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Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats

World Journal of Gastroenterology 2008年第41期14卷 6318-6326页

作者： Mineko Fujimiya Akihiro Asakawa koji ataka Ikuo Kato Akio Inui Department of Anatomy Sapporo Medical University School of Medicine Department of Behavioral Medicine Kagoshima University Graduate School of Medical and Dental Sciences Research Institute Taiko Pharmaceutical Co. Ltd Department of Bioorganic Chemistry Faculty of Pharmaceutical Sciences Hokuriku University

Three peptides, ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. To examine the effects of these peptides, we applied the manometric measurement of gastrointestinal motility in freely moving conscious rat models. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. Des-acyl ghrelin exerts inhibitory effects on the motility of antrum, but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state, but not in the fasted state of animals. NPY Y2 or Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptors in the brain mediate the action of des-acy ghrelin, whereas CRF type 1 and type 2 receptors in the brain mediate the action of obestatin. Vagal afferent pathways might be involved in the action of ghrelin, but not involved in the action of des-acyl ghrelin, whereas vagal afferent pathways might be partially involved in the action of obestatin.

关键词：胃肠动力消化功能下丘脑症状

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Cholangiocarcinoma after flow diversion surgery for congenital biliary dilatation: A case report and review of literature

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World Journal of Hepatology 2019年第11期11卷 743-751页

作者： Ryo ataka Takashi Ito Toshihiko Masui Satoru Seo Takamichi Ishii Satoshi Ogiso Shintaro Yagi kojiro Taura Shinji Uemoto Department of Hepato-Biliary-Pancreatic Surgery and Transplantation Graduate School of Medicine Kyoto University

BACKGROUND Pancreaticobiliary maljunction(PBM)can be classified into two categories,PBM with congenital biliary dilatation(CBD)or PBM without biliary dilatation,and the management of PBM is often controversial.The treatment for PBM with CBD is prophylactic flow diversion surgery,and some authors have reported that the incidence of cancer after extrahepatic bile duct excision is less than 1%.A very rare case of intrahepatic cholangiocarcinoma 6 years after flow diversion surgery for PBM with CBD is reported.CASE SUMMARY A 30-year-old man was diagnosed as having PBM with CBD,Todani classification type IVA,because of abnormal liver enzyme profiles.He underwent flow diversion surgery and cholecystectomy,and the specimen showed adenocarcinoma foci,pT1,pStage IA.Five and a half years passed without any recurrence of bile duct cancer.However,6 years after his operation,computed tomography showed a gradually growing nodule in the bile duct.Fluorodeoxyglucose positron emission tomography showed high uptake,and magnetic resonance imaging showed restricted diffusion signals.On double balloon enteroscopy,the nodule at the posterior bile duct-jejunum anastomosis was directly visualized,and its biopsy specimen showed adenocarcinoma.The patient underwent right lobectomy and biliary reconstruction.The pathological diagnosis was intraductal papillary neoplasm with high-grade intraepithelial neoplasia,pTis,pN0,pStage 0.The patient’s postoperative course was uneventful,and he has had no recurrence up to the present time.CONCLUSION This case suggests the necessity of careful observation after flow diversion surgery,especially when PBM with CBD is detected in adulthood.

关键词： Congenital biliary dilatation Pancreaticobiliary maljunction Cholangiocarcinoma Recurrence Metachronous neoplasm Case report

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SMALL ANGLE NEUTRON SCATTERING STUDY OF THE INITIAL STAGE OF LYSOZYME CRYSTALLIZATION PROCESS

SMALL ANGLE NEUTRON SCATTERING STUDY OF THE INITIAL STAGE OF...

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Sixteenth Congress of the International Union of Crystallography

作者： N.Niimura Y.Minezaki M.ataka T.Katsura Advanced Basic Research Center Japan Atomic Energy Research InstituteTokaiIbaraki-kenJapan & Laboratory of Nuclear ScienceTohoku UniversitySendaiJapan Research Institute for Polymers and Textiles TsukubaJapan

＜正＞Despite the enormous amout of informations obtained from atomic resolution crystal data,the difficulties encountered in growing crystals preclude structural X-ray studies for the majority of known isolated proteins. We have conducted small angle neutron scattering （SANS） experiments on the time evolution from the initial stage to the visible size of crystallization of hen egg-white lysozyme.SANS from several kinds of

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伴痉挛性截瘫的早发阿尔茨海默病的一种新的早老素-1突变(Leu 85 Pro)

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 25-26页

作者： ataka S. Tomiyama T. Takuma H. H.Mori 王英鹏 Department of Neuroscience Osaka City University Medical Schoo l 1-4-3 Asahimachi Abenoku Osaka 545-8585 Japan Dr.

Background: Early onset familial Alzheimer disease is caused by mutations in the amyloid precursor protein (APP), prese nilin 1 (PSEN1), or presenilin 2 ( PSEN2) genes. Phenotypic diversity has been reported to be associated with vario us mutations in PSEN1. Various mutations of PSEN1 have been reported in cases of early onset Alzheimer disease with spastic paraparesis. Objective: To describe a novel mutation in the PSEN1 gene associated with early onset Alzheimer disea se with spastic paraparesis. Patient and Methods: The patient was a 27 year ol d man who developed early onset dementia with spastic paraparesis. We examined sequences of the PSEN1, PSEN2, and APP genes from the patient and his family. To detect a possible mutation effect on the production of amyloid β.peptide (Aβ ), transfected HEK293 cells were examined for Aβ42 and Aβ40 production. Result s: We found a novel mutation (Leu85Pro) in PSEN1. This mutation influenced the p roduction of Aβ, resulting in a 2 fold elevation of Aβ42 production and of th e Aβ42/40 ratio. Conclusion: To our knowledge, this is the first report of very early onset Alzheimer disease with spastic paraparesis and with the visual var iant form of the disease, which is associated with visuospatial cognitive disord er. The Leu85Pro mutation in PSEN1 was pathogenic.

关键词：痉挛性截瘫 Leu 85 Pro 阿尔茨海默病淀粉样前体蛋白基因突变表型差异变异型基因转染突变型基因序列

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