can be depleted by adsorptive granulocyte/monocyte apheresis (GMA) with an Adacolumn. Based on this background, recently GMA has been applied to treat patients with IBD in Japan and in the European Union countries. Efficacy rates have been impressive as well as disappointing. In fact the clinical response to GMA seems to define the patients’ disease course, response to medications, duration of active disease, and severity at entry. The best responders have been first episode cases (up to 100%) followed by steroid naïve and patients with a short duration of active disease prior to GMA. Patients with deep ulcers together with extensive loss of the mucosal tissue and cases with a long duration of IBD refractory to existing medications are not likely to benefit from GMA. It is clinically interesting that patients who respond to GMA have a good long-term disease course by avoiding drugs including corticosteroids in the early st

关键词： Inflammatory bowel disease Myeloid lineage leucocytes Adsorptive granulocytes/monocytes apheresis Corticosteroid sparing effect Complement activation fragments Treating inflammatory bowel disease without drugs

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Zinc-Based Metal-Organic Frameworks for High-Performance Supercapacitor Electrodes:Mechanism Underlying Pore Generation

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Energy & Environmental Materials 2023年第2期6卷 100-112页

作者： Shigeyuki Umezawa Takashi Douura koji Yoshikawa Daisuke tanaka Vlad Stolojan S.Ravi P.Silva Mika Yoneda Kazuma Gotoh Yasuhiko Hayashi Seiwa Electric Mfg.Co.Ltd. Kyoto 610-0192Japan Graduate School of Natural Science and Technology Okayama UniversityOkayama 700-8350Japan School of Science and Technology Kwansei Gakuin UniversityHyogo 669-1337Japan JST PRESTO2-1 GakuenHyogo 669-1337Japan Advanced Technology Institute University of SurreyGuilfordSurreyGU27XHUK

Heat treatment of metal-organic frameworks(MOFs)has provided a wide variety of functional carbons coordinated with metal *** this study,two kinds of zinc-based MOF(ZMOF),C_(16)H_(10)O_(4)Zn(ZMOF1)and C_(8)H_(4)O_(4)Zn(ZMOF2),were ***1 and ZMOF2 were carbonized at 1000℃,forming CZMOF1 and CZMOF2,*** specific surface area(S_(BET))of CZMOF2 was~2700 m^(2)g^(−1),much higher than that of CZMOF1(~1300 m^(2)g^(−1)).A supercapacitor electrode based on CZMOF2 achieved specific capacitances of 360,278,and 221 F g^(−1)at 50,250,and 1000 mA g^(−1)in an aqueous electrolyte(H2SO_(4)),respectively,the highest values reported to date for ZMOF-derived electrodes under identical *** practical applicability of the CZMOF-based supercapacitor was verified in non-aqueous *** initial capacitance retention was 78%after 100000 charge/discharge cycles at 10 A g^(−1).Crucially,the high capacitance of CZMOF2 arises from pore generation during *** 1000℃,pore generation is dominated by the Zn/C ratio of ZMOFs,as carbon atoms reduce the zinc oxides formed during *** 1000℃,a high O/C ratio becomes essential for pore generation because the oxygen functional groups are *** findings will provide insightful information for other metal-based MOFderived multifunctional carbons.

关键词： metal-organic frameworks pore generation porous carbons supercapacitor zinc oxides

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Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第11期24卷 1239-1249页

作者： Naoyuki Fujimori Takeji Umemura Takefumi Kimura Naoki tanaka Ayumi Sugiura Tomoo Yamazaki Satoru Joshita Michiharu Komatsu Yoko Usami Kenji Sano koji Igarashi Akihiro Matsumoto Eiji tanaka Department of Internal Medicine Division of GastroenterologyShinshu University School of MedicineMatsumoto 390-8621Japan Department of Metabolic Regulation Shinshu University Graduate School of MedicineMatsumotoJapanand Research Center for Agricultural Food IndustryShinshu UniversityMatsumoto390-8621Japan Department of Laboratory Medicine Shinshu University HospitalMatsumoto 390-8621Japan Bioscience Division TOSOH CorporationKanagawa 252-1123Japan

AIM To examine the relationship between serum autotaxin(ATX) concentrations and clinicopathological findings in non-alcoholic fatty liver disease(NAFLD) *** One hundred eighty-six NAFLD patients who had undergone liver biopsy between 2008 and 2017 were retrospectively *** samples were collected at the time of biopsy and ATX was measured by enzyme *** obtained from 160 healthy,nonobese individuals were used as *** findings were graded according to an NAFLD scoring system and correlations with serum ATX were calculated by Spearman's *** accuracy was evaluated using the area under the receiver operating characteristic curve(AUC).Cut-off values were identified by the Youden index,and the nearest clinically applicable value to the cutoff was considered the optimal threshold for clinical *** Serum ATX levels were significantly higher in NAFLD patients than in controls(0.86 mg/L vs 0.76 mg/L,P < 0.001) and correlated significantly with ballooning score and fibrosis stage(r = 0.36,P < 0.001 and r = 0.45,P < 0.001,respectively).Such tendencies were stronger in female *** were no remarkable relationships between ATX and serum alanine aminotransferase,lipid profiles,or steatosis *** AUC values of ATX for predicting the presence of fibrosis(≥ F1),significant fibrosis(≥ F2),severe fibrosis(≥ F3),and cirrhosis(F4),were all more than 0.70 in respective *** Serum ATX levels may at least partially reflect histological severity in NAFLD.

关键词： Autotaxin Non-alcoholic fatty liver disease Fibrosis Ballooning

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Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget’s disease with curative responses

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Cancer Communications 2018年第1期38卷 400-409页

作者： Junichi Hiratsuka Nobuhiko Kamitani Ryo tanaka Eisaku Yoden Ryuji Tokiya Minoru Suzuki Rolf F.Barth koji Ono Department of Radiation Oncology Kawasaki Medical School577MatsushimaKurashikiOkayama 701-0192Japan Department of Dermatology Kawasaki Medical SchoolKurashikiOkayama 701-0192Japan Particle Radiation Oncology Kyoto University Research Reactor InstituteOsaka 590-0494Japan Department of Pathology The Ohio State UniversityColumbusOH 43210USA

Background:Although the most commonly recommended treatment for melanoma and extramammary Paget’s disease(EMPD)of the genital region is wide surgical excision of the lesion,the procedure is highly invasive and can lead to functional and sexual *** treatments have been used for local control when wide local exci-sion was not ***,we describe four patients with genital malignancies who were treated with boron neutron capture therapy(BNCT).Methods:The four patients included one patient with vulvar melanoma(VM)and three with genital *** underwent BNCT at the Kyoto University Research Reactor between 2005 and 2014 using para-boronophenylalanine as the boron delivery *** were irradiated with an epithermal neutron beam between the curative tumor dose and the tolerable skin/mucosal ***:All patients showed similar tumor and normal tissue responses following BNCT and achieved complete responses within 6 *** most severe normal tissue response was moderate skin erosion during the first 2 months,which diminished gradually *** or contact pain persisted for 2 months and resolved com-pletely by 4 ***:Treating VM and EMPD with BNCT resulted in complete local tumor *** on our clinical expe-rience,we conclude that BNCT is a promising treatment for primary VM and EMPD of the genital region.

关键词： Boron neutron capture therapy Vulvar melanoma Extramammary Paget’s disease Penis Vulva

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The Fefferman-Stein-Type Inequality for the Kakeya Maximal Operator Ⅱ

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Acta Mathematica Sinica,English Series 2002年第3期18卷 447-454页

作者： Hitoshi tanaka Department of Mathematics Gakushuin University 1-5-1 Mejiro Toshima-ku Tokyo 171-8588 Japan

Let K, 0 ±1, be the Kakeya maximal operator defined as the supremum of averages over tubes of the eccentricity . The (so-called) Fefferman-Stein-type inequality: $|| {K_\delta f} ||_{L^d({{\rm R}^d,w})} \le C_d ({1 \over \delta})^{(d - 2)/2d}(\log ({1 \over \delta } ))^{\alpha_d} || f ||_{L^d ({\rm R}^d,K_{\delta}w})}$is shown, where Cd and d are constants depending only on the dimension d and w is a weight. The result contains the exponent (d-2)/2d which is smaller than the exponent (d-2)(d-1)/d(2d-3) obtained in [7].

关键词： Maximal functions Weighted inequalties

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One-Dimensional Modeling of Multiple Scattering in the Upper Inner Core: Depth Extent of a Scattering Region in the Eastern Hemisphere

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Journal of Earth Science 2013年第5期24卷 706-715页

作者： Satoru tanaka Institute for Research on Earth Evolution Japan Agency for Marine-Earth Science and Technology

Attenuation of PKP（DF） in the Eastern Hemisphere is examined in terms of multiple scattering to simultaneously explain a puzzling relationship, a relatively fast velocity anomaly corre- sponding to strong attenuation. Reflectivity synthetics with one-dimensional random velocity fluctua- tions are compared with observations of PKP（DF）/PKP（Cdiff） amplitude ratios and differential travel times of PKP（Cdiff）-PKP（DF） for the equatorial paths. A Gaussian distribution of P-wave velocity fluctuations with the standard deviations of 5%, 6%, and 7% in the uppermost 200 km of the inner core is superimposed on the velocity structure that is slightly faster than the typical structure in the Eastern Hemisphere, which is likely to explain both the travel time and amplitude data as far as only the one-dimensional structure is considered. Further examinations of the statistic characteristic of scat- terer distribution in two and three-dimensions are required to obtain a realistic conclusion.

关键词： seismology the inner core attenuation scattering.

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Tingley's Problem on Symmetric Absolute Normalized Norms on R^2

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Acta Mathematica Sinica,English Series 2014年第8期30卷 1324-1340页

作者： Ryotaro tanaka Department of Mathematical Science Graduate School of Science and TechnologyNiigata University

In this paper,we study Tingley＇s problem on symmetric absolute normalized norms on R^*** construct new methods for Tingley＇s problem on two-dimensional spaces by using isosceles orthogonality,which does not make use of the notion of natural ***,using our methods,several sufficient conditions for Tingley＇s problem on symmetric absolute normalized norms on R2 are *** applications,we present various new examples including the two-dimensional Lorentz sequence space d^（2）（ω,q） and its dual d^（2）（ω,q）＊by simple arguments.

关键词： Tingley's problem isometric extension problem isosceles orthogonality symmetric absolute normalized norm

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