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Long-term growth of intrahepatic papillary neoplasms: A case report

World Journal of Gastroenterology 2019年第36期25卷 5569-5577页

作者： Takumu Hasebe koji Sawada Hidemi Hayashi Shunsuke Nakajima Hiroyuki Takahashi Masahiro Hagiwara koji imai Sayaka Yuzawa Mikihiro Fujiya Hiroyuki Furukawa Toshikatsu Okumura Department of Medicine Division of Gastroenterology and Hematology/Oncology Asahikawa Medical University Asahikawa 0788510 Hokkaido Japan Department of Surgery Division of Gastroenterological and General Surgery Asahikawa Medical University Asahikawa 0788510 Hokkaido Japan Department of Diagnostic Pathology Asahikawa Medical University Hospital Asahikawa 0788510 Hokkaido Japan

BACKGROUND Intraductal papillary neoplasm of the bile duct (IPNB) is a type of tumor that presents in the intra- or extrahepatic bile ducts. Cystic-type intrahepatic IPNB often mimics simple liver cysts, making the diagnosis difficult. Because the growth of IPNB is slow, careful follow-up and timely therapeutic intervention is recommended. There are few reports with a follow-up period longer than a decade;thus, we report the case of a patient with an IPNB that grew for over 13 years. CASE SUMMARY A 65-year-old man was diagnosed, 13 years prior with a cystic hepatic tumor with abnormal imaging findings. The targeted tumor biopsy results showed no malignancy. Biannual follow-up examinations were performed because of the potential for malignancy. The cystic lesions showed gradual enlargement over 11 years and a 4 mm papillary proliferation appeared on the cyst wall, which is compatible with IPNB. The tumor was observed for another 2 years because of the patient’s wishes. The imaging findings showed enlargement to 8 mm and a new 9 mm papillary proliferation of the cystic tumor. Contrast-enhanced ultrasonography showed hyperenhancement during the arterial phase in both cyst walls, indicating intraductal tumor progression in both tumors. Thus, liver segment 8 subsegmentectomy was performed. The pathological findings indicated that the tumors contained mucin, and high-grade atypia was observed in the papillary lesions, showing *** The development of IPNB should be monitored in patients with cystic lesions and ultrasonography are useful tool for the evaluation.

关键词： Bile duct neoplasm Mucin Disease progression Ultrasonography Perfluorobutane Case report

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Clinicopathological features of small nonfunctioning pancreatic neuroendocrine tumors

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World Journal of Gastroenterology 2014年第47期20卷 17949-17954页

作者： Mariko Furukori koji imai Hidenori Karasaki Kenji Watanabe Kensuke Oikawa Naoyuki Miyokawa Masahiko Taniguchi Hiroyuki Furukawa Division of Gastroenterological and General Surgery Department of SurgeryAsahikawa Medical UniversityHokkaido 078-8510Japan Department of Surgery Sapporo Higashi Tokushukai HospitalSapporo cityHokkaido 065-0033Japan Department of Surgical Pathology Asahikawa Medical College HospitalHokkaido 078-8510Japan

AIM: To present our experiences in studying the clinicopathological features of small nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs).

关键词： Pancreatic neuroendocrine tumor Pancreatic neuroendocrine carcinoma Nonfunctioning Lymphadenectomy Treatment

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Hepatic clearance measured with ^(99m)Tc-GSA single-photon emission computed tomography to estimate liver fibrosis

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World Journal of Gastroenterology 2014年第44期20卷 16714-16720页

作者： Masahiko Taniguchi Atsutaka Okizaki Kenji Watanabe koji imai Koichiro Uchida Takahiro Einama Noriyuki Shuke Naoyuki Miyokawa Hiroyuki Furukawa Division of Gastroenterologic and General Surgery Department of Surgery Asahikawa Medical College Department of Radiology Asahikawa Medical College Department of Pathology Asahikawa Medical College

AIM: To evaluate the clinical utility of hepatic clearance(HC) measured with technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl human serum albumin(99mTc-GSA) single-photon emission computed tomography(SPECT) to estimate the degree of liver ***:Seventy-eight consecutive patients who underwent initial hepatectomy due to hepatocellular carcinoma were enrolled in this *** green clearance(ICG R15),quantitative indices estimated by 99mTc-GSA[the receptor index(LHL15 and HH15)and HC via SPECT analysis],and conventional liver function tests were performed before *** among the quantitative indices for liver functional reserve,conventional liver function tests,andthe degree of liver fibrosis were ***:The degree of liver fibrosis was correlated with ICG R15,HH15,LHL15,and *** showed the best correlation with conventional liver function *** to multivariate analysis,HC and LHL15 were significant independent predictors of severe *** was the most valuable index for predicting severe ***:HC measured with 99mTc-GSA SPECT is a reliable index for assessing liver fibrosis before hepatectomy.

关键词： Fibrosis Technetium-99m-diethylenetri-aminepenta-acetic acid-galactosyl human serum albu-min Single-photon emission computed tomography Hepatic clearance Liver resection

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Successful hepatic resection for recurrent hepatocellular carcinoma after lenvatinib treatment:A case report

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World Journal of Hepatology 2020年第12期12卷 1349-1357页

作者： Hideki Yokoo Hiroyuki Takahashi Masahiro Hagiwara Hiroyoshi Iwata koji imai Yoshinori Saito NaotoMatsuno Hiroyuki Furukawa Division of Hepato-Biliary-Pancreatic Surgery and Transplant Surgery Department of SurgeryAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Department of Gastroenterology Asahikawa-Kosei General HospitalAsahikawa 078-8211HokkaidoJapan

BACKGROUND Lenvatinib has been shown to be noninferior to sorafenib regarding prognosis and recurrence rate in patients with unresectable hepatocellular carcinoma(HCC)who have not received prior systemic *** patients treated with lenvatinib,40%of cases achieved sufficient tumor reduction to make potential surgery ***,the outcomes of such surgery are *** report a successful case of hepatic resection for recurrent HCC after lenvatinib *** SUMMARY A 69-year-old man underwent right anterior sectionectomy for HCC in segment 8 of the *** months later,he was found to have an intrahepatic HCC recurrence that grew rapidly to 10 cm in diameter with sternal bone *** confirming partial response to lenvatinib administration for 2 mo,a second hepatectomy was *** examination showed that 80%of the tumor was *** patient did not develop any adverse effects under lenvatinib *** was discharged at 25 d after *** therapy for bone metastases continued to be given under lenvatinib,and the patient has remained alive for 1 year after the second *** The prognosis of patients with recurrent HCC may be improved by liver resection combined with prior lenvatinib therapy.

关键词： Conversion to surgery Lenvatinib Recurrent hepatocellular carcinoma Case report Neoadjuvant therapy Molecular targeted therapy

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Hepatic schwannoma:Imaging findings on CT,MRI and contrast-enhanced ultrasonography

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World Journal of Gastroenterology 2012年第35期18卷 4967-4972页

作者： Yu Ota Kazunobu Aso Kenji Watanabe Takahiro Einama koji imai Hidenori Karasaki Ryuji Sudo Yosui Tamaki Mituyoshi Okada Yosihiko Tokusashi Toru Kono Naoyuki Miyokawa Masakazu Haneda Masahiko Taniguchi Hiroyuki Furukawa Division of Metabolism and Biosystemic Science Department of MedicineAsahikawa Medical University Division of Gastroenterologic and General Surgery Department of SurgeryAsahikawa Medical University Department of Pathology Asahikawa Medical University

A primary benign schwannoma of the liver is extremely rare and is difficult to preoperatively discriminate from a malignant *** compared the imaging and pathological findings,and examined the possibility of preoperatively diagnosing a benign liver schwannoma.A 72-year-old woman was admitted to our hospital because of a 4.6-cm mass in the liver.A malignant tumor was suspected,and a right hepatectomy was *** this,the diagnosis of a primary benign schwannoma of the liver was made through pathological ***-enhanced ultrasonography(CEUS) with Sonazoid showed minute blood flows into the septum and solid areas of the tumor in the vascular phase;most likely due to increased arterial flow associated with infiltration of chronic inflammatory *** the postvascular phase,CEUS showed contrast defect of cystic areas and delayed enhancement of solid areas;most likely due to aggregation of *** discriminating between a benign and malignant schwannoma of the liver is difficult,surgery is generally ***,the two key findings from CEUS may be useful in discriminating ancient schwannoma by recognizing the hemorrhage involved in the secondary degeneration and aggregation of siderophores.

关键词： Liver schwannoma Contrast-enhanced ul-trasonography Liver resection

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Neural plasticity in Parkinson's disease:a neuroimaging perspective

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Neural Regeneration Research 2024年第6期19卷 1203-1205页

作者： Christina Andica koji Kamagata Department of Radiology Juntendo University Graduate School of MedicineTokyoJapan Faculty of Health Data Science Juntendo UniversityChibaJapan

Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least *** disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.

关键词： rigidity tremor primarily

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Evaluation of excavation damaged zones(EDZs)in Horonobe Underground Research Laboratory(URL)

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 365-378页

作者： koji Hata Sumio Niunoya Kazuhei Aoyagi Nobukatsu Miyara Obayashi Corporation Technology Research InstituteTechnology DivisionKiyoseTokyo204-8558Japan Obayashi Corporation Nuclear Facilities DivisionSinagawaTokyo108-8502Japan Japan Atomic Energy Agency Horonobe Underground Research CenterHoronobeHokkaido098-3224Japan

Excavation of underground caverns,such as mountain tunnels and energy-storage caverns,may cause the damages to the surrounding rock as a result of the stress *** this influenced zone,new cracks and discontinuities are created or propagate in the rock ***,it is effective to measure and evaluate the acoustic emission(AE)events generated by the rocks,which is a small elastic vibration,and permeability *** authors have developed a long-term measurement device that incorporates an optical AE(O-AE)sensor,an optical pore pressure sensor,and an optical temperature sensor in a single multi-optical measurement probe(MOP).Japan Atomic Energy Agency has been conducting R&D activities to enhance the reliability of high-level radioactive waste(HLW)deep geological disposal *** a high-level radioactive disposal project,one of the challenges is the development of methods for long-term monitoring of rock mass ***,in January 2014,the long-term measurements of the hydro-mechanical behavior of the rock mass were launched using the developed MOP in the vicinity of 350 m below the surface at the Horonobe Underground Research *** measurement results show that AEs occur frequently up to 1.5 m from the wall during *** addition,hydraulic conductivity increased by 2e4 orders of *** analysis revealed that the hydraulic behavior of the rock mass affected the pore pressure fluctuations and caused *** on this,a conceptual model is developed to represent the excavation damaged zone(EDZ),which contributes to the safe geological disposal of radioactive waste.

关键词： Excavation damaged zone(EDZ) Optical sensor Long-term monitoring Acoustic emission(AE) Shaft sinking

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Stochastic and Distributed Optimal Energy Management of Active Distribution Networks Within Integrated Office Buildings

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 504-517页

作者： Zening Li Su Su Xiaolong Jin Mingchao Xia Qifang Chen koji Yamashita National Active Distribution Network Technology Research Center Beijing Jiaotong UniversityBeijing 100044China Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China Electrical and Computer Engineering University of California RiversideCA92521USA.

This paper proposes a stochastic and distributed optimal energy management approach for active distribution networks(ADNs)within office *** proposed approach aims at scheduling office buildings fitted with heating ventilation and air conditioning(HVAC)systems,and electric vehicle(EV)charging piles,to participate in the ADN ***,an energy management approach for the ADN with aggregated office buildings is *** the ADN optimization model is formulated considering the detailed building thermal dynamics and the mobile behaviors of ***,to consider un-certainties of photovoltaic(PV)power,scenario-based stochastic programming is integrated into the ADN optimization *** further realize the stochastic energy management of the ADN within office buildings in a distributed manner,the alternating direction method of multipliers(ADMM)is used to solve the ADN optimization *** original ADN optimization problem is divided into the network-side and the building-side sub-problems to effectively protect the privacy of the ADN and the office ***,the ADN optimization model incorporating office buildings is validated in the winter by numerical *** addition,the impacts of comfort temperature range and expected state of charge(SOC)at departure are *** Terms—ADN,EV,HVAC system,Office building,Stochastic and distributed energy management.

关键词： ADN EV HVAC system Office building Stochastic and distributed energy management

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Impact of Microstructural and Surface Modifications on the Ti-45Nb Alloy’s Response to Bio-Environment

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1215-1230页

作者： Ivana Cvijović-Alagić Slađana Laketić MilošMomčilović Jovan Ciganović Jelena Bajat Vesna kojić Vinča Institute of Nuclear Sciences-National Institute of the Republic of Serbia University of BelgradeMike Petrovića Alasa 12-1411000BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411000BelgradeSerbia Oncology Institute of Vojvodina Faculty of MedicineUniversity of Novi SadPut Doktora Goldmana 4Sremska Kamenica21204Sremska KamenicaSerbia

The Ti-45Nb (mass%) alloy’s corrosive and biocompatible response in simulated physiological conditions was investigated before and after its additional high-pressure torsion (HPT) and laser irradiation processing. The grain size reduction from 2.76 µm to ~ 200 nm and the appearance of laser-induced morphologically altered and highly oxidized surface led to the significant improvement of alloy corrosion resistance and cell–implant interaction. Moreover, an additional increase of the laser pulse energy from 5 to 15 mJ during the alloy irradiation in the air led to an increase in the surface oxygen content from 13.64 to 23.89% accompanied by an increase of excellent cell viability from 127.18 to 134.42%. As a result of the controlled alloy microstructural and surface modifications, the formation of protective bi-modal mixed Ti- and Nb-oxide external scale was enabled. The presence of this surface oxide scale enhanced the alloy’s resistance to corrosion deterioration and simultaneously boosted cell viability and proliferation.

关键词： Ti-45Nb alloy High-pressure torsion Laser surface scanning Corrosion resistance Biocompatible properties

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Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro kojima Kenji Watanabe Mikio Kawai Soichi Yagi koji Kaku Maiko Ikenouchi Toshiyuki Sato koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

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