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BDNF pro-peptide：a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing

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Neural Regeneration Research 2017年第7期12卷 1024-1027页

作者： Toshiyuki Mizui koji Ohira Masami kojima Biomedical Research Inst. (BMD) National Institute of Advanced Industrial Science and Technology (AIST) Osaka Japan Laboratory of Nutritional Brain Science Department of Food Science and Nutrition Mukogawa Women's University Hyogo Japan Core Research for Evolutional Science and Technology (CREST) Science and Technology Agency (JST) KawaguchiJapan Graduate School of Frontier Bioscience Osaka University Suita Japan

Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and ***,compared with the expression and function of bioactive mature domain,the biological role of the pro-domain is poorly ***,we found that the pro-domain（or pro-peptide）of brain-derived neurotrophic factor（BDNF）,which is well-known neurotrophic factor in brain,has a potential ability to facilitate hippocampal long-term ***,a BDNF polymorphism Val66Met,which substitute valine into methionine at 66 amino acid,impacted the biological activity of the BDNF *** lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.

关键词： BDNF growth factor neural stem cells ischemia peptide

Experimental study on the in-plane thermal conductivity of Au nanofilms

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Progress in Natural Science:Materials International 2007年第2期17卷 212-216页

作者： TAKAHASHI koji IKUTA Tatsuya FUJII Motoo Graduate School of Engineering Kyushu UniversityFukuoka 812-8581Japan Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan

The in-plane thermal conductivity of Au nanofilms with thickness of 23 nm, which are fabricated by the electron beam-physical vapor deposition method and a suspension technology, is experimentally measured at 80-300 K by a one-dimensional steady-state electrical heating method. Strong size effects are found on the measured nanofilm thermal conductivity. The Au nanofilm in-plane thermal conductivity is much less than that of the bulk material. With the increasing temperature, the nanofilm thermal conductivity increases. This is opposite to the temperature dependence of the bulk property. The Lorenz number of the Au nanofilms is about three times larger than the bulk value and decreases with the increasing temperature, which indicates the invalidity of the Wiedemann-Franz law for metallic nanofilms.

关键词： nanofilm in-plane thermal conductivity size effect Wiedemann-Franz law.

Identifying key traits in high-yielding rice cultivars for adaptability to both temperate and tropical environments

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The Crop Journal 2019年第5期7卷 685-693页

作者： Toshiyuki Takai Patrick Lumanglas Eliza Vie Simon Yumiko Arai-Sanoh Hidetoshi asai Nobuya Kobayashi Japan International Research Center for Agricultural Sciences TsukubaIbaraki 305-8686Japan International Rice Research Institute DAPO Box 7777Metro ManilaPhilippines Institute of Crop Science National Agriculture and Food Research Organization(NARO)TsukubaIbaraki 305-8518Japan

Increasing rice yield potential is a continuous challenge posed by world population *** increase yield potential,favorable alleles of valuable genes need to be accumulated in promising *** conducted comparative yield trials for two years in Tsukuba,Japan,in a temperate region and at the International Rice Research Institute(IRRI),Philippines,in a tropical region using five high-yielding rice cultivars:Takanari and Hokuriku193,developed in Japan,and IR64,NSIC Rc158,and YTH183,developed in the *** plus genotype×environment interaction(GGE)biplot analysis across four environments(two regions×two seasons)classified the five cultivars into four categories:Takanari and YTH183 showed high adaptability to both tropical and temperate regions,Hokuriku193 was suitable for temperate regions,NSIC Rc158 was suitable for the tropics,and IR64 was inferior to the other cultivars in both *** high yield and adaptability in Takanari and YTH183 were attributed to their large sink capacity with good grain *** plant type for high yield was different,however,between the two cultivars;Takanari was a panicle-weight type,whereas YTH183 was a panicle-number *** of F2 progeny of a cross between Takanari and YTH183 showed transgressive segregation for number of panicles per plant as well as number of spikelets per panicle,leading some F2 plants to produce more spikelets per plant(corresponding to larger sink size)than the parental cultivars in both *** results suggest the possibility of developing rice cultivars with high yield potential in both temperate and tropical regions by crossing temperate with tropical high-yielding cultivars.

关键词： Adaptability Genotype×environment interaction Rice Sink capacity Yield potential

Different effects of grain boundary scattering on charge and heat transport in polycrystalline platinum and gold nanofilms

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Chinese Physics B 2009年第5期18卷 2035-2040页

作者：马维刚王海东张兴 Takahashi koji Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua University Graduate School of Engineering Kyushu University

The in-plane electrical and thermal conductivities of several polycrystalline platinum and gold nanofilms with different thicknesses are measured in a temperature range between the boiling point of liquid nitrogen （77K） and room temperature by using the direct current heating method. The result shows that both the electrical and thermal conductivities of the nanofilms reduce greatly compared with their corresponding bulk values. However, the electrical conductivity drop is considerably greater than the thermal conductivity drop, which indicates that the influence of the internal grain boundary on heat transport is different from that of charge transport, hence leading to the violation of the Wiedemann-Franz law. We build an electron relaxation model based on Matthiessen＇s rule to analyse the thermal conductivity and employ the Mayadas ＆ Shatzkes theory to analyse the electrical conductivity. Moreover, a modified Wiedemann-Franz law is provided in this paper, the obtained results from which are in good agreement with the experimental data.

关键词： polycrystalline nanofilm grain boundary scattering thermal and electrical conductivities Wiedemann-Franz law

Root pruning is effective in alleviating the inhibition of soybean growth caused by anaerobic stress for a short period

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Journal of Integrative Agriculture 2023年第4期22卷 1035-1044页

作者： koji YAMANE Miki MARIYAMA Yoshihiro HIROOKA Morio IIJIMA Graduate School of Agriculture Kindai UniversityNara 631-8505Japan

Soybean is an important upland crop,but its productivity is often limited by anaerobic stress caused by *** ability to adjust root growth under environmental constraints is an important physiological trait for adapting to an everchanging environment,and root pruning is an artificial technique for regenerating the root *** the present study,we investigated whether root pruning in soybean can effectively alleviate the inhibitory effects of anaerobic *** plants were affected by anaerobic stress at the germination,vegetative stage 1(V1),and reproductive stage 1(R1)stages,and then the plants were treated with root pruning just after the stress *** plants at the germination stage were treated with root cap and tip removals after hypoxia(N_(2)treatment).Root cap removal was more effective in suppressing the inhibitory effects of hypoxia than root tip removal(5 mm from the tip).The shoot dry weights of the soybean plants with and without root cap removal after hypoxia were 51.2 and 73.8%of the control,respectively,while the root dry weights of plants with and without root cap removal after hypoxia were 43.2 and 62.8%of the control,*** root cap removal effectively enhanced soybean growth after anaerobic stress,the root cap may be the candidate tissue for the stress memory *** soybean plants at the V1 stage of growth were affected by anaerobic stress,the branch number,pod weight in the main stem,root length,and root surface area of the soybean plants treated with anaerobic stress at the R1 stage significantly decreased compared with those of the *** contrast,root pruning(2 mm from the tip)immediately after the stress treatment enhanced root growth,branch number,and pod *** branch number,pod weight,root length,and root surface area of the plants treated with root pruning were 1.13,1.14,1.12,and 1.13 times higher than those of plants treated with anaerobic *** was observed in the roo

关键词： crack fertilization nodulation control root cap removal stress memory waterlogging

Underwater persistent bubble-assisted femtosecond laser ablation for hierarchical micro/nanostructuring

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International Journal of Extreme Manufacturing 2020年第1期2卷 135-154页

作者： Dongshi Zhang Bikas Ranjan Takuo Tanaka koji Sugioka RIKEN Center for Advanced Photonics 2-1 HirosawaWakoSaitama 351-0198Japan Innovative Photon Manipulation Research Team RIKEN Center for Advanced PhotonicsWakoSaitama 351-0198Japan Metamaterials Laboratory RIKEN Cluster for Pioneering ResearchWakoSaitama 351-0198Japan

In this study,we demonstrate a technique termed underwater persistent bubble assisted femtosecond laser ablation in liquids(UPB-fs-LAL)that can greatly expand the boundaries of surface micro/nanostructuring through laser ablation because of its capability to create concentric circular macrostructures with millimeter-scale tails on silicon ***-tailed macrostructures are composed of layered fan-shaped(central angles of 45°–141°)hierarchical micro/nanostructures,which are produced by fan-shaped beams refracted at the mobile bubble interface(.50°light tilt,referred to as the vertical incident direction)during UPB-fs-LAL line-by-line *** flow generated during UPB-fs-LAL induces bubble *** scanning(e.g.1mms−1)allows a long bubble movement(as long as 2mm),while slow scanning(e.g.0.1mms−1)prevents bubble *** persistent bubbles grow considerably(*** of microns in diameter)due to incubation effects,they become sticky and can cause both gas-phase and liquidphase laser ablation in the central and peripheral regions of the persistent *** generates low/high/ultrahigh spatial frequency laser-induced periodic surface structures(LSFLs/HSFLs/UHSFLs)with periods of 550–900,100–200,40–100 nm,which produce complex hierarchical surface structures.A period of 40 nm,less than 1/25th of the laser wavelength(1030 nm),is the finest laser-induced periodic surface structures(LIPSS)ever created on *** NIR-MIR reflectance/transmittance of fan-shaped hierarchical structures obtained by UPB-fs-LAL at a small line interval(5μm versus 10μm)is extremely low,due to both their extremely high light trapping capacity and absorbance characteristics,which are results of the structures’additional layers and much finer *** the absence of persistent bubbles,only grooves covered with HSFLs with periods larger than 100 nm are produced,illustrating the unique attenuation abilities of laser properties(*** rate,energy,inciden

关键词： hierarchical micro/nanostructures persistent bubble femtosecond laser surface structuring beam refraction fan-shaped microstructure LIPSS

Are angiographic culprit lesions true?Disagreement between angiographic and optical coherence tomographic detection

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Journal of Geriatric Cardiology 2021年第10期18卷 844-846页

作者： Osamu Kurihara Masamichi Takano Yusaku Shibata Nobuaki Kobayashi Yasushi Miyauchi Kuniya asai Cardiovascular Center Nippon Medical School Chiba Hokusoh HospitalInzaiChibaJapan Division of Intensive Care Unit Nippon Medical School Chiba Hokusoh HospitalInzaiChibaJapan

Coronary angiography provides a two-dimensional silhouette of the vascular *** is the gold standard for the dia-gnosis of coronary artery disease and is essential during percutaneous coronary intervention(PCI).

关键词： coronary lesions Coronary

Safety of rectal indomethacin(100 mg)for the prevention of post-ERCP pancreatitis in the Japanese population:A single-center prospective pilot study

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 406-408页

作者： Kotaro Takeshita Satoshi asai Naoki Fujimoto Takumi Ichinona Eisuke Akamine Mamoru Takenaka Department of Gastroenterology Tane General HospitalOsaka 550-0025Japan Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-Sayama 589-8511Japan

To the Editor:Endoscopic retrograde cholangiopancreatography(ERCP)causes adverse events;post-ERCP pancreatitis(PEP)is one of the frequent adverse ***,the efficacy of rectal administration of non-steroidal anti-inflamm... 详细信息

关键词： prevention ERCP drugs

Chemotherapy for advanced hepatocellular carcinoma in the sorafenib age

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World Journal of Gastroenterology 2014年第15期20卷 4151-4159页

作者： koji Miyahara Kazuhiro Nouso Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama-cityOkayama 700-8558Japan Department of Molecular Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama-cityOkayama 700-8558Japan

The kinase inhibitor sorafenib is the only systemic therapy proven to have a positive effect on survival of patients with advanced hepatocellular carcinoma(HCC).After development of sorafenib and its introduction as a therapeutic agent used in the clinic,several critical questions have been *** parameters and biomarkers predicting sorafenib efficacy are the most important issues that need to be *** it is difficult to know the responders in advance using conventional characteristics of patients,there are specific serum cytokines and/or gene amplification in tumor tissues that have been reported to predict efficacy of *** and benefits of continuation of sorafenib beyond radiological progression is another issue to consider because no other standard therapy for advanced HCC as yet *** addition,effectiveness of the expanded application of sorafenib is still controversial,although a few studies have shed some light on combinational treatment with sorafenib for intermediate-stage ***,over 50 relevant drugs have been developed and are currently under *** efficacy of some of these drugs has been extensively examined,but none have demonstrated any superiority over sorafenib,so ***,there are several drugs that have shown efficacy for treatment after sorafenib failure,and these are proceeding to further *** address these issues and questions,we have done extensive literature review and summarize the most current status of therapeutic application of sorafenib.

关键词： Biomarker Molecular targeted therapy Clinical trial Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Sorafenib