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Validation of the Japan Coma Scale for the prediction of mortality in children:analysis of a nationwide trauma database

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World Journal of Pediatric Surgery 2022年第2期5卷 23-28页

作者： Yuki Enomoto Yusuke Tsutsumi Asuka Tsuchiya Takahiro Kido koji Ishigami Masahito Togo Susumu Yasuda Yoshiaki Inoue Department of Emergency and Critical Care Medicine University of TsukubaTsukubaIbarakiJapan Department of Emergency and Critical Care Medicine Mito Medical CenterMitoIbarakiJapan Department of Emergency and Critical Care Medicine Tokai University School of Medicine Graduate School of MedicineIseharaKanagawaJapan Department of Clinical Epidemiology and Health Economics The University of TokyoBunkyo-kuTokyoJapan Department of Pediatrics University of Tsukuba HospitalTsukubaIbarakiJapan

Objective The Japan Coma Scale(JCS)is widely used in clinical practice to evaluate levels of consciousness in *** have been several studies on the usefulness of JCS in ***,its usefulness in evaluating children has not been ***,this study aimed to assess the usefulness of the JCS for the prediction of mortality in *** This is a multicenter cohort study which used data from a national trauma registry(Japan Trauma Data Bank).This study included patients under 16 years of age who were treated between 2004 and *** primary outcome measure was in-hospital *** models were used to examine each item of the Glasgow Coma Scale(GCS)and the *** A included the discrete levels of each *** model B,data regarding age,sex,vital signs on arrival to hospital,the Injury Severity Score,and blunt trauma were added to each *** effectivity of the JCS score was then evaluated using the area under the curve(AUC)for discrimination,a calibration plot,and the Hosmer-Lemeshow test for *** A total of 9045 patients were *** AUCs of the GCS and JCS were 0.929(95%confidence interval(CI)0.904 to 0.954)and 0.930(95%CI 0.906 to 0.954)in model A and 0.975(95%CI 0.963 to 0.987)and 0.974(95%CI 0.963 to 0.985)in model B,*** results of the Hosmer-Lemeshow test were 0.00(p=1.00)and 0.00(p=1.00)in model A and 4.14(p=0.84)and 8.55(p=0.38)in model B for the GCS and JCS,*** We demonstrated that the JCS is as valid as the GCS for predicting *** findings of this study indicate that the JCS is a useful and relevant tool for pediatric trauma care and future research.

关键词： Glasgow prediction nationwide

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Tone Modulation in a Passive OTDM Multiplexer for Clock Recovery from a 160 Gbit/s OTDM Signal

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光学学报 2003年第S1期23卷 591-592页

作者： Tetsuya. miyazaki Fumito Kubota Communications Research Laboratory 4-2-1 Nukui-kita Koganei Tokyo 184-8795 JapanCommunications Research Laboratory 4-2-1 Nukui-kita Koganei Tokyo 184-8795 Japan

Tone modulation in a passive OTDM multiplexer for clock recovery from a 160-Gbit/s OTDM signal by using a base-rate receiver is demonstrated. We performed synchronous demultiplexing in back-to-back arrangement and opt... 详细信息

关键词： OTDM Tone Modulation in a Passive OTDM Multiplexer for Clock Recovery from a 160 Gbit/s OTDM Signal in for from

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Two-dimensional laser-induced periodic surface structures formed on crystalline silicon by GHz burst mode femtosecond laser pulses

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International Journal of Extreme Manufacturing 2023年第1期5卷 212-220页

作者： Shota Kawabata Shi Bai Kotaro Obata Godai Miyaji koji Sugioka RIKEN Center for Advanced Photonics 2-1 HirosawaWakoSaitama 351-0198Japan Department of Applied Physics Tokyo University of Agriculture and Technology2-24-16 NakachoKoganeiTokyo 184-8588Japan

Femtosecond laser pulses with GHz burst mode that consist of a series of trains of ultrashort laser pulses with a pulse interval of several hundred picoseconds offer distinct features in material processing that cannot be obtained by the conventional irradiation scheme of femtosecond laser pulses(single-pulse mode).However,most studies using the GHz burst mode femtosecond laser pulses focus on ablation of materials to achieve high-efficiency and high-quality material *** this study,we explore the ability of the GHz burst mode femtosecond laser processing to form laser-induced periodic surface structures(LIPSS)on *** is well known that the direction of LIPSS formed by the single-pulse mode with linearly polarized laser pulses is typically perpendicular to the laser polarization *** contrast,we find that the GHz burst mode femtosecond laser(wavelength:1030 nm,intra-pulse duration:220 fs,intra-pulse interval time(intra-pulse repetition rate):205 ps(4.88 GHz),burst pulse repetition rate:200 kHz)creates unique two-dimensional(2D)*** regard the formation mechanism of 2D LIPSS as the synergetic contribution of the electromagnetic mechanism and the hydrodynamic ***,generation of hot spots with highly enhanced electric fields by the localized surface plasmon resonance of subsequent pulses in the bursts within the nanogrooves of one-dimensional LIPSS formed by the preceding pulses creates 2D ***,hydrodynamic instability including convection flow determines the final structure of 2D LIPSS.

关键词： GHz burst laser-induced periodic surface structures(LIPSS) surface nanostructuring 2D nanostructures

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Salvage brachytherapy for locally recurrent prostate cancer after external beam radiotherapy

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Asian Journal of Andrology 2015年第6期17卷 899-903页

作者： Yasuhiro Yamada koji Okihara Tsuyoshi Iwata koji Masui Kazumi Kamoi Kei Yamada Tsuneharu Miki Department of Urology Kyoto Prefectural Universityof Medicine Kyoto Japan Department of Radiology Kyoto Prefectural University of Medicine KyotoJapan

External beam radiotherapy （EBRT） is a standard treatment for prostate cancer. Despite the development of novel radiotherapy techniques such as intensity-modulated conformal radiotherapy, the risk of local recurrence after EBRT has not been obviated. Various local treatment options （including salvage prostatectomy, brachytherapy, cryotherapy, and high-intensity focused ultrasound [HIFU]） have been employed in cases of local recurrence after primary EBRT. Brachytherapy is the first-line treatment for low-risk and selected intermediate-risk prostate tumors. However, few studies have examined the use of brachytherapy to treat post-EBRT recurrent prostate cancer. The purpose of this paper is to analyze the current state of our knowledge about the effects of salvage brachytherapy in patients who develop locally recurrent prostate cancer after primary EBRT. This article also introduces our novel permanent brachytherapy salvage method.

关键词： Salvage brachytherapy radiotherapy

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Towards understanding structure–property relations in materials with interpretable deep learning

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npj Computational Materials 2023年第1期9卷 157-168页

作者： Tien-Sinh Vu Minh-Quyet Ha Duong-Nguyen Nguyen Viet-Cuong Nguyen Yukihiro Abe Truyen Tran Huan Tran Hiori Kino Takashi Miyake koji Tsuda Hieu-Chi Dam Japan Advanced Institute of Science and Technology NomiIshikawaJapan HPC SYSTEMS Inc. MinatoTokyoJapan Applied Artificial Intelligence Institute Deakin UniversityGeelongVICAustralia School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGAUSA Research and Services Division of Materials Data and Integrated System National Institute for Materials ScienceTsukubaIbarakiJapan Research Center for Computational Design of Advanced Functional Materials National Institute of Advanced Industrial Science and TechnologyTsukubaIbarakiJapan Department of Computational Biology and Medical Sciences Graduate School of Frontier SciencesUniversity of TokyoKashiwa-shiChiba-kenJapan International Center for Synchrotron Radiation Innovation Smart(SRIS) Tohoku UniversityAoba-kuSendaiJapan

Deep learning(DL)models currently employed in materials research exhibit certain limitations in delivering meaningful information for interpreting predictions and comprehending the relationships between structure and material *** address these limitations,we propose an interpretable DL architecture that incorporates the attention mechanism to predict material properties and gain insights into their structure–property *** proposed architecture is evaluated using two well-known datasets(the QM9 and the Materials Project datasets),and three in-house-developed computational materials ***–test–split validations confirm that the models derived using the proposed DL architecture exhibit strong predictive capabilities,which are comparable to those of current state-of-the-art ***,comparative validations,based on first-principles calculations,indicate that the degree of attention of the atoms’local structures to the representation of the material structure is critical when interpreting structure–property relationships with respect to physical *** properties encompass molecular orbital energies and the formation energies of *** proposed architecture shows great potential in accelerating material design by predicting material properties and explicitly identifying crucial features within the corresponding structures.

关键词： properties property structure

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Development of perianal ulcer as a result of acute fulminant amoebic colitis

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World Journal of Gastroenterology 2012年第34期18卷 4794-4797页

作者： Takayuki Torigoe Yoshifumi Nakayama koji Yamaguchi Department of Surgery 1 School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan

We report a case of acute fulminant amoebic colitis that resulted in the development of a perianal ulcer in a 29-year-old Japanese homosexual man with acquired immunodeficiency syndrome (AIDS). The patient was admitted to our hospital with a persistent perianal abscess that was refractory to antibiotic therapy adminis-tered at another hospital. On admission, we observed a giant ulcer in the perianal region. At first, cytomega-lovirus colitis was suspected by blood investigations. Ganciclovir therapy was initiated; however, the patient developed necrosis of the skin around the anus during therapy. We only performed end-sigmoidostomy and necrotomy to avoid excessive surgical invasion. Histopathological examination of the surgical specimen revealed the presence of trophozoite amoebae, indicating a final diagnosis of acute fulminant amoebic colitis. The patient's postoperative course was favorable, and proctectomy of the residual rectum was performed 11 mo later. Amoebic colitis is one of the most severe complications affecting patients with AIDS. Particularly, acute fulminant amoebic colitis may result in a poor prognosis; therefore, staged surgical therapy as a lessinvasive procedure should be considered as one of the treatment options for these patients.

关键词：尖锐暴发性的阿米巴的大肠炎 Perianal 溃疡获得的免疫不全症候群 Cytomegalovirus 大肠炎上演外科

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AIM associated with the IgM pentamer: attackers on stand-by at aircraft carrier

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Cellular & Molecular Immunology 2018年第6期15卷 563-574页

作者： Toru miyazaki Tomoko Yamazaki Ryoichi Sugisawa M Eric Gershwin Satoko Arai Laboratory of Molecular Biomedicine for Pathogenesis Center for Disease Biology and Integrative MedicineFaculty of MedicineThe University of TokyoTokyo 113-0033Japan CREST Japan Agency for Medical Research and DevelopmentTokyo 113-0033Japan Max Planck-The University of Tokyo Center for Integrative Inflammology Tokyo 113-0033Japan Division of Rheumatology Allergy and Clinical Immunology The University of California School of MedicineDavisCA 95616USA

Circulating immunoglobulin M(IgM)exists in a pentameric form,possessing a polyreactive nature that responds not only to foreign antigens but also to autoantigens;thus,it is involved in both beneficial and detrimental immune responses,including protection from infection and the progression of *** the other hand,IgM also behaves as a carrier of the apoptosis inhibitor of macrophage(AIM)protein,storing a large amount of the inactivated form of AIM in the blood through this *** different disease conditions,AIM can dissociate from IgM locally or systemically to exert its function,inducing the removal of various biological debris such as excess fat,bacteria,cancer cells or dead cell *** typically,upon induction of acute kidney injury(AKI),IgM-free AIM is filtered by the glomerulus in the kidney,which stimulates the clearance of intraluminal dead cells debris at the obstructed proximal tubules,thereby facilitating the repair of kidney ***,cats exhibit a deficiency in AIM release from IgM,which may increase their susceptibility to renal ***,association with AIM inhibits IgM binding to the Fcα/μreceptor on follicular dendritic cells at the splenic germinal center,thereby protecting the IgM immune complex from Fcα/μreceptor-mediated internalization,which supports IgM-dependent antigen presentation to B cells and stimulates high-affinity IgG antibody *** regulation of AIM–IgM binding,resulting from the discovery of reciprocal actions between AIM and IgM,could lead to the development of novel therapies against different diseases.

关键词： apoptosis inhibitor of macrophage(AIM) immunoglobulin M(IgM) acute kidney injury(AKI) hepatocellular carcinoma(HCC) cat renal failure

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BDNF pro-peptide：a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing

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Neural Regeneration Research 2017年第7期12卷 1024-1027页

作者： Toshiyuki Mizui koji Ohira Masami kojima Biomedical Research Inst. (BMD) National Institute of Advanced Industrial Science and Technology (AIST) Osaka Japan Laboratory of Nutritional Brain Science Department of Food Science and Nutrition Mukogawa Women's University Hyogo Japan Core Research for Evolutional Science and Technology (CREST) Science and Technology Agency (JST) KawaguchiJapan Graduate School of Frontier Bioscience Osaka University Suita Japan

Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and ***,compared with the expression and function of bioactive mature domain,the biological role of the pro-domain is poorly ***,we found that the pro-domain（or pro-peptide）of brain-derived neurotrophic factor（BDNF）,which is well-known neurotrophic factor in brain,has a potential ability to facilitate hippocampal long-term ***,a BDNF polymorphism Val66Met,which substitute valine into methionine at 66 amino acid,impacted the biological activity of the BDNF *** lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.

关键词： BDNF growth factor neural stem cells ischemia peptide

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Experimental study on the in-plane thermal conductivity of Au nanofilms

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Progress in Natural Science:Materials International 2007年第2期17卷 212-216页

作者： TAKAHASHI koji IKUTA Tatsuya FUJII Motoo Graduate School of Engineering Kyushu UniversityFukuoka 812-8581Japan Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan

The in-plane thermal conductivity of Au nanofilms with thickness of 23 nm, which are fabricated by the electron beam-physical vapor deposition method and a suspension technology, is experimentally measured at 80-300 K by a one-dimensional steady-state electrical heating method. Strong size effects are found on the measured nanofilm thermal conductivity. The Au nanofilm in-plane thermal conductivity is much less than that of the bulk material. With the increasing temperature, the nanofilm thermal conductivity increases. This is opposite to the temperature dependence of the bulk property. The Lorenz number of the Au nanofilms is about three times larger than the bulk value and decreases with the increasing temperature, which indicates the invalidity of the Wiedemann-Franz law for metallic nanofilms.

关键词： nanofilm in-plane thermal conductivity size effect Wiedemann-Franz law.

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Quantitative Analysis of the Removal Ratio of Fine Particles in Water by Gas Bubbling

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Journal of Iron and Steel Research(International) 2011年第S2期18卷 331-334页

作者： Masafumi miyazaki Hideaki Yamamura Satoru Mineta Takehiko Toh Environment & Process Technology Center Technical Development Bureau Nippon Steel Corp. Japan Advanced Technology Research Lab. Technical Development Bureau Nippon Steel Corp. Japan

Removal of non-metallic inclusions in molten steel is important from the viewpoint of improvement of quality, property and yield of the products. As a removal method of inclusions from molten metal, gas bubble flotation adhering inclusions is well known. Gas bubbling is particularly effective for the removal of fine inclusions. Water model experiment is reported the quantitative analysis of the removal ratio of dispersed particles removed from water by gas bubbles.

关键词： inclusion gas bubble water model experiment removal constant collision attachment

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