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Factors Affecting Japanese HPV-Vaccination: Findings from the Semi-Structured Interviews with Adolescent Girls and Caregivers

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Health 2014年第13期6卷 1602-1615页

作者： Rie Wakimizu Kaori Nishigaki Hiroshi Fujioka koji maehara Haruo Kuroki Tadashi Saito Katsuya Uduki Faculty of Medicine University of Tsukuba Tsukuba Japan Investigative Commission of Qualitative Study Society of Ambulatory and General Pediatrics of Japan Tokyo Japan

The objective of the present study was to qualitatively assess the obstructive and facilitative factors affecting adolescent girls and their caregivers when the adolescent had received or was considering receiving the Human Papilloma Virus (HPV) vaccination. Using these data, we propose recommendations for medical and nursing staff concerned with HPV vaccination. Participants were 20 adolescent girls (aged 10 - 19 years) and their caregivers, who had visited any of the 3 pediatric clinics in the Tokyo metropolitan area during a specified period since HPV vaccination began in Japan. The girls and their caregivers were separately interviewed by 2 child and/or family nursing care specialists with a semi-structured interview. The responses were qualitatively analyzed by 2 specialists, and the obstructive and facilitative factors affecting participants’ decision to receive HPV vaccination were extracted from the responses. Among the 20 sets of participants, 7 adolescents had completed HPV vaccination, 9 were going to receive vaccination, and 4 had not received any vaccination. The obstructive/facilitative factors related to considering or receiving HPV vaccination and actual vaccination were extracted and 4 main categories of factors were identified. Facilitators toward HPV-vaccination of daughters included clear future self-image and visions, fear Cervical Cancer (CC) and desire to escape from CC, having discussion with mothers about HPV-vaccination and CC, and to have a boyfriend. Barriers toward vaccination included the mothers’ reluctance to explain the sexual matters about HPV-vaccination to their daughters and difficulty with find the appropriate clinic or hospital to HPV-vaccination. Relevant factors about vaccination included positive family attitudes toward vaccination, having family system allowing consultation and having a public financial support for vaccination for daughters. Our conceptual model adapted from the Katz, et al. conceptual framework integrated

关键词： Adolescents Caregivers HPV Vaccination Japan Qualitative Study Semi-Structured Interview

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Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer

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World Journal of Gastroenterology 2009年第20期15卷 2520-2525页

作者： Eiji Oki Yan Zhao Rintaro Yoshida Takanobu Masuda koji Ando Masahiiko Sugiyama Eriko Tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko maehara Department of Surgery and Science Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan Department of Gastroenterology National Kyushu Cancer Center 3-1-1 Notame Minarni-ku Fukuoka 811-1395 Japan

AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric ***:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c *** microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct ***:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological *** found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation ***:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of ***, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis.

关键词： Checkpoint with forkhead-associated and ring finger Methylation Microsatellite instability Gastric cancer p53

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Preoperative sorting of circulating T lymphocytes in patients with esophageal squamous cell carcinoma: Its prognostic significance

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World Journal of Gastroenterology 2005年第42期11卷 6689-6693页

作者： Tadahiro Nozoe Yoshihiko maehara Keizo Sugimachi Department of Surgery Fukuoka Higashi Medical Center KogaJapan Department of Surgery and Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan Kyushu Central Hospital

AIM: To elucidate the immunologic parameters for the outcome of patients with malignant tumors, especially esophageal squamous cell carcinoma (ESCC) associated with high malignant potential. METHODS: Clinicopathologic features were compared between patients with lower and higher CD4 and CD8 values as well as CD4/CD8 ratio in peripheral blood. RESULTS: The survival rate of patients with higher CD4 value was significantly better than that in patients with lower CD4 value (P = 0.039). The survival rate of patients with higher CD8 value was significantly worse than that of patients with lower CD8 value (P = 0.026). Similarly, the survival rate of patients with higher CD4/ CD8 ratio was significantly better than that of patients with lower CD4/CD8 ratio (P = 0.042). Additionally, multivariate analysis demonstrated that lower CD8 and lower CD4/CD8 ratio were factors independently associated with worse prognosis of patients. CONCLUSION: All the immunologic parameters can predict the outcome of patients with ESCC.

关键词： Lymphocyte sub-population Esophagus Squamous cell carcinoma Prognostic indicator

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Heat generation properties in AC magnetic field for composite powder material of the Y3Fe5O12-nSiC system prepared by reverse coprecipitation method

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Journal of Advanced Ceramics 2016年第3期5卷 262-268页

作者： Hiromichi AONO Yuhi YAMANO Takashi NAOHARA Yoshiteru ITAGAKI Tsunehiro maehara Hideyuki HIRAZAWA Graduate School of Science and Engineering Ehime University Matsuyama 790-8577 Japan National Institute of Technology Niihama College Niihama 792-8580 Japan

Composite powder material of the Y3Fe5O12–nSiC system was synthesized by a reverse coprecipitation method to study its heat generation property in an AC magnetic field. For Y3Fe5O12 (n = 0), the maximum heat generation ability of 0.45 W·g−1 in an AC magnetic field (370 kHz, 1.77 kA·m−1) was obtained for the sample calcined at 1100 °C. The SiC addition helped to suppress the particle growth for Y3Fe5O12 at the calcination temperature. The heat generation ability was improved by the addition of the SiC powder, and the maximum value of 0.93 W·g−1 was obtained for the n = 0.3 sample calcined at 1250 °C. The heat generation ability and the hysteresis loss value were proportional to the cube of the magnetic field (H 3). The heat generation ability (W·g−1) of the Y3Fe5O12–0.3SiC sample calcined at 1250 °C could be expressed by the equation 4.5×10−4 · f · H 3 using the frequency f (kHz) and the magnetic field H (kA·m−1).

关键词： magnetic materials composite material Y3Fe5O12 SiC heat generation ability AC magnetic field

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Management of thrombocytopenia due to liver cirrhosis:A review

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World Journal of Gastroenterology 2014年第10期20卷 2595-2605页

作者： Hiromitsu Hayashi Toru Beppu Ken Shirabe Yoshihiko maehara Hideo Baba Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto 860-8556 Japan Department of Surgery and Science Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan

Thrombocytopenia is a common complication in liver disease and can adversely affect the treatment of liver cirrhosis,limiting the ability to administer therapy and delaying planned surgical/diagnostic procedures because of an increased risk of *** factors,including splenic sequestration,reduced activity of the hematopoietic growth factor thrombopoietin,bone marrow suppression by chronic hepatitis C virus infection and anti-cancer agents,and antiviral treatment with interferon-based therapy,can contribute to the development of thrombocytopenia in cirrhotic *** these factors,the major mechanisms for thrombocytopenia in liver cirrhosis are(1)platelet sequestration in the spleen;and(2)decreased production of thrombopoietin in the *** treatment options,including platelet transfusion,interventional partial splenic embolization,and surgical splenectomy,are now available for severe thrombocytopenia in cirrhotic *** thrombopoietin agonists and targeted agents are alternative tools for noninvasively treating thrombocytopenia due to liver cirrhosis,their ability to improve thrombocytopenia in cirrhotic patients is under investigation in clinical *** this review,we propose a treatment approach to thrombocytopenia according to our novel concept of splenic volume,and we describe the current management of thrombocytopenia due to liver cirrhosis.

关键词： Liver cirrhosis Thrombocytopenia Thrombopoietin Partial splenic embolization Splenectomy

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Successful outcome of retrograde pancreatojejunostomy for chronic pancreatitis and infected pancreatic cysts:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7224-7230页

作者： Koichi Kimura Eisuke Adachi Ayako Toyohara Sachie Omori Kaoru Ezaki Ryo Ihara Takahiro Higashi Kippei Ohgaki Shuhei Ito Shin-ichiro maehara Toshihiko Nakamura Yoshihiko maehara Department of Surgery Kyushu Central Hospital of the Mutual Aid Association of Public School TeachersFukuoka 815-8588Japan Department of Internal Medicine Kyushu Central Hospital of the Mutual Aid Association of Public School TeachersFukuoka 815-8588Japan

BACKGROUND Chronic pancreatitis occasionally requires surgical treatment that can be performed with various ***,this type of surgery presents with postoperative *** report a case of a successful retrograde pancreatojejunostomy for chronic pancreatitis and infected pancreatic *** SUMMARY A 62-year-old male with a 10-year history of chronic pancreatitis presented with epigastric pain for one week and a 20 kg weight loss over one *** tomography showed stones in the pancreas(mainly the head),expansion of the main pancreatic duct,and thinning of the pancreatic *** resonance imaging showed infected pancreatic cysts connected to the stomach with a fistula from the splenic hilum to the caudal portion of the liver’s lateral *** endoscopic retrograde pancreatography was performed;the guide wires could not pass through the stones in the pancreas and therefore,drainage of the main pancreatic duct was not ***,a distal pancreatomy and splenectomy were performed;however,the pancreatic juice in the remaining parenchyma was blocked by the ***,we performed a retrograde pancreatojejunostomy and Roux-en-Y *** patient had no postoperative complications and was discharged from the hospital on postoperative day *** A distal pancreatomy,retrograde pancreatojejunostomy,and Roux-en-Y anastomosis could be an effective surgical procedure for intractable chronic pancreatitis.

关键词： Chronic pancreatitis Infected pancreatic cyst Distal pancreatomy Retrograde pancreatojejunostomy Pancreatic stones Case report

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Prognosis of hepatocellular carcinoma accompanied by microscopic portal vein invasion

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World Journal of Gastroenterology 2009年第21期15卷 2632-2637页

作者： Ken Shirabe Kiyoshi Kajiyama Norifumi Harimoto Hideaki Masumoto Tatsuro Fukuya Masafumi Ooya Yoshihiko maehara Department of Hepatogastroenterological Surgery Aso Iizuka Hospital Department of Surgery and Science Graduate School of Medical SciencesKyushu University Department of Surgery Aso Iizuka Hospital Department of Hepatology Aso Iizuka Hospital Department of Radiology Aso Iizuka Hospital

AIM:To investigate the prognostic factors in patients with hepatocellular carcinoma(HCC) accompanied by microscopic portal vein invasion(PVI).METHODS:Of the 267 patients with HCC undergoing hepatic resection at Aso Iizuka Hospital,71 had *** excluding 16 patients with HCC that invaded the main trunk and the first and second branches of the portal vein,55 patients with microscopic PVI were ***:The patients with HCC accompanied by microscopic invasion were divided into two groups:solitary PVI(PVI-S:n = 44),and multiple PVIs(PVI-M:n = 11).The number of portal vein branches invaded by tumor thrombi was 5.4 ± 3.8(2-16) in patients with *** cumulative survival,PVI-M was found to be a significantly poor prognostic factor(P = 0.0019);while PVI-M and non-anatomical resection were significantly poor prognostic factors in disease-free survival(P = 0.0213,and 0.0115,respectively).In patients with PVI-M,multiple intrahepatic recurrence was more common than in the patients with PVI-S(P = 0.0049).In patients with PVI-S,non-anatomical resection was a significantly poor prognostic factor in disease-free survival(P = 0.0370).Operative procedure was not a significant prognostic factor in patients with ***:The presence of PVI-M was a poor prognostic factor in patients with HCC,accompanied by microscopic *** resection is recommended in these patients with *** with HCC and PVI-M may also be good candidates for adjuvant chemotherapy.

关键词： Hepatocellular carcinoma Microscopic portalvein invasion Hepatectomy Prognosis Recurrence

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Schwannoma mimicking pancreatic carcinoma:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4453-4459页

作者： Koichi Kimura Eisuke Adachi Ayako Toyohara Sachie Omori Kaoru Ezaki Ryo Ihara Takahiro Higashi Kippei Ohgaki Shuhei Ito Shin-ichiro maehara Toshihiko Nakamura Fumiyoshi Fushimi Yoshihiko maehara Department of Surgery Kyushu Central Hospital of the Mutual Aid Association of Public School TeachersFukuoka 815-8588Japan Department of Internal Medicine Kyushu Central Hospital of the Mutual Aid Association of Public School TeachersFukuoka 815-8588Japan Department of Histopathology Kyushu Central Hospital of the Mutual Aid Association of Public School TeachersFukuoka 815-8588Japan

BACKGROUND Schwannoma of the pancreas is extremely *** report a case of pancreatic schwannoma that was difficult to distinguish from pancreatic carcinoma before *** SUMMARY A 66-year-old male underwent a right-lobe hepatectomy for hepatocellular ***-surgical computed tomography showed a 10 mm long solid mass with ischemia,with no expansion into the main pancreatic *** magnetic resonance cholangiopancreatography,the tumor had high signal intensity in diffusion weighted images,consistent with pancreatic *** ultrasound(EUS)was performed to obtain more information about the tumor,and showed a 14 mm solid and hypoechoic mass in the pancreatic *** enhanced EUS revealed that the tumor showed a hyperechoic mass in the early phase,and the contrasting effect continuation was very short;findings also consistent with pancreatic ***,we preoperatively diagnosed his condition as a pancreatic carcinoma and performed distal pancreatectomy with *** examination showed that the tumor was in fact a benign *** showed a proliferation of spindle-shaped cell in a vague fascicular and haphazard pattern,with palisading *** Schwannoma of the pancreas is very rare,however,clinicians should consider schwannoma as the differential diagnosis for pancreatic tumors.

关键词： Schwannoma Pancreatic body Pancreatic carcinoma Pancreatic tumor Distal pancreatectomy Case report

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Lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompensated cirrhosis

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World Journal of Gastroenterology 2012年第20期18卷 2586-2590页

作者： Koichi Honda Masataka Seike Shin-ichiro maehara Koichiro Tahara Hideaki Anai Akira Moriuchi Toyokichi Muro First Department of Internal Medicine Oita UniversityOita 879-5593Japan Department of Surgery National Hospital Organization Oita Medical CenterOita 870-0263Japan Department of Pathology National Hospital Organization Oita Medical CenterOita 870-0263Japan Department of Gastroenterology and Hepatology National Hospital Organization Oita Medical CenterOita 870-0263Japan

A 69-year-old man was admitted to our hospital in October 2003,for further examination of two liver *** was diagnosed with hepatocellular carcinoma(HCC) arising from decompensated hepatitis B virus(HBV)-related ***-term lamivudine administration improved liver function dramatically despite repeated treatment for *** Child-Pugh score was 9 points at start of lamivudine treatment,improving to 5 points after 1 *** indocyanine green at 15 min after injection test score was 48%before lamivudine treat-ment,improving to 22%after 2 years and to 5%after 4 *** ablation controlled the HCC foci and maintained his liver *** April 2009,abdominal computed tomography revealed a tumor thrombus in the right portal *** his indocyanine green test results had improved to less than 10%,we performed a right hepatectomy,which was *** our knowledge,there have been no documented reports of patients undergoing successful right hepatectomy for HCC arising from decompensated *** findings observed in our patient indicate the importance of nucleoside analogs for treating HBV-related HCC.

关键词： Hepatitis B virus Lamivudine Hepatocellular carcinoma Decompensated cirrhosis Hepatectomy

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Improvement of Heat Generation Ability in AC Magnetic Field and Magnetic Properties for Spinel Type MgFe_2O_4 Ferrite by Cu Substitution and Beads Milling

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Journal of Iron and Steel Research International 2012年第S1期19卷 596-599页

作者： Hideyuki HIRAZAWA Hiromichi AONO Takashi Naohara Tsunehiro maehara Yuji WATANABE Department of Environmental Materials Engineering Niihama National College of TechnologyNiihama 792858 0 EhimeJapan Graduate School of Science and Engineering Ehime UniversityMatsuyama 790857 7Ehime Japan Department of Organ Regenerative Surgery Ehime UniversityToon 791029 5EhimeJapan

Mg_(1-X)Cu_XFe_2O_4 type spinel ferrite was prepared by solid reaction method in order to discuss the heat generation ability in AC magnetic *** cubic type ferrite structure was obtained for X=0-0.6 samples calcined at 1200℃,and the mixture phase of cubic and tetragonal structures were obtained for X=0.7,0.8 samples from XRD result. The highest lattice parameter and highest hysteresis loss value were also shown at X=0.6 sample,the crystal distortion was increased with increase the Cu^(2+)substitution in cubic type ferrite *** sized nano Mg_(0.4)Cu_(0.6)Fe_2O_4 powder was prepared by physical milling method using beads *** highest heat generation in the AC magnetic field was obtained for the 6 h milled samples using 0.1mm *** Cu^(2+)substitution for MgFe_2O_4 ferrite and the beads milling were very effective for the improvement of their heat generation ability in AC magnetic field.

关键词： heat generation ability AC magnetic field spinel ferrite beads milling

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