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Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: A case report

World Journal of Gastroenterology 2005年第34期11卷 5394-5397页

作者： Hiroki Oikawa Chihaya Maesawa Ryo Sato Kanta Oikawa Hiroyuki Yamada Seizo Oriso Sadahide Ono Akiko Yashima-Abo koji kotani Kazuyuki Suzuki Tomoyuki Masuda Department of Pathology Iwate Medical University School of Medicine Morioka Japan Department of Internal Medicine I Iwate Medical University School of Medicine Morioka Japan Department of Internal Medicine Iwate Prefectural Ninohe Hospital Ninohe Japan Department of Pathology Iwate Prefectural Central Hospital Morioka Japan

The anti-arrhythmic agent amiodarone （AD） is associated with numerous adverse effects, but serious liver disease is rare. The improved safety of administration of daily low doses of AD has already been established and this regimen is used for long-term medication. Nevertheless, asymptomatic continuous liver injury by AD may increase the risk of step-wise progression of non-alcoholic fatty liver disease. We present an autopsy case of AD-induced liver cirrhosis in a patient who had been treated with a low dose of AD （200 rag/d） daily for 84 too. The patient was a 85-year-old male with a history of ischemic heart disease. Seven years after initiation of treatment with AD, he was admitted with cardiac congestion. The total dose of AD was 528 g. Mild elevation of serum aminotransferase and hepatomegaly were present. Liver biopsy specimens revealed cirrhosis, and under electron microscopy numerous lysosomes with electron-dense, whorled, lamellar inclusions characteristic of a secondary phospholipidosis were observed. Initially, withdrawal of AD led to a slight improvement of serum aminotransferase levels, but unfortunately his general condition deteriorated and he died from complications of pneumonia and renal failure. Long-term administration of daily low doses of AD carries the risk of progression to irreversible liver injury. Therefore, periodic examination of liver function and/or liver biopsy is required for the management of patients receiving long-term treatment with AD.

关键词： Amiodarone Liver cirrhosis NASH NAFLD Liver biopsy

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A BLOCK PARTITIONING VECTOR QUANTIZATION METHOD THROUGH POST-PROCESSING TO ACHIEVE HIGHER PSNR

A BLOCK PARTITIONING VECTOR QUANTIZATION METHOD THROUGH POST...

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2002年第6届信号处理国际会议

作者： koji kotani Tadahiro Ohmi Department of electronic engineering graduate school of engineering Tohoku University SendaiJapan New industry creation hatchery center Tohoku University SendaiJapan AZa-aoba 05AramakiAoba-kuSendai980-8579Japan

＜正＞ In conventional vector quantization（VQ） method, the reachable best PSNR is implemented by full search or its equivalent method when codebook is fixed. To achieve an even higher PSNR by fixed codebook, a post-processing VQ method is proposed in this paper. This method firstly checks how well the VQ matching is for a whole image and locates some bad matching image blocks definitely. Then it partitions a bad matching image block into two partial blocks further by a certain pattern and encodes them once again using the same fixed codebook but two different codes partially. It makes total distortion for current bad matching image block smaller. At the receiving end, current bad matching image block is synthesized by two codes partially according to adopted partitioning pattern so as to realize a better *** 10 gray-level standard images of size 512x512 with different detail, 0.3 dB-1.2 dB PSNR improvement can be reached individually by just partitioning 5% worst matching image blocks at the cost of less than 1 bit degradation of equivalent code length. Moreover this improvement is basically for edge portion of an image. Therefore, subject assessment can be made much better at the same time.

关键词： Vector quantization Block partitioning Post-processing Image quality.

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A Codebook Design Method for Robust VQ-Based Face Recognition Algorithm

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Journal of Software Engineering and Applications 2010年第2期3卷 119-124页

作者： Qiu Chen koji kotani Feifei Lee Tadahiro Ohmi 不详

In this paper, we present a theoretical codebook design method for VQ-based fast face recognition algorithm to im-prove recognition accuracy. Based on the systematic analysis and classification of code patterns, firstly we theoretically create a systematically organized codebook. Combined with another codebook created by Kohonen’s Self-Organizing Maps (SOM) method, an optimized codebook consisted of 2×2 codevectors for facial images is generated. Experimental results show face recognition using such a codebook is more efficient than the codebook consisted of 4×4 codevector used in conventional algorithm. The highest average recognition rate of 98.6% is obtained for 40 persons’ 400 images of publicly available face database of AT&T Laboratories Cambridge containing variations in lighting, posing, and expressions. A table look-up (TLU) method is also proposed for the speed up of the recognition processing. By applying this method in the quantization step, the total recognition processing time achieves only 28 msec, enabling real-time face recognition.

关键词： Face Recognition Vector Quantization (VQ) Codebook Design Code Classification Histogram Method

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Using TiO2-Biocharcoal and TiO2-Diatomite for Photodisinfection in Washing Machine Wastewater

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Journal of Geoscience and Environment Protection 2024年第8期12卷 62-79页

作者： Daphne Montesuma Ferro Paloma Otsuka kotani Regina Affonso Nilce Ortiz Chemistry and Environment Center Nuclear and Energy Research Institute IPEN So Paulo Brazil Biotechnology Center Nuclear and Energy Research Institute IPEN So Paulo Brazil

The photodisinfection process using biomolded semiconductor photocatalysts can inactivate bacteria in wastewater washing machine samples. The comparative study evaluated the photocatalyst material titanium dioxide (TiO2) synthesized with diatomite and biocharcoal biotemplate (TiO2-Biocharcoal and TiO2-Diatomite) in photodisinfection processes using domestic washing machine wastewater samples, the results of bacterial inactivation were above 96%. The efficiency of the photodisinfection process was evaluated by counting the number of colonies of the bacteria. Experiments under LED solar lamps presented similar bacterial inactivation, and a correlation with kinetic models. The kinetic study demonstrated a curved regression, indicating a better fit with the Hom model. A tail at the end of the modeling curve indicates the presence of a high concentration of inactive bacteria in the medium, while a shoulder at the beginning of the curve suggests a heterogeneous sample with a high concentration of gram-positive bacteria. The toxicity tests performed with wastewater samples without light exposure indicated low toxicity for both materials. The study presented promising disinfection results for an accessible and efficient photo-sterilization process of water contaminated with bacteria using abundant solar and renewable energy throughout the national territory. .

关键词： Photodisinfection Diatomite Biocharcoal Wastewater Titanium Dioxide

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IT APPLICATIONS PORTFOLIO MANAGEMENT UNDER BUSINESS AND IMPLEMENTATION UNCERTAINTY

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Journal of Systems Science and Systems Engineering 2008年第1期17卷 109-124页

作者： Masafumi kotani Junichi IIJIMA IBM Japan Industrial Sector Marketing Executive Graduate School of Decision Science and Technology Tokyo Institute of Technology

Corporations need to improve business processes in order to enhance velocity and service levels while reducing their processing costs and differentiating themselves in the face of competition. The levitation of importance beyond support roles has raised IT investment decisions to high priority in chief executive officers＇ agendas. Corporate planning groups as well as lines of business are increasingly applying techniques of IT applications portfolio management in a more systematic fashion to improve decision-making and resource-allocation processes. Recent advances in software engineering and IT service delivery methodologies have achieved the logical separation of business functions from implementation. This separation has made a new breed of innovative IT project possible with a new project risk structure; the adjustment of portfolio management techniques is appropriate. We present an integrated portfolio management model so that the corporation can focus on organic growth through sources at both the department and top management levels. The research gives clear advice as to how top management can seek economic growth by selecting an entrepreneurial strategic posture, implying a strong risk-taking propensity. By integrating a risk-return model and risk-tolerance paradigm to cope with today＇s risk structure, overall capabilities can improve the decision process and the corporation＇s performance as well. The application of the integrated technique to a Japanese manufacturing firm is described.

关键词： IT-investment management application portfolio management real options analysis risk-return model risk-tolerance paradigm timing decision

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Potential role of biofeedback therapy for Parkinson’s disease

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Neural Regeneration Research 2021年第10期16卷 2021-2022页

作者： Naoya kotani Takashi Morishita Tooru Inoue Department of Neurosurgery Fukuoka University Faculty of MedicineFukuokaJapan Department of Rehabilitation Medicine Fukuoka University HospitalFukuokaJapan

Parkinson’s disease(PD)is a neurological disorder characterized by rigidity,tremor,bradykinesia,and postural *** disturbance is one of cardinal symptoms of PD and affects the activities of daily living and quality of *** symptom in advanced PD patients is usually refractory to medication and surgical intervention such as deep brain stimulation(Morishita et al.,2016).

关键词： stimulation instability. al.

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肝静脉压力梯度微创时代:基于前臂静脉入路的探索

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中华肝脏病杂志 2024年第1期32卷 35-39页

作者：王继涛李雷牛猛朱清亮赵中伟 Kohei kotani Akira Yamamoto 张海军李双喜徐丹康宁李小果张昆鹏孙骏吴发宗张海龙刘登湘吕沐瀚纪建松 Norifumi Kawada 徐克祁小龙河北省肝硬化门静脉高压重点实验室河北医科大学附属邢台市人民医院邢台054000 兰州大学第一医院介入科兰州730000 中国医科大学附属第一医院介入科沈阳110000 西南医科大学附属医院消化内科泸州646000 丽水市中心医院介入诊疗中心丽水323000 日本大阪市立大学医院肝病科日本大阪日本大阪市立大学医学院放射介入科日本大阪东南大学附属中大医院门静脉高压中心南京210009

目的经颈静脉或经股动脉途径被用作当前实践中肝静脉压力梯度(HVPG)测量的常用方法。该研究旨在证实经前臂静脉途径测量HVPG的安全性和有效性。方法针对2020年9月至2020年12月前瞻性地从中国和日本的6所医院招募了经前臂静脉进行HVPG检... 详细信息

目的经颈静脉或经股动脉途径被用作当前实践中肝静脉压力梯度(HVPG)测量的常用方法。该研究旨在证实经前臂静脉途径测量HVPG的安全性和有效性。方法针对2020年9月至2020年12月前瞻性地从中国和日本的6所医院招募了经前臂静脉进行HVPG检测肝硬化患者,并收集患者的临床基线资料以及HVPG检测数据。入组患者均选择经右侧肘正中静脉或贵要静脉入路,采用HVPG标准化流程进行测压。研究数据采用SPSS 22.0统计学软件进行分析。定量资料采用中位数(四分位数间距)表示,定性资料采用频数和率表示。两组数据之间的相关性分析采用Pearson相关性分析。结果研究共入组43例患者,其中41例(95.3%)患者成功接受了经前臂静脉途径HVPG检测。无患者出现任何严重并发症。经前臂静脉途径HVPG检测中位操作时间为18.0min(12.3~38.8min)。研究证实HVPG与Child-Pugh评分(r=0.47,P=0.002)、白蛋白-胆红素评分(r=0.37,P=0.001)、Lok指数(r=0.36,P=0.02)、肝脏硬度(r=0.58,P=0.01)、脾硬度(r=0.77,P=0.01)呈正相关,且与白蛋白呈负相关(r=-0.42,P=0.006)。结论多中心回顾性研究结果提示经前臂静脉途径HVPG测量是安全可行的。

关键词：肝硬化肝静脉压力梯度前臂静脉

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Construction of KdV Flow:A Unified Approach

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Peking Mathematical Journal 2023年第2期6卷 469-558页

作者： Shinichi kotani Nanjing University 22 Hankou RoadNanjing 210093China Osaka University 1 MachikaneyamaToyonakaOsaka 560-0043Japan

A KdV flow is constructed on a space whose structure is described in terms of the spectrum of the underlying Schrödinger *** space includes the conventional decaying functions and ergodic ***,any smooth almost periodi... 详细信息

关键词： KdV equation Weyl function Ergodic process

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Perinatal veterinary medicine‐related evaluation in hematological and serum biochemical profiles of experimental beagles throughout pregnancy and parturition

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Animal Models and Experimental Medicine 2018年第4期1卷 282-294页

作者： Tohru Kimura Kazuhiko kotani Laboratory Animal Science Joint Faculty of Veterinary Medicine Yamaguchi University Division of Community and Family Medicine Center for Community MedicineJichi Medical University

Background: The aims of this study were(a) to ascertain age-related changes in the reference values in hematological and serum biochemical examinations of beagles,and(b) to clarify the changes in these findings, including acute phase proteins and oxidative stress, throughout pregnancy and after ***: Clinicopathological parameters were measured in young beagles at 6, 9 and 12 months and in adult beagles aged from 24 to 60 months. Likewise, pregnant beagles were investigated throughout the pregnancy and after ***: Apparent age-related changes were found in erythrocytic parameters during the growth and development of beagles. Most of the parameters(total protein,albumin, blood urea nitrogen, creatinine, urate, alkaline phosphatase(ALP) and creatine kinase(CK) exhibited age-dependent transitions. White cell count significantly increased after 30 days of pregnancy. The values of erythrocytic parameters moderately decreased during the second half of the pregnancy. Triglycerides, total cholesterol, free cholesterol and phospholipid concentrations increased in the mid- and late stages of pregnancy. ALP, lactate dehydrogenase, CK and cholinesterase activities markedly increased during pregnancy and/or after parturition. C-reactive protein(CRP) concentrations gradually increased and reached a maximum after 30-40 days of pregnancy. Serum amyloid A(SAA) levels markedly increased at 30 days of pregnancy before subsiding, and then increased again 3 days after parturition. Reactive oxygen metabolites(d-ROMs) showed significant increases after 30 and 40 days of ***: Reference values for hematological and serum biochemical examinations should be used for health evaluation of dogs, taking sex, age and the stage of pregnancy into consideration. Measurements of CRP, SAA and d-ROM levels are also useful for assessing maternal conditions in mid-pregnancy.

关键词： beagles hematology parturition pregnancy reactive oxygen metabolites serum biochemistry

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An Experimental Study on Transverse Hydrogen Gas Injection into Mach 1.8 Airnow Channel-The lst report:Single Circular Injector

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Journal of Thermal Science 1997年第3期6卷 207-217页

作者： T.Nagashima Y.kotani 等 DepartmentofAeronauticsandAstronautics UniversityofTokyo DepartmentofMechanicalEngineering TokyoElect

Experimental results from a series of injection tests of pressurized H2, N2 gases into Mach 1.8 airfiows between parallel channel walls through a flush-mounted circular sonic opening have been *** pictures revealed complex interaction flow features including the occurrence of bow/separation shock waves due to the injection as well as the barrel shock/Mach disc structure inside the injected gas stream. The injectant penetration measured by the Mach disc height against the injection pressure showed a good agreement with the correlation curve based upon the "effective back pressure" concept. The reversed flow region beneath the separation shock wave, the injectant wake and its associated flow entraimment were also visualized by the oil paint method. Wall static pressure distributions around the injector were measured in detail, which corresponded very well to the above results of flow *** samplings were also undertaken by using the pressure taps to confirm the presence of H2 gas in the separation region ahead of the injector. Traversing of total pressure and H2 gas concentration at the exit of the test channel showed monotonous increase of the loss while its profile was kept very similar with the injection pressure. The area indicating the loss and the presence of H2 gas almost coincided with each other, which remained to be small to indicate very slow gas mixing/diffusion with the main air flow. With the increase of airflow total temperature to 1200 K, a bulk flame was first observed at the exit section. Further increase up to 1460 K observed an ignition flame at the injector. However,the reflection of the bow shock wave was found to be a more likely trigger of the bulk flame ignition within the test section.

关键词： SCRamjet supersonic combustion hydrogen transverse injection

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