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Treatment of over 20 mm gastric cancer by endoscopic submucosal dissection using an insulation-tipped diathermic knife

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World Journal of Gastroenterology 2007年第29期13卷 3981-3984页

作者： Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei fujita Fusao Ikeda Hideaki Taniguchi Eiichiro Yumoto Seiyuu Suzuki From Second Department of Internal Medicine Sumitomo Besshi Hospital 3-1 Ohji-cho Niihama 792-8543 Japan

AIM： To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife （IT-ESD） for the treatment of patients with over 20 mm early gastric cancer （EGC）. METHODS： A total of 112 patients with over 10 mm EGC were treated with IT-ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 5 year period from January 2002 to December 2006, including 40 patients with over 20 mm EGC. We compared patient backgrounds, the one-piece resection rate, complete resection （CR） rate, operation time, bleeding rate, perforation rate between patients with over 20 mm EGC [over 20 mm group （21-40 ram）] and the remaining patients （under 20 mm group）. RESULTS： We found no significant difference in the rate of underlying cardiopulmonary disease （over 20 mm group vs under 20 mm group, 5.0% vs 5.6%）, one- piece resection rate （95% vs 96%）, CR rate （85% vs 89%）, operation time （72.3 rain vs 66.5 rain）, bleeding rate （50 vs 4.2%）, and perforation rate （0% vs 1.4%） between the 2 groups. Three patients in each group had submucosal invasion and two in each groups underwent additional surgery. CONCLUSION： There was no significant difference in the outcome resulting from IT-ESD between the 2 groups. Our study proves that IT-ESD is a feasible treatment for patients with over 20 mm mucosal gastric cancer although the long-term outcome should be evaluated in the future.

关键词： Gastric cancer Endoscopic mucosal resection Insulation-tipped diathermic knife Complication

Benefits of international trauma rotation in South Africa:comparison with a trauma center in Tokyo

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Emergency and Critical Care Medicine 2022年第4期2卷 179-180页

作者： Tsuyoshi Nagao Shinji Nakahara Takashi fujita Tetsuya Sakamoto Elmin Steyn Department of Emergency Medicine Teikyo University School of MedicineTokyoJapan Graduate School of Health Innovation Kanagawa University of Human ServicesKawasakiJapan Department of surgery Stellenbosch University and Tygerberg HospitalCape TownSouth Africa.

International rotations have been an option for young surgeons who face difficulties in obtaining sufficient trauma training in their own coun*** of the authors attended training in trauma surgery in South Africa for 6 months,where there are many trauma caseloads,and could experience the number of emergency operations equivalent to approximately 5 years in *** rotation allows trainees to expose clinical practices intensively and to learn principles and theories of care under experienced academic *** the other hand,they could contribute to the host hospital as part of the workforce and by assisting young surgical *** development of a more systematic and formalized framework for staff exchange between developed and developing countries will provide mutual benefits to both sides.

关键词： Low-and middle-income countries On-the-job training Trauma surgery

Association between colonic polyps and diverticular disease

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World Journal of Gastroenterology 2008年第15期14卷 2411-2413页

作者： Tetsuo Hirata Yuko Kawakami Nagisa Kinjo Susumu Arakaki Tetsu Arakaki Akira Hokama Fukunori Kinjo Jiro fujita Department of Medicine and Therapeutics Control and Prevention of Infectious Diseases Faculty of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Internal Medicine Nishinjo Hospital Okinawa 900-0034 Japan Department of Endoscopy Ryukyu University Hospital Okinawa 903-0215 Japan Department of Coloproctology Nishinjo Hospital Okinawa 900-0034 Japan

AIM: To evaluate the association between colonic polyps and diverticular disease in Japan. METHODS: We retrospectively reviewed the medical records of 672 consecutive patients who underwent total colonoscopy between August 2006 and April 2007 at Nishinjo Hospital, Okinawa, Japan. Patients with a history of any of the following were excluded from the study: previous polypectomy, colonic resection, and inflammatory bowel diseases. The association between colonic polyps and diverticular disease was analyzed by logistic regression analysis, adjusted for age and sex. RESULTS: Prevalence of colonic polyps in all patients with diverticular disease was significantly higher than that in those without diverticular disease (adjusted odds ratio 1.7). CONCLUSION: Our data showed that patients with diverticular disease have a higher risk of colonic polyps compared to those without.

关键词： Colonic polyps Colonic neoplasm Diverticular disease Proximal diverticular disease Colonoscopy

Histological changes at an endosonography-guided biliary drainage site:A case report

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World Journal of Gastroenterology 2007年第41期13卷 5512-5515页

作者： Naotaka fujita Yutaka Noda Go Kobayashi Kei Ito Takashi Obana Jun Horaguchi Osamu Takasawa Kazunari Nakahara Department of Gastroenterology Sendai City Medical CenterSendaiJapan

Endosonography-guided biliary drainage (ESBD) is a new method enabling internal drainage of an obstructed bile duct. However,the histological conditions associated with fistula development via the duodenum to the bile duct have not been reported. We performed ESBD 14 d preoperatively in a patient with an ampullary carcinoma and histologically confirmed changes in and around the fistula. The female patient developed no complications relevant to ESBD. Levels of serum bilirubin and hepatobiliary enzymes declined quickly,and pancreatoduodenectomy was carried out uneventfully. The resected specimen was sliced and stained with hematoxylin-eosin. Histological evaluation of the puncture site in the duodenum and bile-duct wall,and the sinus tract revealed no hematoma,bile leakage,or abscess in or around the sinus tract. Little sign of granulation,fibrosis,and inflammatory cell infiltration was observed. Although further large-scale confirmatory studies are needed,the findings here may encourage more active use of ESBD as a substitute for percutaneous transhepatic drainage in cases with failed/difficult endoscopic biliary stenting.

关键词： Endosonography Endoscopic ultrasound-guided fine needle aspiration Endoscopic biliary drainage Biliary stenting Endoscopic retrograde cholang iopancreatography Obstructive jaundice Biliary stricture

Elicitation-Based Modulation of Shelf Life in Fruits: Physiological and Molecular Insights

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Phyton-International Journal of Experimental Botany 2023年第8期92卷 2283-2300页

作者： Ankita Kundu Abir Das Sayan Pal Arijit Ghosh Malay Kumar Adak Masayuki fujita Mirza Hasanuzzaman Plant Physiology and Molecular Biology Research Unit Department of BotanyUniversity of KalyaniKalyani741235India Laboratory of Plant Stress Responses Faculty of AgricultureKagawa UniversityKagawa761-0795Japan Department of Agronomy Faculty of AgricultureSher-E-Bangla Agricultural UniversityDhaka1207Bangladesh

The process of ripening involves physiological and biochemical events that become a concern during postharvest *** have documented different approaches for the preservation and maintenance of fruit quality during the postharvest period that are biocompatible and fully safe for *** residues that sustain sensory characteristics,such as color,ﬂavor,aroma,and texture,are *** fruit ripening,both physical and chemical elicitors are described that regulate ethylene biosynthesis or its signaling for gene *** key regulatory enzymes,such as ACC synthase and ACC oxidase,for ethylene biosynthesis,are important for both climacteric and non-climacteric ***-oxidizing genes that retain sensory characteristics are concerns in this *** elicitors,including chitosan,polyamine,phenolics,lipopolysaccharide,silver derivatives,and nanocomposites,are *** pressure,light wavelengths,relative humidity,cooling,and other environmental factors are important for improved postharvest *** elicitors maintain redox status by inhibiting the generation of reactive oxygen species(ROS)or their *** regulators,including abscisic acid,auxin,brassinosteroids,jasmonic acid,and salicylic acid,are important for the regulation of *** injuries,ionic imbalances,temperature variations,and tissue dehydration can occur irrespective of ripening *** use of synthetic physiochemically active compounds is discussed in terms of physiological,metabolic,cellular,and molecular ***-induced autocatalytic processes,antioxidant cascades,epigenetic regulation,and homeodomain gene expression are ***–acid metabolism,dissolution of the cell wall,and direct or indirect production of secondary metabolites related to postharvest storage are mentioned regarding chilling *** and agrochemicals that trigger plant defense to increase secondary metabolite production are discussed fo

关键词： Epigenetics ethylene elicitors ripening polyphenolics postharvest storage

Perianal tuberculosis: A case report and review of the literature

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World Journal of Clinical Cases 2015年第9期3卷 848-852页

作者： Sayaka Tago Yuji Hirai Yusuke Ainoda Takahiro fujita Mikio Takamori Ken Kikuchi Department of Infectious Diseases Tokyo Women’s Medical University Department of Pulmonary Medicine Tokyo Metropolitan Tama Medical Center

Tuberculosis(TB) is still a major health problem worldwide. We present a rare case of an immunocompetent patient with perianal TB. A 38-year-old man visited a clinic with pain, swelling, and redness in the perineum. He had been persistently coughing for the past 6 mo. The abscess had formed a fistula to the perianal region, indicating perianal abscess. Mycobacterium tuberculosis was found in sputum and perianal abscess. Surgical drainage was performed, and oral anti-tuberculous drugs were administered for 6 mo. The patient's clinical course was favorable. On review of the literature on 58 cases of perianal TB, we found that the duration of persistent perianal lesion was much longer in patients without active pulmonary TB(APTB) than in those with APTB(66.4 mo vs 8.3 mo; confidence interval, 0.0760-0.9620, P = 0.0380). Thus, in cases of non-healing or recurrent perianal lesions, TB should be considered.

关键词： Tuberculosis Abscess Ulcer Hemorrhoids Fistula

Pancreatic guidewire placement for achieving selective biliary cannulation during endoscopic retrograde cholangio-pancreatography

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World Journal of Gastroenterology 2008年第36期14卷 5595-5600页

作者： Kei Ito Naotaka fujita Yutaka Noda Go Kobayashi Takashi Obana Jun Horaguchi Osamu Takasawa Shinsuke Koshita Yoshihide Kanno Department of Gastroenterology Sendai City Medical Center 5-22-1 Tsurugaya Miyagino-ku Sendai Miyagi 983-0824 Japan

AIM: To investigate the frequency and risk factors for acute pancreatitis after pancreatic guidewire placement (P-GW) in achieving cannulation of the bile duct during endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: P-GW was performed in 113 patients in whom cannulation of the bile duct was difficult. The success rate of biliary cannulation, the frequency and risk factors of post-ERCP pancreatitis, and the frequency of spontaneous migration of the pancreatic duct stent were investigated. RESULTS: Selective biliary cannulation with P-GW was achieved in 73% of the patients. Post-ERCP pancreatitis occurred in 12% (14 patients: mild, 13; moderate, 1). Prophylactic pancreatic stenting was attempted in 59% of the patients. Of the 64 patients who successfully underwent stent placement, three developed mild pancreatitis (4.7%). Of the 49 patients without stent placement, 11 developed pancreatitis (22%: mild, 10; moderate, 1). Of the five patients in whom stent placement was unsuccessful, two developed mild pancreatitis. Univariate and multivariate analyses revealed no pancreatic stenting to be the only significant risk factor for pancreatitis. Spontaneous migration of the stent was observed within two weeks in 92% of the patients who had undergone pancreatic duct ***: P-GW is useful for achieving selective biliary cannulation. Pancreatic duct stenting after P-GW can reduce the incidence of post-ERCP pancreatitis, which requires evaluation by means of prospective randomized controlled trials.

关键词： Endoscopic retrograde cholangio-pancreatography Pancreatic duct stenting Acute pancreatitis Post-endoscopic retrograde cholangio-pancreatography pancreatitis Biliary cannulation

用低碱度硫铝酸盐水泥制备的砂浆和混凝土的物理性能(英文)

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硅酸盐学报 2010年第9期38卷 1623-1630页

作者： fujita Hideki KURAUCHI Hidetoshi NAKARAI Kenichiro TSUJI Yukikazu Research Center Taiheiyo Consultant Co.Ltd. Graduate School of Engneering Department of Civil and Environmental EngineeringGunma University

制备了低碱度硫铝酸盐水泥,并对由该水泥制备的砂浆和混凝土的物理性能进行了测试分析。结果表明:低碱度硫铝酸盐水泥砂浆和混凝土的抗压强度发展良好,过量的缓凝剂会降低其早期强度。在水灰比为0.65的情况下,其砂浆和混凝土的长期抗压... 详细信息

制备了低碱度硫铝酸盐水泥,并对由该水泥制备的砂浆和混凝土的物理性能进行了测试分析。结果表明:低碱度硫铝酸盐水泥砂浆和混凝土的抗压强度发展良好,过量的缓凝剂会降低其早期强度。在水灰比为0.65的情况下,其砂浆和混凝土的长期抗压强度发展缓慢。水灰比和抗压强度之间不存在线性关系。新拌混凝土会出现体积收缩,但随之转变为体积膨胀,并持续10～30d。当粉煤灰和石灰石粉作为掺合料替代部分水泥时,其砂浆和混凝土的强度会下降,但仍能满足实际应用的要求;此外,粉煤灰和石灰石替代部分水泥还能减小混凝土的绝热温升、改善其流动性。

关键词：低碱度硫铝酸盐缓凝剂新拌性能硬化性能

Income Inequality Generates Chaos

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Journal of Modern Physics 2017年第4期8卷 547-551页

作者： Yasunori fujita Keio University Tokyo Japan

The present paper is an attempt to bridge the gulf between economics and econophysics. That is, constructing a chaos-based theoretical model, we show the behavior of the goal-driven agents exhibits the behavior of the purpose-free agents. Main conclusion is: economy becomes chaos if 1) capital gain of the middle class people is large enough for them to consume eight times as much as their income gain and 2) market for the middle class people is large enough and number of the middle class people is 16 times as large as the amount of products made by one producer.

关键词： Income Inequality Econophysics Chaos Logistic Map Maximization of Profits