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Neural plasticity in Parkinson's disease: a neuroimaging perspective

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Neural Regeneration Research 2024年第6期19卷 1203-1205页

作者： Christina Andica koji Kamagata Department of Radiology Juntendo University Graduate School of Medicine Faculty of Health Data Science Juntendo University

Parkinson’s disease(PD) is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least *** disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum,

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Evaluation of excavation damaged zones(EDZs)in Horonobe Underground Research Laboratory(URL)

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 365-378页

作者： koji Hata Sumio Niunoya Kazuhei Aoyagi Nobukatsu Miyara Obayashi Corporation Technology Research InstituteTechnology DivisionKiyoseTokyo204-8558Japan Obayashi Corporation Nuclear Facilities DivisionSinagawaTokyo108-8502Japan Japan Atomic Energy Agency Horonobe Underground Research CenterHoronobeHokkaido098-3224Japan

Excavation of underground caverns,such as mountain tunnels and energy-storage caverns,may cause the damages to the surrounding rock as a result of the stress *** this influenced zone,new cracks and discontinuities are created or propagate in the rock ***,it is effective to measure and evaluate the acoustic emission(AE)events generated by the rocks,which is a small elastic vibration,and permeability *** authors have developed a long-term measurement device that incorporates an optical AE(O-AE)sensor,an optical pore pressure sensor,and an optical temperature sensor in a single multi-optical measurement probe(MOP).Japan Atomic Energy Agency has been conducting R&D activities to enhance the reliability of high-level radioactive waste(HLW)deep geological disposal *** a high-level radioactive disposal project,one of the challenges is the development of methods for long-term monitoring of rock mass ***,in January 2014,the long-term measurements of the hydro-mechanical behavior of the rock mass were launched using the developed MOP in the vicinity of 350 m below the surface at the Horonobe Underground Research *** measurement results show that AEs occur frequently up to 1.5 m from the wall during *** addition,hydraulic conductivity increased by 2e4 orders of *** analysis revealed that the hydraulic behavior of the rock mass affected the pore pressure fluctuations and caused *** on this,a conceptual model is developed to represent the excavation damaged zone(EDZ),which contributes to the safe geological disposal of radioactive waste.

关键词： Excavation damaged zone(EDZ) Optical sensor Long-term monitoring Acoustic emission(AE) Shaft sinking

Stochastic and Distributed Optimal Energy Management of Active Distribution Networks Within Integrated Office Buildings

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 504-517页

作者： Zening Li Su Su Xiaolong Jin Mingchao Xia Qifang Chen koji Yamashita National Active Distribution Network Technology Research Center Beijing Jiaotong UniversityBeijing 100044China Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China Electrical and Computer Engineering University of California RiversideCA92521USA.

This paper proposes a stochastic and distributed optimal energy management approach for active distribution networks(ADNs)within office *** proposed approach aims at scheduling office buildings fitted with heating ventilation and air conditioning(HVAC)systems,and electric vehicle(EV)charging piles,to participate in the ADN ***,an energy management approach for the ADN with aggregated office buildings is *** the ADN optimization model is formulated considering the detailed building thermal dynamics and the mobile behaviors of ***,to consider un-certainties of photovoltaic(PV)power,scenario-based stochastic programming is integrated into the ADN optimization *** further realize the stochastic energy management of the ADN within office buildings in a distributed manner,the alternating direction method of multipliers(ADMM)is used to solve the ADN optimization *** original ADN optimization problem is divided into the network-side and the building-side sub-problems to effectively protect the privacy of the ADN and the office ***,the ADN optimization model incorporating office buildings is validated in the winter by numerical *** addition,the impacts of comfort temperature range and expected state of charge(SOC)at departure are *** Terms—ADN,EV,HVAC system,Office building,Stochastic and distributed energy management.

关键词： ADN EV HVAC system Office building Stochastic and distributed energy management

Impact of Microstructural and Surface Modifications on the Ti-45Nb Alloy’s Response to Bio-Environment

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1215-1230页

作者： Ivana Cvijović-Alagić Slađana Laketić MilošMomčilović Jovan Ciganović Jelena Bajat Vesna kojić Vinča Institute of Nuclear Sciences-National Institute of the Republic of Serbia University of BelgradeMike Petrovića Alasa 12-1411000BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411000BelgradeSerbia Oncology Institute of Vojvodina Faculty of MedicineUniversity of Novi SadPut Doktora Goldmana 4Sremska Kamenica21204Sremska KamenicaSerbia

The Ti-45Nb (mass%) alloy’s corrosive and biocompatible response in simulated physiological conditions was investigated before and after its additional high-pressure torsion (HPT) and laser irradiation processing. The grain size reduction from 2.76 µm to ~ 200 nm and the appearance of laser-induced morphologically altered and highly oxidized surface led to the significant improvement of alloy corrosion resistance and cell–implant interaction. Moreover, an additional increase of the laser pulse energy from 5 to 15 mJ during the alloy irradiation in the air led to an increase in the surface oxygen content from 13.64 to 23.89% accompanied by an increase of excellent cell viability from 127.18 to 134.42%. As a result of the controlled alloy microstructural and surface modifications, the formation of protective bi-modal mixed Ti- and Nb-oxide external scale was enabled. The presence of this surface oxide scale enhanced the alloy’s resistance to corrosion deterioration and simultaneously boosted cell viability and proliferation.

关键词： Ti-45Nb alloy High-pressure torsion Laser surface scanning Corrosion resistance Biocompatible properties

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro kojima Kenji Watanabe Mikio Kawai Soichi Yagi koji Kaku Maiko Ikenouchi Toshiyuki Sato koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

Recent Advances in Nanoengineering of Electrode-Electrolyte Interfaces to Realize High-Performance Li-Ion Batteries

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Energy & Environmental Materials 2024年第3期7卷 1-13页

作者： Na-Yeong Kim Ilgyu Kim Behnoosh Bornamehr Volker Presser Hiroyuki ueda Ho-Jin Lee Jun Young Cheong Ji-Won Jung School of Materials Science and Engineering University of UlsanTechno saneop-ro 55 beon-gilNam-guUlsan 44776Korea INM-Leibniz Institute for New Materials Campus D2266123Saarbrücken Germany Department of Materials Science and Engineering Campus D2266123Saarbrücken Germany saarene-Saarland Center for Energy Materials and Sustainability Campus C4266123Saarbrücken Germany Institute for Frontier Materials(IFM) Deakin University221 Burwood HighwayBurwood Victoria 3125Australia Battery Research and Innovation Hub Deakin University5/154 Highbury RoadBurwood Victoria 3125Australia Bavarian Center for Battery Technology(BayBatt)and Department of Chemistry University of BayreuthUniversitatsstraBe 3095447Bayreuth Germany

A suitable interface between the electrode and electrolyte is crucial in achieving highly stable electrochemical performance for Li-ion batteries,as facile ionic transport is *** research and development have recently been conducted to form a stable interface between the electrode and ***,it is essential to investigate emerging knowledge and contextualize *** nanoengineering of the electrode-electrolyte interface has been actively researched at the electrode/electrolyte and interphase *** review presents and summarizes some recent advances aimed at nanoengineering approaches to build a more stable electrode-electrolyte interface and assess the impact of each approach ***,future perspectives on the feasibility and practicality of each approach will also be reviewed in ***,this review aids in projecting a more sustainable research pathway for a nanoengineered interphase design between electrode and electrolyte,which is pivotal for high-performance,thermally stable Li-ion batteries.

关键词： battery electrode electrolyte interface lithium nanoengineering

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High performance micromachining of sapphire by laser induced plasma assisted ablation(LIPAA)using GHz burst mode femtosecond pulses

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Opto-Electronic Science 2024年第6期3卷 20-29页

作者： Kotaro Obata Shota Kawabata Yasutaka Hanada Godai Miyaji koji Sugioka RIKEN Center for Advanced Photonics(RAP) Wako-shiSaitama 351-0198Japan Faculty of Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo 184-8588Japan Graduate School of Science and Technology Hirosaki UniversityHirosakiAomori 036-8561Japan

GHz burst-mode femtosecond(fs)laser,which emits a series of pulse trains with extremely short intervals of several hundred picoseconds,provides distinct characteristics in materials processing as compared with the conventional irradiation scheme of fs laser(single-pulse mode).In this paper,we take advantage of the moderate pulse interval of 205 ps(4.88 GHz)in the burst pulse for high-quality and high-efficiency micromachining of single crystalline sapphire by laser induced plasma assisted ablation(LIPAA).Specifically,the preceding pulses in the burst generate plasma by ablation of copper placed behind the sapphire substrate,which interacts with the subsequent pulses to induce ablation at the rear surface of sapphire *** a result,not only the ablation quality but also the ablation efficiency and the fabrication resolution are greatly improved compared to the other schemes including single-pulse mode fs laser direct ablation,single-pulse mode fs-LIPAA,and nanosecond-LIPAA.

关键词： femtosecond laser GHz burst mode ablation LIPAA laser induced plasma assisted ablation sapphire

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Lithium Ion Transport Environment by Molecular Vibrations in Ion-Conducting Glasses

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Energy & Environmental Materials 2024年第03期7卷 137-146页

作者： Hiroki Yamada koji Ohara Satoshi Hiroi Atsushi Sakuda Kazutaka lkeda Takahiro Ohkubo Kengo Nakada Hirofumi Tsukasaki Hiroshi Nakajimai Laszlo Temleitner Laszlo Pusztai Shunsuke Ariga Aoto Matsuo Jiong Ding Takumi Nakano Takuya Kimura Ryo Kobayashi Takeshi Usuki Shuta Tahara koji Amezawa Yoshitaka Tateyama Shigeo Mori Akitoshi Hayashi Diffraction and Scattering Division Japan Synchrotron Radiation Research Institute((JASRI) Faculty of Materials for Energy Shimane University Department of Applied Chemistry Graduate School of EngineeringOsaka Metropolitan University Institute of Materials Structure Science High Energy Accelerator Research Organization (KEK) Graduate School of Engineering Chiba University Department of Materials Science Graduate School of EngineeringOsaka Metropolitan University Wigner Research Centre for Physics International Research Organisation of Advanced Science and Technology (IROAST) Kumamoto University Department of Applied Physics Nagoya Institute of Technology Faculty of Science Yamagata University Faculty of Science University of the Ryukyus Institute of Multidisciplinary Research for Advanced Materials Tohoku University Center for Green Research on Energy and Environmental Materials (GREEN) and International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science(NIMS)

Controlling Li ion transport in glasses at atomic and molecular levels is key to realizing all-solid-state batteries,a promising technology for electric *** this context,Li3PS4glass,a promising solid electrolyte candidate,exhibits dynamic coupling between the Li+cation mobility and the PS43-anion libration,which is commonly referred to as the paddlewheel *** addition,it exhibits a concerted cation diffusion effect （i.e.,a cation-cation interaction）,which is regarded as the essence of high Li ion ***,the correlation between the Li+ions within the glass structure can only be vaguely determined,due to the limited experimental information that can be ***,this study reports that the Li ions present in glasses can be classified by evaluating their valence oscillations via Bader analysis to topologically analyze the chemical *** is found that three types of Li ions are present in Li3PS4glass,and that the more mobile Li ions （i.e.,the Li3-type ions） exhibit a characteristic correlation at relatively long distances of 4.0-5.0?.Furthermore,reverse Monte Carlo simulations combined with deep learning potentials that reproduce X-ray,neutron,and electron diffraction pair distribution functions showed an increase in the number of Li3-type ions for partially crystallized glass structures with improved Li ion transport *** results show order within the disorder of the Li ion distribution in the glass by a topological analysis of their ***,considering the molecular vibrations in the glass during the evaluation of the Li ion valences is expected to lead to the development of new solid electrolytes.

关键词： electrolytes ionic conductors modeling molecular dynamics

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Pedestrian trajectory prediction method based on the Social-LSTM model for vehicle collision

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Transportation Safety and Environment 2024年第3期6卷 140-151页

作者： Yong Han Xujie Lin Di Pan Yanting Li Liang Su Robert Thomson koji Mizuno School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen 361024China Fujian Province Key Laboratory of Advanced Design and Manufacturing of Buses Xiamen 361024China Engineering Research Institute of Xiamen Kinglong United Automobile Industry Co. Ltd.Xiamen 361000China Chalmers University of Technology Gothenburg 41296Sweden Department of Mechanical Systems Engineering Nagoya UniversityNagoya 464-8603Japan

Techniques for predicting the trajectory of vulnerable road users are important to the development of perception systems for autonomous vehicles to avoid *** most effective trajectory prediction methods,such as Social-LSTM,are often used to predict pedestrian trajectories in normal passage ***,they can produce unsatisfactory prediction results and data redundancy,as well as difficulties in predicting trajectories using pixel-based coordinate systems in collision avoidance *** is also a lack of validations using real vehicle-to-pedestrian *** address these issues,some insightful approaches to improve the trajectory prediction scheme of Social-LSTM were proposed,such methods included transforming pedestrian trajectory coordinates and converting image coordinates to world *** YOLOv5 detection model was introduced to reduce target loss and improve prediction *** DeepSORT algorithm was employed to reduce the number of target transformations in the tracking *** Perspective Transformation(IPT)and Direct Linear Transformation(DLT)theories were combined to transform the coordinates to world coordinates,identifying the collision location where the accident could *** performance of the proposed method was validated by training tests using MS COCO(Microsoft Common Objects in Context)and ETH/UCY *** results showed that the target detection accuracy was more than 90%and the prediction loss tends to decrease with increasing training steps,with the final loss value less than 1%.The reliability and effectiveness of the improved method were demonstrated by benchmarking system performance to two video recordings of real pedestrian accidents with different lighting conditions.

关键词： vehicle-to-pedestrian collisions pedestrian trajectory prediction YOLOvB DeepSORT Social-LSTM