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Surgical Treatment of Lung Cancer in Patients with Psychiatric Disorders: A Retrospective Study

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Journal of Cancer Therapy 2016年第8期7卷 553-557页

作者： Chie Ushijima koji yamazaki Hidenori Kouso Masakazu Katsura Ryo Mori Sadanori Takeo Kensuke Ishikawa Department of General Thoracic Surgery and Clinical Research Institute National Hospital Organization Kyushu Medical Center Fukuoka Japan Department of Psychiatry National Hospital Organization Kyushu Medical Center Fukuoka Japan

Background: The purpose of this retrospective study was to examine the clinical outcomes of patients with concomitant lung cancer and psychiatric disorders who underwent pulmonary resection at our institution and develop a strategy for treating such patients in the future. Methods: We retrospectively reviewed 23 patients with psychiatric disorders who underwent pulmonary resection for lung cancer at our institution between January 1984 and December 2011. Results: The study population comprised 13 men and 10 women with an average age of 67.4 years. The histological types of lung cancer included adenocarcinoma in 14 patients, squamous cell carcinoma in 4, and other types in 5. Fifteen patients were classified as having pathological TNM stage I cancer, four as having stage II, three as having stage III, and one as having stage IV. The coexisting psychiatric disorders were neurosis in eight patients, depression in seven, schizophrenia in five, dementia in two, and oligophrenia in one. Three patients were admitted without a full understanding of the operation. There were no major complications with the exception of delirium, which was seen in eight patients. None of these patients’ coexisting psychiatric disorders worsened. No perioperative death occurred. Conclusions: At our institution, we cooperate closely with psychiatrists to care for surgical patients with psychiatric disorders. There is a possibility that such cooperation will reduce the frequency of previously reported complications.

关键词： Lung Cancer Surgery Psychiatric Disorder Surgery Incisions Exposure Techniques

Feasibility Study for Biweekly Administration of Cisplatin plus Vinorelbine as Adjuvant-Chemotherapy for Completely Resected Non-Small Cell Lung Cancer Patients in a Japanese Population

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Advances in Lung Cancer 2014年第1期3卷 1-9页

作者： Shuichi Tsukamoto koji yamazaki Ryo Mori Masakazu Katsura Hidenori Kouso Daigo Kawano Chie Ushijima Sadanori Takeo Division of General Thoracic Surgery Respiratory Center and Clinical Research Institute National Hospital Organization Kyushu Medical Center Fukuoka City Japan

Purpose: To evaluate the feasibility of biweekly administration of cisplatin and vinorelbine as adjuvant chemotherapy for patients with completely resected non-small cell lung cancer (NSCLC). Patients and Methods: This was a single-arm, single-institutional study. Patients with completely resected NSCLC (p-Stage IB-IIIA) with no previous chemotherapy or radiotherapy were eligible. Simon’s optimal two-stage design was applied. Both cisplatin (50 mg/m2) and vinorelbine (25 mg/m2) were given on days 1 and 15, every 28 days. The primary endpoint of this study was the feasibility of this combination in the four cycles of treatment. Results: Twenty patients (19 lobectomies and 1 pneumonectomy) were enrolled in this study. 10 (50%) of patients had grade 3/4 neutropenia, and 3 (15%) had grade 3/4 anemia. Severe non-hematologic toxicities were uncommon in this series. No treatment-related death was encountered. 18 (90%) patients completed the planned 4 cycles of chemotherapy. The median intensity was 24.3 (range 18.1 to 25) mg/m2/week with an average of 23.6 (21 - 25) mg/m2/week cisplatin and 12.5 (range 10 to 12.5) mg/m2/week with an average of 12.3 (10 - 12.5) mg/m2/week vinorelbine. The median relative dose intensity of cisplatin was 97.5% (range 72.5% to 100%) with an average of 94.6% (72.5% - 100%) and that of vinorelbine was 100% (range 80% to 100%) with an average of 97.8% (80% - 100%). Conclusion: This regimen is feasible in the treatment of patients with completely resected NSCLC. A phase III trial is warranted to assess the efficacy of this regimen at promoting survival and preventing recurrence.

关键词： NSCLC Adjuvant Chemotherapy Cisplatin and Vinorelbine Biweekly

TCDD induces apoptosis through local circulation failure in midbrain of developing zebrafish

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TCDD induces apoptosis through local circulation failure in ...

中国药理学会第八次全国代表大会

作者： Hiroki Teraoka koji yamazaki Yoshikazu Tsujimoto Tomohiro Imagawa John J. Stegeman Richard E. Peterson Takeo Hiraga Rakuno Gakuen University Ebetsu Japan University of Tottori Japan Woods Hole Oceanographic Institution USA University of Wisconsin USA

2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is the most toxic of a group of synthetic isomers of considerable environmental contaminants. It produces adverse biological effects including carcinogenesis, cardiovascular dysfunction, reproductive toxicity, immune dysfunction, hepatotoxicity, teratogenesis, growth arrest and mortality. This experiment describe that effects of TCDD on local circulation and apoptosis in the midbrain were investigated in zebrafish embryos (Danio

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宋代两浙地区的市舶司行政

海交史研究 2022年第2期 95-110页

作者： [日]山崎觉士高雅云(译) 陈硕炫(校译) 日本佛教大学历史学部日本熊本大学社会文化科学教育部福建师范大学闽台区域研究中心

9世纪以后,海上贸易的兴盛使中国政府重新面临沿海地区地方行政(暂称沿海行政)的问题,即市舶使、市舶司及沿海巡检、沿海制置使的设置。自宋代以来,作为沿海行政一环的市舶司是在沿海地区率先施行的,随着市舶司收取的贸易利润在国家财... 详细信息

9世纪以后,海上贸易的兴盛使中国政府重新面临沿海地区地方行政(暂称沿海行政)的问题,即市舶使、市舶司及沿海巡检、沿海制置使的设置。自宋代以来,作为沿海行政一环的市舶司是在沿海地区率先施行的,随着市舶司收取的贸易利润在国家财政中所占比例不断增加,市舶司行政成为一项重要的政治课题。聚焦于三种与两浙市舶司行政有关的文书,可以厘清宋代沿海行政的特征及其在政治上逐步重要化的变迁历程,以期重新审视两浙市舶司的历史地位。

关键词：海上贸易沿海行政市舶司文书两浙地区

Cortical transcriptome analysis after spinal cord injury reveals the regenerative mechanism of central nervous system in CRMP2 knock-in mice

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Neural Regeneration Research 2021年第7期16卷 1258-1265页

作者： Ayaka Sugeno Wenhui Piao Miki yamazaki Kiyofumi Takahashi koji Arikawa Hiroko Matsunaga Masahito Hosokawa Daisuke Tominaga Yoshio Goshima Haruko Takeyama Toshio Ohshima Laboratory for Molecular Brain Science Department of Life Science and Medical BioscienceGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Biomolecular Engineering Laboratory Department of Life Science and Medical BioscienceGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Computational Bio Big-Data Open Innovation Laboratory(CBBD-OIL) National Institute of Advanced Industrial Science and Technology(AIST)TokyoJapan Research Organization for Nano and Life Innovation Waseda UniversityTokyoJapan Institute for Advanced Research of Biosystem Dynamics Waseda Research Institute for Science and EngineeringGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Cellular and Molecular Biotechnology Research Institute National Institute of Advanced Industrial Science and Technology(AIST)TsukubaJapan Department of Molecular Pharmacology and Neurobiology Graduate School of MedicineYokohama City UniversityYokohamaJapan

Recent studies have shown that mutation at Ser522 causes inhibition of collapsin response mediator protein 2(CRMP2) phosphorylation and induces axon elongation and partial recovery of the lost sensorimotor function after spinal cord injury(SCI).We aimed to reveal the intracellular mechanism in axotomized neurons in the CRMP2 knock-in(CRMP2KI) mouse model by performing transcriptome analysis in mouse sensorimotor cortex using micro-dissection punching *** to that, we analyzed the structural pathophysiology in axotomized or neighboring neurons after SCI and found that somatic atrophy and dendritic spine reduction in sensorimotor cortex were suppressed in CRMP2KI *** analysis of the transcriptome has aided in the identification of four hemoglobin genes Hba-a1, Hba-a2, Hbb-bs, and Hbb-bt that are significantly upregulated in wild-type mice with concomitant upregulation of genes involved in the oxidative phosphorylation and ribosomal pathways after ***, we observed substantial upregulation in channel activity genes and downregulation of genes regulating vesicles, synaptic function, glial cell differentiation in CRMP2KI ***, the transcriptome profile of CRMP2KI mice has been discussed wherein energy metabolism and neuronal pathways were found to be differentially *** results showed that CRMP2KI mice displayed improved SCI pathophysiology not only via microtubule stabilization in neurons, but also possibly via the whole metabolic system in the central nervous system, response changes in glial cells, and *** together, we reveal new insights on SCI pathophysiology and the regenerative mechanism of central nervous system by the inhibition of CRMP2 phosphorylation at *** these experiments were performed in accordance with the guidelines of the Institutional Animal Care and Use Committee at Waseda University, Japan(2017-A027 approved on March 21, 2017;2018-A003 approved on March 25, 2018;2019-A026 approved on March

关键词： CNS regeneration cortex CRMP2 hemoglobin metabolic pathway spinal cord injury spine transcriptome

Threshold dynamics of reaction-diffusion partial differential equations model of Ebola virus disease

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International Journal of Biomathematics 2018年第8期11卷 235-264页

作者： Kazuo yamazaki University of Rochester Department of Mathematics Rochester NY 14627 USA

We study the reaction-diffusion Ebola PDE model that consists of equations that govern the evolution of susceptible, in fee ted, recovered and deceased human individuals, as well as Ebola virus pathogens in the environment, with diffusive terms in all except the equation of the deceased human individuals. Under the setting of a spatial domain that is bounded, we prove the global well-posedness of the system;in contrast to the previous work on similar models such as cholera, avian influenza, malaria and dengue fever, diffusion coefficients may be different. Moreover, we derive its basic reproduction number, and under the condition that the diffusion coefficients of the susceptible and infected hosts are same, we prove the global stability of the disease-free-equilibrium, and uniform persistence in cases when the basic reproduction number lies beneath and above one, respectively. Again, we do not require that the diffusion coefficients of the recovered hosts be the same as the diffusion coefficients of the susceptible and infected hosts, in contrast to previous work on other models of infectious diseases. Another technical difficulty in our model is that the solution semiflow is not compact due to the lack of diffusion in the equation of the deceased human individuals;we overcome this difficulty using functional analysis techniques concerning Kura to wski measure of non-compactness.

关键词： Basic reproduction number Ebola persistence stability

Evaluation of interfacial strength by an instrumented indentation method and its application to an actual TBC vane

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Acta Metallurgica Sinica(English Letters) 2011年第2期24卷 109-117页

作者： Yasuhiro yamazaki Shin-ichiro KUGA Toshihiko YOSHIDA Department of Mechanical and Control Engineering Department of Advanced Production Systems Engineering Niigata Institute of Technology Graduate School Ryodensya Co.

The thermal fatigue behaviour of an air plasma sprayed thermal barrier coating was investigated. And also the interfacial strengths of thermal barrier coated specimens subjected to thermal fatigue, as well as a retired TBC vane were also evaluated by means of an instrumented indentation machine. The results indicated that, （1） the TGO grew at the interface during thermal fatigue cycle as a function of the exposure time at elevated temperature; （2） the microcracks were initiated in the top coating and at the interface after thermal cycle tests; （3） the interfacial strength of TBC, which was evaluated by the indentation method, increased with the thermal cycles; （4） the interfacial strength of the retired TBC vane was almost equal with that of the as-sprayed TBC specimen.

关键词： Thermal barrier coating Interfacial fracture toughness Indentation method

Electron scattering by Friedel oscillations in carbon nanotubes

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Nano Research 2022年第2期15卷 889-897页

作者： Takumi Inaba Takahiro Morimoto Satoshi yamazaki Toshiya Okazaki CNT-Application Research Center National Institute of Advanced Industrial Science and TechnologyTsukuba 305-8565Japan Research Association of High-Throughput Design and Development for Advanced Functional Materials Tsukuba 305-8565Japan

Multi-walled carbon nanotube networks were confirmed to exhibit a linear decrease in resistivity with increasing temperature from 100 to above 400 *** linearity was explained using a defect scattering model that involved Friedel oscillations(that is,electron-electron interactions).The applicability of this model,which was originally proposed for graphene,to carbon nanotubes was assessed based on a comparison of various experimental *** in the slopes of the resistivity-temperature plots following the introduction of defects,as well as an effect of charge concentration on the slope were key predictions of this *** results obtained from few-walled carbon nanotube networks are also *** the literature,linear resistivity-temperature plots were obtained from other graphene derivatives,indicating that the linearity originates from the hexagonal symmetry of these *** present work also indicated a relationship between the appearance of linearity and negative magnetoresistance above 100 *** on a mechanism incorporating scattering in association with Friedel oscillations and conventional electron conduction models,the universality of resistivity-temperature plots obtained from carbon nanotube networks is introduced.

关键词： carbon nanotube electron transport electron-electron interaction Friedel oscillations magnetoresistance

Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第11期24卷 1239-1249页

作者： Naoyuki Fujimori Takeji Umemura Takefumi Kimura Naoki Tanaka Ayumi Sugiura Tomoo yamazaki Satoru Joshita Michiharu Komatsu Yoko Usami Kenji Sano koji Igarashi Akihiro Matsumoto Eiji Tanaka Department of Internal Medicine Division of GastroenterologyShinshu University School of MedicineMatsumoto 390-8621Japan Department of Metabolic Regulation Shinshu University Graduate School of MedicineMatsumotoJapanand Research Center for Agricultural Food IndustryShinshu UniversityMatsumoto390-8621Japan Department of Laboratory Medicine Shinshu University HospitalMatsumoto 390-8621Japan Bioscience Division TOSOH CorporationKanagawa 252-1123Japan

AIM To examine the relationship between serum autotaxin(ATX) concentrations and clinicopathological findings in non-alcoholic fatty liver disease(NAFLD) *** One hundred eighty-six NAFLD patients who had undergone liver biopsy between 2008 and 2017 were retrospectively *** samples were collected at the time of biopsy and ATX was measured by enzyme *** obtained from 160 healthy,nonobese individuals were used as *** findings were graded according to an NAFLD scoring system and correlations with serum ATX were calculated by Spearman's *** accuracy was evaluated using the area under the receiver operating characteristic curve(AUC).Cut-off values were identified by the Youden index,and the nearest clinically applicable value to the cutoff was considered the optimal threshold for clinical *** Serum ATX levels were significantly higher in NAFLD patients than in controls(0.86 mg/L vs 0.76 mg/L,P < 0.001) and correlated significantly with ballooning score and fibrosis stage(r = 0.36,P < 0.001 and r = 0.45,P < 0.001,respectively).Such tendencies were stronger in female *** were no remarkable relationships between ATX and serum alanine aminotransferase,lipid profiles,or steatosis *** AUC values of ATX for predicting the presence of fibrosis(≥ F1),significant fibrosis(≥ F2),severe fibrosis(≥ F3),and cirrhosis(F4),were all more than 0.70 in respective *** Serum ATX levels may at least partially reflect histological severity in NAFLD.

关键词： Autotaxin Non-alcoholic fatty liver disease Fibrosis Ballooning