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A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 175-184页

作者： Katsuhisa Omagari Kazuhito Suruga Akira Kyogoku Satomi Nakamura Ai Sakamoto ShintaNishioka Mayuko Ichimura Yuji Miyata koichi tajima koichi Tsuneyama Kazunari Tanaka Department of Nutrition Faculty of Nursing and NutritionGraduate School of Human Health ScienceUniversity of NagasakiNagasakiJapan Division of Nutritional Science Graduate School of Human Health ScienceUniversity of NagasakiNagasakiJapan Agriculture and Forestry Technical Development Center Nagasaki PrefTea LaboratoryNagasakiJapan Agriculture and Forestry Technical Development Center Nagasaki PrefForest Research SectionNagasakiJapan Department of Pathology and Laboratory Medicine Tokushima University Graduate SchoolTokushimaJapan

Background:Established treatments for non-alcoholic steatohepatitis (NASH) are few, thus it is imperative to develop novel dietary strategies that can prevent NASH. A fermented mixed tea (FMT) made with Camellia japonica (Japanese camellia) and third- crop green tea leaves by tea-rolling processing was reported to reduce body weight and adipose tissue weight in Sprague-Dawley (SD) rats. Because visceral fat is one of the most important factors for the development of hepatic steatosis, this FMT supplementation can be a candidate dietary strategy for the prevention of NASH. Methods:Nine-week-old male SD rats were fed a high-fat and high-cholesterol (HFC) diets with or without FMT (camellia and third-crop green tea leaves at ratios of 1:5, 1:2 and 1:1) for 9 weeks (n=6–7/group). Histopathology, serology and expressions of ifbrogenetic, proinlfammatory, oxidative stress and lipid metabolism-related genes in the liver were evaluated. Results:Histologically, HFC diet with FMT at a ratio of 1:5 dramatically reduced NASH progression (14%) compared to the HFC diet without FMT (100%). FMT at a ratio of 1:5 reduced hepatic steatosis due to the activation of microsomal triglyceride transfer protein, and FMT at a ratio of 1:2 reduced mRNA levels of some proinlfammatory, lipid metabolism-related, ifbrogenic and oxidative stress marker genes. Conclusions:Our data suggest that FMT at a ratio of 1:5 or 1:2 likely possesses a preventive effect on NASH progression.

关键词： Camellia leaves green tea leaves fermented tea nonalcoholic steatohepatitis high-fat and high-cholesterol (HFC) diet

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Involuntary muscle spasm expressed as motor evoked potential after olfactory mucosa autograft in patients with chronic spinal cord injury and complete paraplegia

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Journal of Biomedical Science and Engineering 2013年第9期6卷 908-916页

作者： koichi Iwatsuki Toshiki Yoshimine Yoshiyuki Sankai Fumihiro tajima Masao Umegaki Yu-Ichiro Ohnishi Masahiro Ishihara Koshi Ninomiya Takashi Moriwaki Department of Neurosurgery Osaka University Medical SchoolOsakaJapan Faculty of Engineering‚Information and Systems University of TsukubaTsukubaJapan Department of Rehabilitation Wakayama Medical UniversityWakayamaJapan

Object: The efficacy of olfactory mucosa autograft (OMA) for chronic spinal cord injury has been reported. New activity in response to voluntary effort has been documented by electromyography (EMG), but the emergence of motor evoked potential (MEP) reflecting electrophysiological conductivity in the central nervous system, including the corticospinal pathway, after OMA, and the best indications for OMA, have not been clarified. Here, we report the emergence of MEPs after OMA and offer recom-mendations for appropriate indications based on the presence of involuntary muscle spasm (IMS). We used analysis of MEP to examine the efficacy of OMA for patients with complete paraplegia due to chronic spinal cord injury. To clarify the indications for OMA, we investigated the association of IMS and efficacy of OMA. Methods: Four patients, 3 men and 1 woman, were enrolled. The mean age of the cases was 30.3 ± 9.5 years (range, 19 to 40 years). All 4 cases were American Spinal Injury Association (ASISA) grade A. The mean duration from injury to OMA was 95.8 ± 68.2 months (range, 17 to 300 months). Samples of olfactory mucosa were removed, cut into smaller pieces, and grafted into the sites of spinal cord lesions after laminectomy. Postoperative subcutaneous fluid collection, postoperative meningitis, postoperative nosebleed, postoperative infection in the nasal cavity, impaired olfaction, neoplastic tissue overgrowth at the autograft site, new sensory disturbance, and involuntary muscle spasm were investigated as safety issues. Improvements in ASIA grade, variations in ASIA scores, EMG, SSEP, and improved urological function were evaluated as efficacy indicators. Results: There were no serious adverse events in this series. In 2 of the 4 cases, an improvement in motor function below the level of injury was recognized. In one, the motor score was 50 until 16 weeks after surgery, and it increased to 52 from 20 weeks after surgery. In the other, the motor score was 50 until 20 week

关键词： Olfactory Mucosa Autograft Spinal Cord Injury Transplantation Voluntary Movement Motor Evoked Potential

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High-intensity laser-driven particle and electromagnetic wave sources for science, industry, and medicine

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Frontiers of Optoelectronics 2009年第3期2卷 299-303页

作者： Akito SAGISAKA Hiroyuki DAIDO Alexander S.PIROZHKOV Michiaki MORI Akifumi YOGO koichi OGURA Satoshi ORIMO Mamiko NISHIUCHI Jinglong MA Hiromitsu KIRIYAMA Shuhei KANAZAWA Shuji KONDO Yoshiki NAKAI Takuya SHIMOMURA Manabu TANOUE Atsushi AKUTSU Hajime OKADA Tomohiro MOTOMURA Tetsuya KAWACHI Sergei V.BULANOV Timur Zh.ESIRKEPOV Shigeki NASHIMA Makoto HOSODA Hideo NAGATOMO Yuji OISHI Koshichi NEMOTO Il Woo CHOI Seong Ku LEE Jongmin LEE Advanced Photon Research Center and Photo-Medical Research Center Japan Atomic Energy Agency A.M.Prokhorov Institute of General Physics Russian Academy of Sciences Moscow Institute of Physics and Technology Department of Applied Physics Graduate School and Faculty of Engineering Osaka City University Institute of Laser Engineering Osaka University Central Research Institute of Electric Power Industry Advanced Photonics Research Institute Gwangju Institute of Science and Technology

We simultaneously observed both the fast proton generation and terahertz(THz) radiation in the laser pulse interaction with a thin-foil target. The maximum proton energy of ～2.3 Me V and an intense THz radiation were observed at the pulse duration of～30 fs. We also measured the proton beam and UV harmonics from a thin-foil target by changing the laser pulse duration. In the case of the ～500 fs, peaks of UV harmonics up to fourth order appeared. This unique combination of the multiple beams will provide useful applications such as pump-probe experiments.

关键词： high-intensity laser thin-foil target plasma proton electromagnetic wave

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