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BDNF pro-peptide：a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing

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Neural Regeneration Research 2017年第7期12卷 1024-1027页

作者： Toshiyuki Mizui koji Ohira Masami kojima Biomedical Research Inst. (BMD) National Institute of Advanced Industrial Science and Technology (AIST) Osaka Japan Laboratory of Nutritional Brain Science Department of Food Science and Nutrition Mukogawa Women's University Hyogo Japan Core Research for Evolutional Science and Technology (CREST) Science and Technology Agency (JST) KawaguchiJapan Graduate School of Frontier Bioscience Osaka University Suita Japan

Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and ***,compared with the expression and function of bioactive mature domain,the biological role of the pro-domain is poorly ***,we found that the pro-domain（or pro-peptide）of brain-derived neurotrophic factor（BDNF）,which is well-known neurotrophic factor in brain,has a potential ability to facilitate hippocampal long-term ***,a BDNF polymorphism Val66Met,which substitute valine into methionine at 66 amino acid,impacted the biological activity of the BDNF *** lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.

关键词： BDNF growth factor neural stem cells ischemia peptide

Experimental study on the in-plane thermal conductivity of Au nanofilms

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Progress in Natural Science:Materials International 2007年第2期17卷 212-216页

作者： TAKAHASHI koji IKUTA Tatsuya FUJII Motoo Graduate School of Engineering Kyushu UniversityFukuoka 812-8581Japan Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan

The in-plane thermal conductivity of Au nanofilms with thickness of 23 nm, which are fabricated by the electron beam-physical vapor deposition method and a suspension technology, is experimentally measured at 80-300 K by a one-dimensional steady-state electrical heating method. Strong size effects are found on the measured nanofilm thermal conductivity. The Au nanofilm in-plane thermal conductivity is much less than that of the bulk material. With the increasing temperature, the nanofilm thermal conductivity increases. This is opposite to the temperature dependence of the bulk property. The Lorenz number of the Au nanofilms is about three times larger than the bulk value and decreases with the increasing temperature, which indicates the invalidity of the Wiedemann-Franz law for metallic nanofilms.

关键词： nanofilm in-plane thermal conductivity size effect Wiedemann-Franz law.

Present Assessment of Public Traffic System Based on GIS in Kitakyushu

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Open Journal of Civil Engineering 2014年第4期4卷 397-405页

作者： Kazuyuki watari Weijun Gao Faculty of Environmental Engineering The University of Kitakyushu Kitakyushu Japan Geo Cluster Co. LTD Japan

With increasing of serious environment problems and the coming of the aging society, new traffic systems should be urgently rebuilt. It is necessary to evaluate the traffic service level by utilizing new technique and tool. This paper takes Kitakyushu city as case study to carry out an evaluation of urban traffic system. The concept of accessibility and mobility is used to evaluate the present condition of existing public traffic system based on GIS technology, and then establishment of new route is discussed according to the evaluation results. Additionally, this paper established GIS database and illustrated the relationship between the public traffic and population density. The regions without enough existing traffic were identified. Moreover, the essential terms and considerations were put forward to simulate a new route of public traffic line.

关键词： Urban Public Traffic GIS Technology Kitakyushu Japan

Light chain cardiac amyloidosis in a nonagenarian

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Journal of Geriatric Cardiology 2022年第1期19卷 83-89页

作者： koji Takahashi Mina Yamashita Tomoki Sakaue Daijiro Enomoto Shigeki Uemura Takafumi Okura Shuntaro Ikeda Takanori Senba Akira Saijo Nobuhisa Yamamura Sohei Kitazawa Department of Community Emergency Medicine Ehime University Graduate School of MedicineEhimeJapan Department of Cardiology Yawatahama City General HospitalEhimeJapan Department of Hematology Yawatahama City General HospitalEhimeJapan Department of Clinical Pathology Yawatahama City General HospitalEhimeJapan Department of Molecular Pathology Ehime University Graduate School of MedicineEhimeJapan

Cardiac amyloidosis is an infiltrative and restrictive cardiomyopathy caused by the extracellular deposition of amyloid fib-rils within the heart as systemic amyloidosis,lead-ing to heart failure,reduced quality of life,and death.[1]There are two major amyloid fibril proteins that af-fect the heart:amyloid immunoglobulin light chain(AL)and amyloid transthyretin(ATTR).The latter is further subdivided into wild-type ATTR and variant types based on the presence of a mutation in the transthyretin gene.

关键词： amyloid death. cardiomyopathy

Different effects of grain boundary scattering on charge and heat transport in polycrystalline platinum and gold nanofilms

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Chinese Physics B 2009年第5期18卷 2035-2040页

作者：马维刚王海东张兴 Takahashi koji Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua University Graduate School of Engineering Kyushu University

The in-plane electrical and thermal conductivities of several polycrystalline platinum and gold nanofilms with different thicknesses are measured in a temperature range between the boiling point of liquid nitrogen （77K） and room temperature by using the direct current heating method. The result shows that both the electrical and thermal conductivities of the nanofilms reduce greatly compared with their corresponding bulk values. However, the electrical conductivity drop is considerably greater than the thermal conductivity drop, which indicates that the influence of the internal grain boundary on heat transport is different from that of charge transport, hence leading to the violation of the Wiedemann-Franz law. We build an electron relaxation model based on Matthiessen＇s rule to analyse the thermal conductivity and employ the Mayadas ＆ Shatzkes theory to analyse the electrical conductivity. Moreover, a modified Wiedemann-Franz law is provided in this paper, the obtained results from which are in good agreement with the experimental data.

关键词： polycrystalline nanofilm grain boundary scattering thermal and electrical conductivities Wiedemann-Franz law

Underwater persistent bubble-assisted femtosecond laser ablation for hierarchical micro/nanostructuring

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International Journal of Extreme Manufacturing 2020年第1期2卷 135-154页

作者： Dongshi Zhang Bikas Ranjan Takuo Tanaka koji Sugioka RIKEN Center for Advanced Photonics 2-1 HirosawaWakoSaitama 351-0198Japan Innovative Photon Manipulation Research Team RIKEN Center for Advanced PhotonicsWakoSaitama 351-0198Japan Metamaterials Laboratory RIKEN Cluster for Pioneering ResearchWakoSaitama 351-0198Japan

In this study,we demonstrate a technique termed underwater persistent bubble assisted femtosecond laser ablation in liquids(UPB-fs-LAL)that can greatly expand the boundaries of surface micro/nanostructuring through laser ablation because of its capability to create concentric circular macrostructures with millimeter-scale tails on silicon ***-tailed macrostructures are composed of layered fan-shaped(central angles of 45°–141°)hierarchical micro/nanostructures,which are produced by fan-shaped beams refracted at the mobile bubble interface(.50°light tilt,referred to as the vertical incident direction)during UPB-fs-LAL line-by-line *** flow generated during UPB-fs-LAL induces bubble *** scanning(e.g.1mms−1)allows a long bubble movement(as long as 2mm),while slow scanning(e.g.0.1mms−1)prevents bubble *** persistent bubbles grow considerably(*** of microns in diameter)due to incubation effects,they become sticky and can cause both gas-phase and liquidphase laser ablation in the central and peripheral regions of the persistent *** generates low/high/ultrahigh spatial frequency laser-induced periodic surface structures(LSFLs/HSFLs/UHSFLs)with periods of 550–900,100–200,40–100 nm,which produce complex hierarchical surface structures.A period of 40 nm,less than 1/25th of the laser wavelength(1030 nm),is the finest laser-induced periodic surface structures(LIPSS)ever created on *** NIR-MIR reflectance/transmittance of fan-shaped hierarchical structures obtained by UPB-fs-LAL at a small line interval(5μm versus 10μm)is extremely low,due to both their extremely high light trapping capacity and absorbance characteristics,which are results of the structures’additional layers and much finer *** the absence of persistent bubbles,only grooves covered with HSFLs with periods larger than 100 nm are produced,illustrating the unique attenuation abilities of laser properties(*** rate,energy,inciden

关键词： hierarchical micro/nanostructures persistent bubble femtosecond laser surface structuring beam refraction fan-shaped microstructure LIPSS

GHz bursts in MHz burst(BiBurst) enabling high-speed femtosecond laser ablation of silicon due to prevention of air ionization

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International Journal of Extreme Manufacturing 2023年第2期5卷 208-214页

作者： Kotaro Obata Francesc Caballero-Lucas Shota Kawabata Godai Miyaji koji Sugioka RIKEN Center for Advanced Photonics 2-1 HirosawaWako-shiSaitama 351-0198Japan Department of Applied Physics Tokyo University of Agriculture and Technology2-24-16 NakachoKoganeiTokyo 184-8588Japan

For the practical use of femtosecond laser ablation, inputs of higher laser intensity are preferred to attain high-throughput material removal. However, the use of higher laser intensities for increasing ablation rates can have detrimental effects on ablation quality due to excess heat generation and air ionization. This paper employs ablation using BiBurst femtosecond laser pulses, which consist of multiple bursts(2 and 5 bursts) at a repetition rate of 64 MHz, each containing multiple intra-pulses(2–20 pulses) at an ultrafast repetition rate of 4.88 GHz, to overcome these conflicting conditions. Ablation of silicon substrates using the BiBurst mode with 5 burst pulses and 20 intra-pulses successfully prevents air breakdown at packet energies higher than the pulse energy inducing the air ionization by the conventional femtosecond laser pulse irradiation(single-pulse mode). As a result, ablation speed can be enhanced by a factor of23 without deteriorating the ablation quality compared to that by the single-pulse mode ablation under the conditions where the air ionization is avoided.

关键词： BiBurst mode GHz burst laser ablation silicon air ionization

Design of High Power DC Break For ICRH Of EAST

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Plasma Science and Technology 2005年第2期7卷 2727-2730页

作者：李国超赵燕平毛玉周丁家义薛迪冶秦成明 T.watari R.Kumazawa Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031China National Institute for Fusion Science Furo-cho Nagoya 464-01 Japan

1.5MW Ion Cyclotron Wave Heating system was developed, the transmitter and the antenna both have their ground loops, which will severely perturb the system’s normal operation. To avoid perturbation, a DC break was designed. The S parameter and the VSWR (voltage standing wave ratio) of incident port were calculated; the thermal effect caused by conductor loss and dielectric loss was analyzed.

关键词： DC break ion cyclotron wave heating (ICRH) coaxial line loss

Reference Design of ICRF Antenna for EAST

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Plasma Science and Technology 2006年第3期8卷 358-362页

作者：秦成明赵燕平 Hiroyuki OKADA 张新军毛玉周 T.watari R.KUMAZAWA T.SEKI Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China National Institute for Fusion Science Furo-cho Chikusa-ku Nagoya 464-01 Japan Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China

An antenna array suitable for plasma heating and current drive has been designed for the ion cyclotron resonance frequency range （ICRF） heating on the EAST superconducting tokamak. The ICRF heating is planned to operate in a frequency range of 30 MHz to 80 MHz and hence the antenna geometry is optimized for 55 MHz. The design is based on the conventional strap antenna element. The coupling properties of the antenna are calculated with a slab model of the plasma for the antenna simulation. The coupling code is extended for the analysis of the toroidal antenna array separated by septa.

关键词： ICRF antenna design input impedance plasma coupling